-
公开(公告)号:US11166929B2
公开(公告)日:2021-11-09
申请号:US16165628
申请日:2018-10-19
发明人: Thomas M. Swanick , Joseph Ferraro , Lisa Rogers , Paul Martakos
IPC分类号: A61K31/20 , A61K9/14 , A61K9/70 , A61K31/00 , A61K31/4353 , A61K31/496 , A61K31/7028 , A61K38/13 , A61K9/16 , A61K31/436 , A61K35/60 , A61L27/54 , A61L31/16 , A61K9/10 , A61K31/4545 , A61K31/445 , A61K31/7036 , A61L27/28 , A61L31/08
摘要: The present invention is directed toward fatty acid-based particles, and methods of making such particles. The particles can be associated with an additional, therapeutic agent. Also provided herein is a method of forming fatty acid particles, comprising associating a cross-linked, fatty acid-derived biomaterial with a cryogenic liquid; and fragmenting the bio material/cryogenic liquid composition, such that fatty acid particles are formed. The particles can be used for a variety of therapeutic applications.
-
公开(公告)号:US11083823B2
公开(公告)日:2021-08-10
申请号:US15817018
申请日:2017-11-17
发明人: Thomas M. Swanick , Joe Bienkiewicz , Joseph Ferraro , Paul Martakos , Keith M. Faucher , Alicia Dale
摘要: Exemplary embodiments of the present invention provide adhesion barriers having anti-adhesion and tissue fixating properties. The adhesion barriers are formed of fatty acid based films. The fatty acid-based films may be formed from fatty acid-derived biomaterials. The films may be coated with, or may include, tissue fixating materials to create the adhesion barrier. The adhesion barriers are well tolerated by the body, have anti-inflammation properties, fixate, well to tissue, and have a residence time sufficient to prevent post-surgical adhesions.
-
公开(公告)号:US10016465B2
公开(公告)日:2018-07-10
申请号:US14511765
申请日:2014-10-10
发明人: Roger Labrecque , Philip McNamara , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Keith M. Faucher , Thomas M. Swanick
IPC分类号: A61K47/14 , A61K47/22 , A61L31/08 , A61K31/16 , A61M1/12 , A61K35/60 , A61F13/02 , A61K9/00 , A61K9/06 , A61K31/225 , A61K31/355 , A61K47/12 , A61L2/07 , A61L2/08 , A61L2/20 , A61L27/36 , A61L27/52 , A61L27/54 , A61L31/00 , A61L31/10 , A61L31/14 , A61K38/13 , A61F2/06 , B05D3/06
CPC分类号: A61K35/60 , A61F2/06 , A61F13/02 , A61F13/023 , A61F2250/0067 , A61K9/0024 , A61K9/06 , A61K31/225 , A61K31/355 , A61K38/13 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/206 , A61L2/208 , A61L27/36 , A61L27/3604 , A61L27/52 , A61L27/54 , A61L31/005 , A61L31/10 , A61L31/145 , A61L2202/24 , A61L2300/22 , A61L2300/252 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/602 , B05D3/067
摘要: A cured non-polymeric gel including a plurality of non-polymeric cross-links. The non-polymeric cross-links result from curing an oil or oil composition at selected curing conditions to achieve a desired amount of cross-linking to form the non-polymeric get. The desired amount of cross-linking is selected based on a desired rate of degradation of the gel after the gel is implanted. The oil or oil composition comprises one or more of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), or alphalinolenic acid (ALA).
-
公开(公告)号:US10808054B2
公开(公告)日:2020-10-20
申请号:US13839756
申请日:2013-03-15
发明人: Thomas M. Swanick
IPC分类号: C08F14/26 , B32B27/08 , B32B27/32 , B32B3/04 , C08J5/12 , B29C65/00 , B32B7/02 , B32B27/06 , B29C65/02 , B29C65/82 , B29K105/04
摘要: A method of making expanded fluoropolymer articles thermally bonds portions of expanded fluoropolymers together, without using an adhesive or crushing force, to produce stronger bonds at the joint between the expanded fluoropolymers than the bonds within the constituent expanded fluoropolymers. The method involves placing the portions of expanded fluoropolymers to be thermally bonded together in intimate contact with each other after wet-stretching the expanded fluoropolymers, and removing the wetting agent used to wet-stretch the expanded fluoropolymers, without subsequent expansion or stretching, to yield an expanded fluoropolymer article exhibiting unexpected and superior properties that can be used in a variety of medical and industrial applications.
-
公开(公告)号:US09844611B2
公开(公告)日:2017-12-19
申请号:US15001585
申请日:2016-01-20
发明人: Thomas M. Swanick , Joe Bienkiewicz , Joseph Ferraro , Paul Martakos , Keith M. Faucher , Alicia Dale
CPC分类号: A61L31/148 , A61F2/06 , A61F2250/0067 , A61L31/00 , A61L31/10 , A61L31/145 , A61L2420/02
摘要: Exemplary embodiments of the present invention provide adhesion barriers having anti-adhesion and tissue fixating properties. The adhesion barriers are formed of fatty acid based films. The fatty acid-based films may be formed from fatty acid-derived biomaterials. The films may be coated with, or may include, tissue fixating materials to create the adhesion barrier. The adhesion barriers are well tolerated by the body, have anti-inflammation properties, fixate, well to tissue, and have a residence time sufficient to prevent post-surgical adhesions.
-
公开(公告)号:US20160206789A1
公开(公告)日:2016-07-21
申请号:US15001585
申请日:2016-01-20
发明人: Thomas M. Swanick , Joe Bienkiewicz , Joseph Ferraro , Paul Martakos , Keith M. Faucher , Alicia Dale
CPC分类号: A61L31/148 , A61F2/06 , A61F2250/0067 , A61L31/00 , A61L31/10 , A61L31/145 , A61L2420/02
摘要: Exemplary embodiments of the present invention provide adhesion barriers having anti-adhesion and tissue fixating properties. The adhesion barriers are formed of fatty acid based films. The fatty acid-based films may be formed from fatty acid-derived biomaterials. The films may be coated with, or may include, tissue fixating materials to create the adhesion barrier. The adhesion barriers are well tolerated by the body, have anti-inflammation properties, fixate, well to tissue, and have a residence time sufficient to prevent post-surgical adhesions.
摘要翻译: 本发明的示例性实施方案提供了具有抗粘连和组织固定性质的粘合屏障。 粘合屏障由脂肪酸基膜形成。 脂肪酸基膜可以由脂肪酸衍生的生物材料形成。 膜可以涂覆或可以包括组织固定材料以产生粘合屏障。 粘附屏障由身体良好耐受,具有抗炎特性,固定到组织上,并具有足以防止手术后粘连的停留时间。
-
公开(公告)号:US08920483B2
公开(公告)日:2014-12-30
申请号:US13839929
申请日:2013-03-15
CPC分类号: A61F2/0063
摘要: A deployment device, system, and method for deploying a prosthesis. The deployment device includes a housing, a rod disposed within the housing and adapted to rotate relative to the housing, and one or more support members (e.g., bushings, bearings, etc.) rotatably supporting the rod within the housing. An elongate slit is disposed in and entirely through the housing and is positioned in a way that enables the prosthesis to pass therethrough from a loaded, rolled configuration on the rod. The deployment device is generally flexible, e.g., has a bending stiffness of at most about 0.87 N/mm (e.g., about 0.05 N/mm to about 0.87 N/mm). Furthermore, the deployment device enables a user to deploy (e.g., unroll) a prosthesis therefrom at a rate determined manually by the user and in a piece-by-piece fashion.
摘要翻译: 用于部署假体的部署设备,系统和方法。 展开装置包括壳体,设置在壳体内并适于相对于壳体旋转的杆以及可旋转地支撑杆在壳体内的一个或多个支撑构件(例如衬套,轴承等)。 细长狭缝设置在壳体中并且完全穿过壳体并且以使得假体能够从杆上的加载的卷绕构型穿过其中的方式定位。 展开装置通常是柔性的,例如具有至多约0.87N / mm(例如,约0.05N / mm至约0.87N / mm)的弯曲刚度。 此外,部署装置使得用户能够以由用户手动确定的速率并且逐件地部署(例如,展开)假体)。
-
公开(公告)号:US10285964B2
公开(公告)日:2019-05-14
申请号:US15216873
申请日:2016-07-22
发明人: Thomas M. Swanick , Joseph Ferraro , Lisa Rogers , Paul Martakos
IPC分类号: A61K31/20 , A61L31/16 , A61K31/7036 , A61K9/16 , A61K31/436 , A61K31/445 , A61L31/08 , A61K35/60 , A61L27/28 , A61L27/54 , A61K31/496 , A61K31/4545 , A61K31/4353 , A61K31/00 , A61K9/70 , A61K9/14 , A61K9/10 , A61K38/13 , A61K31/7028
摘要: The present invention is directed toward fatty acid-based particles, and methods of making such particles. The particles can be associated with an additional, therapeutic agent. Also provided herein is a method of forming fatty acid particles, comprising associating a cross-linked, fatty acid-derived biomaterial with a cryogenic liquid; and fragmenting the bio material/cryogenic liquid composition, such that fatty acid particles are formed. The particles can be used for a variety of therapeutic applications.
-
公开(公告)号:US20140099461A1
公开(公告)日:2014-04-10
申请号:US13839756
申请日:2013-03-15
发明人: Thomas M. Swanick
摘要: A method of making expanded fluoropolymer articles thermally bonds portions of expanded fluoropolymers together, without using an adhesive or crushing force, to produce stronger bonds at the joint between the expanded fluoropolymers than the bonds within the constituent expanded fluoropolymers. The method involves placing the portions of expanded fluoropolymers to be thermally bonded together in intimate contact with each other after wet-stretching the expanded fluoropolymers, and removing the wetting agent used to wet-stretch the expanded fluoropolymers, without subsequent expansion or stretching, to yield an expanded fluoropolymer article exhibiting unexpected and superior properties that can be used in a variety of medical and industrial applications.
摘要翻译: 扩展含氟聚合物制品的方法将膨胀的含氟聚合物的一部分热粘合在一起,而不使用粘合剂或破碎力,在膨胀的含氟聚合物之间的接合处,在组分膨胀的含氟聚合物内的键之间产生更强的键。 该方法包括将膨胀的含氟聚合物的热粘合在一起的部分在湿法拉伸膨胀的含氟聚合物之后彼此紧密接触,并且除去用于湿膨胀膨胀的含氟聚合物的润湿剂,而无需随后的膨胀或拉伸,得到 展示了可以用于各种医疗和工业应用中的意想不到的优异性能的扩展的含氟聚合物制品。
-
公开(公告)号:US20130331940A1
公开(公告)日:2013-12-12
申请号:US13839929
申请日:2013-03-15
IPC分类号: A61F2/00
CPC分类号: A61F2/0063
摘要: A deployment device, system, and method for deploying a prosthesis. The deployment device includes a housing, a rod disposed within the housing and adapted to rotate relative to the housing, and one or more support members (e.g., bushings, bearings, etc.) rotatably supporting the rod within the housing. An elongate slit is disposed in and entirely through the housing and is positioned in a way that enables the prosthesis to pass therethrough from a loaded, rolled configuration on the rod. The deployment device is generally flexible, e.g., has a bending stiffness of at most about 0.87 N/mm (e.g., about 0.05 N/mm to about 0.87 N/mm). Furthermore, the deployment device enables a user to deploy (e.g., unroll) a prosthesis therefrom at a rate determined manually by the user and in a piece-by-piece fashion.
摘要翻译: 用于部署假体的部署设备,系统和方法。 展开装置包括壳体,设置在壳体内并适于相对于壳体旋转的杆以及可旋转地支撑杆在壳体内的一个或多个支撑构件(例如衬套,轴承等)。 细长狭缝设置在壳体中并且完全穿过壳体并且以使得假体能够从杆上的加载的卷绕构型穿过其中的方式定位。 展开装置通常是柔性的,例如具有至多约0.87N / mm(例如,约0.05N / mm至约0.87N / mm)的弯曲刚度。 此外,部署装置使得用户能够以由用户手动确定的速率并且逐件地部署(例如,展开)假体)。
-
-
-
-
-
-
-
-
-