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    Process for obtaining alcoholic beverages from vegetal juice
    1.
    发明授权
    Process for obtaining alcoholic beverages from vegetal juice 失效
    从植物汁获得酒精饮料的过程

    公开(公告)号：US4978539A

    公开(公告)日：1990-12-18

    申请号：US261828

    申请日：1988-08-29

    申请人： Gerard Colin ,  Michael Conroy

    发明人： Gerard Colin ,  Michael Conroy

    IPC分类号： C12G1/00 ,  C12C11/00 ,  C12C11/02 ,  C12C11/06 ,  C12G20060101 ,  C12G3/00 ,  C12G3/02 ,  C12G3/08 ,  C12P20060101 ,  C12P7/06 ,  C12R1/86 ,  C12R1/865 ,  C13B10/02

    CPC分类号： C12G3/02 ,  C12G3/085 ,  Y02E50/17

    摘要： This process consists in taking vegetal juice obtained by pressing at least one vegetal substance, adjusting its pH before sulfiting it, clarifying it, then subjecting it to microfiltration through a membrane. The microfiltered juice is subjected to controlled alcoholic fermentation in a carbon dioxide atmosphere. This process results in new alcoholic drinks having very pleasant organoleptic properties. An installation for industrially carrying out the process applied to cane sugar results in cane wine and pure cane spirit.

    摘要翻译： PCT No.PCT / FR87 / 00523 Sec。 371日期1988年8月29日第 102（e）日期1988年8月29日PCT提交1987年12月30日PCT公布。 第WO88 / 05084号公报 日期为1988年7月14日。该方法包括通过冲压至少一种植物物质获得的植物汁，在酸化之前调节其pH，澄清，然后通过膜进行微滤。 微滤过的汁液在二氧化碳气氛中进行受控的酒精发酵。 这个过程导致新的含酒精饮料具有非常愉快的感官特性。 用于工业应用于蔗糖的工艺的装置导致甘蔗葡萄酒和纯甘蔗精油。

    Method for producing glycogens for use in cosmetics by culturing yeast cells in two phases
    3.
    发明授权
    Method for producing glycogens for use in cosmetics by culturing yeast cells in two phases 失效
    通过两相培养酵母细胞生产用于化妆品的糖原的方法

    公开(公告)号：US6146857A

    公开(公告)日：2000-11-14

    申请号：US43830

    申请日：1998-06-15

    申请人： Gilles Pauly ,  Marc Pauly ,  Jean-Marc Engasser ,  Mohamed Ghoul

    发明人： Gilles Pauly ,  Marc Pauly ,  Jean-Marc Engasser ,  Mohamed Ghoul

    IPC分类号： A61K8/00 ,  A61K8/11 ,  A61K8/72 ,  A61K8/73 ,  A61K8/99 ,  A61Q17/04 ,  A61Q19/00 ,  C08B37/18 ,  C12N1/00 ,  C12N1/06 ,  C12N1/14 ,  C12P19/04 ,  C12R1/86 ,  A61K7/035 ,  C12P1/02

    CPC分类号： A61K8/73 ,  A61Q19/00 ,  C12N1/063 ,  C12P19/04 ,  A61Q17/04 ,  Y10S435/911 ,  Y10S435/921 ,  Y10S435/94

    摘要： A process is provided for the production of glycogens or an extract rich in glycogens from yeast cells, and a cosmetic composition containing them. A given quantity of yeast cells, from a specific culture or recovered as residues of a fermentation process, is subjected to an operation of enrichment in intracellular glycogens by culturing in two phases in the presence of a carbon source. The metabolism of the yeast cells is then stopped. The membranes of the yeast cells are then at least partially disintegrated to free intracellular substances, and the freed intracellular substances are subjected to at least one precipation to precipitate glycogens. A cosmetic composition comprising the glycogens is formulated in admixture with a dermatologically acceptable excipient.

    摘要翻译： PCT No.PCT / FR96 / 02008 Sec。 371日期1998年6月15日第 102（e）1998年6月15日PCT PCT 1996年12月13日PCT公布。 公开号WO97 / 21828 日期1996年6月19日提供了用于从酵母细胞中制备糖原或富含糖原的提取物的方法和含有它们的化妆品组合物的方法。 给定量的来自特定培养物的酵母细胞或作为发酵过程的残留物回收的酵母细胞通过在碳源的存在下在两相中培养来进行细胞内糖原的富集操作。 然后停止酵母细胞的代谢。 然后将酵母细胞的膜至少部分地分解成游离细胞内物质，并且释放的细胞内物质经历至少一个沉淀以沉淀糖原。 含有糖原的化妆品组合物与皮肤病学可接受的赋形剂混合配制。

    Optically active carbacyclin intermediates and processes for the preparation thereof
    5.
    发明授权
    Optically active carbacyclin intermediates and processes for the preparation thereof 失效
    光活性的卡巴环素中间体及其制备方法

    公开(公告)号：US4814468A

    公开(公告)日：1989-03-21

    申请号：US868672

    申请日：1986-05-30

    申请人： Kenji Mori ,  Masahiro Tsuji

    发明人： Kenji Mori ,  Masahiro Tsuji

    IPC分类号： C07D317/72 ,  C12P17/02 ,  C12P41/00 ,  C12R1/645 ,  C12R1/85 ,  C12R1/86 ,  C12R1/865

    CPC分类号： C07D317/72 ,  C12P17/02 ,  C12P41/002 ,  C12R1/84 ,  C12R1/85

    摘要： New intermediate, an optically active (1S,5R)-7,7-alkylenedioxy-2-alkoxycarbonylbicyclo[3.3.0]octan-3-one which is useful for the synthesis of an optically active carbacyclin. This intermediate is prepared, as a non-reduced compound, from a racemic compound, (1SR,5RS)-7,7-alkylenedioxy-2-alkoxycarbonyl-cis-bicyclo[3.3.0]octane-3-one, by treatment of the racemic compound with a microorganism. The microorganism has an ability of specifically reducing the keto group of the (1R,5S) epimer of the racemic compound.

    摘要翻译： 新的中间体，可用于合成光学活性的卡巴环素的光学活性（1S，5R）-7,7-亚烷基二氧-2-烷氧基羰基双环[3.3.0]辛-3-酮。 该中间体由外消旋化合物（1SR，5RS）-7,7-亚烷基二氧基-2-烷氧基羰基 - 顺式 - 双环[3.3.0]辛烷-3-酮由未还原的化合物制备， 外消旋化合物与微生物。 该微生物具有特异性还原外消旋化合物的（1R，5S）差向异构体的酮基的能力。

    Continuous alcohol manufacturing process using yeast
    6.
    发明授权
    Continuous alcohol manufacturing process using yeast 失效
    连续酒精制造工艺使用酵母

    公开(公告)号：US4562154A

    公开(公告)日：1985-12-31

    申请号：US522545

    申请日：1983-08-11

    申请人： Keiichiro Watanabe ,  Tomiaki Yamada ,  Tsuneo Sazanami ,  Eiko Asahara

    发明人： Keiichiro Watanabe ,  Tomiaki Yamada ,  Tsuneo Sazanami ,  Eiko Asahara

    IPC分类号： C12P7/06 ,  C12R1/85 ,  C12R1/86 ,  C12R1/865 ,  C12P7/14

    CPC分类号： C12P7/06 ,  Y02E50/17 ,  Y10S435/813 ,  Y10S435/911 ,  Y10S435/942

    摘要： A continuous alcohol manufacturing process using yeast comprising a zone where a conventional yeast (Yeast B) which has an alcohol producing activity is mainly present (zone of Yeast B); a zone disposed in the fore part of said zone of Yeast B where a yeast (Yeast A) which has an alcohol producing activity and is superior in sugar resistance as compared with Yeast B is mainly present (zone of Yeast A); and a zone disposed in the rear part of said zone of Yeast B where a yeast (Yeast C) which has an alcohol has an alcohol producing activity and is superior in alcohol resistance as compared with Yeast B is mainly present (zone of Yeast C), wherein a substrate solution is supplied to said zone of Yeast A thereby to effect alcohol fermentation; the resulting fermentation liquid is introduced in said zone of Yeast B thereby to effect alcohol fermentation; the resulting fermentation liquid is further introduced in said zone of Yeast C thereby to effect alcohol fermentation; and then a product alcohol broth is obtained from said zone of Yeast C.

    摘要翻译： 使用酵母的连续酒精制造方法，其中主要存在具有醇生产活性的常规酵母（酵母B）的区域（酵母B的区域）; 主要存在酵母B的酵母（酵母A），酵母（酵母A）与酵母B相比具有醇生成活性，耐糖性优异的区域;酵母菌A的区域。 和设置在酵母B的所述区域的后部的区域，其中具有醇的酵母（酵母C）具有醇生成活性并且与酵母B相比具有优异的耐酒精性的区域主要存在（酵母C区域） 其中将底物溶液供应到酵母A的所述区域，从而进行酒精发酵; 将所得发酵液引入酵母B的所述区域，从而进行酒精发酵; 将所得发酵液进一步引入酵母C的所述区域，从而进行酒精发酵; 然后从酵母C的所述区域获得产品酒精肉汤。

    Vectors, cells and processes for pyrimidine deoxyribonucleosides production
    8.
    发明申请
    Vectors, cells and processes for pyrimidine deoxyribonucleosides production 有权
    嘧啶脱氧核糖核苷生产的载体，细胞和方法

    公开(公告)号：US20050009083A1

    公开(公告)日：2005-01-13

    申请号：US10914529

    申请日：2004-08-09

    申请人： David Anderson ,  Lin Liu ,  Sergey Podkovyrov ,  Baomin Wang

    发明人： David Anderson ,  Lin Liu ,  Sergey Podkovyrov ,  Baomin Wang

    IPC分类号： C12N15/09 ,  C12N1/16 ,  C12N1/19 ,  C12N1/20 ,  C12N1/21 ,  C12N9/02 ,  C12N9/10 ,  C12N9/12 ,  C12N9/78 ,  C12N15/52 ,  C12N15/53 ,  C12N15/54 ,  C12N15/55 ,  C12P19/38 ,  C12R1/19 ,  C12R1/86 ,  C12Q1/68 ,  C07H21/04 ,  C12N9/22

    CPC分类号： C12N9/0036 ,  C12N9/0093 ,  C12N9/1007 ,  C12N9/1205 ,  C12N9/78 ,  C12N15/52 ,  C12P19/385

    摘要： Novel DNA constructs and host cells comprising the same are disclosed. DNA constructs comprise a transcription unit (e.g. operon) comprising DNA sequences encoding for ribonucleotide reductase and thioredoxin or a uridine kinase gene and/or a dCTP deaminase gene. In preferred embodiments the constructs comprising DNA sequences encoding for ribonucleotide reductase and thioredoxin further comprise DNA sequences encoding for thymidylate synthase and/or transcription units comprising sequences encoding for uridine kinase preferably together with dCTP deaminase. In particularly preferred embodiments, the host cells comprise constructs having all of the above characteristics wherein the host cell displays repressed or no uracil DNA glycosylase activity. This may be achieved by removal of the host cell ung gene. Use of host cells in the manufacture of pyrimidine deoxyribonucleotides e.g. thymidine is also disclosed.

    摘要翻译： 公开了新的DNA构建体和包含其的宿主细胞。 DNA构建体包含包含编码核糖核苷酸还原酶和硫氧还蛋白或尿苷激酶基因和/或dCTP脱氨酶基因的DNA序列的转录单位（例如操纵子）。 在优选实施方案中，包含编码核糖核苷酸还原酶和硫氧还蛋白的DNA序列的构建体还包含编码胸苷酸合酶的DNA序列和/或包含编码尿苷激酶的序列的转录单元，优选与dCTP脱氨酶一起。 在特别优选的实施方案中，宿主细胞包含具有所有上述特征的构建体，其中宿主细胞显示被抑制或没有尿嘧啶DNA糖基化酶活性。 这可以通过去除宿主细胞ung基因来实现。 宿主细胞在制造嘧啶脱氧核糖核苷酸中的用途，例如 还公开了胸苷。

    Optically active carbacyclin intermediates and processes for the preparation thereof
    10.
    发明授权
    Optically active carbacyclin intermediates and processes for the preparation thereof 失效
    光活性的卡巴环素中间体及其制备方法

    公开(公告)号：US4885246A

    公开(公告)日：1989-12-05

    申请号：US286159

    申请日：1988-12-19

    申请人： Kenji Mori ,  Masahiro Tsuji

    发明人： Kenji Mori ,  Masahiro Tsuji

    IPC分类号： C07D317/72 ,  C12P17/02 ,  C12P41/00 ,  C12R1/645 ,  C12R1/85 ,  C12R1/86 ,  C12R1/865

    CPC分类号： C07D317/72 ,  C12P17/02 ,  C12P41/002 ,  C12R1/84 ,  C12R1/85

    摘要： New intermediate, an optically active (1S,5R)-7,7-alkylenedioxy-2-alkoxycarbonylbicyclo[3.3.0]octan-3-one which is useful for the synthesis of an optically active carbacyclin. This intermediate is prepared, as a non-reduced compound, from a racemic compound, (1SR,5RS)-7,7-alkylenedioxy-2-alkoxycarbonyl-cis-bicyclo[3.3.0]octan-3-one, by treatment of the racemic compound with a microorganism. The microorganism has an ability of specifically reducing the keto group of the (1R,5S) epimer of the racemic compound.

    摘要翻译： 新的中间体，可用于合成光学活性的卡巴环素的光学活性（1S，5R）-7,7-亚烷基二氧基-2-烷氧基羰基双环[3.3.0]辛-3-酮。 该中间体作为未还原的化合物由外消旋化合物（1SR，5RS）-7,7-亚烷基二氧基-2-烷氧基羰基 - 顺式 - 双环[3.3.0]辛-3-酮通过处理 外消旋化合物与微生物。 该微生物具有特异性还原外消旋化合物的（1R，5S）差向异构体的酮基的能力。