-
公开(公告)号：US20100273257A1
公开(公告)日：2010-10-28
申请号：US12321115
申请日：2009-01-15
申请人： Avi J. Ashkenazi , Kevin P. Baker , Anan Chuntharapai , Austin Gurney , Kyung Jin Kim , William I. Wood
发明人： Avi J. Ashkenazi , Kevin P. Baker , Anan Chuntharapai , Austin Gurney , Kyung Jin Kim , William I. Wood
IPC分类号： C12N5/10 , C07K14/00 , C07K16/18 , C12N5/16 , C07H21/04 , C12N15/63 , C12N1/19 , C12N1/21 , C12N5/071
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K2039/505 , C07K14/4747 , C07K14/70578 , C07K16/2878 , C07K2319/00 , G01N33/57484 , G01N33/68
摘要： Novel polypeptides, designated Apo-2DcR, which are capable of binding Apo-2 ligand are provided. Compositions including Apo-2DcR chimeras, nucleic acid encoding Apo-2DcR, and antibodies to Apo-2DcR are also provided.
摘要翻译： 提供了能够结合Apo-2配体的新型多肽，称为Apo-2DcR。 还提供了包含Apo-2DcR嵌合体，编码Apo-2DcR的核酸和Apo-2DcR抗体的组合物。
-
公开(公告)号：US20100269184A1
公开(公告)日：2010-10-21
申请号：US12653340
申请日：2009-12-10
IPC分类号： A01K67/00 , C07K14/705 , C07K19/00 , C07K16/28 , C07H21/04 , C12N15/63 , C12N1/19 , A61K38/16 , C12P21/02 , C12N5/02 , A61P35/00
CPC分类号： C07K14/70575 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A61K38/00 , C07K14/70578 , C07K2319/00 , C07K2319/30
摘要： Novel polypeptides, designated Apo-2DcR, which are capable of binding Apo-2 ligand are provided. Compositions including Apo-2DcR chimeras, nucleic acid encoding Apo-2DcR, and antibodies to Apo-2DcR are also provided.
-
公开(公告)号：US07314619B2
公开(公告)日：2008-01-01
申请号：US10052798
申请日：2001-11-02
CPC分类号： C07K14/4747 , A61K38/00 , C07K14/70578 , C07K16/2878 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/20 , C07K2319/21 , C07K2319/30
摘要： Novel polypeptides, designated Apo-2, which are capable of modulating apoptosis are provided. Compositions including Apo-2 chimeras, nucleic acid encoding Apo-2, and antibodies to Apo-2 are also provided.
摘要翻译： 提供了能够调节细胞凋亡的新型多肽，称为Apo-2。 还提供了包含Apo-2嵌合体，编码Apo-2的核酸和Apo-2抗体的组合物。
-
公开(公告)号：US6046048A
公开(公告)日：2000-04-04
申请号：US780496
申请日：1997-01-08
IPC分类号： C07K14/705 , C07K16/28 , C12N5/16
CPC分类号： C07K14/70575 , C07K16/2875 , C07K2317/34
摘要： A novel cytokine, designated Apo-2 ligand, which induces mammalian cell apoptosis is provided. The Apo-2 ligand is believed to be a member of the TNF cytokine family. Compositions including Apo-2 ligand chimeras, nucleic acid encoding Apo-2 ligand, and antibodies to Apo-2 ligand are also provided. Methods of using Apo-2 ligand to induce apoptosis and to treat pathological conditions such as cancer, are further provided.
摘要翻译： 提供了诱导哺乳动物细胞凋亡的新型细胞因子，称为Apo-2配体。 Apo-2配体被认为是TNF细胞因子家族的成员。 还提供了包括Apo-2配体嵌合体，编码Apo-2配体的核酸和Apo-2配体的抗体的组合物。 进一步提供了使用Apo-2配体诱导细胞凋亡和治疗病理状况如癌症的方法。
-
公开(公告)号：US07807153B2
公开(公告)日：2010-10-05
申请号：US10423448
申请日：2003-04-25
IPC分类号： A61K39/395 , C07K16/18 , C07K16/28
CPC分类号： C07K14/4747 , A61K38/00 , C07K14/70578 , C07K16/2878 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/20 , C07K2319/21 , C07K2319/30
摘要： Novel polypeptides, designated Apo-2, which are capable of modulating apoptosis are provided. Compositions including Apo-2 chimeras, nucleic acid encoding Apo-2, and antibodies to Apo-2 are also provided.
摘要翻译： 提供了能够调节细胞凋亡的新型多肽，称为Apo-2。 还提供了包含Apo-2嵌合体，编码Apo-2的核酸和Apo-2抗体的组合物。
-
公开(公告)号：US07595046B2
公开(公告)日：2009-09-29
申请号：US11297327
申请日：2005-12-09
CPC分类号： C07K14/4747 , A61K38/00 , C07K14/70578 , C07K16/2878 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/20 , C07K2319/21 , C07K2319/30
摘要： Novel polypeptides, designated Apo-2, which are capable of modulating apoptosis are provided. Compositions including Apo-2 chimeras, nucleic acid encoding Apo-2, and antibodies to Apo-2 are also provided.
摘要翻译： 提供了能够调节细胞凋亡的新型多肽，称为Apo-2。 还提供了包含Apo-2嵌合体，编码Apo-2的核酸和Apo-2抗体的组合物。
-
公开(公告)号：US06764679B2
公开(公告)日：2004-07-20
申请号：US09896096
申请日：2001-06-28
申请人： Avi J. Ashkenazi , David Botstein , Kelly H. Dodge , Audrey Goddard , Austin L. Gurney , Kyung Jin Kim , David A. Lawrence , Robert Pitti , Margaret A. Roy , Daniel B. Tumas , William I. Wood
发明人： Avi J. Ashkenazi , David Botstein , Kelly H. Dodge , Audrey Goddard , Austin L. Gurney , Kyung Jin Kim , David A. Lawrence , Robert Pitti , Margaret A. Roy , Daniel B. Tumas , William I. Wood
IPC分类号： C07K1628
CPC分类号： A01K67/0275 , A01K2217/05 , A61K38/00 , C07K14/70575 , C07K14/70578 , C07K16/2875 , C07K16/2878 , C07K2317/73 , C07K2319/00 , C12N2799/026
摘要： A TNFR homolog, identified as DcR3, is provided. Nucleic acid molecules encoding DcR3, chimeric molecules and antibodies to DcR3 are also provided.
摘要翻译： 提供了标识为DcR3的TNFR同源物。 还提供了编码DcR3的核酸分子，嵌合分子和DcR3的抗体。
-
公开(公告)号：US07056736B2
公开(公告)日：2006-06-06
申请号：US09989328
申请日：2001-11-19
申请人： Avi J. Ashkenazi , Kevin P. Baker , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Sherman Fong , Hanspeter Gerber , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Ivar J. Kljavin , Mary A. Napier , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Timothy A. Stewart , Daniel Tumas , Colin K. Watanabe , P. Mickey Williams , William I. Wood , Zemin Zhang
发明人： Avi J. Ashkenazi , Kevin P. Baker , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Sherman Fong , Hanspeter Gerber , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Ivar J. Kljavin , Mary A. Napier , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Timothy A. Stewart , Daniel Tumas , Colin K. Watanabe , P. Mickey Williams , William I. Wood , Zemin Zhang
CPC分类号： C07K14/47
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
-
公开(公告)号：US20090191184A1
公开(公告)日：2009-07-30
申请号：US12287810
申请日：2008-10-14
申请人： Avi J. Ashkenazi , David Botstein , Kelly H. Dodge , Audrey Goddard , Austin L. Gurney , Kyung Jin Kim , David A. Lawrence , Robert Pitti , Margaret A. Roy , Daniel B. Tumas , William I. Wood
发明人： Avi J. Ashkenazi , David Botstein , Kelly H. Dodge , Audrey Goddard , Austin L. Gurney , Kyung Jin Kim , David A. Lawrence , Robert Pitti , Margaret A. Roy , Daniel B. Tumas , William I. Wood
IPC分类号： A61K38/17 , A61K39/395
CPC分类号： C07K14/70578 , A01K2217/05 , C07H21/04
摘要： A TNFR homolog, identified as DcR3, is provided. Nucleic acid molecules encoding DcR3, chimeric molecules and antibodies to DcR3 are also provided.
摘要翻译： 提供了标识为DcR3的TNFR同源物。 还提供了编码DcR3的核酸分子，嵌合分子和DcR3的抗体。
-
10.发明申请Novel tumor necrosis factor receptor homolog and nucleic acids encoding the same 审中-公开新型肿瘤坏死因子受体同源物和核酸编码相同公开(公告)号：US20100010195A1
公开(公告)日：2010-01-14
申请号：US12384695
申请日：2009-04-08
申请人： Avi J. Ashkenazi , Audrey Goddard , Austin Gurney , Scot A. Marsters , Robert M. Pitti , William I. Wood
发明人： Avi J. Ashkenazi , Audrey Goddard , Austin Gurney , Scot A. Marsters , Robert M. Pitti , William I. Wood
IPC分类号： C07K14/475
CPC分类号： C07K14/70578 , A61K38/00 , C07K14/4747 , C07K14/70575 , C07K2319/00 , C12N2799/026
摘要： The present invention is directed to novel polypeptides having homology to members of the tumor necrosis factor receptor family and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及与肿瘤坏死因子受体家族的成员具有同源性的新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
-
-
-
-
-
-
-
-
-
搜索结果
85 条记录 (耗时 0.056 秒)
