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公开(公告)号：US06710088B2
公开(公告)日：2004-03-23
申请号：US10060959
申请日：2002-01-29
申请人： Scott T. Moe , Bradford C. Van Wagenen , Eric G. DelMar , Richard Trovato , Manuel F. Balandrin
发明人： Scott T. Moe , Bradford C. Van Wagenen , Eric G. DelMar , Richard Trovato , Manuel F. Balandrin
IPC分类号： A61K31135
CPC分类号： C07C255/58 , A61K31/137 , A61K31/36 , C07C211/29 , C07C211/30 , C07C217/58 , C07C217/62 , C07C255/54 , C07C2601/02 , C07D307/81 , C07D317/58
摘要： The present invention features compounds able to modulate one or more activities of an inorganic ion receptor and methods for treating diseases or disorders using such compounds. Preferred compounds can mimic or block the effect of extracellular calcium on a cell surface calcium receptor.
摘要翻译： 本发明的特征在于能够调节一种或多种无机离子受体活性的化合物和使用这些化合物治疗疾病或病症的方法。 优选的化合物可以模拟或阻断细胞外钙对细胞表面钙受体的作用。
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公开(公告)号：US5981599A
公开(公告)日：1999-11-09
申请号：US846721
申请日：1997-04-30
申请人： Scott T. Moe , Bradford C. Van Wagenen , Eric G. DelMar , Richard Trovato , Manuel F. Balandrin
发明人： Scott T. Moe , Bradford C. Van Wagenen , Eric G. DelMar , Richard Trovato , Manuel F. Balandrin
IPC分类号： C07C211/58 , A61K31/00 , A61K31/135 , A61K31/137 , A61K31/138 , A61K31/36 , A61P3/00 , A61P3/14 , A61P5/00 , A61P5/16 , A61P9/00 , A61P9/12 , A61P19/00 , A61P19/10 , C07C211/29 , C07C211/30 , C07C217/58 , C07C217/62 , C07C217/92 , C07C255/54 , C07C255/58 , C07D307/81 , C07D317/58
CPC分类号： C07C255/58 , A61K31/137 , A61K31/36 , C07C211/29 , C07C211/30 , C07C217/58 , C07C217/62 , C07C255/54 , C07D307/81 , C07D317/58 , C07C2101/02
摘要： The present invention features compounds able to modulate one or more activities of an inorganic ion receptor and methods for treating diseases or disorders using such compounds. Preferred compounds can mimic or block the effect of extracellular calcium on a cell surface calcium receptor.
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公开(公告)号：US06342532B1
公开(公告)日：2002-01-29
申请号：US09415179
申请日：1999-10-06
申请人： Scott T. Moe , Bradford C. Van Wagenen , Eric G. DelMar , Richard Trovato , Manuel F. Balandrin
发明人： Scott T. Moe , Bradford C. Van Wagenen , Eric G. DelMar , Richard Trovato , Manuel F. Balandrin
IPC分类号： A61K31137
CPC分类号： C07C255/58 , A61K31/137 , A61K31/36 , C07C211/29 , C07C211/30 , C07C217/58 , C07C217/62 , C07C255/54 , C07C2601/02 , C07D307/81 , C07D317/58
摘要： The present invention features compounds able to modulate one or more activities of an inorganic ion receptor and methods for treating diseases or disorders using such compounds. Preferred compounds can mimic or block the effect of extracellular calcium on a cell surface calcium receptor.
摘要翻译： 本发明的特征在于能够调节一种或多种无机离子受体活性的化合物和使用这些化合物治疗疾病或病症的方法。 优选的化合物可以模拟或阻断细胞外钙对细胞表面钙受体的作用。
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公开(公告)号：US6001884A
公开(公告)日：1999-12-14
申请号：US469204
申请日：1995-06-06
申请人： Edward F. Nemeth , Bradford C. Van Wagenen , Manuel F. Balandrin , Eric G. Delmar , Scott T. Moe
发明人： Edward F. Nemeth , Bradford C. Van Wagenen , Manuel F. Balandrin , Eric G. Delmar , Scott T. Moe
IPC分类号： A61K31/13 , A61K31/135 , A61K31/137 , A61K31/165 , A61K31/195 , A61K31/215 , A61K31/275 , A61K31/335 , A61K31/34 , A61K31/35 , A61K31/36 , A61K31/38 , A61K31/395 , A61K31/40 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/55 , A61K31/715 , A61K38/16 , C07C211/27 , C07C211/29 , C07C211/30 , C07C211/42 , C07C215/52 , C07C217/58 , C07C217/60 , C07C217/62 , C07C225/16 , C07C229/38 , C07C233/05 , C07C255/58 , C07C317/32 , C07C323/32 , C07D209/14 , C07D209/16 , C07D209/18 , C07D213/38 , C07D233/54 , C07D319/18 , C07K14/705 , G01N33/50 , G01N33/566 , G01N33/567 , G01N33/68 , G01N33/84 , A01N35/00
CPC分类号： G01N33/5044 , A61K31/13 , A61K31/135 , A61K31/137 , A61K31/165 , A61K31/195 , A61K31/215 , A61K31/275 , A61K31/335 , A61K31/34 , A61K31/35 , A61K31/36 , A61K31/38 , A61K31/395 , A61K31/40 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/55 , A61K31/70 , A61K31/715 , A61K38/16 , C07C211/27 , C07C211/29 , C07C211/30 , C07C211/42 , C07C215/52 , C07C217/58 , C07C217/60 , C07C217/62 , C07C225/16 , C07C229/38 , C07C233/05 , C07C255/58 , C07C317/32 , C07C323/32 , C07D209/14 , C07D209/16 , C07D209/18 , C07D213/38 , C07D233/64 , C07D319/18 , C07K14/705 , G01N33/5008 , G01N33/5014 , G01N33/5041 , G01N33/5091 , G01N33/566 , G01N33/567 , G01N33/6872 , G01N33/6893 , G01N33/84 , A01K2227/50 , C07C2101/14 , G01N2500/10 , G01N2800/04
摘要： The present invention features molecules which can modulate one or activities of an inorganic ion receptor. Preferably, the molecule can mimic or block the effect of extracellular Ca.sup.2+ on a calcium receptor. The preferred use of such molecules is to treat diseases or disorders by altering inorganic ion receptor activity, preferably calcium receptor activity.
摘要翻译： 本发明的特征在于可以调节一种或多种无机离子受体活性的分子。 优选地，分子可以模拟或阻断细胞外Ca 2+对钙受体的作用。 这种分子的优选用途是通过改变无机离子受体活性，优选钙受体活性来治疗疾病或病症。
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公开(公告)号：US06211244B1
公开(公告)日：2001-04-03
申请号：US08546998
申请日：1995-10-23
申请人： Bradford C. Van Wagenen , Scott T. Moe , Manuel F. Balandrin , Eric G. DelMar , Edward F. Nemeth
发明人： Bradford C. Van Wagenen , Scott T. Moe , Manuel F. Balandrin , Eric G. DelMar , Edward F. Nemeth
IPC分类号： A61K31135
CPC分类号： G01N33/6872 , A61K31/135 , A61K31/137 , C07C211/27 , C07C211/28 , C07C211/30 , C07C217/58 , C07C217/62 , C07C225/16 , C07C317/32 , C07C323/32 , C07D319/18 , G01N33/566 , G01N2500/10 , G01N2800/04
摘要： The present invention features compounds able to modulate one or more activities of an inorganic ion receptor and methods for treating diseases or disorders by modulating inorganic ion receptor activity. Preferably, the compound can mimic or block the effect of extracellular Ca2+ on a calcium receptor.
摘要翻译： 本发明具有能够调节一种或多种无机离子受体活性的化合物和通过调节无机离子受体活性来治疗疾病或病症的方法。 优选地，化合物可以模拟或阻断细胞外Ca 2+对钙受体的作用。
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公开(公告)号：US6011068A
公开(公告)日：2000-01-04
申请号：US353784
申请日：1994-12-08
申请人： Edward F. Nemeth , Bradford C. Van Wagenen , Manuel F. Balandrin , Eric G. DelMar , Scott T. Moe
发明人： Edward F. Nemeth , Bradford C. Van Wagenen , Manuel F. Balandrin , Eric G. DelMar , Scott T. Moe
IPC分类号： A61K31/135 , A61K20060101 , A61K31/13 , A61K31/137 , A61K31/165 , A61K31/195 , A61K31/215 , A61K31/275 , A61K31/335 , A61K31/34 , A61K31/35 , A61K31/36 , A61K31/38 , A61K31/395 , A61K31/40 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/55 , A61K31/715 , A61K38/16 , A61P3/00 , A61P3/14 , A61P9/12 , A61P19/10 , A61P43/00 , C07C20060101 , C07C211/27 , C07C211/29 , C07C211/30 , C07C211/42 , C07C215/50 , C07C215/52 , C07C217/58 , C07C217/60 , C07C217/62 , C07C219/28 , C07C225/16 , C07C229/38 , C07C233/05 , C07C237/30 , C07C255/58 , C07C317/32 , C07C323/32 , C07D209/14 , C07D209/16 , C07D209/18 , C07D213/38 , C07D233/54 , C07D317/58 , C07D319/18 , C07K14/705 , C12N15/12 , G01N33/50 , G01N33/566 , G01N33/567 , G01N33/68 , G01N33/84 , C07C211/00 , C07C213/00
CPC分类号： G01N33/5044 , A61K31/13 , A61K31/135 , A61K31/137 , A61K31/165 , A61K31/195 , A61K31/215 , A61K31/275 , A61K31/335 , A61K31/34 , A61K31/35 , A61K31/36 , A61K31/38 , A61K31/395 , A61K31/40 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/55 , A61K31/70 , A61K31/715 , A61K38/16 , C07C211/27 , C07C211/29 , C07C211/30 , C07C211/42 , C07C215/52 , C07C217/58 , C07C217/60 , C07C217/62 , C07C225/16 , C07C229/38 , C07C233/05 , C07C255/58 , C07C317/32 , C07C323/32 , C07D209/14 , C07D209/16 , C07D209/18 , C07D213/38 , C07D233/64 , C07D319/18 , C07K14/705 , G01N33/5008 , G01N33/502 , G01N33/5091 , G01N33/566 , G01N33/567 , G01N33/6872 , G01N33/6893 , G01N33/84 , A01K2227/50 , C07C2101/14 , G01N2500/10 , G01N2800/04
摘要： The present invention relates to the different roles inorganic ion receptors have in cellular and body processes. The present invention features: (1) molecules which can modulate one or more inorganic ion receptor activities, preferably the molecule can mimic or block an effect of an extracellular ion on a cell having an inorganic ion receptor, more preferably the extracellular ion is Ca.sup.2+ and the effect is on a cell having a calcium receptor; (2) inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (3) nucleic acids encoding inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (4) antibodies and fragments thereof, targeted to inorganic ion receptor proteins, preferably calcium receptor protein; and (5) uses of such molecules, proteins, nucleic acids and antibodies.
摘要翻译： 本发明涉及无机离子受体在细胞和身体过程中的不同作用。 本发明的特征在于：（1）可以调节一种或多种无机离子受体活性的分子，优选地该分子可以模拟或阻断细胞外离子对具有无机离子受体的细胞的影响，更优选细胞外离子是Ca 2+和 该效果在具有钙受体的细胞上; （2）无机离子受体蛋白及其片段，优选钙受体蛋白及其片段; （3）编码无机离子受体蛋白质及其片段的核酸，优选钙受体蛋白及其片段; （4）抗体及其片段，靶向无机离子受体蛋白，优选钙受体蛋白; 和（5）使用这些分子，蛋白质，核酸和抗体。
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7.发明授权Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases 有权在用于治疗神经障碍和疾病的受体操作的钙通道上的新位点处有活性的化合物
公开(公告)号：US6051610A
公开(公告)日：2000-04-18
申请号：US252433
申请日：1999-02-18
申请人： Alan L. Mueller , Manuel F. Balandrin , Bradford C. Van Wagenen , Eric G. DelMar , Scott T. Moe , Linda D. Artman , Robert M. Barmore
发明人： Alan L. Mueller , Manuel F. Balandrin , Bradford C. Van Wagenen , Eric G. DelMar , Scott T. Moe , Linda D. Artman , Robert M. Barmore
IPC分类号： C07D295/02 , A61K31/135 , A61K31/136 , A61K31/137 , A61K31/138 , A61K31/155 , A61K31/165 , A61K31/295 , A61K31/38 , A61K31/381 , A61K31/395 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/405 , A61K31/44 , A61K31/4409 , A61K31/445 , A61K31/4462 , A61K31/4465 , A61K31/451 , A61K31/495 , A61P25/00 , A61P25/08 , A61P25/28 , A61P43/00 , C07C211/26 , C07C211/27 , C07C211/28 , C07C211/29 , C07C211/40 , C07C211/54 , C07C215/28 , C07C215/54 , C07C217/10 , C07C217/18 , C07C217/26 , C07C217/48 , C07C217/60 , C07C217/62 , C07C217/72 , C07C233/13 , C07C233/22 , C07C235/34 , C07C237/22 , C07C279/14 , C07D207/08 , C07D207/12 , C07D207/20 , C07D209/18 , C07D209/42 , C07D211/10 , C07D211/18 , C07D213/30 , C07D213/38 , C07D227/00 , C07D333/20 , C07C211/35
CPC分类号： C07D207/08 , A61K31/135 , A61K31/136 , A61K31/137 , A61K31/138 , A61K31/155 , A61K31/165 , A61K31/295 , A61K31/381 , A61K31/40 , A61K31/4409 , A61K31/4462 , A61K31/4465 , C07C211/27 , C07C211/28 , C07C211/29 , C07C211/40 , C07C211/54 , C07C215/28 , C07C215/54 , C07C217/10 , C07C217/48 , C07C217/60 , C07C217/62 , C07C233/13 , C07C233/22 , C07C235/34 , C07C237/22 , C07C279/14 , C07D207/12 , C07D207/20 , C07D209/42 , C07D211/18 , C07D213/30 , C07D213/38 , C07D333/20 , C07B2200/07 , C07C2101/08 , C07C2101/14
摘要： Method and compositions for treating a patient having a neurological disease or disorder, such as stroke, head trauma, spinal cord injury, epilepsy, anxiety, or neurodegenerative diseases such as Alzheimer's Disease, Huntington's Disease, Parkinson's Disease, or amyotrophic lateral sclerosis (ALS).
摘要翻译： 用于治疗患有神经系统疾病或病症（例如中风，头部外伤，脊髓损伤，癫痫，焦虑或神经变性疾病如阿尔茨海默氏病，亨廷顿病，帕金森病或肌萎缩性侧索硬化症（ALS））的患者的方法和组合物， 。
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公开(公告)号：US6031003A
公开(公告)日：2000-02-29
申请号：US484719
申请日：1995-06-07
申请人： Edward F. Nemeth , Bradford C. Van Wagenen , Manuel F. Balandrin , Eric G. DelMar , Scott T. Moe
发明人： Edward F. Nemeth , Bradford C. Van Wagenen , Manuel F. Balandrin , Eric G. DelMar , Scott T. Moe
IPC分类号： A61K31/13 , A61K31/135 , A61K31/137 , A61K31/165 , A61K31/195 , A61K31/215 , A61K31/275 , A61K31/335 , A61K31/34 , A61K31/35 , A61K31/36 , A61K31/38 , A61K31/395 , A61K31/40 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/55 , A61K31/715 , A61K38/16 , C07C211/27 , C07C211/29 , C07C211/30 , C07C211/42 , C07C215/52 , C07C217/58 , C07C217/60 , C07C217/62 , C07C225/16 , C07C229/38 , C07C233/05 , C07C255/58 , C07C317/32 , C07C323/32 , C07D209/14 , C07D209/16 , C07D209/18 , C07D213/38 , C07D233/54 , C07D319/18 , C07K14/705 , G01N33/50 , G01N33/566 , G01N33/567 , G01N33/68 , G01N33/84 , A01N33/02 , A01N37/18
CPC分类号： A61K31/13 , A61K31/135 , A61K31/137 , A61K31/165 , A61K31/195 , A61K31/215 , A61K31/275 , A61K31/335 , A61K31/34 , A61K31/35 , A61K31/36 , A61K31/38 , A61K31/395 , A61K31/40 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/55 , A61K31/70 , A61K31/715 , A61K38/16 , C07C211/27 , C07C211/29 , C07C211/30 , C07C211/42 , C07C215/52 , C07C217/58 , C07C217/60 , C07C217/62 , C07C225/16 , C07C229/38 , C07C233/05 , C07C255/58 , C07C317/32 , C07C323/32 , C07D209/14 , C07D209/16 , C07D209/18 , C07D213/38 , C07D233/64 , C07D319/18 , C07K14/705 , G01N33/5008 , G01N33/5014 , G01N33/502 , G01N33/5041 , G01N33/5044 , G01N33/5091 , G01N33/566 , G01N33/567 , G01N33/6872 , G01N33/6893 , G01N33/84 , A01K2227/50 , C07C2101/14 , G01N2500/10 , G01N2800/04
摘要： The present invention relates to the different roles inorganic ion receptors have in cellular and body processes. The present invention features: (1) molecules which can modulate one or more inorganic ion receptor activities, preferably the molecule can mimic or block an effect of an extracellular ion on a cell having an inorganic ion receptor, more preferably the extracellular ion is Ca.sup.2+ and the effect is on a cell having a calcium receptor; (2) inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (3) nucleic acids encoding inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (4) antibodies and fragments thereof, targeted to inorganic ion receptor proteins, preferably calcium receptor protein; and (5) uses of such molecules, proteins, nucleic acids and antibodies.
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公开(公告)号：US06313146B1
公开(公告)日：2001-11-06
申请号：US08484159
申请日：1995-06-07
IPC分类号： A01N4340
CPC分类号： A61K31/13 , A01K2227/50 , A61K31/135 , A61K31/137 , A61K31/165 , A61K31/195 , A61K31/215 , A61K31/275 , A61K31/335 , A61K31/34 , A61K31/35 , A61K31/36 , A61K31/38 , A61K31/395 , A61K31/40 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/55 , A61K31/70 , A61K31/715 , A61K38/16 , C07C211/27 , C07C211/29 , C07C211/30 , C07C211/42 , C07C215/52 , C07C217/58 , C07C217/60 , C07C217/62 , C07C225/16 , C07C229/38 , C07C233/05 , C07C255/58 , C07C317/32 , C07C323/32 , C07C2601/14 , C07D209/14 , C07D209/16 , C07D209/18 , C07D213/38 , C07D233/64 , C07D319/18 , C07K14/705 , G01N33/5008 , G01N33/502 , G01N33/5044 , G01N33/5091 , G01N33/566 , G01N33/567 , G01N33/6872 , G01N33/6893 , G01N33/84 , G01N2500/10 , G01N2800/04
摘要： The present invention relates to the different roles inorganic ion receptors have in cellular and body processes. The present invention features: (1) molecules which can modulate one or more inorganic ion receptor activities, preferably the molecule can mimic or block an effect of an extracellular ion on a cell having an inorganic ion receptor, more preferably the extracellular ion is Ca2+ and the effect is on a cell having a calcium receptor; (2) inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (3) nucleic acids encoding inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (4) antibodies and fragments thereof, targeted to inorganic ion receptor proteins, preferably calcium receptor protein; and (5) uses of such molecules, proteins, nucleic acids and antibodies.
摘要翻译： 本发明涉及无机离子受体在细胞和身体过程中的不同作用。 本发明的特征在于：（1）可以调节一种或多种无机离子受体活性的分子，优选地该分子可以模拟或阻断细胞外离子对具有无机离子受体的细胞的影响，更优选细胞外离子是Ca 2+和 该效果在具有钙受体的细胞上; （2）无机离子受体蛋白及其片段，优选钙受体蛋白及其片段; （3）编码无机离子受体蛋白质及其片段的核酸，优选钙受体蛋白及其片段; （4）抗体及其片段，靶向无机离子受体蛋白，优选钙受体蛋白; 和（5）使用这些分子，蛋白质，核酸和抗体。
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10.发明授权Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases 失效在用于治疗神经障碍和疾病的受体操作的钙通道上的新位点处有活性的化合物公开(公告)号：US06306912B1
公开(公告)日：2001-10-23
申请号：US08483294
申请日：1995-06-07
申请人： Alan L. Mueller , Bradford C. VanWagenen , Eric G. DelMar , Manuel F. Balandrin , Scott T. Moe , Linda D. Artman
发明人： Alan L. Mueller , Bradford C. VanWagenen , Eric G. DelMar , Manuel F. Balandrin , Scott T. Moe , Linda D. Artman
IPC分类号： A61K31135
CPC分类号： A61K31/135 , A61K31/136 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/295 , A61K31/381 , A61K31/40 , A61K31/404 , A61K31/4409 , A61K31/4462 , A61K31/4465 , C07C233/22 , C07C235/34 , C07C237/22 , C07C279/14 , C07D209/18 , G01N2800/28
摘要： Method for identifying a compound useful for the therapeutic treatment of a neurological disease or disorder such as stroke, head trauma, spinal cord injury, epilepsy, anxiety, or neurodegenerative diseases such as Alzheimer's Disease, Huntington's Disease or Parkinson's Disease, or useful as a muscle relaxant, analgesic, or adjuvant to general anesthetics. The compound is active on a receptor-operated calcium channel, including, but not limited to, that present as part of an NMDA receptor-ionophore complex, a calcium-permeable AMPA receptor, or a nicotinic cholinergic receptor, as a noncompetitive antagonist. The method includes identifying a compound which binds to the receptor-operated calcium channel at the site bound by the arylalkylamines Compound 1, Compound 2 or Compound 3.
摘要翻译： 用于鉴定可用于治疗性治疗诸如中风，头部创伤，脊髓损伤，癫痫，焦虑或神经变性疾病如阿尔茨海默氏病，亨廷顿舞蹈病或帕金森病的神经系统疾病或障碍的化合物或用作肌肉的化合物的方法 松弛剂，止痛剂或佐剂用于全身麻醉剂。 该化合物在受体操作的钙通道上是有活性的，包括但不限于作为非竞争性拮抗剂的NMDA受体 - 离子载体复合物，钙可渗透AMPA受体或烟碱型胆碱能受体的一部分。 该方法包括鉴定在由芳烷基胺化合物1，化合物2或化合物3结合的位点处与受体操作的钙通道结合的化合物。
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