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    Iminosugar compounds with antiflavirus activity
    1.
    发明授权
    Iminosugar compounds with antiflavirus activity 有权
    具有抗病毒活性的Iminosugar化合物

    公开(公告)号：US08097728B2

    公开(公告)日：2012-01-17

    申请号：US12112694

    申请日：2008-04-30

    申请人： Baohua Gu ,  Timothy M. Block ,  Robert M. Moriarty ,  Mahendra N. Deshpande ,  Rajendra C. Shah

    发明人： Baohua Gu ,  Timothy M. Block ,  Robert M. Moriarty ,  Mahendra N. Deshpande ,  Rajendra C. Shah

    IPC分类号： C12N9/99 ,  A61P31/14 ,  C07D211/40

    CPC分类号： C07D211/44

    摘要： An anti-viral compounds effective against viruses belonging to the Flaviviridae family, wherein the anti-viral compounds are 1,5-dideoxy-1,5-imino-D-glucitol derivative compounds having the general formula (I) wherein R2, R3, R4 and R5 are the same or different and are selected from the group consisting of hydrogen, acyl, benzyl, alkyl, aryl, sulfonyl, phosphonyl, silyl, R6 is at least one of alkyl or branched alkyl, heteroalkyl or aryl, R6′ is a bridging group selected from at least one of bicycle[2.2.1]heptyl, bicycle[3.2.1]octyl, oxa analogs, admonyl and cubyl, n′=2-10, n″=1-10, enantiomers and stereoisomers of said compounds and physiologically acceptable salts or solvates of said compounds, enantiomer or stereoisomer.

    摘要翻译： 一种对属于黄病毒科的病毒有效的抗病毒化合物，其中抗病毒化合物是具有通式（I）的1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇衍生物化合物，其中R2，R3， R4和R5相同或不同，选自氢，酰基，苄基，烷基，芳基，磺酰基，膦酰基，甲硅烷基，R6是烷基或支链烷基，杂烷基或芳基中的至少一个，R6'是 选自自行车[2.2.1]庚基，自行车[3.2.1]辛基，氧杂类似物，亚丁基和立方中的至少一种的桥连基团，n'= 2-10，n“= 1-10，对映体和立体异构体 所述化合物和所述化合物的生理学上可接受的盐或溶剂化物，对映异构体或立体异构体。

    IMINOSUGAR COMPOUNDS WITH ANTIFLAVIRUS ACTIVITY
    2.
    发明申请
    IMINOSUGAR COMPOUNDS WITH ANTIFLAVIRUS ACTIVITY 有权
    具有抗病毒活性的肌内注射化合物

    公开(公告)号：US20090042268A1

    公开(公告)日：2009-02-12

    申请号：US12112694

    申请日：2008-04-30

    申请人： Baohua Gu ,  Timothy M. Block ,  Robert M. Moriarty ,  Mahendra N. Deshpande ,  Rajendra C. Shah

    发明人： Baohua Gu ,  Timothy M. Block ,  Robert M. Moriarty ,  Mahendra N. Deshpande ,  Rajendra C. Shah

    IPC分类号： C12N9/99 ,  A61P31/14 ,  C07D211/40

    CPC分类号： C07D211/44

    摘要： An anti-viral compounds effective against viruses belonging to the Flaviviridae family, wherein the anti-viral compounds are 1,5-dideoxy-1,5-imino-D-glucitol derivative compounds having the general formula (I) wherein R2, R3, R4 and R5 are the same or different and are selected from the group consisting of hydrogen, acyl, benzyl, alkyl, aryl, sulfonyl, phosphonyl, silyl, R6 is at least one of alkyl or branched alkyl, heteroalkyl or aryl, R6′ is a bridging group selected from at least one of bicycle[2.2.1]heptyl, bicycle[3.2.1]octyl, oxa analogs, admonyl and cubyl, n′=2-10, n″=1-10, enantiomers and stereoisomers of said compounds and physiologically acceptable salts or solvates of said compounds, enantiomer or stereoisomer.

    摘要翻译： 一种对属于黄病毒科的病毒有效的抗病毒化合物，其中抗病毒化合物是具有通式（I）的1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇衍生物化合物，其中R2，R3， R4和R5相同或不同，选自氢，酰基，苄基，烷基，芳基，磺酰基，膦酰基，甲硅烷基，R6是烷基或支链烷基，杂烷基或芳基中的至少一个，R6'是 选自自行车[2.2.1]庚基，自行车[3.2.1]辛基，氧杂类似物，亚戊基和立方中的至少一种的桥连基团，n'= 2-10，n“= 1-10，对映异构体和立体异构体 的所述化合物和所述化合物的生理学上可接受的盐或溶剂合物，对映异构体或立体异构体。

    SYSTEM FOR MANAGING CONSTRUCTION PROJECT BIDDING
    3.
    发明申请
    SYSTEM FOR MANAGING CONSTRUCTION PROJECT BIDDING 审中-公开
    管理施工工程投标制度

    公开(公告)号：US20130046647A1

    公开(公告)日：2013-02-21

    申请号：US13210774

    申请日：2011-08-16

    申请人： Dave Robertson ,  Sharandeep Sekhon ,  Baohua Gu ,  Dariusz Czarkowski

    发明人： Dave Robertson ,  Sharandeep Sekhon ,  Baohua Gu ,  Dariusz Czarkowski

    IPC分类号： G06Q30/08

    CPC分类号： G06Q30/08 ,  G06Q10/00

    摘要： A system is disclosed that facilitates construction project bidding, document distribution, and project management over a computer network. The system enables a project supervisor to efficiently transmit new project information and associated construction project files to one or more planroom provider systems. Each planroom provider system may make project information and associated construction project files available for transfer and viewing by one or more potential bidders connected to the planroom provider system over a public or private network. The planroom provider system(s) may provide a reference or link back to the project supervisor system to enable the potential bidder to bid on the construction project once the project information and project files have been reviewed.

    摘要翻译： 公开了一种通过计算机网络进行项目投标，文件分发和项目管理的系统。 该系统使项目主管有效地将新的项目信息和相关的建设项目文件传送到一个或多个计划供应商系统。 每个计划供应商系统可以使项目信息和相关的建设项目文件可供一个或多个通过公共或私人网络连接到计划室提供者系统的潜在投标人进行转移和查看。 一旦项目信息和项目文件被审查，计划供应商系统可以提供参考或链接回项目主管系统，以使潜在投标人能够对施工项目进行投标。

    VOLUME-LABELED NANOPARTICLES AND METHODS OF PREPARATION
    7.
    发明申请
    VOLUME-LABELED NANOPARTICLES AND METHODS OF PREPARATION 有权
    体积标准的纳米颗粒及其制备方法

    公开(公告)号：US20120168671A1

    公开(公告)日：2012-07-05

    申请号：US12981886

    申请日：2010-12-30

    申请人： Wei Wang ,  Baohua Gu ,  Scott T. Retterer ,  Mitchel J. Doktycz

    发明人： Wei Wang ,  Baohua Gu ,  Scott T. Retterer ,  Mitchel J. Doktycz

    IPC分类号： C09K11/04 ,  C09K11/08 ,  C09K11/02 ,  C09K11/06 ,  H01F1/00 ,  B82Y40/00 ,  B82Y30/00

    CPC分类号： B82Y30/00 ,  B82Y40/00 ,  C09K11/04 ,  C09K11/06 ,  H01F1/0054

    摘要： Compositions comprising nanosized objects (i.e., nanoparticles) in which at least one observable marker, such as a radioisotope or fluorophore, is incorporated within the nanosized object. The nanosized objects include, for example, metal or semi-metal oxide (e.g., silica), quantum dot, noble metal, magnetic metal oxide, organic polymer, metal salt, and core-shell nanoparticles, wherein the label is incorporated within the nanoparticle or selectively in a metal oxide shell of a core-shell nanoparticle. Methods of preparing the volume-labeled nanoparticles are also described.

    摘要翻译： 包含纳米尺寸物体（即，纳米颗粒）的组合物，其中至少一个可观察标记如放射性同位素或荧光团掺入纳米尺度物体内。 纳米尺寸物体包括例如金属或半金属氧化物（例如二氧化硅），量子点，贵金属，磁性金属氧化物，有机聚合物，金属盐和核 - 壳纳米颗粒，其中标记掺入纳米颗粒内 或选择性地在核 - 壳纳米颗粒的金属氧化物壳中。 还描述了制备体积标记的纳米颗粒的方法。

    Volume-labeled nanoparticles and methods of preparation
    9.
    发明授权
    Volume-labeled nanoparticles and methods of preparation 有权
    体积标记的纳米颗粒和制备方法

    公开(公告)号：US09011735B2

    公开(公告)日：2015-04-21

    申请号：US12981886

    申请日：2010-12-30

    申请人： Wei Wang ,  Baohua Gu ,  Scott T. Retterer ,  Mitchel J. Doktycz

    发明人： Wei Wang ,  Baohua Gu ,  Scott T. Retterer ,  Mitchel J. Doktycz

    IPC分类号： C09K11/04 ,  C09K11/06 ,  C09K11/08 ,  B82Y40/00 ,  B82Y30/00 ,  H01F1/00

    CPC分类号： B82Y30/00 ,  B82Y40/00 ,  C09K11/04 ,  C09K11/06 ,  H01F1/0054

    摘要： Compositions comprising nanosized objects (i.e., nanoparticles) in which at least one observable marker, such as a radioisotope or fluorophore, is incorporated within the nanosized object. The nanosized objects include, for example, metal or semi-metal oxide (e.g., silica), quantum dot, noble metal, magnetic metal oxide, organic polymer, metal salt, and core-shell nanoparticles, wherein the label is incorporated within the nanoparticle or selectively in a metal oxide shell of a core-shell nanoparticle. Methods of preparing the volume-labeled nanoparticles are also described.

    摘要翻译： 包含纳米尺寸物体（即，纳米颗粒）的组合物，其中至少一个可观察标记如放射性同位素或荧光团掺入纳米尺度物体内。 纳米尺寸物体包括例如金属或半金属氧化物（例如二氧化硅），量子点，贵金属，磁性金属氧化物，有机聚合物，金属盐和核 - 壳纳米颗粒，其中标记掺入纳米颗粒内 或选择性地在核 - 壳纳米颗粒的金属氧化物壳中。 还描述了制备体积标记的纳米颗粒的方法。

    Functionalized gold surface-enhanced raman scattering substrate for rapid and ultra-sensitive detection of anionic species in the environment
    10.
    发明授权
    Functionalized gold surface-enhanced raman scattering substrate for rapid and ultra-sensitive detection of anionic species in the environment 有权
    功能化的金表面增强拉曼散射底物，用于环境中阴离子物质的快速和超灵敏检测

    公开(公告)号：US07989211B1

    公开(公告)日：2011-08-02

    申请号：US12645017

    申请日：2009-12-22

    申请人： Baohua Gu ,  Chuanmin Ruan ,  Wei Wang

    发明人： Baohua Gu ,  Chuanmin Ruan ,  Wei Wang

    IPC分类号： G01N33/00 ,  G01N21/65

    CPC分类号： G01N33/182 ,  G01N21/658 ,  Y10T436/153333 ,  Y10T436/173076 ,  Y10T436/19 ,  Y10T436/193333

    摘要： This invention relates to the development of a new Raman enhancing reagent and a surface-enhanced Raman scattering (SERS) method for rapid and ultra-sensitive detection and identification of perchlorate (ClO4−) and other anions such as technetium (TcO4−), uranium and nitrate in environmental samples. The method involves the synthesis of controlled gold nanoparticles which are modified with amine functional groups such as 2-(dimethylamino)ethanethiol and N,N,N-trimethylaminethiol. These functionalized Au nanoparticles were found to be reactive with perchlorate and other anions and can be used to detect these anions by Raman spectroscopy at ultra low concentrations in complex environmental matrices. This invention overcomes the limitations of currently-available analytical techniques by offering an inexpensive, rapid, ultra-sensitive, and real-time identification and detection of perchlorate and other anions. The technique is not only sensitive but also highly specific because of the unique Raman vibrational bands of perchlorate and other anions.

    摘要翻译： 本发明涉及新型拉曼增强试剂和表面增强拉曼散射（SERS）方法的开发，用于快速和超灵敏检测和鉴定高氯酸盐（ClO4-）和其他阴离子如锝（TcO4-），铀 和硝酸盐在环境样品中。 该方法涉及用胺官能团如2-（二甲基氨基）乙硫醇和N，N，N-三甲基氨基硫醇修饰的受控金纳米颗粒的合成。 发现这些官能化的Au纳米颗粒与高氯酸盐和其它阴离子反应，可用于通过拉曼光谱法在复杂环境基质中以超低浓度检测这些阴离子。 本发明通过提供廉价，快速，超灵敏和实时鉴定和检测高氯酸盐和其他阴离子来克服当前可用的分析技术的局限性。 由于高氯酸盐和其他阴离子的独特的拉曼振动带，该技术不仅敏感，而且具有高度的特异性。