公开(公告)号：US20220260533A1

公开(公告)日：2022-08-18

申请号：US17676104

申请日：2022-02-18

申请人： BRIGHAM YOUNG UNIVERSITY

发明人： H. Dennis Tolley ,  Samuel Avila ,  Brian D. Iverson ,  Aaron Hawkins ,  Milton L. Lee

IPC分类号： G01N30/32

摘要： The present invention is a system and method for significantly improving gas chromatography resolution using a dynamic and non-linear thermal gradient along the entire column length and is achieved by decreasing the velocity of analytes when approaching the back end of the capillary column in order to compensate for an increase in velocity of carrier gas as the carrier gas expands when approaching the back end, and wherein the thermal gradient is selected so that the analyte achieves a constant velocity through the capillary column.

公开(公告)号：US20180335408A1

公开(公告)日：2018-11-22

申请号：US15984042

申请日：2018-05-18

申请人： Brigham Young University

发明人： Paul B. Farnsworth ,  Milton L. Lee ,  Luke T. Tolley ,  H. Dennis Tolley ,  Xiaofeng Xie

IPC分类号： G01N30/78 ,  G01N21/33 ,  G01N21/31 ,  G01N21/64 ,  G01N30/74

摘要： A system and method for performing UV LED-based absorption detection for capillary liquid chromatography for detecting and quantifying compounds in a liquid, wherein a simplified system eliminates the need for a beam splitter and a reference cell by using a stable UV source, and power requirements are reduced, resulting in a portable and substantially smaller system with relatively low detection limits.

公开(公告)号：US20190265215A1

公开(公告)日：2019-08-29

申请号：US16286562

申请日：2019-02-26

申请人： Brigham Young University

发明人： Xiaofeng Xie ,  Luke T. Tolley ,  Paul B. Farnsworth ,  H. Dennis Tolley ,  Milton L. Lee

IPC分类号： G01N30/88 ,  G01N30/78

摘要： A system and method for separating the functions of a liquid chromatography (LC) system into physically separate systems that allow for a more versatile LC system, wherein an LC device provides column 50 a liquid solvent, a sample, and a pump and injector that pushes the sample in the solvent to an output port, and providing an attachable module containing a module input port, a column, a heater for the column, and at least one detector for on-column detection, then attaching the module to the LC device using a press-fit connection that enables the sample in the solvent to be pumped through the column to the at least one detector in order to separate, identify and quantify substances in the sample and transmit results from the at least one detector to the LC system for collection and analysis.

公开(公告)号：US20150330955A1

公开(公告)日：2015-11-19

申请号：US14713328

申请日：2015-05-15

申请人： BRIGHAM YOUNG UNIVERSITY

发明人： Paul B. Farnsworth ,  Sonika Sharma ,  H. Dennis Tolley ,  Milton L. Lee

IPC分类号： G01N30/74 ,  G01N21/05

CPC分类号： G01N30/74 ,  G01N21/05 ,  G01N21/33 ,  G01N2021/0346 ,  G01N2201/0221 ,  G01N2201/0621 ,  G01N2201/0693

摘要： A system and method for performing UV LED-based absorption detection for capillary liquid chromatography for detecting and quantifying compounds in a liquid, wherein a simplified system eliminates the need for a beam splitter and a reference cell by using a stable UV source, and power requirements are reduced, resulting in a portable and substantially smaller system with relatively low detection limits.

摘要翻译： 一种用于对毛细管液相色谱进行UV基于LED的吸收检测以检测和定量液体中的化合物的系统和方法，其中简化的系统通过使用稳定的UV源而消除了对分束器和参考电池的需要以及功率要求 被减少，导致具有相对较低检测限的便携式和基本上较小的系统。

公开(公告)号：US20180250610A1

公开(公告)日：2018-09-06

申请号：US15912364

申请日：2018-03-05

申请人： Brigham Young University

发明人： Xiaofeng Xie ,  Luke T. Tolley ,  Paul B. Farnsworth ,  H. Dennis Tolley ,  Milton L. Lee

IPC分类号： B01D15/22 ,  G01N30/60 ,  G01N30/78 ,  G01N30/74

摘要： A system and method for performing liquid chromatography for separating molecules in a liquid solution, wherein a single column includes two of more separation segments, each separation segment having a separate detector immediately after each separation segment, wherein a mobile phase is inserted into a first separation segment and moves through the column until passing through a last separation segment, and then using the data from the detectors to perform compound identification.

公开(公告)号：US10060889B2

公开(公告)日：2018-08-28

申请号：US14713328

申请日：2015-05-15

申请人： BRIGHAM YOUNG UNIVERSITY

发明人： Paul B. Farnsworth ,  Sonika Sharma ,  H. Dennis Tolley ,  Milton L. Lee

IPC分类号： G01N30/74 ,  G01N21/05 ,  G01N21/33 ,  G01N21/03

CPC分类号： G01N30/74 ,  G01N21/05 ,  G01N21/33 ,  G01N2021/0346 ,  G01N2201/0221 ,  G01N2201/0621 ,  G01N2201/0693

摘要： A system and method for performing UV LED-based absorption detection for capillary liquid chromatography for detecting and quantifying compounds in a liquid, wherein a simplified system eliminates the need for a beam splitter and a reference cell by using a stable UV source, and power requirements are reduced, resulting in a portable and substantially smaller system with relatively low detection limits.

公开(公告)号：US20150075374A1

公开(公告)日：2015-03-19

申请号：US14488013

申请日：2014-09-16

申请人： Brigham Young University

发明人： H. Dennis Tolley ,  Anzi Wang ,  Samuel E. Tolley ,  Milton L. Lee

IPC分类号： G01N30/30

CPC分类号： G01N30/30 ,  G01N30/6095 ,  G01N2030/3015

摘要： A system and method for thermal gradient gas chromatography wherein a front or injection end of a column is heated to a higher temperature than a back or detector end to thereby create a thermal gradient having a profile that is substantially monotonically non-increasing and has a positive second derivative, and then providing a heat source to raise the thermal gradient and cause it to remain stationary or to travel through the column while maintaining a desired profile.

摘要翻译： 一种用于热梯度气相色谱的系统和方法，其中柱的前部或注射端被加热到比背部或检测器端更高的温度，从而产生具有基本上单调不增加且具有阳性的轮廓的热梯度 然后提供热源以提高热梯度并使其保持静止或在保持所需轮廓的同时行进通过柱。

公开(公告)号：US11143639B2

公开(公告)日：2021-10-12

申请号：US16286562

申请日：2019-02-26

申请人： Brigham Young University

发明人： Xiaofeng Xie ,  Luke T. Tolley ,  Paul B. Farnsworth ,  H. Dennis Tolley ,  Milton L. Lee

IPC分类号： G01N30/88 ,  G01N30/78 ,  G01N30/02

摘要： A system and method for separating the functions of a liquid chromatography (LC) system into physically separate systems that allow for a more versatile LC system, wherein an LC device provides column 50 a liquid solvent, a sample, and a pump and injector that pushes the sample in the solvent to an output port, and providing an attachable module containing a module input port, a column, a heater for the column, and at least one detector for on-column detection, then attaching the module to the LC device using a press-fit connection that enables the sample in the solvent to be pumped through the column to the at least one detector in order to separate, identify and quantify substances in the sample and transmit results from the at least one detector to the LC system for collection and analysis.

公开(公告)号：US09678046B2

公开(公告)日：2017-06-13

申请号：US14488013

申请日：2014-09-16

申请人： BRIGHAM YOUNG UNIVERSITY

发明人： H. Dennis Tolley ,  Anzi Wang ,  Samuel E. Tolley ,  Milton L. Lee ,  Aaron R. Hawkins

IPC分类号： G01N30/30 ,  G01N30/60

CPC分类号： G01N30/30 ,  G01N30/6095 ,  G01N2030/3015

摘要： A system and method for thermal gradient gas chromatography wherein a front or injection end of a column is heated to a higher temperature than a back or detector end to thereby create a thermal gradient having a profile that is substantially monotonically non-increasing and has a positive second derivative, and then providing a heat source to raise the thermal gradient and cause it to remain stationary or to travel through the column while maintaining a desired profile.