公开(公告)号：US20100010195A1

公开(公告)日：2010-01-14

申请号：US12384695

申请日：2009-04-08

申请人： Avi J. Ashkenazi ,  Audrey Goddard ,  Austin Gurney ,  Scot A. Marsters ,  Robert M. Pitti ,  William I. Wood

发明人： Avi J. Ashkenazi ,  Audrey Goddard ,  Austin Gurney ,  Scot A. Marsters ,  Robert M. Pitti ,  William I. Wood

IPC分类号： C07K14/475

CPC分类号： C07K14/70578 ,  A61K38/00 ,  C07K14/4747 ,  C07K14/70575 ,  C07K2319/00 ,  C12N2799/026

摘要： The present invention is directed to novel polypeptides having homology to members of the tumor necrosis factor receptor family and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及与肿瘤坏死因子受体家族的成员具有同源性的新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：US07135334B2

公开(公告)日：2006-11-14

申请号：US10223087

申请日：2002-08-16

申请人： Kevin P. Baker ,  Napoleone Ferrara ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Scot A. Marsters ,  James Pan ,  Jean-Philippe F. Stephan ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Weilan Ye

发明人： Kevin P. Baker ,  Napoleone Ferrara ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Scot A. Marsters ,  James Pan ,  Jean-Philippe F. Stephan ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Weilan Ye

IPC分类号： C12N1/21 ,  C12N1/15 ,  C12N5/10 ,  C12N15/12 ,  C12N15/63

CPC分类号： A61K38/17 ,  C07H21/04 ,  C07K14/435 ,  C07K14/47 ,  C12N5/06 ,  C12N9/00 ,  C12P21/02

摘要： Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 公开了用于刺激或抑制哺乳动物，包括人类的血管发生和/或心血管化的组合物和方法。 药物组合物基于已被鉴定为一种或多种这些用途的多肽或其拮抗剂。 可以通过本文组合物诊断，预防或治疗的疾病包括创伤，例如创伤，各种癌症和血管障碍，包括动脉粥样硬化和心脏肥大。 此外，本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：US20080213837A1

公开(公告)日：2008-09-04

申请号：US11980174

申请日：2007-10-30

申请人： Avi J. Ashkenazi ,  Scot A. Marsters ,  Robert Pitti

发明人： Avi J. Ashkenazi ,  Scot A. Marsters ,  Robert Pitti

IPC分类号： C12P21/02 ,  C07H21/04 ,  C12N15/00 ,  C12N5/00 ,  C12N5/10 ,  C12N1/21 ,  C12N1/19

CPC分类号： C07K14/70575 ,  A61K38/00 ,  C07K2317/24 ,  C07K2319/02 ,  G01N2333/4718

摘要： A tumor necrosis factor and lymphotoxin homolog having apoptotic activity, identified as Apo-3 Ligand, is provided. Nucleic acid molecules encoding Apo-3 Ligand, chimeric molecules and antibodies to Apo-3 Ligand are also provided.

公开(公告)号：US20080171037A1

公开(公告)日：2008-07-17

申请号：US11890702

申请日：2007-08-07

申请人： Avi J. Ashkenazi ,  Scot A. Marsters ,  Robert Pitti

发明人： Avi J. Ashkenazi ,  Scot A. Marsters ,  Robert Pitti

IPC分类号： A61K39/395 ,  C07K14/00 ,  C07K16/00

CPC分类号： C07K14/70575 ,  A61K38/00 ,  C07K2317/24 ,  C07K2319/02 ,  G01N2333/4718

摘要： A tumor necrosis factor and lymphotoxin homolog having apoptotic activity, identified as Apo-3 Ligand, is provided. Nucleic acid molecules encoding Apo-3 Ligand, chimeric molecules and antibodies to Apo-3 Ligand are also provided.

摘要翻译： 提供了具有凋亡活性的肿瘤坏死因子和淋巴毒素同系物，鉴定为Apo-3配体。 还提供了编码Apo-3配体的核酸分子，嵌合分子和Apo-3配体的抗体。

公开(公告)号：US20080050377A1

公开(公告)日：2008-02-28

申请号：US10553491

申请日：2004-04-16

申请人： Heidi Ackerly ,  Avi Ashkenazi ,  David Eberhard ,  Gretchen Frantz ,  Dorothy French ,  Germaine G. Fuh ,  Jo-Anne S. Hongo ,  Chingwei V. Lee ,  Scot A. Marsters ,  Helga A. Raab ,  Evgeny Varfolomeev ,  Beni B. Wolf ,  Robert Maurice Pitti ,  Liliana Soroceanu

发明人： Heidi Ackerly ,  Avi Ashkenazi ,  David Eberhard ,  Gretchen Frantz ,  Dorothy French ,  Germaine G. Fuh ,  Jo-Anne S. Hongo ,  Chingwei V. Lee ,  Scot A. Marsters ,  Helga A. Raab ,  Evgeny Varfolomeev ,  Beni B. Wolf ,  Robert Maurice Pitti ,  Liliana Soroceanu

IPC分类号： C07K16/30 ,  A61K39/395 ,  A61P35/00 ,  C12N1/00 ,  C12N15/63 ,  G01N33/574 ,  G01N33/53 ,  C12N15/13 ,  C07K14/435 ,  C07K16/18

CPC分类号： C07K16/32 ,  C07K16/22 ,  C07K16/4283 ,  C07K2317/24 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622

摘要： The present invention provides novel polypeptides, antibodies, antagonists, agonists, potentiators, nucleic acid molecules, compositions and methods relating to the STOP-1 polypeptide that are useful for treating and preventing diseases and for medical diagnosis and research. The present invention also provides consensus sequences and specific sequences for antibodies that specifically bind to STOP-1 that are useful in the methods described herein.

摘要翻译： 本发明提供了可用于治疗和预防疾病和医学诊断和研究的新型多肽，抗体，拮抗剂，激动剂，增效剂，核酸分子，与STOP-1多肽相关的组合物和方法。 本发明还提供了与本文所述方法有用的特异性结合STOP-1的抗体的共有序列和特异性序列。

公开(公告)号：US20110112279A1

公开(公告)日：2011-05-12

申请号：US12845470

申请日：2010-07-28

申请人： HEIDI ACKERLY ,  Avi Ashkenazi ,  David Eberhard ,  Gretchen Frantz ,  Dorothy French ,  Germaine G. Fuh ,  Jo-Anne S. Hongo ,  Chingwei V. Lee ,  Scot A. Marsters ,  Helga A. Raab ,  Evgeny Varfolomeev ,  Beni B. Wolf ,  Robert Maurice Pitti ,  Liliana Soroceanu

发明人： HEIDI ACKERLY ,  Avi Ashkenazi ,  David Eberhard ,  Gretchen Frantz ,  Dorothy French ,  Germaine G. Fuh ,  Jo-Anne S. Hongo ,  Chingwei V. Lee ,  Scot A. Marsters ,  Helga A. Raab ,  Evgeny Varfolomeev ,  Beni B. Wolf ,  Robert Maurice Pitti ,  Liliana Soroceanu

IPC分类号： C07K16/18

CPC分类号： C07K16/32 ,  C07K16/22 ,  C07K16/4283 ,  C07K2317/24 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622

摘要： The present invention provides novel polypeptides, antibodies, antagonists, agonists, potentiators, nucleic acid molecules, compositions and methods relating to the STOP-1 polypeptide that are useful for treating and preventing diseases and for medical diagnosis and research. The present invention also provides consensus sequences and specific sequences for antibodies that specifically bind to STOP-1 that are useful in the methods described herein.

摘要翻译： 本发明提供了可用于治疗和预防疾病和医学诊断和研究的新型多肽，抗体，拮抗剂，激动剂，增效剂，核酸分子，与STOP-1多肽相关的组合物和方法。 本发明还提供了与本文所述方法有用的特异性结合STOP-1的抗体的共有序列和特异性序列。