公开(公告)号：US09345773B2

公开(公告)日：2016-05-24

申请号：US13880299

申请日：2011-08-08

申请人： Ashok Kumar ,  Rachamalla Maheedhar Reddy

发明人： Ashok Kumar ,  Rachamalla Maheedhar Reddy

IPC分类号： A61K47/32 ,  A61K9/50 ,  A61K9/51 ,  A61K31/78 ,  C08F220/56 ,  C08L33/24

CPC分类号： A61K47/32 ,  A61K9/5026 ,  A61K9/5138 ,  A61K31/78 ,  C08F220/56 ,  C08L33/24 ,  C08F220/54 ,  C08F220/34 ,  C08L29/04

摘要： Provided herein are phenylboronate containing co-polymers (PCC), compositions containing PCC and polyvinyl alcohol (PVA), such compositions further including proteins, methods of making these compositions by water in oil polymerization, and methods of using the protein containing compositions for releasing proteins. Such phenylboronate containing co-polymers are of Formula I: where m, n, p, x, R1-R5, L, X1 and X2 are defined in the application.

摘要翻译： 本文提供含苯基硼酸盐的共聚物（PCC），含有PCC和聚乙烯醇（PVA）的组合物，此类组合物还包括蛋白质，通过水中油聚合制备这些组合物的方法，以及使用含蛋白质组合物释放蛋白质的方法 。 这种苯基硼酸酯的共聚物具有式I：其中m，n，p，x，R 1 -R 5，L，X 1和X 2在本申请中定义。

公开(公告)号：US08916343B2

公开(公告)日：2014-12-23

申请号：US12931116

申请日：2011-01-24

申请人： Arun Kumar ,  Ashok Kumar ,  Shree R. Singh ,  Souheil Zekri

发明人： Arun Kumar ,  Ashok Kumar ,  Shree R. Singh ,  Souheil Zekri

IPC分类号： C12Q1/68 ,  C12M1/36 ,  G01N15/06 ,  C07H21/04 ,  G01N33/569 ,  G01N33/53

CPC分类号： G01N33/56983 ,  C12Q1/6825 ,  C12Q1/6837 ,  G01N33/5308 ,  C12Q2527/125 ,  C12Q2565/501 ,  C12Q2565/607

摘要： The subject invention concerns materials and methods for detecting nucleic acid sequences. One aspect of the invention concerns a silicon-based “biochip” comprising nucleic acid immobilized thereon. In one embodiment, the silicon comprises microcavities. The nucleic acid to be assayed for the presence of one or more target nucleic acid sequences is immobilized on the silicon. A nucleic acid, such as an oligonucleotide probe, having a sequence substantially complementary to the target nucleic acid sequence can be used to detect the immobilized nucleic acid on the silicon. If the nucleic acid used for detection hybridizes with a target nucleic acid sequence, the hybridized sequences can be detected directly or indirectly. In an exemplified embodiment, the oligonucleotide probe can be labeled with a detectable label, for example, a fluorescent molecule. The subject invention also concerns methods for detecting a target nucleic acid using a silicon-based biochip of the invention.

摘要翻译： 本发明涉及用于检测核酸序列的材料和方法。 本发明的一个方面涉及包含固定在其上的核酸的硅基“生物芯片”。 在一个实施例中，硅包括微腔。 要测定的一种或多种靶核酸序列的存在的核酸被固定在硅上。 可以使用具有与靶核酸序列基本上互补的序列的核酸，例如寡核苷酸探针，以检测硅上的固定化核酸。 如果用于检测的核酸与靶核酸序列杂交，则可以直接或间接检测杂交的序列。 在示例性实施方案中，寡核苷酸探针可以用可检测标记，例如荧光分子标记。 本发明还涉及使用本发明的硅基生物芯片检测靶核酸的方法。

公开(公告)号：US08668938B2

公开(公告)日：2014-03-11

申请号：US13575807

申请日：2010-01-29

申请人： Ashok Kumar ,  Aditi Kumar ,  Prakrati Kumar ,  Priti Kumar

发明人： Ashok Kumar ,  Aditi Kumar ,  Prakrati Kumar ,  Priti Kumar

IPC分类号： A01N65/00

CPC分类号： A61K36/23 ,  A61K36/88 ,  A61K2300/00

摘要： This invention discloses composition and manufacturing processes of a toxicity free botanical drug formulation for curative treatment of chronic diseases. It is manufactured from plants Crinum asiaticum and Crocus sativus. This drug was administered to human volunteers by oral and intranasal routes in effective amount for an effective time period. Effective amount and effective time of administration varies from one human volunteer to another depending upon age, body weight, length of disease, severity of disease, type of the disease. In vitro experiments show that this botanical drug causes proliferation and differentiation of stem cells.

摘要翻译： 本发明公开了用于治疗慢性疾病的无毒性植物药物制剂的组合物和制造方法。 它由植物Crinum asiaticum和Crocus sativus制成。 该药物通过口服和鼻内途径以有效的时间段施用于人类志愿者。 根据年龄，体重，疾病长度，疾病的严重程度，疾病的类型，有效量和有效的给药时间因人类志愿者而异。 体外实验表明，这种植物药物引起干细胞的增殖和分化。

公开(公告)号：US20130179833A1

公开(公告)日：2013-07-11

申请号：US13343909

申请日：2012-01-05

申请人： Heath Stallings ,  Omar Abou-Khamis ,  Nathan J. Maxfield ,  Ashok Kumar ,  Andrien J. Wang ,  Don G. Archer ,  Aravind Perumandla

发明人： Heath Stallings ,  Omar Abou-Khamis ,  Nathan J. Maxfield ,  Ashok Kumar ,  Andrien J. Wang ,  Don G. Archer ,  Aravind Perumandla

IPC分类号： G06F3/048

CPC分类号： G06F3/0482

摘要： An exemplary method includes a user computing device 1) determining current states, such as current integration states and/or current operational states, of software applications included in a suite of software applications relative to the user computing device, 2) identifying, based on the current states, access options for the software applications included in the suite of software applications, and 3) providing, by the user computing device for display, a graphical user interface that includes the access options configured to be selected by a user of the user computing device to access the software applications included in the suite of software applications. Corresponding methods and systems are also disclosed.

摘要翻译： 一种示例性方法包括用户计算设备1）确定包括在相对于用户计算设备的软件应用套件中的软件应用的当前状态，例如当前集成状态和/或当前操作状态，2）基于 当前状态，软件应用程序包括的软件应用程序的访问选项，以及3）由用户计算设备提供用于显示的图形用户界面，其包括被配置为由用户计算的用户选择的访问选项 设备访问软件应用程序套件中包含的软件应用程序。 还公开了相应的方法和系统。

公开(公告)号：US08412720B2

公开(公告)日：2013-04-02

申请号：US11927305

申请日：2007-10-29

申请人： Colin P. Britton ,  Ashok Kumar ,  David Bigwood ,  Anthony J. DeFusco ,  Howard Greenblatt

发明人： Colin P. Britton ,  Ashok Kumar ,  David Bigwood ,  Anthony J. DeFusco ,  Howard Greenblatt

IPC分类号： G06F17/30

CPC分类号： G06F17/30979 ,  G06F17/30448 ,  G06F17/30463 ,  G06F17/30536 ,  G06F17/30551 ,  G06F17/30893 ,  G06F17/30917 ,  Y10S707/99931 ,  Y10S707/99932 ,  Y10S707/99934 ,  Y10S707/99936

摘要： The invention provides, in one aspect, a method of searching an RDF triples data store of the type in which the triples are maintained in accord with a first storage schema. The method includes inputting a first query specifying RDF triples that are to be identified in the data store. That first query assumes either (i) that the triples are stored in a schema-less manner (i.e., with no storage schema) or (ii) that the triples are maintained in accord with a second storage schema that differs from the first. The method further includes generating, from the first query, a second query that specifies those same RDF triples, yet, that reflects the first storage schema. That second query can be applied to the RDF triples data store in order to identify and/or retrieve the desired data.

公开(公告)号：US20120185666A1

公开(公告)日：2012-07-19

申请号：US13131832

申请日：2009-11-27

申请人： M. Channabasappa ,  Harsha Sathyanarayana Naga ,  Kavita Khatawate ,  Sukanta Banik ,  Venkata Subba Raju Ganapathi Raju ,  Pramod (Das Pramod) Pramod Das ,  Ashok Kumar

发明人： M. Channabasappa ,  Harsha Sathyanarayana Naga ,  Kavita Khatawate ,  Sukanta Banik ,  Venkata Subba Raju Ganapathi Raju ,  Pramod (Das Pramod) Pramod Das ,  Ashok Kumar

IPC分类号： G06F12/02

CPC分类号： G06F17/3048 ,  G06F12/0875 ,  G06F17/30457

摘要： A query cache stores queries and corresponding results of the queries, the results of the queries being derived from a primary store. A differential store stores a pointer to data of the primary store which has changed and which affects the result of the queries stored in the query store. A new query may be satisfied by accessing the corresponding query in the query store and determining, by reference to the differential store, whether data relating to the query in the primary store has changed since the query store was compiled and, completing the new query, by accessing the corresponding data in the primary store, if applicable. Data in the differential store may be arranged and partitioned according to labels. The partitioning may be varied according to predetermined rules.

摘要翻译： 查询缓存存储查询和相应的查询结果，查询的结果从主存储派生。 差异存储器存储指向主存储器的数据的指针，其已经改变并且影响存储在查询存储器中的查询的结果。 可以通过访问查询存储器中的对应查询来满足新查询，并且通过参考差分存储来确定自从查询存储被编译以来，与主存储中的查询相关的数据是否已经改变并且完成新查询， 通过访问主存储中的相应数据（如果适用）。 差分存储器中的数据可以根据标签进行排列和分区。 划分可以根据预定的规则而变化。

公开(公告)号：US07890517B2

公开(公告)日：2011-02-15

申请号：US11064438

申请日：2005-02-23

申请人： Robert F. Angelo ,  Amir Azmi ,  Chandra Bajpai ,  Colin P. Britton ,  Noah W. Kaufman ,  Ashok Kumar ,  Darren Raybourn

发明人： Robert F. Angelo ,  Amir Azmi ,  Chandra Bajpai ,  Colin P. Britton ,  Noah W. Kaufman ,  Ashok Kumar ,  Darren Raybourn

IPC分类号： G06F17/30

CPC分类号： G06Q10/06

摘要： The invention provides apparatus, platforms and methods according to the invention provide a surveillance, monitoring and real-time events platform to (i) enable the integration and communication of information between government agencies and organizations specifically tasked with ensuring the security and safety of our nation and its communities, (ii) to integrate information systems from federal, state and/or local agencies (from disparate data sources if necessary) in order to obtain a single, real-time view of the entire organization, and (iii) to extract more complete, actionable information from their existing systems, thereby dramatically improving decision making speed and accuracy.

摘要翻译： 本发明提供了根据本发明的装置，平台和方法，提供监视，监控和实时事件平台，以（i）使得政府机构和专门负责确保我们国家安全和安全的组织之间的信息的集成和通信 （ii）整合来自联邦，州和/或地方机构的信息系统（如果需要，从不同的数据来源），以获得整个组织的单一实时视图，以及（iii）提取 来自现有系统的更完整，可操作的信息，从而大大提高决策速度和准确性。

公开(公告)号：US07847094B2

公开(公告)日：2010-12-07

申请号：US11808360

申请日：2007-06-08

申请人： Ashok Kumar ,  Dharmendra Singh ,  Swapnali Hemant Patil ,  Ganesh Devidas Mahale ,  Uttamrao Arjunrao Sawant ,  Balasaheb Ganpat Jadhav ,  Ragneshkumar Rana

发明人： Ashok Kumar ,  Dharmendra Singh ,  Swapnali Hemant Patil ,  Ganesh Devidas Mahale ,  Uttamrao Arjunrao Sawant ,  Balasaheb Ganpat Jadhav ,  Ragneshkumar Rana

IPC分类号： C07D281/16

CPC分类号： C07D281/16

摘要： Disclosed herein is an industrial preparation of Quetiapine by the reaction of 11-piperazinyldibenzo[b,f][1,4]-thiazepine or its salt with 2-(2-chloroethoxy)ethanol in presence of an organic or inorganic base under neat or aqueous condition to form 11-[4-{2-(2-hydroxyethoxy)ethyl}-1-piperazinyl]dibenzo[b,f]-[1,4]thiazepine. The quetiapine free base obtained is further converted to its hemi-fumarate salt.

摘要翻译： 本文公开的是在有机或无机碱存在下，在纯净或无机碱存在下，通过11-哌嗪基二苯并[b，f] [1,4] - 噻嗪或其盐与2-（2-氯乙氧基）乙醇的反应， 形成11- [4- {2-（2-羟基乙氧基）乙基} -1-哌嗪基]二苯并[b，f] - [1,4]硫杂吖庚因。 获得的喹硫平游离碱进一步转化为其半富马酸盐。

公开(公告)号：US20100210848A1

公开(公告)日：2010-08-19

申请号：US12681386

申请日：2008-10-03

申请人： Ashok Kumar ,  Dharmendra Singh ,  Nellithanath Thankachen Byju ,  Prasad Shankar Kadam ,  Harishankar Prahladkumar Vishwakarma ,  Vijay Ojha ,  Umeshkumar Suresh Ninawe

发明人： Ashok Kumar ,  Dharmendra Singh ,  Nellithanath Thankachen Byju ,  Prasad Shankar Kadam ,  Harishankar Prahladkumar Vishwakarma ,  Vijay Ojha ,  Umeshkumar Suresh Ninawe

IPC分类号： C07D401/12

CPC分类号： C07D401/12

摘要： The present invention discloses novel processes for preparing optically active sulphoxide compounds of formula I by asymmetric oxidation of prochiral sulphide compounds of Formula II. More particularly, the invention discloses processes for preparation of optically active proton pump Inhibitors (PPIs) or their optically active precursor (=intermediate) compounds (Formula I) that can be converted into pharmaceutically useful PPIs.

摘要翻译： 本发明公开了通过式II的前手性硫化物化合物的不对称氧化制备式I的光学活性亚砜化合物的新方法。 更具体地，本发明公开了可转化为药学上有用的PPI的光学活性质子泵抑制剂（PPI）或其光学活性前体（=中间体）化合物（式I）的制备方法。

公开(公告)号：US20090200232A1

公开(公告)日：2009-08-13

申请号：US11920256

申请日：2006-05-11

申请人： Bo Mattiasson ,  Igor Galaev ,  Ashok Kumar ,  Maria Dainiak

发明人： Bo Mattiasson ,  Igor Galaev ,  Ashok Kumar ,  Maria Dainiak

IPC分类号： B01D15/08 ,  B01J20/28

CPC分类号： B01J20/26 ,  B01D15/20 ,  B01D15/3804 ,  B01D15/424 ,  B01J20/265 ,  B01J20/28042 ,  B01J20/28047 ,  B01J20/28085 ,  B01J20/3242

摘要： A process for adsorption-based separation of bioparticles from an aqueous suspension containing such bioparticles is disclosed which process comprisesa) bringing said aqueous suspension into contact with a macroporous cryogel monolith carrying on its surface a ligand capable of interacting specifically or non-specifically with a receptor on the surface of a bioparticle to be separated to adsorb said bioparticle to said macroporous cryogen monolith; andb) liberating said bioparticle from said macroporous cryogel monolith by elution, wherein said macroporous cryogel monolith is subjected to a physical deformation in conjunction with exposure to eluting medium.

摘要翻译： 公开了一种从含有这种生物颗粒的含水悬浮液中吸附分离生物颗粒的方法，该方法包括：a）使所述水悬浮液与其表面上带有能够特异性或非特异性相互作用的配体的大孔冷冻凝胶整料接触 受体在待分离的生物颗粒的表面上以将所述生物颗粒吸附到所述大孔冷冻剂整料上; 和b）通过洗脱从所述大孔冷冻凝胶整料中释放所述生物颗粒，其中所述大孔冷冻凝胶整料与暴露于洗脱介质一起经受物理变形。