公开(公告)号：US20210130285A1

公开(公告)日：2021-05-06

申请号：US17020380

申请日：2020-09-14

申请人： AurimMed Pharma, Inc.

发明人： Amir Pesyan ,  Manuel F. Balandrin

IPC分类号： C07C233/11 ,  A61P25/28 ,  A61P25/16 ,  C07C235/28 ,  C07C233/58 ,  C07C237/22 ,  C07D295/155 ,  C07C235/34 ,  C07D319/18 ,  C07D317/60 ,  C07C255/54 ,  C07D295/185 ,  C07D307/81 ,  C07D211/62 ,  C07D211/16 ,  C07D207/16 ,  C07D213/56 ,  C07D213/643 ,  C07D213/61 ,  C07D211/60 ,  C07C235/36 ,  C07C237/20

摘要： A series of novel amides showing broad pharmaceutical activity. Compounds described herein are effective as anticonvulsants, chemical countermeasures, and analgesics. Such compounds also show, neuroprotective/neuroreparative effects and activity against spinal muscular atrophy. Such pharmaceutically active compounds show utility in the treatment of central nervous system (“CNS”) diseases and disorders, such as anxiety, depression, insomnia, migraine headaches, schizophrenia, neurodegenerative diseases (e.g., Parkinson's disease, Alzheimer's, ALS, and Huntington's disease) spasticity, and bipolar disorder. Furthermore, such compounds may additionally find utility as analgesics (e.g., for the treatment of chronic or neuropathic pain) and as neuroprotective agents useful in the treatment of stroke(s), and/or traumatic brain and/or spinal cord injuries.

公开(公告)号：US10793515B2

公开(公告)日：2020-10-06

申请号：US14938341

申请日：2015-11-11

申请人： AurimMed Pharma, Inc.

发明人： Amir Pesyan ,  Manuel F. Balandrin

IPC分类号： A61K31/165 ,  C07C237/22 ,  C07C233/08 ,  C07D295/033 ,  C07D295/155 ,  A61K31/36 ,  A61K31/495 ,  C07D295/185 ,  A61K31/353 ,  A61K31/445 ,  A61K31/5375 ,  C07D211/26 ,  A61K45/06 ,  A61K31/44 ,  C07D213/61 ,  C07D211/16 ,  C07D213/56 ,  C07D213/65 ,  C07C233/11 ,  C07D319/18 ,  C07C235/20 ,  C07C233/58 ,  C07D211/60 ,  C07C255/54 ,  C07C235/34 ,  C07D211/62 ,  C07D317/60 ,  C07D307/79 ,  C07D207/16 ,  C07C235/78

摘要： A series of novel amides showing broad pharmaceutical activity. Compounds described herein are effective as anticonvulsants, chemical countermeasures, and analgesics. Such compounds also show, neuroprotective/neuroreparative effects and activity against spinal muscular atrophy. Such pharmaceutically active compounds show utility in the treatment of central nervous system (“CNS”) diseases and disorders, such as anxiety, depression, insomnia, migraine headaches, schizophrenia, neurodegenerative diseases (e.g., Parkinson's disease, Alzheimer's, ALS, and Huntington's disease) spasticity, and bipolar disorder. Furthermore, such compounds may additionally find utility as analgesics (e.g., for the treatment of chronic or neuropathic pain) and as neuroprotective agents useful in the treatment of stroke(s), and/or traumatic brain and/or spinal cord injuries.

公开(公告)号：US20240239739A1

公开(公告)日：2024-07-18

申请号：US17870490

申请日：2022-07-21

申请人： AurimMed Pharma, Inc.

发明人： Amir Pesyan ,  Manuel F. Balandrin

IPC分类号： C07C233/11 ,  A61P25/16 ,  A61P25/28 ,  C07C233/58 ,  C07C235/28 ,  C07C235/34 ,  C07C235/36 ,  C07C237/20 ,  C07C237/22 ,  C07C255/54 ,  C07D207/16 ,  C07D211/16 ,  C07D211/60 ,  C07D211/62 ,  C07D213/56 ,  C07D213/61 ,  C07D213/643 ,  C07D295/155 ,  C07D295/185 ,  C07D307/81 ,  C07D317/60 ,  C07D319/18

CPC分类号： C07C233/11 ,  A61P25/16 ,  A61P25/28 ,  C07C233/58 ,  C07C235/28 ,  C07C235/34 ,  C07C235/36 ,  C07C237/20 ,  C07C237/22 ,  C07C255/54 ,  C07D207/16 ,  C07D211/16 ,  C07D211/60 ,  C07D211/62 ,  C07D213/56 ,  C07D213/61 ,  C07D213/643 ,  C07D295/155 ,  C07D295/185 ,  C07D307/81 ,  C07D317/60 ,  C07D319/18

摘要： A series of novel amides showing broad pharmaceutical activity. Compounds described herein are effective as anticonvulsants, chemical countermeasures, and analgesics. Such compounds also show, neuroprotective/neuroreparative effects and activity against spinal muscular atrophy. Such pharmaceutically active compounds show utility in the treatment of central nervous system (“CNS”) diseases and disorders, such as anxiety, depression, insomnia, migraine headaches, schizophrenia, neurodegenerative diseases (e.g., Parkinson's disease, Alzheimer's, ALS, and Huntington's disease) spasticity, and bipolar disorder. Furthermore, such compounds may additionally find utility as analgesics (e.g., for the treatment of chronic or neuropathic pain) and as neuroprotective agents useful in the treatment of stroke(s), and/or traumatic brain and/or spinal cord injuries.

公开(公告)号：US20160137592A1

公开(公告)日：2016-05-19

申请号：US14938341

申请日：2015-11-11

申请人： AurimMed Pharma, Inc.

发明人： Amir Pesyan ,  Manuel F. Balandrin

IPC分类号： C07C233/08 ,  C07D295/033

CPC分类号： C07C233/08 ,  A61K31/165 ,  A61K31/353 ,  A61K31/36 ,  A61K31/44 ,  A61K31/445 ,  A61K31/495 ,  A61K31/5375 ,  A61K45/06 ,  C07C233/11 ,  C07C233/58 ,  C07C235/20 ,  C07C235/34 ,  C07C235/78 ,  C07C237/22 ,  C07C255/54 ,  C07C2601/02 ,  C07D207/16 ,  C07D211/16 ,  C07D211/26 ,  C07D211/60 ,  C07D211/62 ,  C07D213/56 ,  C07D213/61 ,  C07D213/65 ,  C07D295/033 ,  C07D295/155 ,  C07D295/185 ,  C07D307/79 ,  C07D317/60 ,  C07D319/18

摘要： A series of novel amides showing broad pharmaceutical activity. Compounds described herein are effective as anticonvulsants, chemical countermeasures, and analgesics. Such compounds also show, neuroprotective/neuroreparative effects and activity against spinal muscular atrophy. Such pharmaceutically active compounds show utility in the treatment of central nervous system (“CNS”) diseases and disorders, such as anxiety, depression, insomnia, migraine headaches, schizophrenia, neurodegenerative diseases (e.g., Parkinson's disease, Alzheimer's, ALS, and Huntington's disease) spasticity, and bipolar disorder. Furthermore, such compounds may additionally find utility as analgesics (e.g., for the treatment of chronic or neuropathic pain) and as neuroprotective agents useful in the treatment of stroke(s), and/or traumatic brain and/or spinal cord injuries.

摘要翻译： 一系列具有广泛药学活性的小分子酰胺。 本文所述的化合物作为抗惊厥药，化学应对措施和止痛剂是有效的。 这些化合物还显示神经保护/神经修复作用和针对脊髓性肌肉萎缩的活性。 这些药物活性化合物在治疗中枢神经系统（“CNS”）的疾病和病症中具有效用，例如焦虑，抑郁，失眠，偏头痛，精神分裂症，神经变性疾病（例如帕金森病，阿尔茨海默病，ALS和亨廷顿舞蹈病 ）痉挛和双相情感障碍。 此外，这些化合物还可用作镇痛药（例如用于治疗慢性或神经性疼痛）和用作治疗中风和/或创伤性脑和/或脊髓损伤的神经保护剂。