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    Modulation of Abeta levels by beta-secretase BACE2
    2.
    发明申请
    Modulation of Abeta levels by beta-secretase BACE2 审中-公开
    通过β-分泌酶BACE2调节Abeta水平

    公开(公告)号：US20070224656A1

    公开(公告)日：2007-09-27

    申请号：US11712211

    申请日：2007-02-27

    申请人： Barbara Cordell ,  Frauke Schimmoller ,  Yu-Wang Liu ,  Diana Quon

    发明人： Barbara Cordell ,  Frauke Schimmoller ,  Yu-Wang Liu ,  Diana Quon

    IPC分类号： C12Q1/37

    CPC分类号： C12Q1/37 ,  C07K14/4711 ,  C12N9/6421 ,  G01N2500/04

    摘要： The present invention is based on the findings that BACE2, a homolog of β-secretase BACE, is able to stimulate processing of APP in a non-amyloidogenic pathway, thereby suppressing the level of Aβ. Accordingly, the present invention provides methods and means for the identification and use of modulators of this unique activity of BACE2 to suppress Aβ production. The compounds identified using the methods and means provided herein may be used as potential candidates for the treatment of Alzheimer's disease and other neurological diseases.

    摘要翻译： 本发明基于以下发现：BACE2是β-分泌酶BACE的同源物，能够刺激非淀粉样蛋白生成途径中APP的加工，从而抑制Abeta的水平。 因此，本发明提供了鉴定和使用BACE2独特活性调节剂来抑制Abeta生产的方法和手段。 使用本文提供的方法和手段鉴定的化合物可以用作治疗阿尔茨海默病和其他神经疾病的潜在候选物。

    Inhibition of Aβ production by β-secretase BACE2
    4.
    发明授权
    Inhibition of Aβ production by β-secretase BACE2 失效
    通过β-分泌酶BACE2抑制Abeta生产

    公开(公告)号：US07183070B2

    公开(公告)日：2007-02-27

    申请号：US10749714

    申请日：2003-12-31

    申请人： Barbara Cordell ,  Frauke Schimmöoller ,  Yu-Wang Liu ,  Diana Hom Quon

    发明人： Barbara Cordell ,  Frauke Schimmöoller ,  Yu-Wang Liu ,  Diana Hom Quon

    IPC分类号： C12Q1/37

    CPC分类号： C12Q1/37 ,  C07K14/4711 ,  C12N9/6421 ,  G01N2500/04

    摘要： The present invention is based on the findings that BACE2, a homolog of β-secretase BACE, is able to stimulate processing of APP in a non-amyloidogenic pathway, thereby suppressing the level of Aβ. Accordingly, the present invention provides methods and means for the identification and use of modulators of this unique activity of BACE2 to suppress Aβ production. The compounds identified using the methods and means provided herein may be used as potential candidates for the treatment of Alzheimer's disease and other neurological diseases by reducing β-amyloid deposit formation.

    摘要翻译： 本发明基于以下发现：BACE2是β-分泌酶BACE的同源物，能够刺激非淀粉样蛋白生成途径中APP的加工，从而抑制Abeta的水平。 因此，本发明提供了鉴定和使用BACE2独特活性调节剂来抑制Abeta生产的方法和手段。 使用本文提供的方法和手段鉴定的化合物可以用作通过减少β-淀粉样蛋白沉积物形成来治疗阿尔茨海默氏病和其他神经疾病的潜在候选物。

    Modulation of A&bgr; levels by &bgr;-secretase BACE2
    6.
    发明授权
    Modulation of A&bgr; levels by &bgr;-secretase BACE2 失效
    通过β-分泌酶BACE2调节Abeta水平

    公开(公告)号：US06713276B2

    公开(公告)日：2004-03-30

    申请号：US09886143

    申请日：2001-06-20

    申请人： Barbara Cordell ,  Frauke Schimmöller ,  Yu-Wang Liu ,  Diana Hom Quon

    发明人： Barbara Cordell ,  Frauke Schimmöller ,  Yu-Wang Liu ,  Diana Hom Quon

    IPC分类号： C12Q137

    CPC分类号： C12Q1/37 ,  C07K14/4711 ,  C12N9/6421 ,  G01N2500/04

    摘要： The present invention is based on the findings that BACE 2, a homolog of &bgr;-secretase BACE, is able to stimulate processing of APP in a non-amyloidogenic pathway, thereby suppressing the level of A&bgr;. Accordingly, the present invention provides methods and means for the identification and use of modulators of this unique activity of BACE 2 to suppress A&bgr; production. The compounds identified using the methods and means provided herein may be used as potential candidates for the treatment of Alzheimer's disease and other neurological diseases.

    摘要翻译： 本发明基于以下发现：BACE 2是β-分泌酶BACE的同系物，能够刺激非淀粉样蛋白生成途径中APP的加工，从而抑制Aβ的水平。 因此，本发明提供了用于鉴定和使用BACE 2独特活性的抑制Abeta产生的调节剂的方法和手段。 使用本文提供的方法和手段鉴定的化合物可以用作治疗阿尔茨海默病和其他神经疾病的潜在候选物。

    DNA sequence useful for the detection of Alzheimer's disease
    9.
    发明授权
    DNA sequence useful for the detection of Alzheimer's disease 失效
    用于检测阿尔茨海默病的DNA序列

    公开(公告)号：US5220013A

    公开(公告)日：1993-06-15

    申请号：US444118

    申请日：1989-11-30

    申请人： Phyllis A. Ponte ,  Barbara Cordell

    发明人： Phyllis A. Ponte ,  Barbara Cordell

    IPC分类号： A61K38/00 ,  A61K51/08 ,  C07K14/47 ,  C12N15/71 ,  C12N15/863 ,  C12Q1/68 ,  G01N33/68

    CPC分类号： C12N15/86 ,  C07K14/4711 ,  C12N15/71 ,  C12Q1/6883 ,  G01N33/6896 ,  A61K2123/00 ,  A61K38/00 ,  C12N2710/24143 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N2800/2821

    摘要： DNA sequences encoding the beta-amyloid core protein, and beta-amyloid-related proteins associated with Alzheimer's disease are disclosed. These sequences are used in producing or constructing recombinant beta-amyloid core protein, beta-amyloid-related proteins and recombinant or synthetic immunogenic peptides. These sequences are also used to identify genomic mutations and/or restriction site alterations which are associated with a predisposition to Alzheimer's disease, for purposes of genetic screening. Antibodies generated against the recombinant proteins or immunogenic peptides derived therefrom can be used for cerebral fluid or serum protein diagnosis of Alzheimer's disease.

    摘要翻译： 公开了编码β-淀粉样蛋白核心蛋白的DNA序列和与阿尔茨海默病相关的β-淀粉样蛋白相关蛋白。 这些序列用于生产或构建重组β-淀粉样蛋白核心蛋白，β-淀粉样蛋白相关蛋白和重组或合成的免疫原性肽。 为了遗传筛选的目的，这些序列还用于鉴定与阿尔茨海默氏病倾向相关的基因组突变和/或限制性位点改变。 针对重组蛋白产生的抗体或由其衍生的免疫原性肽可用于脑血液或阿尔茨海默病的血清蛋白诊断。