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35 条记录 (耗时 0.034 秒)

    Human GLP-1 mimetibodies, compositions, methods and uses
    7.
    发明申请
    Human GLP-1 mimetibodies, compositions, methods and uses 审中-公开
    人类GLP-1模拟物，组合物，方法和用途

    公开(公告)号：US20070135338A1

    公开(公告)日：2007-06-14

    申请号：US11091181

    申请日：2005-03-28

    申请人： Karyn O'Neil ,  Kristen Picha

    发明人： Karyn O'Neil ,  Kristen Picha

    IPC分类号： A61K38/26 ,  C07H21/04 ,  C07K14/605

    CPC分类号： C07K14/605 ,  A61K38/00 ,  C07K2319/30

    摘要： The present invention relates to at least one novel human GLP-1 mimetibody or specified portion or variant, including isolated nucleic acids that encode at least one GLP-1 mimetibody or specified portion or variant, GLP-1 mimetibody or specified portion or variants, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.

    摘要翻译： 本发明涉及至少一种新的人GLP-1模拟体或特定部分或变体，包括编码至少一种GLP-1模拟体或特定部分或变体的分离的核酸，GLP-1模拟体或特定部分或变体，载体 ，宿主细胞，转基因动物或植物，及其制备和使用方法，包括治疗组合物，方法和装置。

    Fibronectin type III domain based scaffold compositions, methods and uses
    8.
    发明授权
    Fibronectin type III domain based scaffold compositions, methods and uses 有权
    纤连蛋白III型结构域的支架组合物，方法和用途

    公开(公告)号：US09200059B2

    公开(公告)日：2015-12-01

    申请号：US13595484

    申请日：2012-08-27

    申请人： Steve Jacobs ,  Karyn O'Neil

    发明人： Steve Jacobs ,  Karyn O'Neil

    IPC分类号： C40B50/06 ,  C07K14/78

    CPC分类号： C07K14/78 ,  C40B40/08 ,  C40B50/06

    摘要： A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin), including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. In particular, protein scaffold molecules binding to IgG have been identified as useful for diagnostic and/or therapeutic applications.

    摘要翻译： 基于纤连蛋白III（FN3）蛋白的共有序列的蛋白质支架，例如来自人纤连蛋白（人腱生蛋白）的第十FN3重复序列，包括编码蛋白质支架的分离的核酸，载体，宿主细胞和制备方法 并且其使用在诊断和/或治疗组合物，方法和装置中具有应用。 特别地，已经鉴定了结合IgG的蛋白质支架分子可用于诊断和/或治疗应用。

    Fibronectin type III domain based scaffold compositions, methods and uses
    9.
    发明授权
    Fibronectin type III domain based scaffold compositions, methods and uses 有权
    纤连蛋白III型结构域的支架组合物，方法和用途

    公开(公告)号：US08293482B2

    公开(公告)日：2012-10-23

    申请号：US12704824

    申请日：2010-02-12

    申请人： Steven Jacobs ,  Karyn O'Neil

    发明人： Steven Jacobs ,  Karyn O'Neil

    IPC分类号： C07K16/00 ,  G01N33/53

    CPC分类号： C12N15/1044 ,  A61K38/00 ,  C07K14/78 ,  C40B40/08 ,  C40B50/06

    摘要： A protein scaffold based on a consensus sequence of the tenth fibronectin type III (FN3) repeat from human fibronectin, including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. In particular, protein scaffold molecules binding to IgG based on the consensus sequence have been identified as useful for diagnostic and/or therapeutic applications.

    摘要翻译： 基于来自人纤连蛋白的第十纤维连接蛋白III型（FN3）重复共有序列的蛋白质支架，包括编码蛋白质支架的分离的核酸，载体，宿主细胞及其制备和使用的方法具有诊断和/ 或治疗组合物，方法和装置。 特别地，已经鉴定了基于共有序列与IgG结合的蛋白质支架分子对于诊断和/或治疗应用是有用的。