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公开(公告)号:US20140031339A1
公开(公告)日:2014-01-30
申请号:US13942988
申请日:2013-07-16
申请人: Asitha ABEYWARDANE , Steven Richard BRUNETTE , Michael Jason BURKE , Thomas Martin KIRRANE, JR. , Chuk Chui MAN , Daniel Richard MARSHALL , Anil Kumar PADYANA , Hossein RAZAVI , Robert SIBLEY , Lana Louise SMITH KEENAN , Roger John SNOW , Ronald John SORCEK , Hidenori TAKAHASHI , Steven John TAYLOR , Michael Robert TURNER , Erick Richard Roush YOUNG , Qiang ZHANG , Yunlong ZHANG , Renee M. ZINDELL
发明人: Asitha ABEYWARDANE , Steven Richard BRUNETTE , Michael Jason BURKE , Thomas Martin KIRRANE, JR. , Chuk Chui MAN , Daniel Richard MARSHALL , Anil Kumar PADYANA , Hossein RAZAVI , Robert SIBLEY , Lana Louise SMITH KEENAN , Roger John SNOW , Ronald John SORCEK , Hidenori TAKAHASHI , Steven John TAYLOR , Michael Robert TURNER , Erick Richard Roush YOUNG , Qiang ZHANG , Yunlong ZHANG , Renee M. ZINDELL
IPC分类号: C07D401/14 , C07D413/14 , C07D487/04 , C07D498/04 , C07D497/08 , A61K31/5377 , A61K31/55 , A61K31/549 , A61K31/496 , A61K31/4545 , A61K31/454 , C07D405/12 , A61K31/551
CPC分类号: C07D487/04 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/549 , A61K31/55 , A61K31/551 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/20 , C07D491/20 , C07D497/08 , C07D498/04
摘要: The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein A1, A2, L1 and B are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorders. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐,其中A1,A2,L1和B如本文所定义。 式(I)化合物可用作白三烯A4水解酶(LTA4H)的抑制剂和治疗LTA4H相关疾病。 本发明还涉及包含式(I)化合物的药物组合物,使用这些化合物治疗各种疾病和病症的方法,以及制备这些化合物的方法。
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公开(公告)号:US20130244996A1
公开(公告)日:2013-09-19
申请号:US13785034
申请日:2013-03-05
申请人: Asitha ABEYWARDANE , Steven Richard BRUNETTE , Michael J. BURKE , Suresh R. KAPADIA , Thomas Martin KIRRANE , Matthew Russell NETHERTON , Hossein RAZAVI , Sonia RODRIGUEZ , Anjan SAHA , Robert SIBLEY , Lana Louise SMITH-KEENAN , Hidenori TAKAHASHI , Michael Robert TURNER , Jiang-Ping WU , Erick Richard Roush YOUNG , Qiang ZHANG , Qing ZHANG , Renee M. ZINDELL
发明人: Asitha ABEYWARDANE , Steven Richard BRUNETTE , Michael J. BURKE , Suresh R. KAPADIA , Thomas Martin KIRRANE , Matthew Russell NETHERTON , Hossein RAZAVI , Sonia RODRIGUEZ , Anjan SAHA , Robert SIBLEY , Lana Louise SMITH-KEENAN , Hidenori TAKAHASHI , Michael Robert TURNER , Jiang-Ping WU , Erick Richard Roush YOUNG , Qiang ZHANG , Qing ZHANG , Renee M. ZINDELL
IPC分类号: C07D491/052 , C07D513/04 , C07D295/155 , C07D405/10 , C07D295/096
CPC分类号: C07D491/052 , A61K31/357 , C07D295/096 , C07D295/155 , C07D319/20 , C07D405/10 , C07D405/12 , C07D405/14 , C07D413/10 , C07D417/10 , C07D417/14 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/04 , C07D513/04 , C07D519/00
摘要: The present invention relates to compounds of formula (I): wherein R1 to R3, A, X and n are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorder. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.
摘要翻译: 本发明涉及式(I)的化合物:其中R1至R3,A,X和n如本文所定义。 式(I)化合物可用作白三烯A4水解酶(LTA4H)的抑制剂和治疗LTA4H相关病症。 本发明还涉及包含式(I)化合物的药物组合物,使用这些化合物治疗各种疾病和病症的方法,以及制备这些化合物的方法。
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公开(公告)号:US20120178752A1
公开(公告)日:2012-07-12
申请号:US13171701
申请日:2011-06-29
申请人: John David GINN , Daniel Richard MARSHALL , Robert SIBLEY , Ronald John SORCEK , Erick Richard Roush YOUNG , Yunlong ZHANG
发明人: John David GINN , Daniel Richard MARSHALL , Robert SIBLEY , Ronald John SORCEK , Erick Richard Roush YOUNG , Yunlong ZHANG
IPC分类号: A61K31/5377 , A61K31/437 , C07D277/82 , A61K31/428 , C07D417/08 , C07D413/10 , C07D401/12 , A61K31/4725 , C07D413/12 , A61K31/4245 , C07D413/08 , A61K31/496 , A61P9/10 , A61P9/12 , A61P9/00 , A61P25/28 , A61P35/00 , A61P11/06 , A61P13/12 , A61P27/06 , A61P19/02 , A61P1/00 , A61P29/00 , C07D513/04
CPC分类号: C07D401/12 , C07D207/09 , C07D217/22 , C07D277/60 , C07D417/12 , C07D417/14 , C07D513/04
摘要: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1 and X are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译: 本发明涉及式(I)化合物及其药学上可接受的盐,其中R 1和X如本文所定义。 本发明还涉及包含这些化合物的药物组合物,使用这些化合物治疗各种疾病和病症的方法,制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号:US20100280028A1
公开(公告)日:2010-11-04
申请号:US12768268
申请日:2010-04-27
申请人: Jennifer A. KOWALSKI , Daniel Richard MARSHALL , Anthony S. PROKOPOWICZ, III , Sabine SCHLYER , Robert SIBLEY , Ronald John SORCEK , Di WU , Frank WU , Erick Richard Roush YOUNG
发明人: Jennifer A. KOWALSKI , Daniel Richard MARSHALL , Anthony S. PROKOPOWICZ, III , Sabine SCHLYER , Robert SIBLEY , Ronald John SORCEK , Di WU , Frank WU , Erick Richard Roush YOUNG
IPC分类号: A61K31/5377 , C07D403/14 , A61K31/506 , C07D413/14 , A61K31/497 , C07D241/04 , A61K31/4965 , C07D401/12 , A61P29/00 , A61P9/00 , A61P37/00
CPC分类号: C07D471/04 , C07D209/48 , C07D213/26 , C07D213/56 , C07D213/65 , C07D213/74 , C07D217/00 , C07D231/10 , C07D233/90 , C07D235/04 , C07D239/34 , C07D239/42 , C07D277/30 , C07D295/185 , C07D307/68 , C07D317/68 , C07D319/18 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/12 , C07D417/12 , C07D491/08
摘要: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1 to R5, A, B, D and X are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译: 本发明涉及式(I)化合物及其药学上可接受的盐,其中R 1至R 5,A,B,D和X如本文所定义。 本发明还涉及包含这些化合物的药物组合物,使用这些化合物治疗各种疾病和病症的方法,制备这些化合物的方法和可用于这些方法的中间体。
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