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19 条记录 (耗时 0.023 秒)

    Compositions and methods for immunotherapy of human immunodeficiency virus (HIV)
    3.
    发明申请
    Compositions and methods for immunotherapy of human immunodeficiency virus (HIV) 审中-公开
    人类免疫缺陷病毒（HIV）免疫治疗的组成和方法

    公开(公告)号：US20050058658A1

    公开(公告)日：2005-03-17

    申请号：US10893581

    申请日：2004-07-15

    申请人： Barnett Rosenberg

    发明人： Barnett Rosenberg

    IPC分类号： A61K39/002 ,  A61K39/21 ,  C07K14/455 ,  C12N20060101

    CPC分类号： A61K39/002 ,  A01K2267/0337 ,  A61K2039/53 ,  C07K14/455

    摘要： The present invention provides compositions and methods for the prevention and treatment of an infectious disease caused by infection with HIV and for stimulating an immune response in a subject. In particular, the present invention provides Apicomlexa-related proteins (ARPs) that have immune stimulatory activity and thus have uses in the treatment and prevention of an infectious disease caused by infection with HIV and in immune modulation. Compositions comprising an ARP are provided. Methods of use of an ARP for the prevention and/or treatment of an infectious disease caused with infection with HIV, and for eliciting an immune response in a subject, are also provided.

    摘要翻译： 本发明提供了用于预防和治疗由HIV感染引起的感染性疾病和刺激受试者的免疫应答的组合物和方法。 特别地，本发明提供具有免疫刺激活性的Apicomlexa相关蛋白（ARP），因此具有用于治疗和预防由HIV感染和免疫调节引起的感染性疾病的用途。 提供了包含ARP的组合。 还提供了使用ARP来预防和/或治疗由HIV感染引起的感染性疾病和用于在受试者中引发免疫应答的方法。

    Microprobe for monitoring biophysical phenomena associated with cardiac and neural activity
    4.
    发明授权
    Microprobe for monitoring biophysical phenomena associated with cardiac and neural activity 失效
    用于监测与心脏和神经活动相关的生物物理现象的微探针

    公开(公告)号：US4344440A

    公开(公告)日：1982-08-17

    申请号：US136317

    申请日：1980-04-01

    申请人： Trygve Aaby ,  Barnett Rosenberg

    发明人： Trygve Aaby ,  Barnett Rosenberg

    IPC分类号： A61B5/05 ,  A61B5/04

    CPC分类号： A61B5/0507 ,  A61B5/05 ,  A61B5/407

    摘要： A portable microprobe uses 10 gigahertz CW microwave radiation at a power level of less than 10 milliwatts for recording of a number of biophysical phenomena associated with the cardiac and neural activity of the life system. The microprobe consists of a Gunn diode feeding power into a short, insulated dielectric waveguide, the free end of which houses a point contact semiconductor diode isolated by a metal shield from the incident beam. The wave guide concentrates and delivers a pencil shaped beam into the tissue of interest and the back-scattered radiation is modulated and detected by the diode. The detected signal is filtered, amplified and recorded to reflect on-going biological activity. The receiver electronics is housed in a small self-contained package and has its output connected through a flexible attachment to two ear tubes which enable continuous monitoring of the audio response through an electrical and audio converter indicative of the on-going biological activity. By scanning step wise across the chest, the microprobe allows localization of many details of cardiac activity. The microprobe can also be used to monitor activities of the brain and the spinal cord.

    摘要翻译： 便携式微探针使用10千兆赫CW微波辐射，功率水平低于10毫瓦，用于记录与生命系统的心脏和神经活动相关的许多生物物理现象。 微探针由一个耿氏二极管组成，将一个绝缘的绝缘介质波导输入一个短路绝缘介质波导，其自由端容纳一个由金属屏蔽与入射光束隔离的点接触半导体二极管。 波导集中并将铅笔形光束传送到感兴趣的组织中，并且反向散射的辐射被二极管调制和检测。 检测到的信号被过滤，扩增和记录以反映正在进行的生物活性。 接收器电子器件容纳在小的独立包装中，并且其输出通过柔性附件连接到两个耳管，其能够通过指示正在进行的生物活性的电和音频转换器连续监视音频响应。 通过逐步扫描胸部，微探针允许定位心脏活动的许多细节。 微探针还可用于监测大脑和脊髓的活动。

    Method of preparing gel containing capillaries
    7.
    发明授权
    Method of preparing gel containing capillaries 失效
    制备凝胶含毛细血管的方法

    公开(公告)号：US5522974A

    公开(公告)日：1996-06-04

    申请号：US140680

    申请日：1993-10-21

    申请人： Laurence A. Fishel ,  Barnett Rosenberg ,  David A. Juckett

    发明人： Laurence A. Fishel ,  Barnett Rosenberg ,  David A. Juckett

    IPC分类号： C08J3/075 ,  G01N27/447 ,  C08L5/00

    CPC分类号： C08J3/075 ,  G01N27/44704 ,  G01N27/44747 ,  C08J2333/26

    摘要： Described is a method of preparing polyacrylamide gel containing capillary tube wherein acrylamide is polymerized from a liquid to a gel within the tube, the improvement comprising the steps of: a) after the polymerization, annealing the gel inside the tube by cycling the gel/tube at least once in a temperature range from 20.degree. C. to a temperature not to exceed about 75.degree. C. and back to ambient; and b) recovering the stress released gel-filled tube. Preferably, the polymerization commences at the middle of the tube and commences toward the extremities of the tube.

    摘要翻译： 描述了一种制备含有毛细管的聚丙烯酰胺凝胶的方法，其中丙烯酰胺从管内的液体聚合成凝胶，改进包括以下步骤：a）聚合后，通过循环凝胶/管使管内的凝胶退火 至少在20℃的温度范围内至不超过约75℃的温度回到环境温度; 和b）回收释放凝胶填充管的应力。 优选地，聚合在管的中间开始并且朝向管的末端开始。