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1.发明申请公开(公告)号：US20130216492A1
公开(公告)日：2013-08-22
申请号：US13819882
申请日：2011-09-01
申请人： Aya Kato , Naoko Saito , Etsuji Wakisaka
发明人： Aya Kato , Naoko Saito , Etsuji Wakisaka
CPC分类号： A61K8/33 , A61K31/11 , A61Q15/00 , C12Q1/66 , G01N33/5058 , G01N33/566 , G01N33/74 , G01N2333/726 , G01N2500/00
摘要： Provided are a method for searching for a malodor inhibitor by using the response of an olfactory receptor as an indicator; a method for inhibiting malodor based on the antagonism of olfactory receptors; and a malodor inhibitor. Disclosed are a method for searching for a malodor inhibitor, the method including: adding a test substance and a malodor-causing substance to any one olfactory receptor selected from the group consisting of OR51E1, OR2W1, OR10A6, OR51I2, and OR51L1, measuring the response of the olfactory receptor to the malodor-causing substance, identifying the test substance that suppresses the response of the olfactory receptor on the basis of the measured response, and selecting the identified test substance as a malodor inhibitor; an antagonist to any one olfactory receptor selected from the group consisting of OR51E1, OR2W1, OR10A6, OR51I2, and OR51L1; a method for inhibiting malodor using the antagonist.
摘要翻译： 提供了通过使用嗅觉受体的反应作为指标来搜索恶臭抑制剂的方法; 基于嗅觉受体的拮抗作用抑制恶臭的方法; 和恶臭抑制剂。 公开了一种寻找恶臭抑制剂的方法，所述方法包括：将测试物质和恶臭物质添加到选自OR51E1，OR2W1，OR10A6，OR51I2和OR51L1中的任何一种嗅觉受体中，测量反应 的嗅觉受体与产生恶臭的物质，根据测定的反应鉴定抑制嗅觉受体的反应的检测物质，选择鉴定的检测物质作为恶臭抑制剂; 任何一种选自OR51E1，OR2W1，OR10A6，OR51I2和OR51L1的嗅觉受体的拮抗剂; 使用拮抗剂抑制恶臭的方法。
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2.发明授权公开(公告)号：US09233082B2
公开(公告)日：2016-01-12
申请号：US13819882
申请日：2011-09-01
申请人： Aya Kato , Naoko Saito , Etsuji Wakisaka
发明人： Aya Kato , Naoko Saito , Etsuji Wakisaka
IPC分类号： A61K31/11 , C12Q1/66 , G01N33/50 , G01N33/566 , G01N33/74
CPC分类号： A61K8/33 , A61K31/11 , A61Q15/00 , C12Q1/66 , G01N33/5058 , G01N33/566 , G01N33/74 , G01N2333/726 , G01N2500/00
摘要： Provided are a method for searching for a malodor inhibitor by using the response of an olfactory receptor as an indicator; a method for inhibiting malodor based on the antagonism of olfactory receptors; and a malodor inhibitor. Disclosed are a method for searching for a malodor inhibitor, the method including: adding a test substance and a malodor-causing substance to any one olfactory receptor selected from the group consisting of OR51E1, OR2W1, OR10A6, OR51I2, and OR51L1, measuring the response of the olfactory receptor to the malodor-causing substance, identifying the test substance that suppresses the response of the olfactory receptor on the basis of the measured response, and selecting the identified test substance as a malodor inhibitor; an antagonist to any one olfactory receptor selected from the group consisting of OR51E1, OR2W1, OR10A6, OR51I2, and OR51L1; a method for inhibiting malodor using the antagonist.
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公开(公告)号：US07488499B2
公开(公告)日：2009-02-10
申请号：US10246466
申请日：2002-09-19
IPC分类号： A61K36/00
摘要： The present invention relates to a hair growth inhibitor and a depilation accelerator, each comprising a crude drug selected from Bupleuri Radix, Perillae Herba, Rhel Rhizoma and Akebiae Caulis, or an extract thereof. This inhibitor or accelerator makes it possible to inhibit the growth of body hair or promote depilation, respectively, thereby reducing the frequency of hair removal treatment. Moreover, it makes the hair body finer, thereby facilitating the removal of the hair from feet or arms.
摘要翻译： 本发明涉及一种毛发生长抑制剂和脱毛促进剂，每种毛发生长抑制剂和去毛刺促进剂均含有选自柴胡，紫苏，枸杞子和Akebiae Caulis的生药，或其提取物。 这种抑制剂或促进剂可以分别抑制体毛的生长或促进脱毛，从而降低脱毛处理的频率。 此外，它使得头发主体更细，从而便于从脚或手臂去除头发。
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公开(公告)号：US07504116B2
公开(公告)日：2009-03-17
申请号：US10973452
申请日：2004-10-27
IPC分类号： A61K36/00
摘要： The present invention relates to a hair growth inhibitor and a depilation accelerator, each comprising a crude drug selected from Bupleuri Radix, Perillae Herba, Rhei Rhizoma and Akebiae Caulis, or an extract thereof. This inhibitor or accelerator makes it possible to inhibit the growth of body hair or promote depilation, respectively, thereby reducing the frequency of hair removal treatment.Moreover, it makes the hair body finer, thereby facilitating the removal of the hair from feet or arms.
摘要翻译： 本发明涉及一种毛发生长抑制剂和脱毛促进剂，每种毛发生长抑制剂和去毛刺促进剂均含有选自柴胡，紫苏，莱氏根和白僵菌的生药，或其提取物。 这种抑制剂或促进剂可以分别抑制体毛的生长或促进脱毛，从而降低脱毛处理的频率。 此外，它使得头发主体更细，从而便于从脚或手臂去除头发。
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公开(公告)号：US20050053573A1
公开(公告)日：2005-03-10
申请号：US10973452
申请日：2004-10-27
摘要： The present invention relates to a hair growth inhibitor and a depilation accelerator, each comprising a crude drug selected from Bupleuri Radix, Perillae Herba, Rhei Rhizoma and Akebiae Caulis, or an extract thereof. This inhibitor or accelerator makes it possible to inhibit the growth of body hair or promote depilation, respectively, thereby reducing the frequency of hair removal treatment. Moreover, it makes the hair body finer, thereby facilitating the removal of the hair from feet or arms.
摘要翻译： 本发明涉及一种毛发生长抑制剂和脱毛促进剂，每种毛发生长抑制剂和去毛刺促进剂均含有选自柴胡，紫苏，莱氏根和白僵菌的生药，或其提取物。 这种抑制剂或促进剂可以分别抑制体毛的生长或促进脱毛，从而降低脱毛处理的频率。 此外，它使得头发主体更细，从而便于从脚或手臂去除头发。
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