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    MULTIFUNCTIONAL Fe3O4 CORED MAGNETIC-QUANTUM DOT FLUORESCENT NANOCOMPOSITES FOR RF NANO-HYPERTHERMIA OF CANCER CELLS
    2.
    发明申请
    MULTIFUNCTIONAL Fe3O4 CORED MAGNETIC-QUANTUM DOT FLUORESCENT NANOCOMPOSITES FOR RF NANO-HYPERTHERMIA OF CANCER CELLS 审中-公开
    多功能Fe3O4 CORED磁性量子点荧光纳米复合体用于射频纳米超细胞癌

    公开(公告)号：US20140161890A1

    公开(公告)日：2014-06-12

    申请号：US14181981

    申请日：2014-02-17

    申请人： Board of Trustees of the University of Arkansas

    发明人： Alexandru S. Biris ,  Yang Xu ,  Daoyuan Wang

    IPC分类号： A61K41/00

    CPC分类号： A61K41/0047 ,  A61K41/0052 ,  A61K49/0067 ,  A61K49/1836 ,  A61N1/406 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y40/00 ,  H01F1/0054

    摘要： A magnetic oxide-quantum dot nanocomposite has at least one magnetic oxide nanoparticle coated with a silica (SiO2) shell and terminated with at least one thiol group (—SH) and at least one CdSe/ZnS quantum dot linked with the at least one SiO2-coated magnetic oxide nanoparticle via the at least one thiol group. The at least one magnetic oxide nanoparticle can be an iron oxide (Fe3O4) nanoparticle. A method of cancer treatment using the magnetic oxide-quantum dot nanocomposites, includes the steps of delivering a plurality of nmagnetic oxide-quantum dot nanocomposites to a cancer cell, and subjecting the cancer cell with the plurality of magnetic oxide-quantum dot nanocomposites to a radio frequency induction for a period of time effective to cause the cancer cell to die.

    摘要翻译： 磁性氧化物 - 量子点纳米复合材料具有至少一个涂覆有二氧化硅（SiO 2）壳的磁性氧化物纳米颗粒，并用至少一个硫醇基（-SH）和至少一个与至少一个SiO 2连接的CdSe / ZnS量子点封端 包覆的磁性氧化物纳米颗粒通过至少一个硫醇基团。 所述至少一种磁性氧化物纳米颗粒可以是氧化铁（Fe 3 O 4）纳米颗粒。 使用磁性氧化物 - 量子点纳米复合材料的癌症治疗方法包括将多个磁性氧化物 - 量子点纳米复合物递送到癌细胞，并将多个磁性氧化物 - 量子点纳米复合材料的癌细胞进行 射频诱导一段时间有效导致癌细胞死亡。

    NANOCOMPOSITES, METHODS OF MAKING SAME, AND APPLICATIONS OF SAME FOR MULTICOLOR SURFACE ENHANCED RAMAN SPECTROSCOPY (SERS) DETECTIONS
    3.
    发明申请
    NANOCOMPOSITES, METHODS OF MAKING SAME, AND APPLICATIONS OF SAME FOR MULTICOLOR SURFACE ENHANCED RAMAN SPECTROSCOPY (SERS) DETECTIONS 有权
    纳米复合材料，其制备方法及其应用于多面体表面增强拉曼光谱（SERS）检测

    公开(公告)号：US20160153975A1

    公开(公告)日：2016-06-02

    申请号：US14513744

    申请日：2014-10-14

    申请人： BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS

    发明人： Alexandru S. Biris ,  Zeid Nima ,  Yang Xu

    IPC分类号： G01N33/543 ,  G01N33/574

    CPC分类号： G01N33/54346 ,  G01N33/54353 ,  G01N33/553

    摘要： A nanoagent for surface enhanced Raman spectroscopy (SERS) detection of a target of interest, includes one or more nanocomposites. The target of interest may include at least one tumor cell or at least one pathogen. Each nanocomposite includes at least one gold nanorod, a silver layer coated on a surface of the gold nanorod and having silver nanoparticles, a Raman reporter molecule layer assembled on the silver layer and having Raman reporter molecules, a pegylated layer coated on the Raman reporter molecule layer, and an antibody layer conjugated to the pegylated layer. The different nanocomposites of the nanoagent can be represented by different colors when SERS images are collected upon the nanoagent.

    摘要翻译： 用于感兴趣靶标的表面增强拉曼光谱（SERS）检测的纳米级包括一个或多个纳米复合材料。 感兴趣的靶标可以包括至少一种肿瘤细胞或至少一种病原体。 每个纳米复合材料包括至少一个金纳米棒，涂覆在金纳米棒表面上并具有银纳米颗粒的银层，组装在银层上并具有拉曼报告分子的拉曼报告分子层，涂覆在拉曼报告分子上的聚乙二醇化层 层，以及与聚乙二醇化层结合的抗体层。 当SERS图像收集在纳米级时，纳米纳米的不同纳米复合材料可以由不同的颜色表示。

    METALLIC NANOPARTICLES WITH COATED SHELLS AND APPLICATIONS OF SAME
    7.
    发明申请
    METALLIC NANOPARTICLES WITH COATED SHELLS AND APPLICATIONS OF SAME 审中-公开
    具有涂层的金属纳米颗粒及其应用

    公开(公告)号：US20130136696A1

    公开(公告)日：2013-05-30

    申请号：US13745282

    申请日：2013-01-18

    申请人： Board of Trustees of the University of Arkansas

    发明人： Alexandru S. Biris ,  Yang Xu ,  Zhongrui Li ,  Alexandru R. Biris

    IPC分类号： A61K9/14 ,  A61K51/02

    CPC分类号： A61K9/141 ,  A61K9/0009 ,  A61K9/5115 ,  A61K41/0052 ,  A61K51/02 ,  A61N1/406 ,  A61N5/0601 ,  A61N5/062 ,  B82Y25/00 ,  H01F1/0054 ,  Y10T428/2991 ,  Y10T428/2998

    摘要： A process or method for treating cancer. In one embodiment, the method includes the steps of providing a plurality of metallic nanoparticles, wherein each of the plurality of metallic nanoparticles has a core formed with a first metallic material, and a shell formed with a non-metallic material containing carbon, and wherein the shell is formed to enclose the metallic core completely, introducing said metallic nanoparticles into a mammal such that said metallic nanoparticles selectively target at least one type of cancerous cell, and subsequently applying at least one radio frequency of electromagnetic waves to said mammal for a period of time effective to induce skin currents in the cores of the first metallic material of said metallic nanoparticles to cause heat generated locally around targeted at least one type of cancerous cell to kill said cancerous cell.

    摘要翻译： 用于治疗癌症的方法或方法。 在一个实施方案中，该方法包括提供多个金属纳米颗粒的步骤，其中多个金属纳米颗粒中的每一个具有形成有第一金属材料的芯和由含有碳的非金属材料形成的壳，并且其中 壳体被形成为完全包围金属芯，将所述金属纳米颗粒引入到哺乳动物中，使得所述金属纳米粒子选择性地靶向至少一种类型的癌细胞，并且随后向所述哺乳动物施加至少一个电磁波射频一段时间 的时间有效地诱导所述金属纳米颗粒的第一金属材料的芯中的皮肤电流，以引起局部周围的靶向至少一种类型的癌细胞杀死所述癌细胞的热。