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公开(公告)号：US20220259580A1
公开(公告)日：2022-08-18
申请号：US17416480
申请日：2019-12-09
Applicant: BASF SE
Inventor： Kai-Uwe Baldenius , Michael Breuer , Corinna Ruffer , Melanie Weingarten , Reinhard Zschoche , Stefan Seemayer , Bernd Nidetzky , Katharina Schmoelzer , Michael Puhl
Abstract: The present disclosure relates to methods for producing human milk oligosaccharide (HMO) core structures using glycosidases from family GH20 hexosaminidases. In particular, the present disclosure provides methods for producing lacto-N-triose II (LNT II) and/or lacto-N-tetraose (LNT) by reacting glucosamine-oxazoline and/or lacto-N-biose-oxazoline with lactose catalysed by an enzyme of the glycoside hydrolase family 20 (GH20) according to the classification of the Carbohydrate-Active-Enzymes (CAZy) database. Specific optimized enzymes are identified to catalyse the reactions.
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2.发明授权公开(公告)号：US10227621B2
公开(公告)日：2019-03-12
申请号：US15514321
申请日：2015-09-30
Applicant: BASF SE
Inventor： Michael Guenter Braun , Juergen Daeuwel , Hans-Juergen Lang , Peter Oedman , Kai-Uwe Baldenius , Matthias Kleiner , Michael Kiefer , Stephan Freyer , Michael Budde
Abstract: The present invention relates to methods for preparing an aqueous acrylamide solution having a low acrylic acid concentration. In addition, the present invention relates to methods for reducing the acrylic acid concentration of an aqueous acrylamide solution. The methods involve a bioconversion of acrylonitrile to acrylamide in the presence of a biocatalyst, wherein during the bioconversion the content of acrylonitrile is maintained at 0.3 w/w % or more referred to the total weight of the composition in the reactor. Also provided is an aqueous acrylamide solution which is obtained by the methods of the present invention. Furthermore, the present invention is related to an acrylamide homopolymer or copolymer obtained by polymerizing the acrylamide of the aqueous solution.
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公开(公告)号：US20150259713A1
公开(公告)日：2015-09-17
申请号：US14423448
申请日：2013-09-03
Applicant: BASF SE
Inventor： Andrea Piatesi , Kai-Uwe Baldenius , Klaus Ditrich , Alois Kindler , Marta Zajaczkowski-Fischer , Ralf Boehling , Alwin Rehfinger
IPC: C12P7/64 , C07C51/235 , C07C51/373
CPC classification number: C12P7/6427 , C07C51/235 , C07C51/373 , C12P7/6409 , C12Y402/01053 , C07C59/147 , C07C55/20
Abstract: A process for preparing sebacic acid by reacting in a first step (i) linoleic acid with water catalyzed by an oleate hydratase to form 10-hydroxy-12-octadecenoic acid, in a second step (ii) pyrolysing the 10-hydroxy-12-octadecenoic acid to 1-octene and 10-oxo-decanoic acid and in a third step (iii) oxidizing the 10-oxo-decanoic acid to sebacic acid.
Abstract translation: 在第二步（ii）中热解10-羟基-12-十八碳烯酸，通过在第一步骤（i）中将亚油酸与由油酸水合酶催化形成10-羟基-12-十八碳烯酸的水反应制备癸二酸的方法， 十八碳烯酸至1-辛烯和10-氧代癸酸，并且在第三步骤（iii）中将10-氧代癸酸氧化成癸二酸。
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公开(公告)号：US09834798B2
公开(公告)日：2017-12-05
申请号：US14423448
申请日：2013-09-03
Applicant: BASF SE
Inventor： Andrea Piatesi , Kai-Uwe Baldenius , Klaus Ditrich , Alois Kindler , Marta Zajaczkowski-Fischer , Ralf Boehling , Alwin Rehfinger
IPC: C12P7/64 , C12N9/88 , C07H21/04 , C07K1/00 , C07C51/235 , C07C51/373
CPC classification number: C12P7/6427 , C07C51/235 , C07C51/373 , C12P7/6409 , C12Y402/01053 , C07C59/147 , C07C55/20
Abstract: A process for preparing sebacic acid by reacting in a first step (i) linoleic acid with water catalyzed by an oleate hydratase to form 10-hydroxy-12-octadecenoic acid, in a second step (ii) pyrolysing the 10-hydroxy-12-octadecenoic acid to 1-octene and 10-oxo-decanoic acid and in a third step (iii) oxidizing the 10-oxo-decanoic acid to sebacic acid.
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公开(公告)号：US20170145451A1
公开(公告)日：2017-05-25
申请号：US15323515
申请日：2015-07-02
Applicant: BASF SE
Inventor： Kai-Uwe Baldenius , Michael Breuer , Klaus Ditrich , Vaidotas Navickas , Francesco Mutti , Tanja Knaus , Nicholas Turner
CPC classification number: C12P13/001 , C12N9/0006 , C12N9/0016 , C12N9/0018 , C12Y101/01001 , C12Y104/01009 , C12Y104/0102
Abstract: The present invention relates to a novel biocatalytic method for the production of primary and secondary amines, comprising coupled enzymatic oxidation and reduction processes simultaneously regenerating the required cofactor; making use of two enzymes—i.e. an alcohol dehydrogenase and an amine dehydrogenase—operating simultaneously in a one pot process (i.e. biocatalytic cascade). Furthermore, the overall process is redox neutral, since the hydride generated from the first oxidative step is internally recycled in the second reductive step. The invention also relates to recombinant expression systems and microorganisms procuring the required enzyme activities; and bioreactors for performing such methods.
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Patent Agency Ranking
公开(公告)号：US20220017931A1
公开(公告)日：2022-01-20
申请号：US17424824
申请日：2020-01-20
Applicant: BASF SE
Inventor： Diego Ghislieri , Christian Willrodt , Christopher Koradin , Stefan Seemayer , Doreen Schachtschabel , Kai-Uwe Baldenius , Roland Goetz
Abstract: Described herein are methods for the production of 4-cyano benzoic acid or salts thereof from terephthalonitrile using nitrilase as catalyst. Also described herein are compositions including 4-cyano benzoic acid.
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7.发明授权Method for biocatalytic production of nitriles from oximes and oxime dehydratases usable therein 有权从其中可用的肟和肟脱水酶生物催化生产腈的方法公开(公告)号：US09080191B2
公开(公告)日：2015-07-14
申请号：US13798365
申请日：2013-03-13
Applicant: BASF SE
Inventor： Andrea Piatesi , Wolfgang Siegel , Kai-Uwe Baldenius
CPC classification number: C12P13/002 , C12N9/88 , C12Y499/01007
Abstract: The present invention relates to novel methods for biocatalytic production of nitriles from oximes using oxime dehydratases and novel mutants with oxime dehydratase activity and use thereof in a process for biocatalytic production of nitriles, such as in particular for the production of citral nitrile, neral nitrile, geranial nitrile or citronellyl nitrile from citral oxime, neral oxime, geranial oxime or citronellal oxime; and oxime dehydratases usable therefor, nucleotide sequences therefor and expression constructs or microorganisms comprising these.
Abstract translation: 本发明涉及使用肟脱水酶的肟生物催化生产腈的新方法和具有肟脱水酶活性的新型突变体及其在生物催化生产腈的方法中的用途，特别是用于制备柠檬醛腈，腈类， 柠檬醛肟，香橼肟，香叶肟或香茅醛肟的香叶腈或香茅腈; 和可用于其的肟脱水酶，其核苷酸序列和包含它们的表达构建体或微生物。
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公开(公告)号：US10533201B2
公开(公告)日：2020-01-14
申请号：US15509993
申请日：2015-06-30
Applicant: BASF SE
Inventor： Vaidotas Navickas , Kai-Uwe Baldenius , Michael Breuer , Patricia Wildberger , Martin Pfeiffer , Bernd Nidetzky
Abstract: The present invention relates to methods of producing sugar phosphates by enzymatic transphosphorylation, wherein the phosphoryl transfer from phosphate donor substrates to sugar substrates is catalyzed by an enzyme having alpha-glucose-1-phosphatase activity. Furthermore, the present invention relates to a biocatalyst having sucrose phosphorylase as well as alpha-glucose-1-phosphatase activity and its use. The production of an enzyme having alpha-glucose-1-phosphatase activity and its use in the transphosphorylation of sugar substrates is also presented herein.
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公开(公告)号：US10428361B2
公开(公告)日：2019-10-01
申请号：US15559962
申请日：2016-02-19
Applicant: BASF SE
Inventor： Vaidotas Navickas , Michael Breuer , Michael Puhl , Melanie Weingarten , Kai-Uwe Baldenius , Wolfgang Siegel
Abstract: The present invention relates to biocatalytic methods, comprising purely enzymatic, mixed enzymatic-fermentative and purely fermentative methods, for the direct single-step conversion of L-fucitol to L-fucose, in order to easily obtain L-fucose at high amounts and levels of purity. Suitable recombinant microorganisms and fungi are further disclosed and also the use thereof in said method for the single-step conversion to L-fucose.
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10.发明申请METHOD FOR BIOCATALYTIC PRODUCTION OF NITRILES FROM OXIMES AND OXIME DEHYDRATASES USABLE THEREIN 有权用于生物活性生产硝酸盐的方法及其可用的氧化脱氢酶公开(公告)号：US20130244298A1
公开(公告)日：2013-09-19
申请号：US13798365
申请日：2013-03-13
Applicant: BASF SE
Inventor： Andrea Piatesi , Wolfgang Siegel , Kai-Uwe Baldenius
CPC classification number: C12P13/002 , C12N9/88 , C12Y499/01007
Abstract: The present invention relates to novel methods for biocatalytic production of nitriles from oximes using oxime dehydratases and novel mutants with oxime dehydratase activity and use thereof in a process for biocatalytic production of nitriles, such as in particular for the production of citral nitrile, neral nitrile, geranial nitrile or citronellyl nitrile from citral oxime, neral oxime, geranial oxime or citronellal oxime; and oxime dehydratases usable therefor, nucleotide sequences therefor and expression constructs or microorganisms comprising these.
Abstract translation: 本发明涉及使用肟脱水酶的肟生物催化生产腈的新方法和具有肟脱水酶活性的新型突变体及其在生物催化生产腈的方法中的用途，特别是用于制备柠檬醛腈，腈类， 柠檬醛肟，香橼肟，香叶肟或香茅醛肟的香叶腈或香茅腈; 和可用于其的肟脱水酶，其核苷酸序列和包含它们的表达构建体或微生物。
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