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    SYSTEM AND METHOD FOR MONITORING AUTONOMIC BALANCE AND PHYSICAL ACTIVITY
    2.
    发明申请
    SYSTEM AND METHOD FOR MONITORING AUTONOMIC BALANCE AND PHYSICAL ACTIVITY 有权
    用于监测自动平衡和物理活动的系统和方法

    公开(公告)号：US20090299159A1

    公开(公告)日：2009-12-03

    申请号：US12538553

    申请日：2009-08-10

    申请人： Avram Scheiner ,  Donald Hopper ,  Gerrard M. Carlson

    发明人： Avram Scheiner ,  Donald Hopper ,  Gerrard M. Carlson

    IPC分类号： A61B5/0205

    CPC分类号： A61B5/4035 ,  A61B5/029 ,  A61B5/0472 ,  A61N1/36585 ,  G06F19/00

    摘要： An implantable device monitors the balance between sympathetic tone and parasympathetic tone as a function of an activity level. Cardio-neurological healthy users exhibit a generally sympathetic tone in conjunction with heavy activity level and a generally parasympathetic tone in conjunction with periods of low activity level. Deviations from expected results are associated with a health problem. Measured conditions are stored and available for subsequent reporting to a remote programmer. Therapy delivered by an implantable device is determined as a function of the relationship between autonomic balance and activity level.

    摘要翻译： 可植入装置监测交感神经张力和副交感神经紧张度之间的平衡，作为活动水平的函数。 心脏神经系统健康用户表现出与大量活动水平和大体上副交感神经紧张以及低活动水平结合的共同心情。 与预期结果的偏差与健康问题有关。 测量条件存储并可用于后续报告给远程程序员。 由植入式装置提供的治疗作为自主平衡与活动水平之间关系的函数确定。

    System and method for monitoring autonomic balance and physical activity
    3.
    发明授权
    System and method for monitoring autonomic balance and physical activity 有权
    监测自主性平衡和身体活动的系统和方法

    公开(公告)号：US07572226B2

    公开(公告)日：2009-08-11

    申请号：US10695430

    申请日：2003-10-28

    申请人： Avram Scheiner ,  Donald Hopper ,  Gerrard M. Carlson

    发明人： Avram Scheiner ,  Donald Hopper ,  Gerrard M. Carlson

    IPC分类号： A61B5/00

    CPC分类号： A61B5/4035 ,  A61B5/029 ,  A61B5/0472 ,  A61N1/36585 ,  G06F19/00

    摘要： An implantable device monitors the balance between sympathetic tone and parasympathetic tone as a function of an activity level. Cardio-neurological healthy users exhibit a generally sympathetic tone in conjunction with heavy activity level and a generally parasympathetic tone in conjunction with periods of low activity level. Deviations from expected results are associated with a health problem. Measured conditions are stored and available for subsequent reporting to a remote programmer. Therapy delivered by an implantable device is determined as a function of the relationship between autonomic balance and activity level.

    摘要翻译： 可植入装置监测交感神经张力和副交感神经紧张度之间的平衡，作为活动水平的函数。 心脏神经系统健康用户表现出与大量活动水平和大体上副交感神经紧张以及低活动水平结合的共同心情。 与预期结果的偏差与健康问题有关。 测量条件存储并可用于后续报告给远程程序员。 由植入式装置提供的治疗作为自主平衡与活动水平之间关系的函数确定。

    Chronotropic status monitor for implantable cardiac device
    4.
    发明授权
    Chronotropic status monitor for implantable cardiac device 有权
    用于可植入心脏装置的变时状态监测器

    公开(公告)号：US07142920B2

    公开(公告)日：2006-11-28

    申请号：US10853574

    申请日：2004-05-25

    申请人： Avram Scheiner ,  Donald Hopper

    发明人： Avram Scheiner ,  Donald Hopper

    IPC分类号： A61N1/30

    CPC分类号： A61N1/36514

    摘要： An implantable cardiac device with an exertion level sensor is programmed to determine a heart rate appropriate for a given measured exertion level in accordance with a physiological model and/or previously collected physiologic data. The device then compares the model's heart rate with a measured intrinsic heart rate. Based upon this data, the device is able to recognize changes in the patient's heart rate response and predict or recognize a chronotropically incompetent condition.

    摘要翻译： 具有消耗水平传感器的可植入心脏装置被编程以根据生理模型和/或先前收集的生理数据确定适合于给定测量的运动水平的心率。 然后，该装置将模型的心率与测量的内在心率进行比较。 基于该数据，该装置能够识别患者的心率响应的变化并且预测或识别慢性无能力的状况。

    Chronotropic status monitor for implantable cardiac device
    5.
    发明申请
    Chronotropic status monitor for implantable cardiac device 有权
    用于可植入心脏装置的变时状态监测器

    公开(公告)号：US20050267541A1

    公开(公告)日：2005-12-01

    申请号：US10853574

    申请日：2004-05-25

    申请人： Avram Scheiner ,  Donald Hopper

    发明人： Avram Scheiner ,  Donald Hopper

    IPC分类号： A61N1/365

    CPC分类号： A61N1/36514

    摘要： An implantable cardiac device with an exertion level sensor is programmed to determine a heart rate appropriate for a given measured exertion level in accordance with a physiological model and/or previously collected physiologic data. The device then compares the model's heart rate with a measured intrinsic heart rate. Based upon this data, the device is able to recognize changes in the patient's heart rate response and predict or recognize a chronotropically incompetent condition.

    摘要翻译： 具有消耗水平传感器的可植入心脏装置被编程以根据生理模型和/或先前收集的生理数据确定适合于给定测量的运动水平的心率。 然后，该装置将模型的心率与测量的内在心率进行比较。 基于该数据，该装置能够识别患者的心率响应的变化并且预测或识别慢性无能力的状况。

    System and method for monitoring autonomic balance and physical activity
    6.
    发明申请
    System and method for monitoring autonomic balance and physical activity 有权
    监测自主性平衡和身体活动的系统和方法

    公开(公告)号：US20050090719A1

    公开(公告)日：2005-04-28

    申请号：US10695430

    申请日：2003-10-28

    申请人： Avram Scheiner ,  Donald Hopper ,  Gerrard Carlson

    发明人： Avram Scheiner ,  Donald Hopper ,  Gerrard Carlson

    IPC分类号： A61B5/029 ,  A61B5/0472 ,  A61N1/365 ,  A61B5/00

    CPC分类号： A61B5/4035 ,  A61B5/029 ,  A61B5/0472 ,  A61N1/36585 ,  G06F19/00

    摘要： An implantable device monitors the balance between sympathetic tone and parasympathetic tone as a function of an activity level. Cardio-neurological healthy users exhibit a generally sympathetic tone in conjunction with heavy activity level and a generally parasympathetic tone in conjunction with periods of low activity level. Deviations from expected results are associated with a health problem. Measured conditions are stored and available for subsequent reporting to a remote programmer. Therapy delivered by an implantable device is determined as a function of the relationship between autonomic balance and activity level.

    摘要翻译： 可植入装置监测交感神经张力和副交感神经紧张度之间的平衡，作为活动水平的函数。 心脏神经系统健康用户表现出与大量活动水平和大体上副交感神经紧张以及低活动水平结合的共同心情。 与预期结果的偏差与健康问题有关。 测量条件存储并可用于后续报告给远程程序员。 由植入式装置提供的治疗作为自主平衡与活动水平之间关系的函数确定。

    Self-calibrating rate-adaptive pacemaker
    9.
    发明授权
    Self-calibrating rate-adaptive pacemaker 失效
    自校准速率自适应起搏器

    公开(公告)号：US06823214B1

    公开(公告)日：2004-11-23

    申请号：US09657402

    申请日：2000-09-08

    申请人： Weimin Sun ,  Bruce R. Jones ,  Douglas J. Lang ,  Donald Hopper

    发明人： Weimin Sun ,  Bruce R. Jones ,  Douglas J. Lang ,  Donald Hopper

    IPC分类号： A61N118

    CPC分类号： A61N1/365 ,  A61N1/36585

    摘要： A system and method for automatically adjusting the operating parameters of a rate-adaptive cardiac pacemaker. In accordance with the method, maximum exertion levels attained by the patient are measured at periodic intervals and stored. The stored maximum exertion levels may then be used to update a long-term maximal exertion level, and the slope of the rate-response curve is adjusted to map the updated long-term maximal exertion level to a maximum allowable pacing rate. The stored maximum exertion levels may also be used to update a sensor target rate which is used to adjust the slope of the rate response curve.

    摘要翻译： 一种用于自动调整速率适应性心脏起搏器的操作参数的系统和方法。 按照该方法，以周期性的间隔测量患者获得的最大功耗水平并存储。 然后可以使用存储的最大消耗水平来更新长期最大消耗水平，并且调整速率 - 响应曲线的斜率以将更新的长期最大消耗水平映射到最大允许起搏速率。 存储的最大消耗电平也可用于更新用于调整速率响应曲线的斜率的传感器目标速率。

    Systems and methods for improving heart rate kinetics in heart failure patients
    10.
    发明授权
    Systems and methods for improving heart rate kinetics in heart failure patients 有权
    改善心力衰竭患者心率动力学的系统和方法

    公开(公告)号：US08311631B2

    公开(公告)日：2012-11-13

    申请号：US12545676

    申请日：2009-08-21

    申请人： Donald Hopper ,  Yinghong Yu ,  Yanting Dong

    发明人： Donald Hopper ,  Yinghong Yu ,  Yanting Dong

    IPC分类号： A61N1/365

    CPC分类号： A61N1/3627 ,  A61N1/36542

    摘要： Adaptive rate pacing for improving heart rate kinetics in heart failure patients involves determining onset and sustaining of patient activity. The patient's heart rate response to the sustained activity is evaluated during a time window defined between onset of the activity and a steady-state exercise level. If the patient's heart rate response to the sustained activity is determined to be slow, a pacing therapy is delivered at a rate greater than the patient's intrinsic heart rate based on a profile of the patient's heart rate response to varying workloads. If determined not to be slow, the pacing therapy is withheld. Monitoring-only configurations provide for acquisition and organization of physiological data for heart failure patients. These data can be acquired on a per-patient basis and used to assess the HF status of the patient.

    摘要翻译： 用于改善心力衰竭患者心率动力学的适应性起搏速率包括确定患者活动的发病和持续时间。 在活动开始和稳态运动水平之间定义的时间窗口期间评估患者对持续活动的心率反应。 如果患者对持续活动的心率反应被确定为缓慢，则基于患者对不同工作负荷的心率反应的简档，起搏治疗以大于患者内在心率的速率递送。 如果确定不要慢，起搏疗法就被扣留。 仅监测配置提供心脏病患者生理数据的采集和组织。 这些数据可以在每个患者的基础上获得，并用于评估患者的HF状态。