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8 条记录 (耗时 0.014 秒)

    MEDICAL COMPOSITIONS AND THEIR USES
    1.
    发明申请
    MEDICAL COMPOSITIONS AND THEIR USES 有权

    公开(公告)号：US20220409686A1

    公开(公告)日：2022-12-29

    申请号：US17773736

    申请日：2020-10-28

    申请人： BIOMILLENIA SAS

    发明人： Aleksander Dajkovic ,  Dirk Loeffert

    IPC分类号： A61K36/064 ,  A61K35/74 ,  A61P31/10 ,  A61P17/08

    摘要： The invention relates to a pharmaceutical composition comprising (i) a live strain from the genus of Kazachstania spp, Acetobacter spp. and/or Stenotrophomonas spp, (ii) an attenuated strain from the genus of Kazachstania spp, Acetobacter spp. and/or Stenotrophomonas spp or, (iii) a medically active substance isolated from a strain from the genus of Kazachstania spp, Acetobacter spp. and/or Stenotrophomonas spp.

    MEDICAL COMPOSITIONS AND THEIR USE IN TREATING INFLAMMATORY BOWEL DISEASE
    2.
    发明公开
    MEDICAL COMPOSITIONS AND THEIR USE IN TREATING INFLAMMATORY BOWEL DISEASE 审中-公开

    公开(公告)号：US20230405057A1

    公开(公告)日：2023-12-21

    申请号：US17781276

    申请日：2020-10-28

    申请人： BIOMILLENIA SAS

    发明人： Aleksander Dajkovic ,  Dirk Loeffert

    IPC分类号： A61K35/74 ,  A61K36/064 ,  A61P31/10

    CPC分类号： A61K35/74 ,  A61P31/10 ,  A61K36/064

    摘要： The invention also relates to a microbial strain selected from the genus of Kazachstania spp, Acetobacter spp. and/or Stenotrophomonas spp for use as a medicament, (i) a cellular extract from a strain selected from the genus of Kazachstania spp, Acetobacter spp. and/or Stenotrophomonas spp for use in treating inflammatory bowel disease, (ii) the supernatant from the cell culture from a strain selected from the genus of Kazachstania spp, Acetobacter spp. and/or Stenotrophomonas spp for use in treating inflammatory bowel disease or, (iii) a medically active molecule or a medically active substance obtained from a strain selected from the genus of Kazachstania spp, Acetobacter spp. and/or Stenotrophomonas spp for use in treating inflammatory bowel disease.

    Microparticle For Cultivating And Testing Cells
    4.
    发明申请
    Microparticle For Cultivating And Testing Cells 审中-公开

    公开(公告)号：US20200003770A1

    公开(公告)日：2020-01-02

    申请号：US16490804

    申请日：2018-03-02

    申请人： Biomillenia SAS

    发明人： Dirk Loeffert ,  Aleksander Dajkovic ,  Thomas Duboys

    IPC分类号： G01N33/543 ,  C12N5/071 ,  C12Q1/02

    摘要： Cultivation and/or test-system comprising at least two cultivation spaces combined in a microparticle, wherein the sperically shaped microparticle comprises, (i) a first cultivation space in the center core of said spherically shaped microparticle, (ii) a second cultivation space in the wall surrounding the core of said microparticle, (iii) wherein the wall surrounding the core allows for the exchange of molecules as, salts, nutrients, peptides, chemicals and other compounds in order for the cells in the first cultivation space to interact with the cells in second cultivation space and vice versa. In the test system, the cells are co-cultivated and the microparticles are then selected based on the phenotype of the cells in the first or second cultivation space.

    AUXOTROPHIC SELECTION SYSTEM
    5.
    发明申请
    AUXOTROPHIC SELECTION SYSTEM 审中-公开

    公开(公告)号：US20190316165A1

    公开(公告)日：2019-10-17

    申请号：US16348252

    申请日：2017-11-09

    申请人： BIOMILLENIA SAS

    发明人： Dirk Loeffert ,  Eric Shiue ,  Guansheng Du

    IPC分类号： C12Q1/04 ,  B01L3/00 ,  C12M3/06 ,  C12M1/12 ,  C12M1/42 ,  C12M1/00 ,  C12N1/02

    摘要： A method for the analysis of microorganisms, which produce a compound, the method comprising: a. providing a microorganism which produces a compound of interest and a detector microorganism which comprises a reporter gene or reporter gene operon, wherein the microorganism producing said compound of interest and the detector microorganism are combined into single droplets, wherein each droplet comprises at least one cell of each strain; b. subjecting the droplets to a microfluidic system; c. analyzing the droplets for the activation of the reporter gene of the detector strain; d. sorting and collecting the droplets comprising the detector microorganism with expressed reporter gene.

    Method And System Of Producing A Library Of Microorganisms
    7.
    发明公开
    Method And System Of Producing A Library Of Microorganisms 审中-公开

    公开(公告)号：US20230227920A1

    公开(公告)日：2023-07-20

    申请号：US18009969

    申请日：2021-06-14

    申请人： Biomillenia SAS

    发明人： Guansheng Du ,  Laurine Thomas ,  Aleksander Dajkovic ,  Dirk Loeffert

    IPC分类号： C12Q1/689 ,  C12M1/34 ,  C12M3/06 ,  C12M1/12 ,  C12Q1/04

    CPC分类号： C12Q1/689 ,  C12M23/16 ,  C12M25/01 ,  C12M41/36 ,  C12Q1/04 ,  C12Q1/6869

    摘要： In a first aspect, the present invention relates to a method of producing a library of microorganisms, the method comprising the steps of: a. providing a first fluid comprising at least one single cell, b. dispersing said first fluid comprising at least one single cell in a second fluid, thereby obtaining a plurality of single-layer microfluidic droplets, wherein at least one single- layer microfluidic droplet comprises at least one single cell, wherein the second fluid is immiscible with the first fluid, c. optionally, adding to said at least one single-layer microfluidic droplet a third fluid comprising a sensing compound, wherein the third fluid is miscible with said first fluid, and wherein the third fluid is immiscible with said second fluid, d. injecting said at least one single-layer microfluidic droplet optionally comprising the sensing compound into a fourth fluid, wherein said fourth fluid is immiscible with said second fluid, thereby obtaining at least one double-layer microfluidic droplet, e. dispensing said at least one double-layer microfluidic droplet into a culture medium based on the viability of the cell, f. incubating said culture medium, thereby obtaining said library. In a second aspect, the present invention relates to a system comprising: a. a first microfluidic chip for producing a plurality of single-layer microfluidic droplets wherein at least one single-layer microfluidic droplet comprises at least one single cell, b. a first microfluidic device for collecting said plurality of single-layer microfluidic droplets, c. a second device for adding a sensing compound into said at least one single-layer microfluidic droplet comprising at least one single cell, d. a second microfluidic chip for producing a double-layer microfluidic droplet, and e. a dispensing unit. In a third aspect, the present invention relates to the use of the method according to the first aspect of the present invention in a system according to the second aspect of the present invention.

    Microparticle for cultivating and testing cells
    8.
    发明授权
    Microparticle for cultivating and testing cells 有权

    公开(公告)号：US11448645B2

    公开(公告)日：2022-09-20

    申请号：US16490804

    申请日：2018-03-02

    申请人： Biomillenia SAS

    发明人： Dirk Loeffert ,  Aleksander Dajkovic ,  Thomas Duboys

    IPC分类号： G01N33/543 ,  C12N5/071 ,  C12Q1/02

    摘要： Cultivation and/or test-system comprising at least two cultivation spaces combined in a microparticle, wherein the sperically shaped microparticle comprises, (i) a first cultivation space in the center core of said spherically shaped microparticle, (ii) a second cultivation space in the wall surrounding the core of said microparticle, (iii) wherein the wall surrounding the core allows for the exchange of molecules as, salts, nutrients, peptides, chemicals and other compounds in order for the cells in the first cultivation space to interact with the cells in second cultivation space and vice versa. In the test system, the cells are co-cultivated and the microparticles are then selected based on the phenotype of the cells in the first or second cultivation space.