公开(公告)号：US5772949A

公开(公告)日：1998-06-30

申请号：US908217

申请日：1997-08-07

申请人： M. Ishaq Haider ,  James E. Kuder ,  Barbara J. Long ,  Joseph D. Menczel ,  James B. Stamatoff ,  Michael Bayer

发明人： M. Ishaq Haider ,  James E. Kuder ,  Barbara J. Long ,  Joseph D. Menczel ,  James B. Stamatoff ,  Michael Bayer

IPC分类号： C08K5/00 ,  C09K5/06 ,  H01H37/36 ,  B29C35/02 ,  B29C35/08

CPC分类号： C09K5/06 ,  C08K5/0016 ,  H01H37/36

摘要： A thermally expandable wax composition and its use in polymer-based actuators is disclosed and claimed. The compositions are wax-based and include conductive filler as well as a viscosity modifier to stabilize the composition against segregation. Optionally included are thermoxidative stabilizers.

公开(公告)号：US5762830A

公开(公告)日：1998-06-09

申请号：US547043

申请日：1995-10-23

申请人： Barbara J. Long ,  M. Ishaq Haider ,  Joseph D. Menczel ,  James B. Stamatoff

发明人： Barbara J. Long ,  M. Ishaq Haider ,  Joseph D. Menczel ,  James B. Stamatoff

IPC分类号： C08K7/28 ,  C08K9/00 ,  C08K9/02 ,  C08K9/10 ,  C08L91/06 ,  H01B1/22

CPC分类号： H01B1/22 ,  C08K7/28 ,  C08K9/00 ,  C08K9/02 ,  C08K9/10 ,  C08L91/06

摘要： This invention discloses a thermally expandable composition for use in actuators. The composition contains about 10-50 volume percent hollow glass spheres in a wax or a polymer. The spheres contain a conducting coating affixed thereon. During use in an actuator, the composition is heated to melt the wax or polymer, when the density of the spheres substantially match the density of the melt, thereby substantially eliminating phase separation. The high thermal conductivity of the composition increases the speed of heat transfer out of the composition during the cooling cycles.

摘要翻译： 本发明公开了一种用于致动器的热膨胀组合物。 该组合物在蜡或聚合物中含有约10-50体积％的中空玻璃球。 球体上涂有导电涂层。 在致动器使用期间，当球体的密度基本上与熔体的密度匹配时，组合物被加热以熔化蜡或聚合物，从而基本上消除了相分离。 组合物的高热导率在冷却循环期间增加了组合物的热传递速度。

公开(公告)号：US5709740A

公开(公告)日：1998-01-20

申请号：US606111

申请日：1996-02-23

申请人： M. Ishaq Haider ,  James E. Kuder ,  Barbara J. Long ,  Joseph D. Menczel ,  James B. Stamatoff ,  Michael Bayer

发明人： M. Ishaq Haider ,  James E. Kuder ,  Barbara J. Long ,  Joseph D. Menczel ,  James B. Stamatoff ,  Michael Bayer

IPC分类号： C08K5/00 ,  C09K5/06 ,  H01H37/36 ,  C08L91/06 ,  H01B1/22 ,  H01B1/24

CPC分类号： C09K5/06 ,  C08K5/0016 ,  H01H37/36

摘要： A thermally expandable wax composition and its use in polymer-based actuators is disclosed and claimed. The compositions are wax-based and include conductive filler as well as a viscosity modifier to stabilize the composition against segregation. Optionally included are thermoxidative stabilizers.

摘要翻译： 公开并要求保护热膨胀蜡组合物及其在基于聚合物的致动器中的用途。 组合物是蜡基的，并且包括导电填料以及粘度调节剂以稳定组合物以防止分离。 任选地包括热氧化稳定剂。

公开(公告)号：US09775956B2

公开(公告)日：2017-10-03

申请号：US13810675

申请日：2010-07-22

申请人： Frank Martin ,  Richard J. Klug ,  M. Ishaq Haider

发明人： Frank Martin ,  Richard J. Klug ,  M. Ishaq Haider

IPC分类号： A61M37/00 ,  A61M5/32 ,  A61M5/24 ,  A61M5/34

CPC分类号： A61M5/3294 ,  A61M5/2448 ,  A61M5/346 ,  A61M5/347 ,  A61M2005/2474

摘要： In one aspect of the invention, a needle assembly is provided, including: a body having a proximal end, a distal end, and a channel located therebetween, the body being configured to be mounted to an injector; a needle fixed to the body, the needle having proximal and distal ends, the distal end extending distally from the distal end of the body and being formed for insertion into a patient, the proximal end of the needle being in communication with the channel; and, a filter disposed in the channel proximally of the proximal end of the needle. Advantageously, a needle assembly is provided which permits mixing of at least two substances in preparation for injection, without modification to the associated injector.

公开(公告)号：US08075826B2

公开(公告)日：2011-12-13

申请号：US12487374

申请日：2009-06-18

申请人： Alexander G. Lastovich ,  Jason B. Alarcon ,  John P. Dekker, III ,  M. Ishaq Haider ,  John A. Mikszta ,  Frank E. Martin ,  Scott A. O'Connor

发明人： Alexander G. Lastovich ,  Jason B. Alarcon ,  John P. Dekker, III ,  M. Ishaq Haider ,  John A. Mikszta ,  Frank E. Martin ,  Scott A. O'Connor

IPC分类号： B29C59/02

CPC分类号： A61M37/0015 ,  A61B17/205 ,  A61B2017/320004 ,  A61M31/002 ,  A61M37/00 ,  A61M2037/0007 ,  A61M2037/0023 ,  A61M2037/0038 ,  A61M2037/0046 ,  A61M2037/0053

摘要： Improved microprotrusion abrasion devices having fluid retaining or directing patterns, and specific design parameters and method for delivery of substances into the skin. Various configurations of such devices are disclosed, including domed, channeled, patterned and stepped.

摘要翻译： 具有流体保持或引导图案的改进的微冲击磨损装置，以及用于将物质输送到皮肤中的具体设计参数和方法。 公开了这样的装置的各种构造，包括圆顶形，沟道状，图案化和阶梯状。

公开(公告)号：US20080103434A1

公开(公告)日：2008-05-01

申请号：US11942138

申请日：2007-11-19

申请人： Alexander Lastovich ,  Jason Alarcon ,  John Dekker ,  M. Ishaq Haider ,  John Mikszta ,  Frank Martin ,  Scott O'Connor

发明人： Alexander Lastovich ,  Jason Alarcon ,  John Dekker ,  M. Ishaq Haider ,  John Mikszta ,  Frank Martin ,  Scott O'Connor

IPC分类号： A61M37/00 ,  B29C41/46

CPC分类号： A61M37/0015 ,  A61B17/205 ,  A61B2017/320004 ,  A61M31/002 ,  A61M37/00 ,  A61M2037/0007 ,  A61M2037/0023 ,  A61M2037/0038 ,  A61M2037/0046 ,  A61M2037/0053

摘要： Improved microprotrusion abrasion devices having fluid retaining or directing patterns, and specific design parameters and method for delivery of substances into the skin. Various configurations of such devices are disclosed, including domed, channeled, patterned and stepped.

摘要翻译： 具有流体保持或引导图案的改进的微冲击磨损装置，以及用于将物质输送到皮肤中的具体设计参数和方法。 公开了这样的装置的各种构造，包括圆顶形，沟道状，图案化和阶梯状。

公开(公告)号：US07166086B2

公开(公告)日：2007-01-23

申请号：US10649134

申请日：2003-08-27

申请人： M. Ishaq Haider ,  Alexander G. Lastovich ,  Timothy J. Erskine ,  John A. Mikszta ,  Frank E. Martin ,  Scott A. O'Connor ,  Jason B. Alarcon ,  John P. Dekker, III

发明人： M. Ishaq Haider ,  Alexander G. Lastovich ,  Timothy J. Erskine ,  John A. Mikszta ,  Frank E. Martin ,  Scott A. O'Connor ,  Jason B. Alarcon ,  John P. Dekker, III

IPC分类号： A61B17/20

CPC分类号： A61M37/0015 ,  A61B17/205 ,  A61B2017/320004 ,  A61M31/002 ,  A61M37/00 ,  A61M2037/0007 ,  A61M2037/0023 ,  A61M2037/0038 ,  A61M2037/0046 ,  A61M2037/0053

摘要： A method and device for the delivery of a substance into skin via the rotational movement of a microabrader device reduces the effects of operator variability. The method includes applying a substance to an area of a patient's skin through the rotational movement of microprotrusions which may be imparted by a spring device present in the microabrader device or the motion of the operator through the handle of the microabrader device. The device may further include system and methods for monitoring pressure of the device against the skin and thereby promote consistency between applications and control of penetration depth. The delivered substance may be placed on the microprotrusions and a reconstituting liquid included in the microabrader device.

摘要翻译： 用于通过微型冲击装置的旋转运动将物质输送到皮肤中的方法和装置减少了操作员变异性的影响。 该方法包括通过可以通过存在于微推进器装置中的弹簧装置或操作者通过微推进器装置的手柄的运动来施加微突起的旋转运动将物质施加到患者皮肤区域。 该装置还可以包括用于监测装置对皮肤的压力并由此促进应用之间的一致性和穿透深度的控制的系统和方法。 递送的物质可以被放置在微突起物上，以及包含在微推进器装置中的重构液体。

公开(公告)号：US07076987B2

公开(公告)日：2006-07-18

申请号：US10912308

申请日：2004-08-05

申请人： Frank E. Martin ,  M. Ishaq Haider ,  Marcelino Munoz

发明人： Frank E. Martin ,  M. Ishaq Haider ,  Marcelino Munoz

IPC分类号： B21D37/16

CPC分类号： B21C37/18 ,  B21C5/00 ,  Y10T225/12

摘要： A method of producing a tubular device is provided. The method comprises providing a tubular stock having an axial passage, heating the tubular stock at a first heating location to form a softened section, the softened section separating a workpiece portion of the tubular stock from a remaining portion of the tubular stock, and drawing the workpiece portion away from the remaining portion to elongate the softened section and separate the workpiece portion from the remaining portion to form the tubular device. The drawing is performed at a rate such that the tubular device has an axial passage having a substantially uniform inside diameter, and an end of the tubular device formed from the elongated softened section is tapered.

公开(公告)号：US06808506B2

公开(公告)日：2004-10-26

申请号：US10357502

申请日：2003-02-04

申请人： Alexander G. Lastovich ,  James K. Fentress ,  Julia Griggs ,  Ronald J. Pettis ,  Diane Sutter ,  Frank E. Martin ,  M. Ishaq Haider

发明人： Alexander G. Lastovich ,  James K. Fentress ,  Julia Griggs ,  Ronald J. Pettis ,  Diane Sutter ,  Frank E. Martin ,  M. Ishaq Haider

IPC分类号： A61B1720

CPC分类号： A61M5/425 ,  A61M5/14244 ,  A61M5/3007 ,  A61M5/46 ,  A61M37/0015

摘要： An apparatus for delivering or withdrawing a fluid through at least one layer of the skin is provided. A device includes a body having a top face, a bottom face, a side edge and at least one channel. The bottom face includes a first surface area and a second surface area adjacent to and recessed at a first distance from the first surface area. The bottom face further includes at least one raised protrusion disposed on the second surface area. The protrusion has a height from the first surface greater than the first distance. At least one dermal-access member is provided in the protrusion and is in fluid communication with the channel to deliver or withdraw the fluid. The dermal-access member extends at least 1 mm from the protrusion. A mechanism drives the device against the skin at a calculated speed of about 6 m/s to about 18 m/s.

摘要翻译： 提供了一种用于通过至少一层皮肤递送或取出流体的装置。 一种装置包括具有顶面，底面，侧缘和至少一个通道的主体。 底面包括与第一表面区域相邻并且与第一表面区域第一距离凹陷的第一表面区域和第二表面区域。 底面还包括设置在第二表面区域上的至少一个凸起突起。 突起具有从第一表面的高度大于第一距离。 在突起中提供至少一个真皮进入构件，并且与通道流体连通以输送或抽出流体。 真皮进入构件从突起延伸至少1mm。 机构以约6m / s至约18m / s的计算速度驱动装置抵靠皮肤。

公开(公告)号：US5945216A

公开(公告)日：1999-08-31

申请号：US150853

申请日：1998-09-10

申请人： John Anthony Flint ,  Michael J. Jaffe ,  M. Ishaq Haider ,  Joseph J. DiBiase ,  John Edward Cornetta

发明人： John Anthony Flint ,  Michael J. Jaffe ,  M. Ishaq Haider ,  Joseph J. DiBiase ,  John Edward Cornetta

IPC分类号： D01F6/62 ,  D01D5/08 ,  D01F6/60 ,  D01F6/82 ,  D01F6/84 ,  D02J13/00 ,  B32B9/00

CPC分类号： D01F6/82 ,  D01F6/84 ,  Y10T428/2913 ,  Y10T428/2964 ,  Y10T428/2969

摘要： The present invention discloses and claims a novel process for the formation of high denier as-spun and heat-treated filaments of a thermotropic liquid crystalline polymer. Preferred embodiments include process for the formation of as-spun and heat treated monofilaments of a few wholly aromatic polyesters and polyesteramides. The process involves (a) heating of a thermotropic liquid crystalline polymer to above its melting transition temperature; (b) passing said molten polymer through an extrusion chamber equipped with an extrusion capillary of an aspect ratio of greater than about 1 and less than about 15 to form a filament; and (c) winding the filament at a draw-down ratio of at least about 4. The filaments so formed are of at least 50 denier per filament (dpf) and feature essentially uniform molecular orientation across the cross-section. In a final optional step, the filaments are heat treated in stages to form filaments exhibiting excellent tensile properties. Both as-spun and heat-treated filaments feature remarkably good tensile properties retaining at least 80 to 90 percent of the properties expected of conventional low denier (5 to 10 dpf) filaments.