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公开(公告)号：US20130244996A1
公开(公告)日：2013-09-19
申请号：US13785034
申请日：2013-03-05
申请人： Asitha ABEYWARDANE , Steven Richard BRUNETTE , Michael J. BURKE , Suresh R. KAPADIA , Thomas Martin KIRRANE , Matthew Russell NETHERTON , Hossein RAZAVI , Sonia RODRIGUEZ , Anjan SAHA , Robert SIBLEY , Lana Louise SMITH-KEENAN , Hidenori TAKAHASHI , Michael Robert TURNER , Jiang-Ping WU , Erick Richard Roush YOUNG , Qiang ZHANG , Qing ZHANG , Renee M. ZINDELL
发明人： Asitha ABEYWARDANE , Steven Richard BRUNETTE , Michael J. BURKE , Suresh R. KAPADIA , Thomas Martin KIRRANE , Matthew Russell NETHERTON , Hossein RAZAVI , Sonia RODRIGUEZ , Anjan SAHA , Robert SIBLEY , Lana Louise SMITH-KEENAN , Hidenori TAKAHASHI , Michael Robert TURNER , Jiang-Ping WU , Erick Richard Roush YOUNG , Qiang ZHANG , Qing ZHANG , Renee M. ZINDELL
IPC分类号： C07D491/052 , C07D513/04 , C07D295/155 , C07D405/10 , C07D295/096
CPC分类号： C07D491/052 , A61K31/357 , C07D295/096 , C07D295/155 , C07D319/20 , C07D405/10 , C07D405/12 , C07D405/14 , C07D413/10 , C07D417/10 , C07D417/14 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/04 , C07D513/04 , C07D519/00
摘要： The present invention relates to compounds of formula (I): wherein R1 to R3, A, X and n are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorder. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.
摘要翻译： 本发明涉及式（I）的化合物：其中R1至R3，A，X和n如本文所定义。 式（I）化合物可用作白三烯A4水解酶（LTA4H）的抑制剂和治疗LTA4H相关病症。 本发明还涉及包含式（I）化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，以及制备这些化合物的方法。
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公开(公告)号：US20120165322A1
公开(公告)日：2012-06-28
申请号：US13171696
申请日：2011-06-29
申请人： Brian Nicholas Cook , Jennifer A. Kowalski , Xiang Li , Daniel Richard Marshall , Sabine Schlyer , Robert Sibley , Lana Louise Smith-Keenan , Fariba Soleymanzadeh , Ronald John Sorcek , Erick Richard Roush Young , Yunlong Zhang
发明人： Brian Nicholas Cook , Jennifer A. Kowalski , Xiang Li , Daniel Richard Marshall , Sabine Schlyer , Robert Sibley , Lana Louise Smith-Keenan , Fariba Soleymanzadeh , Ronald John Sorcek , Erick Richard Roush Young , Yunlong Zhang
IPC分类号： A61K31/472 , A61K31/4725 , C07D471/04 , C07D487/04 , A61K31/4985 , C07D417/14 , C07D417/12 , A61K31/5415 , A61K31/541 , C07D413/12 , C07D413/14 , C07D401/12 , A61K31/506 , C07D405/12 , A61K31/5377 , A61K31/538 , A61K31/497 , A61K31/4439 , C07D513/04 , A61K31/428 , A61P9/12 , A61P9/10 , A61P9/00 , A61P25/00 , A61P15/10 , A61P13/12 , A61P11/06 , A61P27/06 , A61P35/00 , A61P25/28 , A61P29/00 , A61P17/06 , A61P1/00 , A61K31/437 , C07D217/02
CPC分类号： C07D217/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04 , C07D519/00
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1 and R2 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其中R 1和R 2如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号：US20110275800A1
公开(公告)日：2011-11-10
申请号：US12937006
申请日：2009-04-08
申请人： Asitha Abeywardane , Derek Cogan , Younggi Choi , Donghong A. Gao , Daniel R. Goldberg , Alexander Heim-Riether , Craig Andrew Miller , Philip Dean Ramsden , Lana Louise Smith Keenan , Roger John Snow , Yang Yu
发明人： Asitha Abeywardane , Derek Cogan , Younggi Choi , Donghong A. Gao , Daniel R. Goldberg , Alexander Heim-Riether , Craig Andrew Miller , Philip Dean Ramsden , Lana Louise Smith Keenan , Roger John Snow , Yang Yu
IPC分类号： C07D403/14 , C07D249/04 , C07D401/06 , C07D405/14 , C07D401/14
CPC分类号： C07D211/16 , C07D207/34 , C07D403/12 , C07D513/04
摘要： This invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein R1, R2, R4. Ar and Het are as defined herein. The invention also relates to methods of using the compound of formula (I) to treat a diseases and disorders that are mediated or sustained through the activity of CCR10.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其中R1，R2，R4。 Ar和Het如本文所定义。 本发明还涉及使用式（I）化合物治疗通过CCR10的活性介导或维持的疾病和病症的方法。
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公开(公告)号：US08946203B2
公开(公告)日：2015-02-03
申请号：US13785034
申请日：2013-03-05
申请人： Asitha Abeywardane , Steven Richard Brunette , Michael J. Burke , Suresh R. Kapadia , Thomas Martin Kirrane , Matthew Russell Netherton , Hossein Razavi , Sonia Rodriguez , Anjan Saha , Robert Sibley , Lana Louise Smith-Keenan , Hidenori Takahashi , Michael Robert Turner , Jiang-Ping Wu , Erick Richard Roush Young , Qiang Zhang , Qing Zhang , Renee M. Zindell
发明人： Asitha Abeywardane , Steven Richard Brunette , Michael J. Burke , Suresh R. Kapadia , Thomas Martin Kirrane , Matthew Russell Netherton , Hossein Razavi , Sonia Rodriguez , Anjan Saha , Robert Sibley , Lana Louise Smith-Keenan , Hidenori Takahashi , Michael Robert Turner , Jiang-Ping Wu , Erick Richard Roush Young , Qiang Zhang , Qing Zhang , Renee M. Zindell
IPC分类号： C07D519/00 , C07D491/04 , C07D487/08 , A61K31/357 , C07D491/052 , C07D405/10 , C07D295/096 , C07D295/155 , C07D513/04 , C07D405/14 , C07D319/20 , C07D405/12 , C07D487/10 , C07D413/10 , C07D417/10 , C07D417/14 , C07D471/10 , C07D487/04
CPC分类号： C07D491/052 , A61K31/357 , C07D295/096 , C07D295/155 , C07D319/20 , C07D405/10 , C07D405/12 , C07D405/14 , C07D413/10 , C07D417/10 , C07D417/14 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/04 , C07D513/04 , C07D519/00
摘要： The present invention relates to compounds of formula (I): wherein R1 to R3, A, X and n are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorder. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.
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公开(公告)号：US08697911B2
公开(公告)日：2014-04-15
申请号：US13171696
申请日：2011-06-29
申请人： Brian Nicholas Cook , Jennifer A. Kowalski , Xiang Li , Daniel Richard Marshall , Sabine Schlyer , Robert Sibley , Lana Louise Smith-Keenan , Fariba Soleymanzadeh , Ronald John Sorcek , Erick Richard Roush Young , Yunlong Zhang
发明人： Brian Nicholas Cook , Jennifer A. Kowalski , Xiang Li , Daniel Richard Marshall , Sabine Schlyer , Robert Sibley , Lana Louise Smith-Keenan , Fariba Soleymanzadeh , Ronald John Sorcek , Erick Richard Roush Young , Yunlong Zhang
IPC分类号： A01N37/18 , A61K31/165 , C07C239/00 , C07C279/16 , C07D473/00 , C07D417/00 , C07C45/78 , C07C271/06 , C07D271/12 , C07D413/00 , C07D271/00 , C07D285/02 , C07D285/04 , C07D498/00 , C07D513/00 , C07D277/82 , C07D263/60 , C07D249/04 , C07D249/08 , C07D233/02 , C07D231/00
CPC分类号： C07D217/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04 , C07D519/00
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1 and R2 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其中R 1和R 2如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号：US20110275625A1
公开(公告)日：2011-11-10
申请号：US13127256
申请日：2009-11-05
申请人： Neil Alexander Farrow , Donghong Amy Gao , Alexander Heim-Riether , Shuang Liang , Sabine Schlyer , Lana Louise Smith Keenan , Steven John Taylor , Bernd Wellenzohn , Dieter Wiedenmayer , Zhaoming Xiong , Qiang Zhang
发明人： Neil Alexander Farrow , Donghong Amy Gao , Alexander Heim-Riether , Shuang Liang , Sabine Schlyer , Lana Louise Smith Keenan , Steven John Taylor , Bernd Wellenzohn , Dieter Wiedenmayer , Zhaoming Xiong , Qiang Zhang
IPC分类号： A61K31/444 , C07D405/04 , A61K31/443 , A61K31/4433 , C07D401/12 , A61K31/4439 , C07D401/14 , A61K31/4178 , C07D407/12 , A61K31/341 , C07D471/04 , A61K31/437 , A61K31/506 , A61K31/497 , A61K31/501 , C07D413/12 , A61K31/5377 , A61P29/00 , A61P19/10 , A61P9/10 , A61P9/00 , A61P25/00 , A61P35/00 , C07D405/14
CPC分类号： C07D407/10 , C07D231/14 , C07D263/16 , C07D277/56 , C07D307/68 , C07D401/04 , C07D407/14 , C07D411/12 , C07D471/04
摘要： Disclosed are compounds and compositions of the formula (I) as described herein which are inhibitors of MMP-13. Also disclosed are methods of using and making compounds of the formula (I).
摘要翻译： 公开了作为MMP-13抑制剂的如本文所述的式（I）的化合物和组合物。 还公开了使用和制备式（I）化合物的方法。
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公开(公告)号：US09573957B2
公开(公告)日：2017-02-21
申请号：US14330307
申请日：2014-07-14
申请人： Asitha Abeywardane , John Broadwater , Steven Richard Brunette , Thomas Martin Kirrane, Jr. , Hossein Razavi , Robert Sibley , Lana Louise Smith Keenan , Qiang Zhang
发明人： Asitha Abeywardane , John Broadwater , Steven Richard Brunette , Thomas Martin Kirrane, Jr. , Hossein Razavi , Robert Sibley , Lana Louise Smith Keenan , Qiang Zhang
IPC分类号： C07D487/08 , C07D401/14 , A61K31/4439 , A61K31/496 , A61K31/4709 , C07D403/14 , A61K31/506 , C07D413/14 , A61K31/4995 , A61K31/551 , C07D405/14 , C07D471/04
CPC分类号： C07D487/08 , A61K31/4439 , A61K31/4709 , A61K31/496 , A61K31/4995 , A61K31/506 , A61K31/551 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D471/04
摘要： The present invention relates to aryl pyrazoles, and pharmaceutically acceptable salts thereof. The aryl pyrazoles of the present invention are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorders. The present invention also relates to pharmaceutical compositions comprising the aryl pyrazoles of the present invention, methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.
摘要翻译： 本发明涉及芳基吡唑及其药学上可接受的盐。 本发明的芳基吡唑可用作白三烯A4水解酶（LTA4H）的抑制剂和治疗LTA4H相关疾病。 本发明还涉及包含本发明的芳基吡唑的药物组合物，使用这些化合物治疗各种疾病和病症的方法，以及制备这些化合物的方法。
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8.发明授权Alpha-substituted N-sulfonyl gylcine amides antagonists of CCR10, compositions containing the same and methods for using them 有权CCR10的α-取代的N-磺酰基Gylcine酰胺拮抗剂，含有它们的组合物和使用它们的方法公开(公告)号：US08859814B2
公开(公告)日：2014-10-14
申请号：US12992766
申请日：2009-05-14
申请人： Derek Cogan , Alexander Heim-Riether , Wang Mao , Craig Andrew Miller , Philip Dean Ramsden , Lana Louise Smith Keenan , Roger John Snow , Jiang-Ping Wu , Yu Yang
发明人： Derek Cogan , Alexander Heim-Riether , Wang Mao , Craig Andrew Miller , Philip Dean Ramsden , Lana Louise Smith Keenan , Roger John Snow , Jiang-Ping Wu , Yu Yang
IPC分类号： C07C303/00 , C07C307/00 , C07C309/00 , C07C311/00 , C07C241/00 , C07C241/02 , C07D211/00 , C07D211/68 , C07D211/80 , C07D213/02 , C07D217/00 , C07D209/04 , C07D231/00 , C07D277/60 , C07D277/62 , C07D211/22 , C07D403/12 , C07D217/06 , C07D295/185 , C07D513/04 , C07D487/04 , C07D211/70 , C07D401/14 , C07D209/08 , C07D211/62 , C07C311/19 , C07D211/16 , C07D409/12 , C07D413/12 , C07C311/44 , C07D407/12 , C07D401/12
CPC分类号： C07C311/19 , C07C311/44 , C07D209/08 , C07D211/16 , C07D211/22 , C07D211/62 , C07D211/70 , C07D217/06 , C07D295/185 , C07D401/12 , C07D401/14 , C07D403/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D487/04 , C07D513/04
摘要： Disclosed is a compound of formula (I). Wherein R1, R2Ar and Cy are as defined herein, or a pharmaceutically acceptable salt thereof. Also disclosed are pharmaceutical compositions of the compound of formula (I), methods of making the compounds of formula I, and methods of using the compounds of formula (I) to treat a disorder associated with activation of CCR10.
摘要翻译： 公开了式（I）的化合物。 其中R1，R2Ar和Cy如本文所定义，或其药学上可接受的盐。 还公开了式（I）化合物的药物组合物，制备式I化合物的方法和使用式（I）化合物治疗与CCR10活化相关的病症的方法。
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9.发明授权公开(公告)号：US08785489B2
公开(公告)日：2014-07-22
申请号：US13123048
申请日：2009-10-13
申请人： Asitha Abeywardane , Bennett Farmer , Neil Alexander Farrow , Donghong Amy Gao , Alexander Heim-Riether , Lana Louise Smith Keenan , Ingo Andreas Mugge , Steven John Taylor , Zhaoming Xiong , Yang Yu , Qiang Zhang
发明人： Asitha Abeywardane , Bennett Farmer , Neil Alexander Farrow , Donghong Amy Gao , Alexander Heim-Riether , Lana Louise Smith Keenan , Ingo Andreas Mugge , Steven John Taylor , Zhaoming Xiong , Yang Yu , Qiang Zhang
IPC分类号： A61K31/5377 , A61K31/506 , A61K31/497 , A61K31/454 , A61K31/444 , A61K31/4439 , A61K31/427 , A61K31/422 , A61K31/4178 , A61K31/4155 , A61K31/404 , C07D413/14 , C07D413/04 , C07D409/14 , C07D409/04 , C07D405/14 , C07D405/04 , C07D403/14 , C07D403/04 , C07D401/14 , C07D401/04 , C07D487/04 , C07D405/12 , C07D417/14 , C07D471/04 , C07D209/42
CPC分类号： A61K31/427 , A61K31/404 , A61K31/4155 , A61K31/4178 , A61K31/422 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/497 , A61K31/506 , A61K31/5377 , C07D209/42 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04
摘要： Disclosed are compounds and compositions of the formula I as described herein which are inhibitors of MMP-13. Also disclosed are methods of using and making compounds of the formula I.
摘要翻译： 公开了本文所述的式I化合物和组合物，其是MMP-13的抑制剂。 还公开了使用和制备式I化合物的方法。
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公开(公告)号：US20130196973A1
公开(公告)日：2013-08-01
申请号：US13418377
申请日：2012-03-13
申请人： Asitha Abeywardane , Michael J. Burke , Thomas Martin Kirrane , Matthew Russell Netherton , Anil Kumar Padyana , Lana Louise Smith Keenan , Hidenori Takahashi , Michael Robert Turner , Qiang Zhang , Qing Zhang
发明人： Asitha Abeywardane , Michael J. Burke , Thomas Martin Kirrane , Matthew Russell Netherton , Anil Kumar Padyana , Lana Louise Smith Keenan , Hidenori Takahashi , Michael Robert Turner , Qiang Zhang , Qing Zhang
IPC分类号： C07D319/20 , C07D417/10 , C07D471/10 , C07D417/14 , C07D405/14 , C07D491/056 , C07D487/04 , C07D487/10 , C07D405/10 , C07D487/08
CPC分类号： C07D295/16 , A61K31/397 , A61K31/5377 , C07D295/096 , C07D319/20 , C07D405/10 , C07D405/12 , C07D405/14 , C07D417/10 , C07D417/14 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/056
摘要： The present invention relates to compounds of formula (I): wherein R1 to R3, A, X and n are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorder. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.
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