-
公开(公告)号:US10005999B2
公开(公告)日:2018-06-26
申请号:US15071921
申请日:2016-03-16
发明人: Curtis J. Larimer , Jonathan D. Suter , Raymond S. Addleman , George T. Bonheyo , Michelle R. Brann
CPC分类号: C12M41/46 , C12M23/12 , C12M23/22 , C12M23/58 , C12M29/10 , C12M41/36 , C12M41/48 , G01B9/02021 , G01B9/0209 , G01B11/0675 , G01B11/2441 , G01N33/48
摘要: An apparatus and method of measuring biofilm and biological activity on a surface is disclosed. The apparatus includes a biofilm, which includes one or more microorganisms, grown on a substrate. A viewing window is placed on a surface of the biofilm and a gas bubble is introduced between the viewing window and the surface of the biofilm. The space between the substrate and the viewing window may be enclosed in a casing that has an inlet and an outlet, forming a flow cell. A microscope system, such as a white light interferometer, captures data of the biofilm in situ and non-destructively. The 3D images of biofilm surface have high resolution while maintaining a large field of view. The apparatuses and methods will be useful for fundamental studies of biofilms, biomedical and environmental screening, and many other applications in biology and the life sciences.
-
2.
公开(公告)号:US20160272933A1
公开(公告)日:2016-09-22
申请号:US15071921
申请日:2016-03-16
发明人: Curtis J. Larimer , Jonathan D. Suter , Raymond S. Addleman , George T. Bonheyo , Michelle R. Brann
CPC分类号: C12M41/46 , C12M23/12 , C12M23/22 , C12M23/58 , C12M29/10 , C12M41/36 , C12M41/48 , G01B9/02021 , G01B9/0209 , G01B11/0675 , G01B11/2441 , G01N33/48
摘要: An apparatus and method of measuring biofilm and biological activity on a surface is disclosed. The apparatus includes a biofilm, which includes one or more microorganisms, grown on a substrate. A viewing window is placed on a surface of the biofilm and a gas bubble is introduced between the viewing window and the surface of the biofilm. The space between the substrate and the viewing window may be enclosed in a casing that has an inlet and an outlet, forming a flow cell. A microscope system, such as a white light interferometer, captures data of the biofilm in situ and non-destructively. The 3D images of biofilm surface have high resolution while maintaining a large field of view. This invention will be useful for fundamental studies of biofilms, biomedical and environmental screening, and many other applications in biology and the life sciences.
摘要翻译: 公开了一种在表面上测量生物膜和生物活性的装置和方法。 该装置包括在基底上生长的生物膜,其包括一种或多种微生物。 将观察窗放置在生物膜的表面上,并且在观察窗和生物膜的表面之间引入气泡。 衬底和观察窗之间的空间可以封闭在具有入口和出口的壳体中,形成流动池。 诸如白光干涉仪的显微镜系统在原位和非破坏性地捕获生物膜的数据。 生物膜表面的3D图像具有高分辨率,同时保持较大的视野。 本发明将有助于生物膜,生物医学和环境筛选以及生物学和生命科学等许多其他应用的基础研究。
-
公开(公告)号:US10577511B2
公开(公告)日:2020-03-03
申请号:US15410225
申请日:2017-01-19
发明人: Curtis J. Larimer , Raymond S. Addleman , Michelle R. Brann , George T. Bonheyo , Eric M. Winder
IPC分类号: C09D7/62 , C09D5/00 , C09D109/04 , A61B42/10 , C09D7/65 , A61B42/00 , C09D7/61 , C09D107/02 , B05D1/12 , B05D5/00 , B05D7/00 , C08K3/36 , A61B17/00 , B05D5/08 , B05D7/02
摘要: Hydrophobic materials, processes for their production, and uses thereof are described. The materials can be made with silica or polytetrafluoroethylene particles embedded into a liquid polymer. The hydrophobic materials are stretchable.
-
公开(公告)号:US20170204279A1
公开(公告)日:2017-07-20
申请号:US15410225
申请日:2017-01-19
发明人: Curtis J. Larimer , Raymond S. Addleman , Michelle R. Brann , George T. Bonheyo , Eric M. Winder
CPC分类号: C09D7/62 , A61B42/00 , A61B42/10 , A61B2017/00526 , B05D1/12 , B05D5/00 , B05D5/08 , B05D7/02 , B05D7/548 , B05D2451/00 , C08K3/36 , C09D5/00 , C09D7/61 , C09D7/65 , C09D107/02 , C09D109/04 , B05D2401/20 , B05D2401/32
摘要: Hydrophobic materials, processes for their production, and uses thereof are described. The materials can be made with silica or polytetrafluoroethylene particles embedded into a liquid polymer. The hydrophobic materials are stretchable.
-
公开(公告)号:US20180274905A1
公开(公告)日:2018-09-27
申请号:US15988808
申请日:2018-05-24
发明人: Curtis J. Larimer , Jonathan D. Suter , Raymond S. Addleman , George T. Bonheyo , Michelle R. Brann
CPC分类号: G01B11/0675 , C12M23/12 , C12M23/22 , C12M23/58 , C12M29/10 , C12M41/36 , C12M41/46 , C12M41/48 , G01B9/0209 , G01B11/2441 , G02B21/00
摘要: An apparatus and method of measuring biofilm and biological activity on a surface is disclosed. The apparatus includes a biofilm, which includes one or more microorganisms, grown on a substrate. A viewing window is placed on a surface of the biofilm and a gas bubble is introduced between the viewing window and the surface of the biofilm. The space between the substrate and the viewing window may be enclosed in a casing that has an inlet and an outlet, forming a flow cell. A microscope system, such as a white light interferometer, captures data of the biofilm in situ and non-destructively. The 3D images of biofilm surface have high resolution while maintaining a large field of view. This invention will be useful for fundamental studies of biofilms, biomedical and environmental screening, and many other applications in biology and the life sciences.
-
-
-
-