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1.发明申请公开(公告)号：US20050090719A1
公开(公告)日：2005-04-28
申请号：US10695430
申请日：2003-10-28
申请人： Avram Scheiner , Donald Hopper , Gerrard Carlson
发明人： Avram Scheiner , Donald Hopper , Gerrard Carlson
IPC分类号： A61B5/029 , A61B5/0472 , A61N1/365 , A61B5/00
CPC分类号： A61B5/4035 , A61B5/029 , A61B5/0472 , A61N1/36585 , G06F19/00
摘要： An implantable device monitors the balance between sympathetic tone and parasympathetic tone as a function of an activity level. Cardio-neurological healthy users exhibit a generally sympathetic tone in conjunction with heavy activity level and a generally parasympathetic tone in conjunction with periods of low activity level. Deviations from expected results are associated with a health problem. Measured conditions are stored and available for subsequent reporting to a remote programmer. Therapy delivered by an implantable device is determined as a function of the relationship between autonomic balance and activity level.
摘要翻译： 可植入装置监测交感神经张力和副交感神经紧张度之间的平衡，作为活动水平的函数。 心脏神经系统健康用户表现出与大量活动水平和大体上副交感神经紧张以及低活动水平结合的共同心情。 与预期结果的偏差与健康问题有关。 测量条件存储并可用于后续报告给远程程序员。 由植入式装置提供的治疗作为自主平衡与活动水平之间关系的函数确定。
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2.发明申请公开(公告)号：US20090299159A1
公开(公告)日：2009-12-03
申请号：US12538553
申请日：2009-08-10
IPC分类号： A61B5/0205
CPC分类号： A61B5/4035 , A61B5/029 , A61B5/0472 , A61N1/36585 , G06F19/00
摘要： An implantable device monitors the balance between sympathetic tone and parasympathetic tone as a function of an activity level. Cardio-neurological healthy users exhibit a generally sympathetic tone in conjunction with heavy activity level and a generally parasympathetic tone in conjunction with periods of low activity level. Deviations from expected results are associated with a health problem. Measured conditions are stored and available for subsequent reporting to a remote programmer. Therapy delivered by an implantable device is determined as a function of the relationship between autonomic balance and activity level.
摘要翻译： 可植入装置监测交感神经张力和副交感神经紧张度之间的平衡，作为活动水平的函数。 心脏神经系统健康用户表现出与大量活动水平和大体上副交感神经紧张以及低活动水平结合的共同心情。 与预期结果的偏差与健康问题有关。 测量条件存储并可用于后续报告给远程程序员。 由植入式装置提供的治疗作为自主平衡与活动水平之间关系的函数确定。
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3.发明授权公开(公告)号：US07572226B2
公开(公告)日：2009-08-11
申请号：US10695430
申请日：2003-10-28
IPC分类号： A61B5/00
CPC分类号： A61B5/4035 , A61B5/029 , A61B5/0472 , A61N1/36585 , G06F19/00
摘要： An implantable device monitors the balance between sympathetic tone and parasympathetic tone as a function of an activity level. Cardio-neurological healthy users exhibit a generally sympathetic tone in conjunction with heavy activity level and a generally parasympathetic tone in conjunction with periods of low activity level. Deviations from expected results are associated with a health problem. Measured conditions are stored and available for subsequent reporting to a remote programmer. Therapy delivered by an implantable device is determined as a function of the relationship between autonomic balance and activity level.
摘要翻译： 可植入装置监测交感神经张力和副交感神经紧张度之间的平衡，作为活动水平的函数。 心脏神经系统健康用户表现出与大量活动水平和大体上副交感神经紧张以及低活动水平结合的共同心情。 与预期结果的偏差与健康问题有关。 测量条件存储并可用于后续报告给远程程序员。 由植入式装置提供的治疗作为自主平衡与活动水平之间关系的函数确定。
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公开(公告)号：US07142920B2
公开(公告)日：2006-11-28
申请号：US10853574
申请日：2004-05-25
申请人： Avram Scheiner , Donald Hopper
发明人： Avram Scheiner , Donald Hopper
IPC分类号： A61N1/30
CPC分类号： A61N1/36514
摘要： An implantable cardiac device with an exertion level sensor is programmed to determine a heart rate appropriate for a given measured exertion level in accordance with a physiological model and/or previously collected physiologic data. The device then compares the model's heart rate with a measured intrinsic heart rate. Based upon this data, the device is able to recognize changes in the patient's heart rate response and predict or recognize a chronotropically incompetent condition.
摘要翻译： 具有消耗水平传感器的可植入心脏装置被编程以根据生理模型和/或先前收集的生理数据确定适合于给定测量的运动水平的心率。 然后，该装置将模型的心率与测量的内在心率进行比较。 基于该数据，该装置能够识别患者的心率响应的变化并且预测或识别慢性无能力的状况。
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公开(公告)号：US20060195149A1
公开(公告)日：2006-08-31
申请号：US11067964
申请日：2005-02-28
申请人： Donald Hopper , John Voegele , Jesse Hartley , Avram Scheiner
发明人： Donald Hopper , John Voegele , Jesse Hartley , Avram Scheiner
IPC分类号： A61N1/378
CPC分类号： A61B5/686 , A61B5/0022 , A61B5/0024 , A61B5/02028 , A61B5/0205 , A61B5/04012 , A61B5/0402 , A61B5/076 , A61B5/0809 , A61B5/0816 , A61B5/0826 , A61B5/085 , A61B5/091 , A61B5/1118 , A61B5/4836 , A61B5/7275 , A61B5/7282 , A61B5/746 , A61B5/747 , A61N1/3627 , A61N1/36585 , A61N1/3702 , A61N1/3987 , G06F19/00 , G16H50/20 , G16H50/30
摘要： Cardiac monitoring and/or stimulation methods and systems employing dyspnea measurement. An implantable cardiac device may sense transthoracic impedance and determine a patient activity level. An index indicative of pulmonary function is implantably computed to detect an episode of dyspnea based on a change, trend, and/or value exceeding a threshold at a determined patient activity level. Trending one or more pulmonary function index values may be done to determine a patient's pulmonary function index profile, which may be used to adapt a cardiac therapy. A physician may be automatically alerted in response to a pulmonary function index value and/or a trend of the patient's pulmonary index being beyond a threshold. Computed pulmonary function index values and their associated patient's activity levels may be stored periodically in a memory and/or transmitted to a patient-external device.
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公开(公告)号：US20050267541A1
公开(公告)日：2005-12-01
申请号：US10853574
申请日：2004-05-25
申请人： Avram Scheiner , Donald Hopper
发明人： Avram Scheiner , Donald Hopper
IPC分类号： A61N1/365
CPC分类号： A61N1/36514
摘要： An implantable cardiac device with an exertion level sensor is programmed to determine a heart rate appropriate for a given measured exertion level in accordance with a physiological model and/or previously collected physiologic data. The device then compares the model's heart rate with a measured intrinsic heart rate. Based upon this data, the device is able to recognize changes in the patient's heart rate response and predict or recognize a chronotropically incompetent condition.
摘要翻译： 具有消耗水平传感器的可植入心脏装置被编程以根据生理模型和/或先前收集的生理数据确定适合于给定测量的运动水平的心率。 然后，该装置将模型的心率与测量的内在心率进行比较。 基于该数据，该装置能够识别患者的心率响应的变化并且预测或识别慢性无能力的状况。
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7.发明申请公开(公告)号：US20060020295A1
公开(公告)日：2006-01-26
申请号：US10897856
申请日：2004-07-23
CPC分类号： A61B5/087 , A61B5/02405 , A61B5/053 , A61B5/4878 , A61N1/3627 , A61N1/36521
摘要： A system receives signals indicative of cardiopulmonary conditions sensed by a plurality of sensors and provides for monitoring and automated differential diagnosis of the cardiopulmonary conditions based on the signals. Cardiogenic pulmonary edema is detected based on one or more signals sensed by implantable sensors. If the cardiogenic pulmonary edema is not detected, obstructive pulmonary disease and restrictive pulmonary disease are each detected based on a forced vital capacity (FVC) parameter and a forced expiratory volume (FEV) parameter measured from a respiratory signal sensed by an implantable or non-implantable sensor. In one embodiment, an implantable medical device senses signals indicative of the cardiopulmonary conditions, and an external system detects the cardiopulmonary conditions based on these signals by executing an automatic detection algorithm.
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公开(公告)号：US09079033B2
公开(公告)日：2015-07-14
申请号：US12356289
申请日：2009-01-20
CPC分类号： A61N1/3627 , A61B5/0031 , A61B5/021 , A61B5/02405 , A61B5/0816 , A61N1/36521 , A61N1/36592 , A61N1/37247 , A61N1/37258 , G06F19/00 , G06F19/3418 , G16H10/20 , G16H40/63 , G16H50/30
摘要： Changes in patient status are assessed based at least in part on respiration parameters. A user can make selections regarding alert criteria options to be used in assessing patient status. Respiration is implantably sensed and respiration data is stored by an implantable device. A respiration parameter, such as respiration rate, is measured from the respiration data. The change in patient status is assessed by comparing the respiration parameter to the configured alert criteria. If the comparison of the respiration parameter and the configured alert criteria indicates a significant change in patient status, an alert signal is generated.
摘要翻译： 至少部分地基于呼吸参数来评估患者状态的变化。 用户可以对用于评估患者状态的警报标准选项进行选择。 呼吸被植入式感测，呼吸数据由可植入装置储存。 从呼吸数据测量呼吸参数，如呼吸速率。 通过将呼吸参数与配置的警报标准进行比较来评估患者状态的变化。 如果呼吸参数和配置的警报标准的比较表示患者状态的显着变化，则产生警报信号。
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公开(公告)号：US20090234240A1
公开(公告)日：2009-09-17
申请号：US12356289
申请日：2009-01-20
CPC分类号： A61N1/3627 , A61B5/0031 , A61B5/021 , A61B5/02405 , A61B5/0816 , A61N1/36521 , A61N1/36592 , A61N1/37247 , A61N1/37258 , G06F19/00 , G06F19/3418 , G16H10/20 , G16H40/63 , G16H50/30
摘要： Changes in patient status are assessed based at least in part on respiration parameters. A user can make selections regarding alert criteria options to be used in assessing patient status. Respiration is implantably sensed and respiration data is stored by an implantable device. A respiration parameter, such as respiration rate, is measured from the respiration data. The change in patient status is assessed by comparing the respiration parameter to the configured alert criteria. If the comparison of the respiration parameter and the configured alert criteria indicates a significant change in patient status, an alert signal is generated.
摘要翻译： 至少部分地基于呼吸参数来评估患者状态的变化。 用户可以对用于评估患者状态的警报标准选项进行选择。 呼吸被植入式感测，呼吸数据由可植入装置储存。 从呼吸数据测量呼吸参数，如呼吸速率。 通过将呼吸参数与配置的警报标准进行比较来评估患者状态的变化。 如果呼吸参数和配置的警报标准的比较表示患者状态的显着变化，则产生警报信号。
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公开(公告)号：US06823214B1
公开(公告)日：2004-11-23
申请号：US09657402
申请日：2000-09-08
申请人： Weimin Sun , Bruce R. Jones , Douglas J. Lang , Donald Hopper
发明人： Weimin Sun , Bruce R. Jones , Douglas J. Lang , Donald Hopper
IPC分类号： A61N118
CPC分类号： A61N1/365 , A61N1/36585
摘要： A system and method for automatically adjusting the operating parameters of a rate-adaptive cardiac pacemaker. In accordance with the method, maximum exertion levels attained by the patient are measured at periodic intervals and stored. The stored maximum exertion levels may then be used to update a long-term maximal exertion level, and the slope of the rate-response curve is adjusted to map the updated long-term maximal exertion level to a maximum allowable pacing rate. The stored maximum exertion levels may also be used to update a sensor target rate which is used to adjust the slope of the rate response curve.
摘要翻译： 一种用于自动调整速率适应性心脏起搏器的操作参数的系统和方法。 按照该方法，以周期性的间隔测量患者获得的最大功耗水平并存储。 然后可以使用存储的最大消耗水平来更新长期最大消耗水平，并且调整速率 - 响应曲线的斜率以将更新的长期最大消耗水平映射到最大允许起搏速率。 存储的最大消耗电平也可用于更新用于调整速率响应曲线的斜率的传感器目标速率。
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