公开(公告)号：US20160024103A1

公开(公告)日：2016-01-28

申请号：US14773123

申请日：2014-03-12

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： KAP-SUN YEUNG ,  KYLE J. EASTMAN ,  KYLE E. PARCELLA

IPC: C07D491/048 ,  C07D307/84

CPC classification number: C07D491/048 ,  C07D307/84 ,  C07D491/04

Abstract: The disclosure provides compounds of formula I or II, including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.

Abstract translation: 本公开提供式I或II的化合物，包括其盐，以及使用该化合物的组合物和方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。

公开(公告)号：US20170107202A1

公开(公告)日：2017-04-20

申请号：US15290167

申请日：2016-10-11

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： KAP-SUN YEUNG ,  Timothy P. Connolly ,  David B. Frennesson ,  Katharine A. Grant-Young ,  Piyasena Hewawasam ,  David R. Langley ,  Zhaoxing Meng ,  Eric Mull ,  Kyle E. Parcella ,  Mark George Saulnier ,  Li-Qiang Sun ,  Alan Xiangdong Wang ,  Ningning Xu ,  Juliang Zhu ,  Paul Michael Scola

IPC: C07D401/14 ,  A61K31/5377 ,  C07D213/85 ,  A61K31/4439 ,  C07D401/12 ,  A61K31/4545 ,  A61K31/44 ,  C07D471/04 ,  C07D405/14 ,  A61K31/454 ,  C07D403/12 ,  A61K31/4025 ,  A61K31/496 ,  C07D205/04 ,  A61K31/397 ,  A61K31/4427 ,  A61K31/4453 ,  C07D211/22 ,  A61K31/40 ,  C07D207/14 ,  C07D207/12 ,  A61K31/138 ,  C07C215/20 ,  C07D413/14 ,  C07D213/82 ,  C07D491/08 ,  C07D417/14 ,  A61K31/541 ,  C07D471/08 ,  C07D405/12 ,  A61K31/135 ,  C07D213/80 ,  C07D207/16 ,  C07D265/30 ,  A61K31/5375 ,  A61K31/166 ,  C07C235/46 ,  C07D417/12 ,  A61K45/06

Abstract: The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.

公开(公告)号：US20180057455A1

公开(公告)日：2018-03-01

申请号：US15689115

申请日：2017-08-29

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： KAP-SUN YEUNG ,  Katharine A. Grant-Young ,  Juliang Zhu ,  Mark G. Saulnier ,  David B. Frennesson ,  David R. Langley ,  Piyasena Hewawasam ,  Tao Wang ,  Zhongxing Zhang ,  Zhaoxing Meng ,  Li-Qiang Sun ,  Eric Mull ,  Paul Michael Scola

IPC: C07D207/12 ,  C07D211/66 ,  C07D207/16 ,  C07D403/12 ,  C07D401/12 ,  C07D207/14 ,  C07D211/22 ,  C07D213/38 ,  C07D401/14 ,  C07C237/06 ,  C07D295/088 ,  C07D205/04 ,  C07D213/85 ,  C07C217/18 ,  C07D213/73 ,  C07D405/12 ,  C07C255/24 ,  C07D413/14 ,  C07D405/14 ,  C07D213/79 ,  C07D231/12 ,  C07D239/26 ,  C07D277/28 ,  C07D211/90

CPC classification number: C07D207/12 ,  C07C217/18 ,  C07C217/28 ,  C07C217/58 ,  C07C229/14 ,  C07C235/08 ,  C07C237/04 ,  C07C237/06 ,  C07C255/24 ,  C07C255/25 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07D205/04 ,  C07D207/14 ,  C07D207/16 ,  C07D211/22 ,  C07D211/46 ,  C07D211/58 ,  C07D211/60 ,  C07D211/66 ,  C07D211/90 ,  C07D213/38 ,  C07D213/42 ,  C07D213/55 ,  C07D213/73 ,  C07D213/79 ,  C07D213/85 ,  C07D231/12 ,  C07D239/26 ,  C07D277/28 ,  C07D295/088 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D413/14 ,  C07D417/12

Abstract: The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.