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公开(公告)号：US20120064082A1
公开(公告)日：2012-03-15
申请号：US13162559
申请日：2011-06-16
申请人： Jeffry Dean Watkins , Alain P. Vasserot , Rajesh Belani , Leslie Ann Greene , Ryan Andrew Adams
发明人： Jeffry Dean Watkins , Alain P. Vasserot , Rajesh Belani , Leslie Ann Greene , Ryan Andrew Adams
IPC分类号： A61K39/395 , A61P7/00 , C07K16/18
CPC分类号： C07K16/40 , A61K38/53 , A61K39/39533 , C07K2317/20 , C07K2317/33 , A61K2300/00
摘要： Hematopoietic-modulating compositions are provided comprising aminoacyl-tRNA synthetase polypeptides, including active fragments and/or variants thereof, as well as compositions comprising related agents such as antibodies and other binding agents. Also provided are methods of using such compositions in the treatment of conditions that benefit from the modulation of hematopoiesis.
摘要翻译： 提供造血调节组合物，其包含氨酰-tRNA合成酶多肽，包括其活性片段和/或变体，以及包含相关试剂如抗体和其它结合剂的组合物。 还提供了使用这些组合物治疗受益于造血细胞调节的病症的方法。
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公开(公告)号：US08828395B2
公开(公告)日：2014-09-09
申请号：US13162559
申请日：2011-06-16
申请人： Jeffry Dean Watkins , Alain P. Vasserot , Rajesh Belani , Leslie Ann Greene , Ryan Andrew Adams
发明人： Jeffry Dean Watkins , Alain P. Vasserot , Rajesh Belani , Leslie Ann Greene , Ryan Andrew Adams
IPC分类号： A61K39/395 , C07K16/40
CPC分类号： C07K16/40 , A61K38/53 , A61K39/39533 , C07K2317/20 , C07K2317/33 , A61K2300/00
摘要： Hematopoietic-modulating compositions are provided comprising aminoacyl-tRNA synthetase polypeptides, including active fragments and/or variants thereof, as well as compositions comprising related agents such as antibodies and other binding agents. Also provided are methods of using such compositions in the treatment of conditions that benefit from the modulation of hematopoiesis.
摘要翻译： 提供造血调节组合物，其包含氨酰-tRNA合成酶多肽，包括其活性片段和/或变体，以及包含相关试剂如抗体和其它结合剂的组合物。 还提供了使用这些组合物治疗受益于造血细胞调节的病症的方法。
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公开(公告)号：US20110150885A1
公开(公告)日：2011-06-23
申请号：US12965655
申请日：2010-12-10
申请人： Jeffry Dean Watkins , Alain P. Vasserot , Rajesh Belani , Leslie Ann Greene , Ryan Andrew Adams
发明人： Jeffry Dean Watkins , Alain P. Vasserot , Rajesh Belani , Leslie Ann Greene , Ryan Andrew Adams
IPC分类号： A61K39/395 , A61K38/53 , C12N5/078 , A61K35/12 , C07H21/00 , C12N15/63 , C12N5/10 , C12N9/00 , C07K16/18 , C07K14/00 , A61P7/00
CPC分类号： A61K38/53 , A61K2300/00
摘要： Hematopoietic-modulating compositions are provided comprising aminoacyl-tRNA synthetase polypeptides, including active fragments and/or variants thereof, as well as compositions comprising related agents such as antibodies and other binding agents. Also provided are methods of using such compositions in the treatment of conditions that benefit from the modulation of hematopoiesis.
摘要翻译： 提供造血调节组合物，其包含氨酰-tRNA合成酶多肽，包括其活性片段和/或变体，以及包含相关试剂如抗体和其它结合剂的组合物。 还提供了使用这些组合物治疗受益于造血细胞调节的病症的方法。
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4.发明授权公开(公告)号：US06787133B2
公开(公告)日：2004-09-07
申请号：US10330872
申请日：2002-12-24
申请人： Scott L. Weinrich , Edward M. Atkinson, III , Serge P. Lichtsteiner , Alain P. Vasserot , Ronald A. Pruzan
发明人： Scott L. Weinrich , Edward M. Atkinson, III , Serge P. Lichtsteiner , Alain P. Vasserot , Ronald A. Pruzan
IPC分类号： A61K3851
CPC分类号： C12N9/1241 , A61K39/00 , C12Y207/07049 , Y10S435/935
摘要： This invention provides purified telomerase and methods of purifying it. The methods involve the use of several sequential steps, including the use of matrices that bind molecules bearing negative charges, matrices that bind molecules bearing positive charges, intermediate-selectivity matrices, methods that separate molecules based on their size, shape, or buoyant density, and by affinity purification.
摘要翻译： 本发明提供了纯化的端粒酶及其纯化方法。 该方法包括使用几个连续的步骤，包括使用结合带负电荷的分子的基质，结合带正电荷的分子的基质，中间选择性基质，基于其大小，形状或浮力密度分离分子的方法， 并通过亲和纯化。
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公开(公告)号：US07435799B2
公开(公告)日：2008-10-14
申请号：US10541260
申请日：2004-01-08
CPC分类号： C07K16/241 , A61K38/00 , A61K2039/505 , C07K2317/24 , C07K2317/565 , C07K2317/92
摘要： The present invention relates to TNF-α binding molecules and nucleic acid sequences encoding TNF-α binding molecules. In particular, the present invention relates to TNF-α binding molecules with a high binding affinity, a high association rate, a low dissociation rate with regard to human TNF-α and that are capable of neutralizing TNF-α at low concentrations. Preferably, the TNF-α binding molecules of the present invention comprise light and/or heavy chain variable regions with fully human frameworks (e.g. human germline frameworks).
摘要翻译： 本发明涉及TNF-α结合分子和编码TNF-α结合分子的核酸序列。 特别地，本发明涉及具有高结合亲和力，高缔合率，相对于人TNF-α的低解离速率且能够以低浓度中和TNF-α的TNF-α结合分子。 优选地，本发明的TNF-α结合分子包含具有完全人框架（例如人种系框架）的轻链和/或重链可变区。
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6.发明授权Producing telomerase activators and inhibitors by screening with purified telomerase 失效通过用纯化的端粒酶筛选生产端粒酶激活剂和抑制剂公开(公告)号：US07067283B2
公开(公告)日：2006-06-27
申请号：US10811033
申请日：2004-03-26
申请人： Scott L. Weinrich , Edward M. Atkinson, III , Serge P. Lichtsteiner , Alain P. Vasserot , Ronald A. Pruzan
发明人： Scott L. Weinrich , Edward M. Atkinson, III , Serge P. Lichtsteiner , Alain P. Vasserot , Ronald A. Pruzan
CPC分类号： C12N9/1241 , A61K39/00 , C12Y207/07049 , Y10S435/935
摘要： This invention provides purified telomerase and methods of purifying it. The methods involve the use of several sequential steps, including the use of matrices that bind molecules bearing negative charges, matrices that bind molecules bearing positive charges, intermediate-selectivity matrices, methods that separate molecules based on their size, shape, or buoyant density, and by affinity purification.
摘要翻译： 本发明提供了纯化的端粒酶及其纯化方法。 该方法包括使用几个连续的步骤，包括使用结合带负电荷的分子的基质，结合带正电荷的分子的基质，中间选择性基质，基于其大小，形状或浮力密度分离分子的方法， 并通过亲和纯化。
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公开(公告)号：US06517834B1
公开(公告)日：2003-02-11
申请号：US09717828
申请日：2000-11-20
申请人： Scott L. Weinrich , Edward M. Atkinson, III , Serge P. Lichtsteiner , Alain P. Vasserot , Ronald A. Pruzan
发明人： Scott L. Weinrich , Edward M. Atkinson, III , Serge P. Lichtsteiner , Alain P. Vasserot , Ronald A. Pruzan
IPC分类号： A61K3851
CPC分类号： C12N9/1241 , A61K39/00 , C12Y207/07049 , Y10S435/935
摘要： This invention provides purified telomerase and methods of purifying it. The methods involve the use of several sequential steps, including the use of matrices that bind molecules bearing negative charges, matrices that bind molecules bearing positive charges, intermediate-selectivity matrices, methods that separate molecules based on their size, shape, or buoyant density, and by affinity purification.
摘要翻译： 本发明提供了纯化的端粒酶及其纯化方法。 该方法包括使用几个连续的步骤，包括使用结合带负电荷的分子的基质，结合带正电荷的分子的基质，中间选择性基质，基于其大小，形状或浮力密度分离分子的方法， 并通过亲和纯化。
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公开(公告)号：US06777203B1
公开(公告)日：2004-08-17
申请号：US09244438
申请日：1999-02-04
申请人： Gregg B. Morin , Serge P. Lichtsteiner , Alain P. Vasserot , Robert R. Adams , William H. Andrews
发明人： Gregg B. Morin , Serge P. Lichtsteiner , Alain P. Vasserot , Robert R. Adams , William H. Andrews
IPC分类号： C12P2106
CPC分类号： C12N9/1276 , A01K67/0271 , A01K2217/05 , A01K2217/30 , A01K2227/105 , A01K2267/0331 , A01K2267/0393 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N7/00 , C12N9/1241 , C12N15/1137 , C12N15/8509 , C12N2310/15 , C12N2310/315 , C12N2795/10343 , C12Y207/07049
摘要： The present invention is related to novel nucleic acids comprising telomerase reverse transcriptase (TERT) cis-acting transcriptional control sequences, including TERT human and mouse promoter sequences. The present invention is further directed to methods of using these cis-acting transcriptional control sequences, for example, to drive heterologous gene sequences; to modulate the level of transcription of TERT or to isolate novel trans-acting regulatory factors which bind to and modulate the activity of a TERT promoter.
摘要翻译： 本发明涉及包含端粒酶逆转录酶（TERT）顺式作用转录控制序列的新型核酸，包括TERT人和小鼠启动子序列。 本发明还涉及使用这些顺式作用转录控制序列的方法，例如驱动异源基因序列; 以调节TERT的转录水平或分离结合并调节TERT启动子的活性的新的反式作用调节因子。
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公开(公告)号：US06261556B1
公开(公告)日：2001-07-17
申请号：US09420056
申请日：1999-10-18
申请人： Scott L. Weinrich , Edward M. Atkinson, III , Serge P. Lichtsteiner , Alain P. Vasserot , Ronald A. Pruzan , James T. Kealey
发明人： Scott L. Weinrich , Edward M. Atkinson, III , Serge P. Lichtsteiner , Alain P. Vasserot , Ronald A. Pruzan , James T. Kealey
IPC分类号： A61K3851
CPC分类号： C12N9/1241 , A61K39/00 , C12Y207/07049
摘要： This invention provides purified human telomerase and methods of purifying it. The methods involve the use of several sequential steps, including the use of a first matrix that binds molecules bearing negative charges, a matrix that binds molecules bearing positive charges, a second matrix that binds molecules bearing negative charges, an affinity purification step and a matrix that separates molecules according to their size.
摘要翻译： 本发明提供纯化的人端粒酶及其纯化方法。 该方法包括使用几个连续的步骤，包括使用结合带有负电荷的分子的第一基质，结合带正电荷的分子的基质，结合带负电荷的分子的第二基质，亲和纯化步骤和基质 根据其大小分离分子。
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公开(公告)号：US20140255378A1
公开(公告)日：2014-09-11
申请号：US14237544
申请日：2012-08-08
申请人： Jeffrey D. Watkins , Ying Ji Buechler , Chi-Fang Wu , Minh-Ha Do , Alain P. Vasserot , John D. Mendlein
发明人： Jeffrey D. Watkins , Ying Ji Buechler , Chi-Fang Wu , Minh-Ha Do , Alain P. Vasserot , John D. Mendlein
IPC分类号： C12N9/00
CPC分类号： C12N9/93 , A61K38/00 , A61K47/60 , C12Y601/01001
摘要： The present invention provides PEGylated tyrosyl-tRNA synthetase (YRS) polypeptides, compositions comprising the same, and methods of using such polypeptides and compositions for treating or diagnosing a variety of conditions. The PEGylated YRS polypeptides of the invention have improved controlled release properties, stability, half-life, and other pharmacokinetic properties compared to non-PEGylated YRS polypeptides.
摘要翻译： 本发明提供聚乙二醇化酪氨酰-tRNA合成酶（YRS）多肽，包含其的组合物，以及使用这些多肽和组合物治疗或诊断各种病症的方法。 本发明的聚乙二醇化YRS多肽与非聚乙二醇化的YRS多肽相比具有改善的控制释放性质，稳定性，半衰期和其他药代动力学性质。
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