公开(公告)号：US20080182275A1

公开(公告)日：2008-07-31

申请号：US11786466

申请日：2007-04-10

申请人： Avi J Ashkenazi ,  Kevin P. Baker ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Ivar J. Kljavin ,  Sophia S. Kuo ,  Mary A. Napier ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  David L. Shelton ,  Timothy A. Stewart ,  Daniel Tumas ,  P. Mickey Williams ,  William I. Wood

发明人： Avi J Ashkenazi ,  Kevin P. Baker ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Ivar J. Kljavin ,  Sophia S. Kuo ,  Mary A. Napier ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  David L. Shelton ,  Timothy A. Stewart ,  Daniel Tumas ,  P. Mickey Williams ,  William I. Wood

IPC分类号： G01N33/53 ,  C07H21/04 ,  C12N15/63 ,  C12N5/06 ,  C12N5/16 ,  C12N1/21 ,  C12N1/19 ,  C12P21/00 ,  C07K2/00 ,  C07K16/46 ,  C07K16/18 ,  G01N33/566

CPC分类号： C07K14/47 ,  G01N33/6872

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US07196165B2

公开(公告)日：2007-03-27

申请号：US09978375

申请日：2001-10-16

申请人： Avi J. Ashkenazi ,  Kevin P. Baker ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Ivar J. Kljavin ,  Sophia S. Kuo ,  Mary A. Napier ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  David L. Shelton ,  Timothy A. Stewart ,  Daniel Tumas ,  P. Mickey Williams ,  William I. Wood

发明人： Avi J. Ashkenazi ,  Kevin P. Baker ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Ivar J. Kljavin ,  Sophia S. Kuo ,  Mary A. Napier ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  David L. Shelton ,  Timothy A. Stewart ,  Daniel Tumas ,  P. Mickey Williams ,  William I. Wood

IPC分类号： C07K14/00

CPC分类号： C07K14/705

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：US07189529B2

公开(公告)日：2007-03-13

申请号：US10013927

申请日：2001-10-25

申请人： Avi J. Ashkenazi ,  Kevin P. Baker ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Ivar J. Kljavin ,  Sophia S. Kuo ,  Mary A. Napier ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  David L. Shelton ,  Timothy A. Stewart ,  Daniel Tumas ,  P. Mickey Williams ,  William I. Wood

发明人： Avi J. Ashkenazi ,  Kevin P. Baker ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Ivar J. Kljavin ,  Sophia S. Kuo ,  Mary A. Napier ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  David L. Shelton ,  Timothy A. Stewart ,  Daniel Tumas ,  P. Mickey Williams ,  William I. Wood

IPC分类号： C12P21/06 ,  C12N1/12 ,  C12N15/00 ,  C07H21/04

CPC分类号： C07K14/47

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：US07029874B2

公开(公告)日：2006-04-18

申请号：US10013917

申请日：2001-10-25

申请人： Kevin P. Baker ,  Luc Desnoyers ,  Dan L. Eaton ,  Ellen Filvaroff ,  Wei-Qiang Gao ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Sophia S. Kuo ,  James Pan ,  Margaret Ann Roy ,  Timothy A. Stewart ,  Daniel Tumas ,  William I. Wood

发明人： Kevin P. Baker ,  Luc Desnoyers ,  Dan L. Eaton ,  Ellen Filvaroff ,  Wei-Qiang Gao ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Sophia S. Kuo ,  James Pan ,  Margaret Ann Roy ,  Timothy A. Stewart ,  Daniel Tumas ,  William I. Wood

IPC分类号： C12P21/06 ,  C12N15/74 ,  C12N5/02 ,  C07K14/00

CPC分类号： C07K14/705

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US20100331251A1

公开(公告)日：2010-12-30

申请号：US12730034

申请日：2010-03-23

申请人： Napoleone Ferrara ,  Sophia S. Kuo

发明人： Napoleone Ferrara ,  Sophia S. Kuo

IPC分类号： A61K38/18 ,  C12N15/12 ,  C12N15/63 ,  C12N1/00 ,  C12N5/07 ,  C12N1/21 ,  C12N1/19 ,  C12P21/00 ,  C07K14/475 ,  C07K16/00 ,  C12Q1/68 ,  C12Q1/02 ,  C07K16/22 ,  A61P9/00 ,  G01N33/53 ,  A61P19/08 ,  B65D85/00

CPC分类号： C07K14/52 ,  A61K38/00 ,  C07K2319/00 ,  C12N2799/026

摘要： The present invention involves the identification and preparation of vascular endothelial growth factor-E (VEGF-E). VEGF-E is a novel polypeptide related to vascular endothelial growth factor (VEGF) and bone morphogenetic protein 1. VEGF-E has homology to VEGF including conservation of the amino acids required for activity of VEGF. VEGF-E can be useful in wound repair, as well as in the generation and regeneration of tissue.

摘要翻译： 本发明涉及血管内皮生长因子-E（VEGF-E）的鉴定和制备。 VEGF-E是与血管内皮生长因子（VEGF）和骨形态发生蛋白1相关的新型多肽.VC-E与VEGF具有同源性，包括对VEGF活性所需氨基酸的保守性。 VEGF-E可用于伤口修复，以及组织的产生和再生。

公开(公告)号：US07575879B2

公开(公告)日：2009-08-18

申请号：US11536590

申请日：2006-09-28

申请人： Napoleone Ferrara ,  Sophia S. Kuo

发明人： Napoleone Ferrara ,  Sophia S. Kuo

IPC分类号： G01N33/53 ,  G01N33/567 ,  C07K16/22

CPC分类号： C07K14/52 ,  A61K38/00 ,  C07K2319/00 ,  C12N2799/026

摘要： The present invention involves the identification and preparation of vascular endothelial growth factor-E (VEGF-E). VEGF-E is a novel polypeptide related to vascular endothelial growth factor (VEGF) and bone morphogenetic protein 1. VEGF-E has homology to VEGF including conservation of the amino acids required for activity of VEGF. VEGF-E can be useful in wound repair, as well as in the generation and regeneration of tissue.

摘要翻译： 本发明涉及血管内皮生长因子-E（VEGF-E）的鉴定和制备。 VEGF-E是与血管内皮生长因子（VEGF）和骨形态发生蛋白1相关的新型多肽.VC-E与VEGF具有同源性，包括对VEGF活性所需氨基酸的保守性。 VEGF-E可用于伤口修复，以及组织的产生和再生。

公开(公告)号：US06391311B1

公开(公告)日：2002-05-21

申请号：US09040220

申请日：1998-03-17

申请人： Napoleone Ferrara ,  Sophia S. Kuo

发明人： Napoleone Ferrara ,  Sophia S. Kuo

IPC分类号： A61K3818

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K48/00 ,  C07K14/4702 ,  C07K14/4703 ,  C07K14/475 ,  C07K14/52 ,  C07K14/521 ,  C07K14/54 ,  C07K14/705 ,  C07K14/70503 ,  C07K14/70578 ,  C07K16/18 ,  C07K16/28 ,  C07K2317/24 ,  C07K2319/00 ,  C07K2319/30 ,  C12N9/00 ,  C12N2799/026 ,  C12N2799/027 ,  G01N33/573 ,  G01N33/57484 ,  G01N33/68 ,  G01N2333/99 ,  G01N2800/042

摘要： The present invention involves the identification and preparation of vascular endothelial growth factor-E (VEGF-E). VEGF-E is a novel polypeptide related to vascular endothelial growth factor (VEGF) and bone morphogenetic protein 1. VEGF-E has homology to VEGF including conservation of the amino acids required for activity of VEGF. VEGF-E is shown herein to induce enhanced survival of cells, proliferation of cells and hypertrophy of cells. Thus, VEGF-E can be useful in wound repair, as well as the generation and regeneration of tissue.

摘要翻译： 本发明涉及血管内皮生长因子-E（VEGF-E）的鉴定和制备。 VEGF-E是与血管内皮生长因子（VEGF）和骨形态发生蛋白1相关的新型多肽.VC-E与VEGF具有同源性，包括对VEGF活性所需氨基酸的保守性。 本文显示VEGF-E以诱导细胞增殖的存活，细胞增殖和细胞肥大。 因此，VEGF-E可用于伤口修复，以及组织的产生和再生。

公开(公告)号：US20110319327A1

公开(公告)日：2011-12-29

申请号：US13095097

申请日：2011-04-27

申请人： Napoleone Ferrara ,  Sophia S. Kuo

发明人： Napoleone Ferrara ,  Sophia S. Kuo

IPC分类号： A61K38/18 ,  C12N15/63 ,  C12N5/10 ,  C12N1/21 ,  C12N1/19 ,  C12P21/02 ,  C07K14/475 ,  C07K19/00 ,  G01N33/53 ,  C12Q1/68 ,  G01N33/567 ,  C12Q1/02 ,  C12Q1/42 ,  C07K16/22 ,  A61P9/00 ,  A61P19/08 ,  A61B19/02 ,  C12N15/12

CPC分类号： C07K14/52 ,  A61K38/00 ,  C07K2319/00 ,  C12N2799/026

摘要： The present invention involves the identification and preparation of vascular endothelial growth factor-E (VEGF-E). VEGF-E is a novel polypeptide related to vascular endothelial growth factor (VEGF) and bone morphogenetic protein 1. VEGF-E has homology to VEGF including conservation of the amino acids required for activity of VEGF. VEGF-E can be useful in wound repair, as well as in the generation and regeneration of tissue.

摘要翻译： 本发明涉及血管内皮生长因子-E（VEGF-E）的鉴定和制备。 VEGF-E是与血管内皮生长因子（VEGF）和骨形态发生蛋白1相关的新型多肽.VC-E与VEGF具有同源性，包括对VEGF活性所需氨基酸的保守性。 VEGF-E可用于伤口修复，以及组织的产生和再生。

公开(公告)号：US20090264370A9

公开(公告)日：2009-10-22

申请号：US12189012

申请日：2008-08-08

申请人： Napoleone Ferrara ,  Sophia S. Kuo

发明人： Napoleone Ferrara ,  Sophia S. Kuo

IPC分类号： A61K38/00 ,  C07K7/00 ,  C12N15/11 ,  C12N15/00 ,  C12N5/06 ,  C12N1/19 ,  C12N1/20 ,  C12N7/00 ,  A61P43/00

CPC分类号： C07K14/52 ,  A61K38/00 ,  C07K2319/00 ,  C12N2799/026

摘要： The present invention involves the identification and preparation of vascular endothelial growth factor-E (VEGF-E). VEGF-E is a novel polypeptide related to vascular endothelial growth factor (VEGF) and bone morphogenetic protein 1. VEGF-E has homology to VEGF including conservation of the amino acids required for activity of VEGF. VEGF-E can be useful in wound repair, as well as in the generation and regeneration of tissue.

公开(公告)号：US20090012003A1

公开(公告)日：2009-01-08

申请号：US12189012

申请日：2008-08-08

申请人： Napoleone Ferrara ,  Sophia S. Kuo

发明人： Napoleone Ferrara ,  Sophia S. Kuo

IPC分类号： A61K38/00 ,  C07K7/00 ,  C12N15/11 ,  C12N15/00 ,  C12N5/06 ,  C12N1/19 ,  C12N1/20 ,  C12N7/00 ,  A61P43/00

CPC分类号： C07K14/52 ,  A61K38/00 ,  C07K2319/00 ,  C12N2799/026

摘要： The present invention involves the identification and preparation of vascular endothelial growth factor-E (VEGF-E). VEGF-E is a novel polypeptide related to vascular endothelial growth factor (VEGF) and bone morphogenetic protein 1. VEGF-E has homology to VEGF including conservation of the amino acids required for activity of VEGF. VEGF-E can be useful in wound repair, as well as in the generation and regeneration of tissue.

摘要翻译： 本发明涉及血管内皮生长因子-E（VEGF-E）的鉴定和制备。 VEGF-E是与血管内皮生长因子（VEGF）和骨形态发生蛋白1相关的新型多肽.VC-E与VEGF具有同源性，包括对VEGF活性所需氨基酸的保守性。 VEGF-E可用于伤口修复，以及组织的产生和再生。