-
公开(公告)号：US20100273257A1
公开(公告)日：2010-10-28
申请号：US12321115
申请日：2009-01-15
申请人： Avi J. Ashkenazi , Kevin P. Baker , Anan Chuntharapai , Austin Gurney , Kyung Jin Kim , William I. Wood
发明人： Avi J. Ashkenazi , Kevin P. Baker , Anan Chuntharapai , Austin Gurney , Kyung Jin Kim , William I. Wood
IPC分类号： C12N5/10 , C07K14/00 , C07K16/18 , C12N5/16 , C07H21/04 , C12N15/63 , C12N1/19 , C12N1/21 , C12N5/071
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K2039/505 , C07K14/4747 , C07K14/70578 , C07K16/2878 , C07K2319/00 , G01N33/57484 , G01N33/68
摘要： Novel polypeptides, designated Apo-2DcR, which are capable of binding Apo-2 ligand are provided. Compositions including Apo-2DcR chimeras, nucleic acid encoding Apo-2DcR, and antibodies to Apo-2DcR are also provided.
摘要翻译： 提供了能够结合Apo-2配体的新型多肽，称为Apo-2DcR。 还提供了包含Apo-2DcR嵌合体，编码Apo-2DcR的核酸和Apo-2DcR抗体的组合物。
-
公开(公告)号：US20100269184A1
公开(公告)日：2010-10-21
申请号：US12653340
申请日：2009-12-10
IPC分类号： A01K67/00 , C07K14/705 , C07K19/00 , C07K16/28 , C07H21/04 , C12N15/63 , C12N1/19 , A61K38/16 , C12P21/02 , C12N5/02 , A61P35/00
CPC分类号： C07K14/70575 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A61K38/00 , C07K14/70578 , C07K2319/00 , C07K2319/30
摘要： Novel polypeptides, designated Apo-2DcR, which are capable of binding Apo-2 ligand are provided. Compositions including Apo-2DcR chimeras, nucleic acid encoding Apo-2DcR, and antibodies to Apo-2DcR are also provided.
-
3.发明申请Novel tumor necrosis factor receptor homolog and nucleic acids encoding the same 审中-公开新型肿瘤坏死因子受体同源物和核酸编码相同公开(公告)号：US20100010195A1
公开(公告)日：2010-01-14
申请号：US12384695
申请日：2009-04-08
申请人： Avi J. Ashkenazi , Audrey Goddard , Austin Gurney , Scot A. Marsters , Robert M. Pitti , William I. Wood
发明人： Avi J. Ashkenazi , Audrey Goddard , Austin Gurney , Scot A. Marsters , Robert M. Pitti , William I. Wood
IPC分类号： C07K14/475
CPC分类号： C07K14/70578 , A61K38/00 , C07K14/4747 , C07K14/70575 , C07K2319/00 , C12N2799/026
摘要： The present invention is directed to novel polypeptides having homology to members of the tumor necrosis factor receptor family and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及与肿瘤坏死因子受体家族的成员具有同源性的新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
-
公开(公告)号：US20120042400A1
公开(公告)日：2012-02-16
申请号：US12927919
申请日：2010-11-29
申请人： Avi J. Ashkenazi , Austin Gurney
发明人： Avi J. Ashkenazi , Austin Gurney
IPC分类号： A01K67/027 , C07K19/00 , C07K16/28 , C12N15/12 , C12N15/63 , G01N33/566 , C12N1/21 , C12N5/10 , C12P21/02 , A61K38/17 , A61K39/395 , C12N5/071 , C07K14/705 , C12N1/19
CPC分类号： C07K14/70578
摘要： Novel polypeptides, designated RTD, which are capable of binding Apo-2 ligand are provided. Compositions including RTD chimeras, nucleic acid encoding RTD, and antibodies to RTD are also provided.
摘要翻译： 提供了能够结合Apo-2配体的命名为RTD的新型多肽。 还提供了包括RTD嵌合体，编码RTD的核酸和RTD抗体的组合物。
-
公开(公告)号：US20070037191A1
公开(公告)日：2007-02-15
申请号：US11475718
申请日：2006-06-27
申请人： Avi Ashkenazi , Kevin Baker , Anan Chuntharapai , Austin Gurney , Kyung Kim , William Wood
发明人： Avi Ashkenazi , Kevin Baker , Anan Chuntharapai , Austin Gurney , Kyung Kim , William Wood
IPC分类号： C12Q1/68 , G01N33/574 , C07H21/04 , C12P21/06 , C07K14/705
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K2039/505 , C07K14/4747 , C07K14/70578 , C07K16/2878 , C07K2319/00 , G01N33/57484 , G01N33/68
摘要： Novel polypeptides, designated Apo-2DcR, which are capable of binding Apo-2 ligand are provided. Compositions including Apo-2DcR chimeras, nucleic acid encoding Apo-2DcR, and antibodies to Apo-2DcR are also provided.
摘要翻译： 提供了能够结合Apo-2配体的新型多肽，称为Apo-2DcR。 还提供了包含Apo-2DcR嵌合体，编码Apo-2DcR的核酸和Apo-2DcR抗体的组合物。
-
公开(公告)号：US07256264B2
公开(公告)日：2007-08-14
申请号：US10410552
申请日：2003-04-08
IPC分类号： C07K14/00
CPC分类号： C07K14/705 , A61K38/00 , C07K14/54 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N2500/04
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
-
公开(公告)号：US07217412B2
公开(公告)日：2007-05-15
申请号：US09854208
申请日：2001-05-10
申请人： Jian Chen , Ellen Filvaroff , Audrey Goddard , Austin Gurney , Hanzhong Li , William I. Wood
发明人： Jian Chen , Ellen Filvaroff , Audrey Goddard , Austin Gurney , Hanzhong Li , William I. Wood
IPC分类号： A61K45/00
CPC分类号： C07K14/47 , A61K38/00 , C07K14/52 , C07K14/54 , C07K2319/00 , C07K2319/30 , C12N2799/026
摘要： The present invention is directed to novel polypeptides having sequence identity with IL-17 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders.
摘要翻译： 本发明涉及与IL-17具有序列同一性的新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本文还提供了治疗退行性软骨疾病的方法。
-
公开(公告)号：US07074592B2
公开(公告)日：2006-07-11
申请号：US09909320
申请日：2001-07-18
申请人： Avi Ashkenazi , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin Gurney , Kenneth J. Hillan , Ivar J. Kljavin , Jenni P. Mather , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Timothy A. Stewart , Daniel Tumas , P. Mickey Williams , William I. Wood
发明人： Avi Ashkenazi , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin Gurney , Kenneth J. Hillan , Ivar J. Kljavin , Jenni P. Mather , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Timothy A. Stewart , Daniel Tumas , P. Mickey Williams , William I. Wood
CPC分类号： C07K14/47
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
-
公开(公告)号：US20090291097A1
公开(公告)日：2009-11-26
申请号：US11802794
申请日：2007-05-25
申请人： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Daniel Tumas , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura
发明人： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Daniel Tumas , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura
IPC分类号： A61K39/395 , C07K16/18 , A61P37/00
摘要： The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
-
10.发明申请NUCLEIC ACIDS ENCODING RECEPTOR FOR IL-17 HOMOLOGOUS POLYPEPTIDES AND USES THEREOF 审中-公开IL-17同种异体多核苷酸编码受体的核酸及其用途公开(公告)号：US20090227017A1
公开(公告)日：2009-09-10
申请号：US12417097
申请日：2009-04-02
申请人： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Daniel Tumas , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura
发明人： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Daniel Tumas , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura
CPC分类号： C07K14/705 , A61K38/00 , C07K14/54 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N2500/04
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
-
-
-
-
-
-
-
-
-
搜索结果
254 条记录 (耗时 0.061 秒)
