公开(公告)号：US4256885A

公开(公告)日：1981-03-17

申请号：US749433

申请日：1976-12-10

申请人： Atsushi Kojima ,  Yoshitsugu Kohno ,  Yoshimasa Ike ,  Tatsuro Yokoyama ,  Makoto Odate

发明人： Atsushi Kojima ,  Yoshitsugu Kohno ,  Yoshimasa Ike ,  Tatsuro Yokoyama ,  Makoto Odate

IPC分类号： A61K31/505 ,  C07D20060101 ,  C07D239/00 ,  C07D239/10 ,  C07D239/30 ,  C07D239/54 ,  C07D307/04 ,  C07D307/22 ,  C07D405/04

摘要： A process for efficiently preparing 1-(2-tetrahydrofuryl)-5-fluorouracil useful as an antitumor agent or an antiviral agent which comprises reacting 5-fluorouracil with 2,3-dihydrofuran. This reaction proceeds advantageously in the presence of a reaction accelerator such as a Lewis acid in a polar solvent such as pyridine.

摘要翻译： 一种有效制备用作抗肿瘤剂或抗病毒剂的1-（2-四氢呋喃基）-5-氟尿嘧啶的方法，其包括使5-氟尿嘧啶与2,3-二氢呋喃反应。 该反应有利地在诸如吡啶等极性溶剂中的路易斯酸等反应促进剂的存在下进行。

公开(公告)号：US4868292A

公开(公告)日：1989-09-19

申请号：US888183

申请日：1986-07-22

申请人： Tatsuro Yokoyama ,  Haruki Mori ,  Masanobu Arita ,  Atsushi Kojima

发明人： Tatsuro Yokoyama ,  Haruki Mori ,  Masanobu Arita ,  Atsushi Kojima

IPC分类号： C08B37/00 ,  A61K31/7028 ,  A61K31/715 ,  A61P25/00 ,  C07H15/10

CPC分类号： C07H15/10

摘要： Monosialoganglioside is prepared by heating ganglioside at a temperature higher than 50.degree. C. in a liquid medium containing water.

摘要翻译： 通过在含有水的液体培养基中加热高于50℃的神经节苷脂制备单唾液酸神经节苷脂。

公开(公告)号：US20060102074A1

公开(公告)日：2006-05-18

申请号：US11311738

申请日：2005-12-19

申请人： Hironori Hatono ,  Masakatsu Kiyohara ,  Katsuhiko Mori ,  Tatsuro Yokoyama ,  Atsushi Yoshida ,  Tomokazu Ito ,  Jun Akedo

发明人： Hironori Hatono ,  Masakatsu Kiyohara ,  Katsuhiko Mori ,  Tatsuro Yokoyama ,  Atsushi Yoshida ,  Tomokazu Ito ,  Jun Akedo

IPC分类号： B05C11/00 ,  B05C5/00 ,  B05B7/00

CPC分类号： C23C30/00 ,  C23C24/04 ,  Y10T428/249967 ,  Y10T428/25 ,  Y10T428/26 ,  Y10T428/265

摘要： An apparatus for manufacturing a composite structure body is provided which forms structure body having the constitution in which the crystals of more than one type of brittle material are dispersed and having novel properties without involving a heating/sintering process. The apparatus includes an aerosol generator configured to generate an aerosol. The aerosol is generated through dispersing fine particles of more than one type of brittle material, or dispersing composite fine particles, in a gas. The apparatus also includes a nozzle configured to spray the aerosol, a classifier configured to classify the brittle material fine particles in the aerosol, and a disintegrating machine for disintegrating agglomerations of the brittle material fine particles in the aerosol. The composite structure body is manufactured in reduced pressure conditions by bombarding a substrate with the aerosol at a high velocity, whereby at least one of crystals and microstructures of said brittle materials are dispersed.

公开(公告)号：US20060141144A1

公开(公告)日：2006-06-29

申请号：US11360187

申请日：2006-02-17

申请人： Hironori Hatono ,  Masakatsu Kiyohara ,  Katsuhiko Mori ,  Tatsuro Yokoyama ,  Atsushi Yoshida ,  Tomokazu Ito ,  Jun Akedo

发明人： Hironori Hatono ,  Masakatsu Kiyohara ,  Katsuhiko Mori ,  Tatsuro Yokoyama ,  Atsushi Yoshida ,  Tomokazu Ito ,  Jun Akedo

IPC分类号： B05D1/12

CPC分类号： C23C30/00 ,  C23C24/04 ,  Y10T428/249967 ,  Y10T428/26 ,  Y10T428/265 ,  Y10T428/31678 ,  Y10T428/31681

摘要： A method for manufacturing a composite structure body, comprising the steps of bombarding brittle material fine particles and ductile material fine particles separately or simultaneously against a surface of a substrate with high velocities such that an anchor portion biting said substrate surface is formed; the brittle material fine particles are simultaneously distorted or fractured by impact of the bombardment; mutual rejoining of the fine particles is made through intermediary of a newly generated active surface formed by the distortion or fracture; and thereby forming a structure body, above the anchor portion, in which crystals of the brittle material and crystals and/or microstructures of the ductile material fine particles are dispersed.

摘要翻译： 一种复合结构体的制造方法，其特征在于，包括以高速度分别或同时地将脆性材料细颗粒和延性材料细颗粒轰击到基板的表面，形成咬合所述基板表面的锚定部分的步骤; 脆性材料细颗粒通过轰击的冲击同时变形或断裂; 通过由变形或断裂形成的新生成的活性表面的介质来进行微粒的相互重合; 从而在脆性材料的晶体和延展性材料微粒的微结构分散的锚固部分上方形成结构体。

公开(公告)号：US5332739A

公开(公告)日：1994-07-26

申请号：US971059

申请日：1992-11-02

申请人： Tsutomu Katakami ,  Tatsuro Yokoyama ,  Michihiko Miyamoto ,  Haruki Mori ,  Nobuya Kawauchi ,  Tadahito Nobori ,  Joji Kamiya ,  Masaaki Ishii

发明人： Tsutomu Katakami ,  Tatsuro Yokoyama ,  Michihiko Miyamoto ,  Haruki Mori ,  Nobuya Kawauchi ,  Tadahito Nobori ,  Joji Kamiya ,  Masaaki Ishii

IPC分类号： C07D239/54 ,  A61K31/505 ,  A61P9/00 ,  A61P9/06 ,  C07D239/545 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  A61K31/50 ,  C07D239/42 ,  C07D403/04

CPC分类号： C07D239/545 ,  C07D401/12

摘要： Pyrimidinedione derivatives of the formula: ##STR1## wherein R.sup.1 and R.sup.2 is so linked with each other as to make an alkylene chain and thus form a heterocyclic structure, A, R.sup.3, R.sup.4, X.sup.1, X.sup.2 and X.sup.3 are substituents, respectively, and n is 2 or 3 have a basic backbone in which a phenyl group part and a pyrimidinedione part are linked by a structure comprising an alkyl chain and a heterocyclic ring having two nitrogen atoms. These compounds are useful for a medical treatment of cardiac arrhythmias.

摘要翻译： 其中R1和R2彼此连接以形成亚烷基链，从而形成杂环结构，其中A，R 3，R 4，X 1，X 2和X 3分别是取代基，并且n 2或3具有其中苯基部分和嘧啶二酮部分通过包含烷基链和具有两个氮原子的杂环的结构连接的基本主链。 这些化合物可用于治疗心律失常。

公开(公告)号：US5114941A

公开(公告)日：1992-05-19

申请号：US618245

申请日：1990-11-27

申请人： Tsutomu Katakami ,  Tatsuro Yokoyama ,  Haruki Mori ,  Nobuya Kawauchi ,  Joji Kamiya ,  Masaaki Ishii

发明人： Tsutomu Katakami ,  Tatsuro Yokoyama ,  Haruki Mori ,  Nobuya Kawauchi ,  Joji Kamiya ,  Masaaki Ishii

IPC分类号： A61K31/505 ,  A61P9/06 ,  C07D405/12 ,  C07D405/14

CPC分类号： C07D405/12

摘要： A pyrimidinedione derivative compound has a basic backbone in which a 4-oxobenzopyran ring group part and a pyrimidinedione part are linked by a structure comprising an alkyl chain containing at least two nitrogen atoms and one oxygen. The pyrimidinedione derivative is useful for a medical treatment of cardiac arrhythmias.

公开(公告)号：US07736731B2

公开(公告)日：2010-06-15

申请号：US11981089

申请日：2007-10-31

申请人： Jun Akedo ,  Tomokazu Ito ,  Tatsuro Yokoyama ,  Katsuhiko Mori ,  Hironori Hatono ,  Masakatsu Kiyohara ,  Yuji Aso

发明人： Jun Akedo ,  Tomokazu Ito ,  Tatsuro Yokoyama ,  Katsuhiko Mori ,  Hironori Hatono ,  Masakatsu Kiyohara ,  Yuji Aso

IPC分类号： B32B5/16

CPC分类号： C03C17/06 ,  B22F9/04 ,  B22F2009/045 ,  C03C17/22 ,  C03C17/23 ,  C03C2217/214 ,  C03C2217/268 ,  C03C2217/282 ,  C03C2218/17 ,  C23C24/04 ,  Y10T428/25 ,  Y10T428/2839 ,  Y10T428/31678

摘要： A composite structure forming method comprises the steps of first pre-treating brittle material fine particles to impart an internal strain to the brittle material fine particles, secondly causing the brittle material fine particles in which the internal strain has been created to collide with a substrate surface at high speed or applying a mechanical impact force to the brittle material fine particles containing the internal strain therein provided on the substrate surface, to deform or fracture the brittle material fine particles, re-joining the fine particles through active new surfaces generated by the deformation or fracture, forming an anchor section made of polycrystalline brittle material of which part bites into the substrate surface at a boundary section between the new surfaces and the substrate, and further forming a structure made of polycrystalline brittle material on the anchor section.

摘要翻译： 复合结构形成方法包括以下步骤：首先，预处理脆性材料细颗粒以向脆性材料细颗粒施加内部应变; 第二，使得产生内部应变的脆性材料微粒高速碰撞基板表面，或者对设置在基板上的脆性材料微粒（其中含有内部应变）施加机械冲击力 表面，任一方法的目的是使脆性材料细颗粒变形或断裂; 第三，通过由变形或断裂产生的主动新表面重新连接细颗粒; 第四，形成由多晶脆性材料制成的锚固部分，其在新表面和基底之间的边界部分部分咬入基片表面; 第五，在锚定部分上进一步形成由多晶脆性材料制成的结构。

公开(公告)号：US07553376B2

公开(公告)日：2009-06-30

申请号：US11419121

申请日：2006-05-18

申请人： Jun Akedo ,  Tomokazu Ito ,  Tatsuro Yokoyama ,  Katsuhiko Mori ,  Hironori Hatono ,  Masakatsu Kiyohara ,  Yuji Aso

发明人： Jun Akedo ,  Tomokazu Ito ,  Tatsuro Yokoyama ,  Katsuhiko Mori ,  Hironori Hatono ,  Masakatsu Kiyohara ,  Yuji Aso

IPC分类号： B05C5/02

CPC分类号： C03C17/06 ,  B22F9/04 ,  B22F2009/045 ,  C03C17/22 ,  C03C17/23 ,  C03C2217/214 ,  C03C2217/268 ,  C03C2217/282 ,  C03C2218/17 ,  C23C24/04 ,  Y10T428/25 ,  Y10T428/2839 ,  Y10T428/31678

摘要： A composite structure forming apparatus adapted to ejecting and causing an aerosol generated by scattering brittle material fine particles in a gas to collide with a substrate at high speed to form a structure made of the brittle material. The apparatus includes an aerosol generator for generating the aerosol, a nozzle for ejecting the aerosol, a shredder for shredding the brittle particles cohering in the aerosol and preventing cohesion of the brittle material fine particles, and a classifier for classifying the brittle material fine particles in the aerosol. The apparatus also includes a pretreatment device for creating internal strain in the brittle material fine particles, and a position control device for controlling the position of the nozzle relative to the substrate. The apparatus further includes a container having a sieve and a vibration device, and one or more of these components may be associated with the aerosol generator.

摘要翻译： 一种复合结构形成装置，适于喷射并引起气体中的脆性材料细颗粒散射而产生的气溶胶，以高速与基板碰撞，形成由脆性材料构成的结构。 该装置包括用于产生气溶胶的气溶胶发生器，用于喷射气溶胶的喷嘴，用于粉碎粘附在气溶胶中的脆性颗粒的粉碎机和防止脆性材料微粒的内聚力的碎纸机，以及用于将脆性材料微粒分类的分级机 气溶胶。 该设备还包括用于在脆性材料微粒中产生内部应变的预处理装置，以及用于控制喷嘴相对于基底的位置的位置控制装置。 该装置还包括具有筛子和振动装置的容器，并且这些部件中的一个或多个可以与气溶胶发生器相关联。

公开(公告)号：US20060201419A1

公开(公告)日：2006-09-14

申请号：US11419121

申请日：2006-05-18

申请人： Jun Akedo ,  Tomokadsu Ito ,  Tatsuro Yokoyama ,  Katsuhiko Mori ,  Hironori Hatono ,  Masakatsu Kiyohara ,  Yuji Aso

发明人： Jun Akedo ,  Tomokadsu Ito ,  Tatsuro Yokoyama ,  Katsuhiko Mori ,  Hironori Hatono ,  Masakatsu Kiyohara ,  Yuji Aso

IPC分类号： B05B7/00

CPC分类号： C03C17/06 ,  B22F9/04 ,  B22F2009/045 ,  C03C17/22 ,  C03C17/23 ,  C03C2217/214 ,  C03C2217/268 ,  C03C2217/282 ,  C03C2218/17 ,  C23C24/04 ,  Y10T428/25 ,  Y10T428/2839 ,  Y10T428/31678

摘要： A composite structure forming apparatus adapted to ejecting and causing an aerosol generated by scattering brittle material fine particles in a gas to collide with a substrate at high speed to form a structure made of the brittle material. The apparatus includes an aerosol generator for generating the aerosol, a nozzle for ejecting the aerosol, a shredder for shredding the brittle particles cohering in the aerosol and preventing cohesion of the brittle material fine particles, and a classifier for classifying the brittle material fine particles in the aerosol. The apparatus also includes a pretreatment device for creating internal strain in the brittle material fine particles, and a position control device for controlling the position of the nozzle relative to the substrate. The apparatus further includes a container having a sieve and a vibration device, and one or more of these components may be associated with the aerosol generator.

摘要翻译： 一种复合结构形成装置，适于喷射并引起气体中的脆性材料细颗粒散射而产生的气溶胶，以高速与基板碰撞，形成由脆性材料构成的结构。 该装置包括用于产生气溶胶的气溶胶发生器，用于喷射气溶胶的喷嘴，用于粉碎粘附在气溶胶中的脆性颗粒的粉碎机和防止脆性材料细颗粒的内聚力的粉碎机，以及用于将脆性材料微粒分类的分级机 气溶胶。 该设备还包括用于在脆性材料微粒中产生内部应变的预处理装置，以及用于控制喷嘴相对于基底的位置的位置控制装置。 该装置还包括具有筛子和振动装置的容器，并且这些部件中的一个或多个可以与气溶胶发生器相关联。

公开(公告)号：US4532137A

公开(公告)日：1985-07-30

申请号：US568826

申请日：1984-01-06

申请人： Isao Sakano ,  Tatsuro Yokoyama ,  Seitaro Kajiya ,  Yutaka Okazaki ,  Hiroshi Tokuda ,  Hiroshi Kawazura ,  Mikio Kumakura ,  Takuo Nakano ,  Akira Awaya

发明人： Isao Sakano ,  Tatsuro Yokoyama ,  Seitaro Kajiya ,  Yutaka Okazaki ,  Hiroshi Tokuda ,  Hiroshi Kawazura ,  Mikio Kumakura ,  Takuo Nakano ,  Akira Awaya

IPC分类号： A61K31/425 ,  A61K31/426 ,  A61P29/00 ,  A61P31/12 ,  A61P35/00 ,  A61P37/00 ,  C07D277/20 ,  C07D277/44 ,  C07D277/46 ,  C07D277/48

CPC分类号： C07D277/587

摘要： Disclosed are 2-thiazol derivatives having the general formula ##STR1## where R.sub.1 and R.sub.2 independently represent lower alkyl radicals having 1 to 4 carbon atoms and X represents a lower alkyl radical, a lower alkoxy radical, a lower alkoxycarbonyl radical, a halogenoalkoxy radical, a radical of the formula ##STR2## or a radical of the formula ##STR3## Also disclosed are a process for preparing the derivatives and pharmaceutical compositions having immunomodulatory activity which comprise the derivatives as the active ingredient.

摘要翻译： 公开了具有通式的2-噻唑衍生物，其中R 1和R 2独立地表示具有1至4个碳原子的低级烷基，X表示低级烷基，低级烷氧基，低级烷氧基羰基，卤代烷氧基， 还公开了具有式（IMAGE）的基团或式（ⅠA）的基团。还公开了制备具有免疫调节活性的衍生物和药物组合物的方法，其包含该衍生物作为活性成分。