-
公开(公告)号：US10745382B2
公开(公告)日：2020-08-18
申请号：US15290167
申请日：2016-10-11
发明人： Kap-Sun Yeung , Timothy P. Connolly , David B. Frennesson , Katharine A. Grant-Young , Piyasena Hewawasam , David R. Langley , Zhaoxing Meng , Eric Mull , Kyle E. Parcella , Mark George Saulnier , Li-Qiang Sun , Alan Xiangdong Wang , Ningning Xu , Juliang Zhu , Paul Michael Scola
IPC分类号： C07D401/14 , C07D213/71 , C07D455/02 , A61K31/135 , A61K31/138 , A61K31/166 , A61K31/397 , A61K31/40 , A61K31/4025 , A61K31/44 , A61K31/4427 , A61K31/4439 , A61K31/4453 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5375 , A61K31/5377 , A61K31/541 , A61K45/06 , C07C215/20 , C07C235/46 , C07D205/04 , C07D207/12 , C07D207/14 , C07D207/16 , C07D211/22 , C07D213/80 , C07D213/82 , C07D213/85 , C07D265/30 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/08 , C07D491/08
摘要： The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.
-
2.发明授权公开(公告)号：US09879046B2
公开(公告)日：2018-01-30
申请号：US15204627
申请日：2016-07-07
发明人： Michael Matthew Miller , Martin Patrick Allen , Michael S. Bowsher , Kenneth M. Boy , Eric P. Gillis , David R. Langley , Eric Mull , Li-Qiang Sun , Kap-Sun Yeung , Patrick C. Reid , Paul Michael Scola
IPC分类号： C07K7/56 , A61K38/12 , C07K7/08 , A61K38/10 , A61K39/39 , A61K45/06 , G01N33/574 , A61K38/00
CPC分类号： C07K7/56 , A61K38/00 , A61K38/10 , A61K39/39 , A61K45/06 , C07K7/08 , G01N33/574 , G01N2333/70532 , G01N2500/02 , G01N2800/26 , Y02A50/463
摘要： The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.
-
公开(公告)号：US09856292B2
公开(公告)日：2018-01-02
申请号：US14938327
申请日：2015-11-11
发明人： Kevin W. Gillman , Jason Goodrich , Kenneth M. Boy , Yunhui Zhang , Claudio Mapelli , Michael A. Poss , Paul Michael Scola , David R. Langley , Nicholas A. Meanwell
CPC分类号： C07K7/08 , A61K38/00 , A61K38/10 , A61K45/06 , A61K51/088 , C07K7/56 , Y02A50/463
摘要： The present disclosure provides compounds which are immunomodulators and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.
-
4.发明授权公开(公告)号：US09850283B2
公开(公告)日：2017-12-26
申请号：US15009575
申请日：2016-01-28
发明人： Michael Matthew Miller , Claudio Mapelli , Martin Patrick Allen , Michael S. Bowsher , Kenneth M. Boy , Eric P. Gillis , David R. Langley , Eric Mull , Maude A. Poirier , Nishith Sanghvi , Li-Qiang Sun , Daniel J. Tenney , Kap-Sun Yeung , Juliang Zhu , Patrick C. Reid , Paul Michael Scola
IPC分类号： C07K7/56 , A61K38/12 , C07K7/08 , G01N33/68 , A61K38/10 , A61K39/39 , A61K45/06 , G01N33/574 , A61K38/00
CPC分类号： C07K7/56 , A61K38/00 , A61K38/10 , A61K39/39 , A61K45/06 , C07K7/08 , G01N33/574 , G01N2333/70532 , G01N2500/02 , G01N2800/26 , Y02A50/463
摘要： The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.
-
公开(公告)号：US09758487B2
公开(公告)日：2017-09-12
申请号：US15194980
申请日：2016-06-28
发明人： Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Gan Wang , Lawrence G. Hamann
IPC分类号： A61K38/20 , A61K31/4164 , A61K31/517 , A61K31/715 , A61K38/46 , A61P31/00 , C07D403/02 , C07D401/00 , C07D233/64 , C07D401/14 , C07D403/14 , A61K31/4178 , A61K45/06 , C07D405/14 , C07D413/14 , C07D409/14 , C07D417/14
CPC分类号： C07D233/64 , A61K31/4178 , A61K45/06 , C07D207/16 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07F5/025 , C07F7/0812
摘要： The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
-
公开(公告)号：US20140051692A1
公开(公告)日：2014-02-20
申请号：US13959268
申请日：2013-08-05
发明人： B. Narasimhulu Naidu , Manoj Patel , Stanley D'Andrea , Zhizhen Barbara Zheng , Timothy P. Connolly , David R. Langley , Kevin Peese , Zhongyu Wang , Michael A. Walker , John F. Kadow
IPC分类号： A61K31/5383 , A61K45/06 , C07D491/22 , C07D498/22 , A61K31/519
CPC分类号： A61K31/5383 , A61K31/519 , A61K45/06 , C07D487/16 , C07D491/22 , C07D498/16 , C07D498/22
摘要： The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection.
摘要翻译： 本公开一般涉及式I化合物，包括用于治疗人类免疫缺陷病毒（HIV）感染的组合物和方法。 本公开提供了HIV的新型抑制剂，含有这些化合物的药物组合物，以及使用这些化合物治疗HIV感染的方法。
-
公开(公告)号：US11358988B2
公开(公告)日：2022-06-14
申请号：US16711105
申请日：2019-12-11
发明人： Kevin W. Gillman , Jason Goodrich , Kenneth M. Boy , Yunhui Zhang , Claudio Mapelli , Michael A. Poss , Paul Michael Scola , David R. Langley , Nicholas A. Meanwell
摘要： The present disclosure provides compounds which are immunomodulators and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.
-
公开(公告)号：US10144706B2
公开(公告)日：2018-12-04
申请号：US15689115
申请日：2017-08-29
发明人： Kap-Sun Yeung , Katharine A. Grant-Young , Juliang Zhu , Mark G. Saulnier , David B. Frennesson , David R. Langley , Piyasena Hewawasam , Tao Wang , Zhongxing Zhang , Zhaoxing Meng , Li-Qiang Sun , Eric Mull , Paul Michael Scola
IPC分类号： C07D207/12 , C07D217/18 , C07D237/06 , C07D205/04 , C07D207/14 , C07D207/16 , C07D211/22 , C07D211/66 , C07D211/90 , C07D213/38 , C07D213/73 , C07D213/79 , C07D213/85 , C07D231/12 , C07D239/26 , C07D277/28 , C07D295/088 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/14 , C07D401/04 , C07D405/06 , C07D417/12 , C07D211/46 , C07D211/58 , C07D211/60 , C07D213/42 , C07D213/55 , C07C237/04 , C07C235/08 , C07C229/14 , C07C217/58 , C07C217/28 , C07C217/18 , C07C237/06 , C07C255/24 , C07C255/25
摘要： The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.
-
9.发明申请公开(公告)号：US20170369530A1
公开(公告)日：2017-12-28
申请号：US15672526
申请日：2017-08-09
发明人： Michael Matthew Miller , Claudio Mapelli , Martin Patrick Allen , Michael S. Bowsher , Kenneth M. Boy , Eric P. Gillis , David R. Langley , Eric Mull , Maude A. Poirier , Nishith Sanghvi , Li-Qiang Sun , Daniel J. Tenney , Kap-Sun Yeung , Juliang Zhu , Patrick C. Reid , Paul Michael Scola
CPC分类号： C07K7/56 , A61K38/00 , A61K38/10 , A61K39/39 , A61K45/06 , C07K7/08 , G01N33/574 , G01N2333/70532 , G01N2500/02 , G01N2800/26 , Y02A50/463
摘要： The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.
-
公开(公告)号：US20170107202A1
公开(公告)日：2017-04-20
申请号：US15290167
申请日：2016-10-11
发明人： KAP-SUN YEUNG , Timothy P. Connolly , David B. Frennesson , Katharine A. Grant-Young , Piyasena Hewawasam , David R. Langley , Zhaoxing Meng , Eric Mull , Kyle E. Parcella , Mark George Saulnier , Li-Qiang Sun , Alan Xiangdong Wang , Ningning Xu , Juliang Zhu , Paul Michael Scola
IPC分类号： C07D401/14 , A61K31/5377 , C07D213/85 , A61K31/4439 , C07D401/12 , A61K31/4545 , A61K31/44 , C07D471/04 , C07D405/14 , A61K31/454 , C07D403/12 , A61K31/4025 , A61K31/496 , C07D205/04 , A61K31/397 , A61K31/4427 , A61K31/4453 , C07D211/22 , A61K31/40 , C07D207/14 , C07D207/12 , A61K31/138 , C07C215/20 , C07D413/14 , C07D213/82 , C07D491/08 , C07D417/14 , A61K31/541 , C07D471/08 , C07D405/12 , A61K31/135 , C07D213/80 , C07D207/16 , C07D265/30 , A61K31/5375 , A61K31/166 , C07C235/46 , C07D417/12 , A61K45/06
摘要： The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.
-
-
-
-
-
-
-
-
-
搜索结果
43 条记录 (耗时 0.086 秒)
