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    Methods of detecting antibodies to .alpha.-Fodrin and fragments thereof in diagnosing sjogrens'
    3.
    发明授权
    Methods of detecting antibodies to .alpha.-Fodrin and fragments thereof in diagnosing sjogrens' 失效
    检测α-Fodrin抗体及其片段在诊断sj + E，uml o + EE grens'

    公开(公告)号：US6121057A

    公开(公告)日：2000-09-19

    申请号：US076938

    申请日：1998-05-13

    申请人： Yoshio Hayashi ,  Hiromu Sugino

    发明人： Yoshio Hayashi ,  Hiromu Sugino

    IPC分类号： A61K38/17 ,  A61K39/00 ,  G01N33/536 ,  G01N33/564

    CPC分类号： G01N33/564 ,  G01N2800/24

    摘要： Screening of the autoantibodies and autoantigens which are specific to Sjogren's syndrome, particularly primary Sjogren's syndrome, and provision of a prophylactic and therapeutic drug for Sjogren's syndrome, particularly primary Sjogren's syndrome, and a highly sensitive diagnostic agent for Sjogren's syndrome. The .alpha.-fodrin or .alpha.-fodrin fragment of the invention is an antigen to the autoantibodies specifically found in Sjogren's syndrome and this autoantigen finds application as a prophylactic and therapeutic drug for autoimmune diseases, particularly Sjogren's syndrome, or a diagnostic agent for such diseases.

    摘要翻译： 筛选特异于Sj + E，uml o + EE gren综合征，特别是原发性Sj + E，uml o + EE gren综合征的自身抗体和自身抗原，以及为Sj + E，uml + +提供预防和治疗药物 EE格伦综合征，特别是原发性Sj + E，uml o + EE gren综合征，以及Sj + E，uml o + EE gren综合征的高敏感性诊断剂。 本发明的α-纤维蛋白或α-纤维蛋白片段是在Sj + E，uml o + EE gren综合征中特异性发现的自身抗体的抗原，并且该自身抗原被用作自身免疫疾病的预防和治疗药物，特别是Sj + E ，uml o + EE gren综合征，或这种疾病的诊断剂。

    Composition containing &agr;-fodrin or &agr;-fodrin fragment protein
    4.
    发明授权
    Composition containing &agr;-fodrin or &agr;-fodrin fragment protein 失效
    含有α-fodrin或α-fodrin片段蛋白的组合物

    公开(公告)号：US06703021B2

    公开(公告)日：2004-03-09

    申请号：US09499765

    申请日：2000-02-08

    申请人： Yoshio Hayashi ,  Hiromu Sugino

    发明人： Yoshio Hayashi ,  Hiromu Sugino

    IPC分类号： A61K3900

    CPC分类号： G01N33/564 ,  G01N2800/24

    摘要： Screening of the autoantibodies and autoantigens which are specific to Sjögren's syndrome, particularly primary Sjögren's syndrome, and provision of a prophylactic and therapeutic drug for Sjögren's syndrome, particularly primary Sjögren's syndrome, and a highly sensitive diagnostic agent for Sjögren's syndrome. The &agr;-fodrin or &agr;-fodrin fragment of the invention is an antigen to the autoantibodies specifically found in Sjögren's syndrome and this autoantigen finds application as a prophylactic and therapeutic drug for autoimmune diseases, particularly Sjögren's syndrome, or a diagnostic agent for such diseases.

    摘要翻译： 筛查Sjögren综合征，特别是原发性Sjögren综合征特有的自身抗体和自身抗体，以及为Sjögren综合征，特别是Sjögren综合征提供预防和治疗药物，以及Sjögren综合征的高度敏感诊断剂。 本发明的α-纤维蛋白或α-fodrin片段是针对Sjögren综合征中特异性发现的自身抗体的抗原，并且该自身抗原可用作自身免疫性疾病特别是Sjögren综合征的预防和治疗药物，或用于此类疾病的诊断剂。

    DNA encoding a neuronal cell-specific receptor protein
    5.
    发明授权
    DNA encoding a neuronal cell-specific receptor protein 失效
    编码神经元细胞特异性受体蛋白的DNA

    公开(公告)号：US6132988A

    公开(公告)日：2000-10-17

    申请号：US738168

    申请日：1996-10-25

    申请人： Hiromu Sugino ,  Takanori Nakamura ,  Hiroki Shouji

    发明人： Hiromu Sugino ,  Takanori Nakamura ,  Hiroki Shouji

    IPC分类号： C07K14/71 ,  C12N15/12 ,  C12N15/63 ,  C12N15/85

    CPC分类号： C07K14/71

    摘要： To provide a method of isolating and detecting a new receptor gene, as a means of elucidating the function of neuronal cell-specific receptors, especially of elucidating the detailed mechanism of the neuronal cell differentiation inhibitory and nerve nutrition factor-like actions of activin receptors, DNA containing said new receptor gene, a method of producing a protein encoded by this new receptor gene, and use for this DNA and protein. The receptor protein of the present invention and DNA encoding this protein can be used for various purposes, including 1) ligand determination, 2) obtainment of antibodies and antisera, 3) construction of recombinant receptor protein expression systems, 4) development of receptor binding assay systems and screening for pharmaceutical candidate compounds using expression systems, 5) drug designing based on comparison with structurally similar ligand receptors, 6) reagent for preparation of probes and PCR primers for gene diagnosis, and 7) drug for gene therapy.

    摘要翻译： 为了提供分离和检测新受体基因的方法，作为阐明神经元细胞特异性受体功能的手段，特别是阐明神经元细胞分化抑制和激活素受体的神经营养因子样作用的详细机制， 含有所述新受体基因的DNA，由该新受体基因编码的蛋白质的制备方法，以及该DNA和蛋白质的用途。 本发明的受体蛋白质和编码该蛋白质的DNA可用于各种目的，包括1）配体测定，2）抗体和抗血清的获得，3）重组受体蛋白表达系统的构建，4）受体结合试验的发展 系统和使用表达系统筛选药物候选化合物，5）基于与结构相似的配体受体比较的药物设计，6）用于基因诊断的探针和PCR引物的制备试剂和7）用于基因治疗的药物。