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公开(公告)号：US20190185415A1
公开(公告)日：2019-06-20
申请号：US16230957
申请日：2018-12-21
发明人： Michael HAHN , Thomas LAMPE , Johannes-Peter STASCH , Karl-Heinz SCHLEMMER , Frank WUNDER , Volkhart Min-Jian LI , Eva-Maria BECKER-PELSTER , Friederike STOLL , Andreas KNORR , Elisabeth WOLTERING
IPC分类号： C07C231/14 , A61K9/00 , A61K45/06 , C07C233/55 , A61K31/196 , C07C235/38
CPC分类号： C07C231/14 , A61K9/0053 , A61K31/196 , A61K45/06 , C07C233/55 , C07C235/38 , C07C2601/02 , C07C2601/04 , C07C2601/08
摘要： The present application relates to novel 3-phenylpropionic acid derivatives which carry a branched or cyclic alkyl substituent in the 3-position, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular diseases.
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公开(公告)号：US20180282262A1
公开(公告)日：2018-10-04
申请号：US16001146
申请日：2018-06-06
发明人： Michael HAHN , Thomas LAMPE , Johannes-Peter STASCH , Karl-Heinz SCHLEMMER , Frank WUNDER , Volkhart Min-Jian LI , Eva-Maria BECKER-PELSTER , Friederike STOLL , Andreas KNORR , Elisabeth WOLTERING
IPC分类号： C07C231/14 , A61K31/196 , C07C235/38 , C07C233/55 , A61K45/06 , A61K9/00
CPC分类号： C07C231/14 , A61K9/0053 , A61K31/196 , A61K45/06 , C07C233/55 , C07C235/38 , C07C2601/02 , C07C2601/04 , C07C2601/08
摘要： The present application relates to novel 3-phenylpropionic acid derivatives which carry a branched or cyclic alkyl substituent in the 3-position, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular diseases.
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公开(公告)号：US20160264515A1
公开(公告)日：2016-09-15
申请号：US15158331
申请日：2016-05-18
发明人： Michael HAHN , Thomas LAMPE , Johannes-Peter STASCH , Karl-Heinz SCHLEMMER , Frank WUNDER , Volkhart Min-Jian LI , Eva-Maria BECKER , Friederike STOLL , Andreas KNORR , Elisabeth WOLTERING
IPC分类号： C07C231/14 , A61K45/06 , A61K9/00 , A61K31/196
CPC分类号： C07C231/14 , A61K9/0053 , A61K31/196 , A61K45/06 , C07C233/55 , C07C235/38 , C07C2601/02 , C07C2601/04 , C07C2601/08
摘要： The present application relates to novel 3-phenylpropionic acid derivatives which carry a branched or cyclic alkyl substituent in the 3-position, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular diseases.
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公开(公告)号：US20170204137A1
公开(公告)日：2017-07-20
申请号：US15472476
申请日：2017-03-29
发明人： Ingo FLAMME , Johannes KÖBBERLING , Hans-Georg LERCHEN , Nils GRIEBENOW , Rudolf SCHOHE-LOOP , Sven WITTROCK , Maria KÖLLNBERGER , Frank WUNDER , Gorden REDLICH , Andreas KNORR , Julie MARLEY , Iain PRITCHARD
IPC分类号： C07K5/062
CPC分类号： C07K5/06017 , A61K9/007 , A61K38/22 , A61K45/06 , A61K47/60 , C07K5/02 , C07K5/06078 , C07K14/575
摘要： The invention relates to novel polyethylene glycol (PEG) based prodrug of Adrenomedullin, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for producing medicaments for treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders.
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公开(公告)号：US20150080414A1
公开(公告)日：2015-03-19
申请号：US14552122
申请日：2014-11-24
发明人： Markus FOLLMANN , Johannes-Peter STASCH , Gorden REDLICH , Jens ACKERSTAFF , Nils GRIEBENOW , Walter KROH , Andreas KNORR , Eva-Maria BECKER , Frank WUNDER , Volkhart Min-Jian LI , Elke HARTMANN , Joachim MITTENDORF , Karl-Heinz SCHLEMMER , Rolf JAUTELAT , Donald BIERER
IPC分类号： C07D471/04 , A61K45/06 , A61K31/506
CPC分类号： A61K31/506 , A61K45/06 , C07C57/145 , C07C309/04 , C07C309/05 , C07D471/04
摘要： The present application relates to novel substituted 5-fluoro-1H-pyrazolopyridines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新的取代的5-氟-1H-吡唑并吡啶，其制备方法，单独使用或组合用于治疗和/或预防疾病，以及它们用于制备用于治疗和/ 或预防疾病，特别是用于治疗和/或预防心血管疾病。
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公开(公告)号：US20140142069A1
公开(公告)日：2014-05-22
申请号：US14045630
申请日：2013-10-03
发明人： Thomas LAMPE , Michael HAHN , Johannes-Peter STASCH , Karl-Heinz SCHLEMMER , Frank WUNDER , Sherif EL SHEIKH , Volkhart Min-Jian LI , Eva-Maria BECKER-PELSTER , Friederike STOLL , Andreas KNORR
IPC分类号： C07C233/88 , A61K31/655 , C07C231/02 , A61K31/196
CPC分类号： C07C233/88 , A61K31/196 , A61K31/655 , C07C205/38 , C07C231/02 , C07C233/45 , C07C233/55 , C07C255/60 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D305/06
摘要： The present application relates to novel 3-phenylpropionic acid derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新的3-苯基丙酸衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途，特别是 治疗和/或预防心血管疾病。
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7.发明申请公开(公告)号：US20150306084A1
公开(公告)日：2015-10-29
申请号：US14705967
申请日：2015-05-07
发明人： Hans-Georg LERCHEN , Barbara ALBRECHT-KÜPPER , Andreas KNORR , Peter SANDNER , Daniel MEIBOM , Carsten SCHMECK , Hubert TRÜBEL
IPC分类号： A61K31/4439 , A61K38/05 , A61K45/06
CPC分类号： A61K31/4439 , A61K9/0048 , A61K9/08 , A61K38/05 , A61K45/06 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present invention relates to the use of selective adenosine A1 agonists, in particular the dicyanopyridines of formula (I), for the treatment and/or prophylaxis of glaucoma and ocular hypertension as well as the their use for the production of a medicament for the treatment and/or prophylaxis of glaucoma and ocular hypertension.
摘要翻译： 本发明涉及选择性腺苷A1激动剂，特别是式（I）的二氰基吡啶用于治疗和/或预防青光眼和高眼压症及其用于生产治疗药物的用途的用途 和/或预防青光眼和高眼压症。
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公开(公告)号：US20140309307A1
公开(公告)日：2014-10-16
申请号：US14304171
申请日：2014-06-13
发明人： Michael HAHN , Thomas LAMPE , Johannes-Peter STASCH , Karl-Heinz SCHLEMMER , Frank WUNDER , Volkhart Min-Jian LI , Eva-Maria BECKER , Friederike STOLL , Andreas KNORR , Elisabeth WOLTERING
IPC分类号： C07C233/55 , A61K45/06 , A61K31/196
CPC分类号： C07C231/14 , A61K9/0053 , A61K31/196 , A61K45/06 , C07C233/55 , C07C235/38 , C07C2601/02 , C07C2601/04 , C07C2601/08
摘要： The present application relates to novel 3-phenylpropionic acid derivatives which carry a branched or cyclic alkyl substituent in the 3-position, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular diseases.
摘要翻译： 本申请涉及在3-位上带有支链或环状烷基取代基的新型3-苯基丙酸衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备药物的用途 用于治疗和/或预防疾病，特别是用于治疗和/或预防心血管疾病。
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9.发明申请NOVEL SUBSTITUTED BIPYRIDINE DERIVATIVES AND THEIR USE AS ADENOSINE RECEPTOR LIGANDS 审中-公开新的替代苄嘧啶衍生物及其作为腺苷受体配体使用公开(公告)号：US20140155401A1
公开(公告)日：2014-06-05
申请号：US14175719
申请日：2014-02-07
IPC分类号： C07D417/14 , A61K45/06 , C07D401/14 , A61K31/5377 , A61K31/501 , C07D409/14 , C07D413/14 , A61K31/444 , A61K31/506
CPC分类号： A61K31/444 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D213/85 , C07D401/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present invention relates to novel substituted 2,4′- and 3,4′-bipyridine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of hypertension and other cardiovascular disorders.
摘要翻译： 本发明涉及新的取代的2,4'-和3,4'-联吡啶衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备治疗用药物和 /或预防疾病，优选用于治疗和/或预防高血压和其它心血管疾病。
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公开(公告)号：US20130237551A1
公开(公告)日：2013-09-12
申请号：US13851373
申请日：2013-03-27
发明人： Markus FOLLMANN , Johannes-Peter STASCH , Gorden REDLICH , Jens ACKERSTAFF , Nils GRIEBENOW , Walter KROH , Andreas KNORR , Eva-Maria BECKER , Frank WUNDER , Volkhart Min-Jian LI , Elke HARTMANN , Joachim MITTENDORF , Karl-Heinz SCHLEMMER , Rolf JAUTELAT , Donald BIERER
IPC分类号： A61K31/506 , A61K45/06
CPC分类号： A61K31/506 , A61K45/06 , C07C57/145 , C07C309/04 , C07C309/05 , C07D471/04
摘要： The present application relates to novel substituted 5-fluoro-1H-pyrazolopyridines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
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