公开(公告)号：US3933814A

公开(公告)日：1976-01-20

申请号：US397812

申请日：1973-09-17

申请人： Axel Haberkorn ,  Heinrich Kolling ,  Eckart Kranz ,  Jurgen Schramm

发明人： Axel Haberkorn ,  Heinrich Kolling ,  Eckart Kranz ,  Jurgen Schramm

IPC分类号： C07D251/30 ,  A01N43/64 ,  A23K1/16 ,  A61K31/53 ,  A61K31/535 ,  A61P33/02 ,  C07C275/36 ,  C07C275/60 ,  C07C275/64 ,  C07C335/18 ,  C07D251/26 ,  C07D251/34 ,  C07D251/38 ,  C07D495/04

CPC分类号： C07C275/36 ,  C07C275/60 ,  C07C275/64 ,  C07C335/18

摘要： 1-(4-Phenoxyphenyl)-1,3,5-triazines of the formula: ##SPC1##Or pharmaceutically acceptable nontoxic salts thereof are produced by reacting a urea or thiourea derivative of the formula: ##SPC2##With a carbonylisocyanate of the formula: ##EQU1## to produce a 1-(4-phenoxyphenyl)-1,3,5-triazine as above defined wherein R.sup.11 is hydrogen, and when a 1-(4-phenoxyphenyl)-1,3,5-triazine as above defined wherein R.sup.11 is alkyl is desired, reacting the triazine wherein R.sup.11 is hydrogen with a compound of the formula (alk).sub.n Y.The above defined triazines and their salts are useful as agents against protozoan infections and are particularly useful against coccidiosis.

摘要翻译： 1-（4-苯氧基苯基）-1,3,5-三嗪的下式：

公开(公告)号：US3948893A

公开(公告)日：1976-04-06

申请号：US452140

申请日：1974-03-18

申请人： Gerd Aichinger ,  Axel Haberkorn ,  Heinrich Kolling ,  Eckart Kranz ,  Josef Reisdorff

发明人： Gerd Aichinger ,  Axel Haberkorn ,  Heinrich Kolling ,  Eckart Kranz ,  Josef Reisdorff

IPC分类号： C07D251/34 ,  A23K1/16 ,  A61K31/53 ,  C07C317/42 ,  C07C323/44 ,  C07C323/66 ,  C07D209/48 ,  C07D251/04 ,  C07D251/38 ,  C07D51/26

CPC分类号： C07D209/48 ,  A23K20/116 ,  C07C317/42 ,  C07C323/44 ,  C07C323/66

摘要： 1-Phenyl-substituted 1,3,5-triazines of the formula: ##SPC1##And pharmaceutically acceptable nontoxic salts thereof whereinR.sub.1, r.sub.2, r.sub.3, r.sub.4, r.sub.5, r.sub.6, r.sub.7, r.sub.8 and R.sub.9 are the same or different and each is selected from the group consisting of hydrogen, straight or branched chain alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, halogen, nitro, cyano, amino, acylamino, alkoxycarbonylamino, carboxy, alkoxycarbonyl, carbamoyl, acyl, haloacyl, alkylsulphinyl, alkylsulphonyl, haloalkylsulphonyl and sulphamoyl;R.sub.10 is hydrogen, straight or branched chain alkyl, cycloalkyl, haloalkyl, alkoxy, alkoxyalkyl, haloalkoxyalkyl, alkylthioalkyl, haloalkylthioalkyl, alkenyl, alkynyl, alkoxycarbonyl, (alkylthio)carbonyl, (alkylthio)thiocarbonyl, acylamino, diacylamino, amino, dialkylamino, polymethyleneimino, polymethyleneimino interrupted by a heteroatom in the chain, or unsubstituted or substituted benzyl or aryl;R.sub.11 is hydrogen, or alkyl;X is sulphur, sulphinyl, or sulphonyl; andY is oxygen or sulphur,Are useful for their activity against coccidiosis in humans and animals.

摘要翻译： 具有下式的1-苯基取代的1,3,5-三嗪：

公开(公告)号：US3970752A

公开(公告)日：1976-07-20

申请号：US532221

申请日：1974-12-12

申请人： Gerd Aichinger ,  Axel Haberkorn ,  Heinrich Kolling ,  Eckart Kranz ,  Josef Reisdorff

发明人： Gerd Aichinger ,  Axel Haberkorn ,  Heinrich Kolling ,  Eckart Kranz ,  Josef Reisdorff

IPC分类号： A23K1/16 ,  C07C317/42 ,  C07C323/66 ,  A61K31/53

CPC分类号： C07C323/66 ,  A23K20/116 ,  C07C317/42

摘要： 1-Phenyl-substituted 1,3,5-triazines of the formula: ##SPC1##And pharmaceutically acceptable nontoxic salts thereofWherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8 and R.sub. 9 are the same or different and each is selected from the group consisting of hydrogen, straight or branched chain alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, halogen, nitro, cyano, amino, acylamino, alkoxycarbonylamino, carboxy, alkoxycarbonyl, carbamoyl, acyl, haloacyl, alkylsulphinyl, alkylsulphonyl, haloalkylsulphonyl and sulphamoyl;R.sub.10 is hydrogen, straight or branched chain alkyl, cycloalkyl, haloalkyl, alkoxy, alkoxyalkyl, haloalkoxyalkyl, alkylthioalkyl, haloalkylthioalkyl, alkenyl, alkynyl, alkoxycarbonyl, (alkylthio)carbonyl, (alkylthio)thiocarbonyl, acylamino, diacylamino, amino, dialkylamino, polymethyleneimino, polymethyleneimino interrupted by a heteroatom in the chain, or unsubstituted or substituted benzyl or aryl;R.sub.11 is hydrogen, or alkyl;X is sulphur, sulphinyl, or sulphonyl; andY is oxygen or sulphur,Are useful for their activity against coccidiosis in humans and animals.

摘要翻译： 具有下式的1-苯基取代的1,3,5-三嗪：

公开(公告)号：US3966725A

公开(公告)日：1976-06-29

申请号：US559562

申请日：1975-03-18

申请人： Josef Helmut Reisdorff ,  Gerd Aichinger ,  Axel Haberkorn ,  Heinrich Kolling ,  Eckart Kranz

发明人： Josef Helmut Reisdorff ,  Gerd Aichinger ,  Axel Haberkorn ,  Heinrich Kolling ,  Eckart Kranz

IPC分类号： C07D251/34 ,  A23K1/16 ,  A61K31/53 ,  A61P33/02 ,  C07C273/18 ,  C07C275/36 ,  C07C319/20 ,  C07C323/20 ,  C07D251/38

CPC分类号： C07D251/26 ,  A23K20/116 ,  C07C273/1827 ,  C07C319/20

摘要： 1-(4-Phenoxy-phenyl)-1,3,5-triazine derivatives of the formula ##SPC1##And pharmaceutically-acceptable, nontoxic salts thereof whereinR.sub.1 to R.sub.9 are the same or different and each is hydrogen, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, halo, nitro, cyano, amino, acylamino, alkoxycarbonylamino, carboxy, alkoxycarbonyl, carbamoyl, acyl, haloacyl, alkylsulphinyl, alkylsulphonyl, haloalkylsulphinyl, haloalkylsulphonyl or sulphamoyl; provided that at least one of R.sub.1 to R.sub.9 is haloalkyl, haloalkylthio, haloalkylsulphinyl or haloalkylsulphonyl;R.sub.10 is hydrogen, alkyl, cycloalkyl, haloalkyl, alkoxy, alkoxyalkyl, haloalkoxyalkyl, alkylthioalkyl, haloalkylthioalkyl, alkenyl, alkinyl, alkoxycarbonyl, alkylthiocarbonyl, alkylthiothiocarbonyl, acylamino, diacylamino, dialkylamino, polymethylene-imino, polymethylene-imino interrupted by a heteroatom, unsubstituted or substituted benzyl or unsubstituted or substituted aryl;R.sub.11 is hydrogen or alkyl; andY is oxygen or sulphur;Are useful in treating coccidiosis in humans and animals.

摘要翻译： 1-（4-苯氧基 - 苯基）-1,3,5-三嗪衍生物及其药学上可接受的，其中R 1至R 9相同或不同并且各自为氢，烷基，卤代烷基，烷氧基，卤代烷氧基的非对映体 烷硫基，卤代烷硫基，卤素，硝基，氰基，氨基，酰氨基，烷氧基羰基氨基，羧基，烷氧基羰基，氨基甲酰基，酰基，卤代酰基，烷基亚磺酰基，烷基磺酰基，卤代烷基亚磺酰基，卤代烷基磺酰基或氨磺酰基。 条件是R 1至R 9中的至少一个为卤代烷基，卤代烷硫基，卤代烷基亚磺酰基或卤代烷基磺酰基; R 10为氢，烷基，环烷基，卤代烷基，烷氧基，烷氧基烷基，卤代烷氧基烷基，烷硫基烷基，卤代烷硫基烷基，烯基，炔基，烷氧基羰基，烷硫基羰基，烷基硫代羰基，酰氨基，二酰基氨基，二烷基氨基，聚亚甲基亚氨基，被杂原子中断的聚亚甲基亚氨基， 取代的苄基或未取代或取代的芳基; R11是氢或烷基; Y为氧或硫; 有用于治疗人类和动物的结核病。

公开(公告)号：US4386953A

公开(公告)日：1983-06-07

申请号：US299919

申请日：1981-09-08

申请人： Eckart Kranz ,  Kurt Findeisen ,  Robert Schmidt ,  Ludwig Eue

发明人： Eckart Kranz ,  Kurt Findeisen ,  Robert Schmidt ,  Ludwig Eue

IPC分类号： C07D253/06 ,  A01N43/707 ,  C07D253/075 ,  A01N43/64

CPC分类号： C07D253/075 ,  A01N43/707

摘要： A substituted 6-halogeno-tert.-butyl-1,2,4-triazin-5-one of the formula ##STR1## in which R.sup.1 is an amino or methyl group,R.sup.2 is an alkylmercapto, alkylamino or dialkylamino group,X is a halogen atom, andY and Z each independently is a hydrogen or halogen atom,which possesses selective herbicidal activity. A synthesis involving the novel intermediates ##STR2## in which X, Y and Z have the above-mentioned meaning andQ is CN, CONH.sub.2 or COOH,is also shown.

摘要翻译： R 1为氨基或甲基的取代的6-卤代叔丁基-1,2,4-三嗪-5-酮，其中R 1为烷基巯基，烷基氨基或二烷基氨基，X为 卤素原子，Y和Z各自独立地为具有选择性除草活性的氢或卤素原子。 涉及其中X，Y和Z具有上述含义且Q为CN，CONH 2或COOH的新中间体“IMAGE”的合成也显示。

公开(公告)号：US4162280A

公开(公告)日：1979-07-24

申请号：US887899

申请日：1978-03-17

申请人： Eckart Kranz

发明人： Eckart Kranz

IPC分类号： A01N57/26 ,  B01J27/00 ,  B01J31/00 ,  C07F9/24 ,  C07F9/44

CPC分类号： A01N57/26 ,  C07F9/2458

摘要： Preparation of a phosphorylated amidine of the formula ##STR1## wherein X is oxygen or sulfur and R, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are various organic radicals, which comprises reacting a phosphoric acid ester-amide of the formula ##STR2## with a carboxamide of the formula ##STR3## at a temperature between about 0.degree. and 50.degree. C., and then reacting the mixture with a base. Advantageously the reaction is effected at about 0.degree. to 15.degree. C. in the presence of an aliphatic or aromatic optionally chlorinated hydrocarbon or an alcohol as an inert solvent, and in the presence of a catalyst.

摘要翻译： 制备式IMAMA的磷酸化脒，其中X是氧或硫，R，R 1，R 2，R 3和R 4是各种有机基团，其包括使下式的磷酸酯 - 酰胺与羧酰胺 在约0℃至50℃之间的温度下，使式“IMAGE”进行反应，然后使该混合物与碱反应。 有利地，反应在约0℃至15℃下在脂族或芳族任选氯化烃或作为惰性溶剂的醇存在下进行，并在催化剂存在下进行。

公开(公告)号：US4132736A

公开(公告)日：1979-01-02

申请号：US729933

申请日：1976-10-06

申请人： Gunther Cramm ,  Eckart Kranz ,  Gunter Hellrung

发明人： Gunther Cramm ,  Eckart Kranz ,  Gunter Hellrung

IPC分类号： C07B61/00 ,  B01J27/00 ,  C07C67/00 ,  C07C325/00 ,  C07C337/06 ,  C07D285/12 ,  C07D285/135 ,  C07C159/00

CPC分类号： C07D285/135

摘要： 4-Alkylthiosemicarbazides of the formulaAlkyl--NH--CS--NH--NH.sub.2are produced by heating at about 40 to 90.degree. C the novel hydrazinium salts of N-alkyldithiocarbamic acids of the formulaAlkyl--NH--CS--S.sup.- + NH.sub.3 --NH.sub.2in a solvent while removing by-product H.sub.2 S as by use of vacuum or passage of an inert gas through the reaction mixture, advantageously in the presence of a catalytic amount of sulfur to speed up the reaction. Hydrazine hydrate may also be present. The hydrazinium salt starting material can be prepared by reacting the corresponding alkylamine, ammonia, carbon disulfide and hydrazine, and the reaction solution directly employed in the heating step of the present invention without isolation of the intermediate.

摘要翻译： 通过在约40至90℃下加热式烷基-NH-CS-S-NH-NH 2的N-烷基二硫代氨基甲酸的新的肼鎓盐，制备式烷基-NH-CS-NH-NH 2的4-烷基硫代氨基脲 在溶剂中，同时通过使用真空或通过惰性气体通过反应混合物除去副产物H 2 S，有利地在催化量的硫存在下加速反应。 也可以存在水合肼。 肼盐起始原料可以通过使相应的烷基胺，氨，二硫化碳和肼与本发明的加热步骤中直接使用的反应溶液反应而不分离中间体来制备。

公开(公告)号：US4921967A

公开(公告)日：1990-05-01

申请号：US54551

申请日：1987-05-27

申请人： Wolfgang Kramer ,  Manfred Jautelat ,  Eckart Kranz

发明人： Wolfgang Kramer ,  Manfred Jautelat ,  Eckart Kranz

IPC分类号： A01N43/653 ,  C07C17/26 ,  C07C43/225 ,  C07C45/51 ,  C07C49/327 ,  C07D249/08 ,  C07D521/00

CPC分类号： C07D249/08 ,  A01N43/653 ,  C07C17/269 ,  C07C43/225 ,  C07C45/513 ,  C07C49/327 ,  C07D231/12 ,  C07D233/56 ,  C07C2101/08

摘要： New alkylcycloalkyl triazolylmethyl ketones of the general formula ##STR1## in which R represents an alkyl group andn is 3, 4, 5, 6 and 7,are produced as described and find use as intermediate products for the preparation of cycloalkyl (.alpha.-triazolyl-.beta.-hydroxy)-ketones, which possess fungicidal and plant growth-regulating properties.

摘要翻译： 其中R表示烷基且n为3,4,5,6和7的通式为“IMAGE”（I）的新的烷基环烷基三唑基甲基酮如所述制备，可用作制备环烷基的中间产物（ α-三唑基-β-羟基） - 酮，其具有杀真菌和植物生长调节性质。

公开(公告)号：US4536353A

公开(公告)日：1985-08-20

申请号：US667524

申请日：1984-11-02

申请人： Eckart Kranz ,  Kurt Findeisen

发明人： Eckart Kranz ,  Kurt Findeisen

IPC分类号： C07C255/40 ,  C07C67/00 ,  C07C253/00 ,  C07C253/30 ,  C07C255/56 ,  C07C120/00

CPC分类号： C07C255/00

摘要： A process for preparing an .alpha.-ketonitrile of the formula ##STR1## in which R is optionally substituted aryl, comprising reacting a cyanohydrin of the formula ##STR2## with sulphuryl chloride or thionyl chloride.

摘要翻译： 制备式“IMAGE”的α-甲基腈的方法，其中R是任选取代的芳基，包括使下式的氰醇与磺酰氯或亚硫酰氯反应。

公开(公告)号：US4371700A

公开(公告)日：1983-02-01

申请号：US232461

申请日：1981-02-09

申请人： Eckart Kranz

发明人： Eckart Kranz

IPC分类号： A01N43/50 ,  A01N43/653 ,  C07D233/56 ,  C07D233/60 ,  C07D233/64 ,  C07D249/08 ,  C07D521/00

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08

摘要： A process for the preparation of a 1-azolyl-3,3-dimethyl-1-phenoxy-butan-2-ol of the formula ##STR1## in which X is a nitrogen atom or a CH group,Y each independently is halogen, phenyl, phenoxy, nitro, alkyl, alkoxy or cycloalkyl, andn is 0, 1, 2 or 3,comprising reacting a 1-azolyl-3,3-dimethyl-1-phenoxy-butan-2-one of the formula ##STR2## with formic acid/triethylamine in the form of a 5:2 addition compound of the formula5HCOOHx2N(C.sub.2 H.sub.5).sub.3.The product is a known fungicide.

摘要翻译： 制备其中X为氮原子或CH基团的式“IMAGE”的1-吡唑基-3,3-二甲基-1-苯氧基 - 丁-2-醇的方法Y各自独立地为卤素， 苯基，苯氧基，硝基，烷基，烷氧基或环烷基，n为0,1,2或3，包括使式（I）的1-吡唑基-3,3-二甲基-1-苯氧基 - 丁-2-酮 与甲酸/三乙胺以5:2式5HCOOH 2 N（C 2 H 5）3的加成化合物的形式存在。 该产品是已知的杀真菌剂。