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    Immunomodulating polymers
    1.
    发明授权
    Immunomodulating polymers 有权
    免疫调节聚合物

    公开(公告)号：US07026285B2

    公开(公告)日：2006-04-11

    申请号：US10848779

    申请日：2004-05-19

    申请人： Arthur O. Tzianabos ,  Dennis L. Kasper ,  Andrew B. Onderdonk ,  Julia Ying Wang

    发明人： Arthur O. Tzianabos ,  Dennis L. Kasper ,  Andrew B. Onderdonk ,  Julia Ying Wang

    IPC分类号： A61K47/36 ,  A61K47/42

    CPC分类号： A61K31/715 ,  A61K31/785 ,  A61K35/742 ,  A61K38/00 ,  A61K45/06

    摘要： Methods and products for inducing IL-2 secretion, inducing IL-10 secretion, activating T cells, suppressing IgG antibody response to specific antigen, promoting allograft survival, reducing postoperative surgical adhesion formation, and protecting against abscess formation associated with surgery, trauma or diseases that predispose the host to abscess formation are provided. The methods of the invention are accomplished using an immunomodulator which is a polymer having at least two repeating charge motifs separated by at least a certain minimum distance.

    摘要翻译： 用于诱导IL-2分泌，诱导IL-10分泌，激活T细胞，抑制对特异性抗原的IgG抗体应答，促进同种异体移植物存活，减少术后外科粘连形成以及防止与手术，创伤或疾病相关的脓肿形成的方法和产品 提供宿主脓肿形成的易感性。 本发明的方法是使用免疫调节剂完成的，所述免疫调节剂是具有至少两个重复电荷基序的聚合物，所述至少两个重复电荷基序至少隔开一定的最小距离。

    Immunomodulating polymers
    2.
    发明授权
    Immunomodulating polymers 有权
    免疫调节聚合物

    公开(公告)号：US07083777B1

    公开(公告)日：2006-08-01

    申请号：US09540024

    申请日：2000-03-31

    申请人： Arthur O. Tzianabos ,  Dennis L. Kasper ,  Andrew B. Onderdonk ,  Ying Wang

    发明人： Arthur O. Tzianabos ,  Dennis L. Kasper ,  Andrew B. Onderdonk ,  Ying Wang

    IPC分类号： A61K38/16 ,  A61K38/20

    CPC分类号： A61K31/715 ,  A61K31/785 ,  A61K35/742 ,  A61K38/00 ,  A61K45/06

    摘要： A pharmaceutical composition consisting of identical repeating units, each unit having a charge motif composed of a positively charged free amino moiety and a negatively charged moiety, wherein the positively charged free amino moiety and the negatively charged moiety of each charge motif are separated by at least one neutral amino acid, and wherein the positively charged free amino moiety of one of the charge motifs is separated by a distance of at least 8 amino acids from the positively charged amino moiety of another charge motif, and a pharmaceutically acceptable carrier. Said pharmaceutical composition is useful for inducing IL-2, activating T cells to produce a T helper 1 cytokine profile, suppressing IgG antibody response to specific antigen, promoting allograft survival, reducing postoperative surgical adhesion formation, and/or protecting against abscess formation associated with surgery, trauma or diseases that predispose the host to abscess formation.

    摘要翻译： 由相同的重复单元组成的药物组合物，每个单元具有由带正电的游离氨基部分和带负电荷的部分组成的电荷基序，其中带电荷的游离氨基部分和每个电荷基序的带负电荷的部分至少分开 一个中性氨基酸，并且其中一个电荷基序的带正电荷的游离氨基部分与另一个电荷基序的带正电荷的氨基部分至少8个氨基酸的距离和药学上可接受的载体分开。 所述药物组合物可用于诱导IL-2，激活T细胞以产生T辅助细胞1细胞因子谱，抑制IgG抗体对特异性抗原的反应，促进同种异体移植物存活，减少术后外科粘连形成和/或防止与 手术，外伤或易导致脓肿形成的疾病。

    Method for overexpression of zwitterionic polysaccharides
    8.
    发明授权
    Method for overexpression of zwitterionic polysaccharides 有权
    两性离子多糖过表达方法

    公开(公告)号：US07803602B2

    公开(公告)日：2010-09-28

    申请号：US11894552

    申请日：2007-08-20

    申请人： Laurie E. Comstock ,  Katja G. Weinacht ,  Michael J. Coyne ,  Dennis L. Kasper ,  Arthur O. Tzianabos

    发明人： Laurie E. Comstock ,  Katja G. Weinacht ,  Michael J. Coyne ,  Dennis L. Kasper ,  Arthur O. Tzianabos

    IPC分类号： C12N1/20 ,  C12N15/87 ,  C12N15/74 ,  C12P21/06 ,  C12P19/04 ,  C12P19/34 ,  A01N63/00

    CPC分类号： C12P19/04 ,  C07K14/195 ,  C07K2319/00

    摘要： The present invention is directed to methods for producing and selecting new mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; compositions directed to the new mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; improved methods for purification of individual capsular polysaccharides; and compositions directed to new res02 and inv19 genes and their gene products. Significantly, the present invention provides methods and compositions for overexpressing and purifying immunomodulatory capsular polysaccharide A (PSA) in high yield.

    摘要翻译： 本发明涉及用于生产和选择组成型表达特定荚膜多糖或仅选择的荚膜多糖的脆弱杆菌的新突变菌株的方法; 针对组成型表达特定荚膜多糖或仅选择的荚膜多糖的脆弱脆弱病毒的新突变菌株的组合物; 改进单个荚膜多糖纯化方法; 以及针对新的res02和inv19基因及其基因产物的组合物。 显着地，本发明提供了以高产率过量表达和纯化免疫调节荚膜多糖A（PSA）的方法和组合物。