公开(公告)号：US20020131891A1

公开(公告)日：2002-09-19

申请号：US09976832

申请日：2001-10-13

Applicant: Baxter International Inc.

Inventor： Kelly B. Smith ,  Mark R. Vandlik ,  Michael J. Kast

IPC: A61M001/34 ,  A61M037/00 ,  B01D033/15 ,  C02F001/38

CPC classification number: A61M1/1037 ,  A61M1/0209 ,  A61M1/0218 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3633 ,  A61M1/3636 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2205/12 ,  A61M2205/128 ,  A61M2205/331 ,  A61M2205/3393

Abstract: Blood processing systems and methods convey blood cells from a blood cell source into a blood component collection flow channel that includes a blood cell storage container and an in-line filter to remove leukocytes from blood cells before entering the blood cell storage container. The systems and methods also convey additive solution from an additive solution source into the blood component collection flow channel. The systems and methods alternate the conveyance of blood cells through the filter with the conveyance of additive solution through the filter.

Abstract translation: 血液处理系统和方法将血液细胞从血细胞源传送到血液成分收集流通道中，该血液成分收集流通道包括血细胞储存容器和在线过滤器，以在进入血细胞储存容器之前从血液细胞中除去白细胞。 所述系统和方法还将添加剂溶液从添加剂溶液源输送到血液成分收集流动通道中。 系统和方法通过过滤器输送添加剂溶液来交替通过过滤器的血细胞的输送。

公开(公告)号：US20020090319A1

公开(公告)日：2002-07-11

申请号：US09976833

申请日：2001-10-13

Applicant: Baxter International Inc.

Inventor： Mark R. Vandlik ,  Michael J. Kast ,  Kelly B. Smith

IPC: A61M001/14 ,  A61M037/00 ,  B01D033/15 ,  C02F001/00

CPC classification number: A61M1/3696 ,  A61M1/0209 ,  A61M1/0218 ,  A61M1/1006 ,  A61M1/1037 ,  A61M1/1062 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3633 ,  A61M1/3636 ,  A61M1/3693 ,  A61M2205/12 ,  A61M2205/128 ,  A61M2205/331 ,  A61M2205/3393

Abstract: Systems and methods separate blood cells from whole blood and pump the separated blood cells through an in-line leukofilter to a blood cell storage container. The leukofilter comprises a filtration medium enclosed within a flexile housing. The systems and methods include a fixture to restrain expansion of the flexible filter housing during operation of the pump. The fixture includes a bracket to enable its releasable attachment to the blood processing device employed to carry out the separation process.

Abstract translation: 系统和方法将血液细胞与全血分离，并将分离的血液细胞通过直列式白细胞滤器泵送至血细胞储存容器。 白细胞滤器包括封装在柔性壳体内的过滤介质。 该系统和方法包括在泵的操作期间抑制柔性过滤器壳体的膨胀的夹具。 固定装置包括支架，以使其能够可释放地附接到用于执行分离过程的血液处理装置。

公开(公告)号：US20030138334A1

公开(公告)日：2003-07-24

申请号：US10287560

申请日：2002-11-04

Applicant: Baxter International Inc.

Inventor： Mark R. Vandlik ,  Tom Westberg

IPC: F04B043/08

CPC classification number: A61M1/3696 ,  A61M1/1006 ,  A61M1/1037 ,  A61M1/1053 ,  A61M1/1062 ,  A61M1/1087 ,  A61M1/1096 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/308 ,  A61M2205/128 ,  A61M2205/331 ,  A61M2205/3393 ,  F04B13/02 ,  F04B43/026 ,  F04B49/065 ,  F04B2205/09 ,  Y10T137/87861

Abstract: A blood processing system comprises a processing chamber to process blood and a fluid flow cassette that communicates with the processing chamber. The cassette comprises a body, a pump chamber formed in the body, and a flexible diaphragm on the pump chamber responsive to an applied fluid pressures for flexure toward and away from the pump chamber to pump fluid through the pump chamber. The cassette also includes a flow path formed, at least in part, in the body to couple the pump chamber in fluid flow communication with the processing chamber, to convey fluid pumped by the pump chamber into the processing chamber. The cassette also includes an in line cavity formed in the body and located in the flow path to trap air to prevent entry of air into the processing chamber.

Abstract translation: 血液处理系统包括处理血液的处理室和与处理室连通的流体流动盒。 盒体包括主体，形成在主体中的泵室，以及响应于所施加的流体压力的柔性膜片，其响应于朝向和远离泵室的挠曲，以将流体泵送通过泵室。 该盒还包括至少部分地形成在主体中的流路，以将泵室与处理室流体流动连通，以将泵室泵送的流体输送到处理室中。 该盒还包括形成在主体中并且位于流动路径中的吸入空气以防止空气进入处理室的入口腔。

公开(公告)号：US20030070969A1

公开(公告)日：2003-04-17

申请号：US10156496

申请日：2002-05-28

Applicant: Baxter International Inc.

Inventor： Matthew R. Muller ,  Michel L.F. Joie ,  Mark R. Vandlik

IPC: B01D017/12

CPC classification number: B01D21/302 ,  A61M1/0236 ,  A61M1/367 ,  A61M1/3696 ,  A61M1/38 ,  A61M2205/128 ,  A61M2205/3393 ,  A61M2230/207 ,  B01D17/0217 ,  B01D21/2444 ,  B01D21/245 ,  B01D21/26 ,  B01D21/262 ,  B01D21/34 ,  B01D2221/08 ,  B01D2221/10

Abstract: Red blood cell sensing systems and methods rely upon straightforward measurement geometries. the systems and methods comprise an incident light source, an optical sensor, and a blood collection tube. The systems and methods hold the blood collection tube a predetermined radial distance from the incident light source where a linear relationship exists between sensed reflected light measured by the optical sensor and red blood cell hematocrit in a range of at least 10 to 90. The systems and methods make possible accurate red blood sensing without use of special optical cuvettes, mirrors, or focusing lenses. The systems and methods also make possible the use of standard transparent plastic tubing, without reliance upon special optical cuvettes.

公开(公告)号：US20040156745A1

公开(公告)日：2004-08-12

申请号：US10765498

申请日：2004-01-26

Applicant: Baxter International Inc.

Inventor： Mark R. Vandlik ,  Michael J. Kast ,  Kelly B. Smith

IPC: A61M001/14 ,  A61M037/00 ,  B01D033/15 ,  C02F001/00

CPC classification number: A61M1/3696 ,  A61M1/0209 ,  A61M1/0218 ,  A61M1/1006 ,  A61M1/1037 ,  A61M1/1062 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3633 ,  A61M1/3636 ,  A61M1/3693 ,  A61M2205/12 ,  A61M2205/128 ,  A61M2205/331 ,  A61M2205/3393

Abstract: Systems and methods separate pump the blood cells through an in-line leukofilter to a blood cell storage container. The leukofilter has a filtration medium enclosed within a flexile housing. The systems and methods can employ a fixture to restrain expansion of the flexible filter housing during operation of the pump.

Abstract translation: 系统和方法将血液细胞通过直列式过滤器分离成血细胞储存容器。 白细胞滤器具有封装在柔性壳体内的过滤介质。 该系统和方法可以使用夹具来在泵的操作期间抑制柔性过滤器壳体的膨胀。

公开(公告)号：US20020094927A1

公开(公告)日：2002-07-18

申请号：US09976830

申请日：2001-10-13

Applicant: Baxter International Inc.

Inventor： Sanjay Odak ,  Michael Kast ,  Vaughn E. Rice ,  Tom Westberg ,  Kelly B. Smith ,  Michel Joie ,  Mark R. Vandlik

IPC: B04B007/00

CPC classification number: A61M1/38 ,  A61M1/3633 ,  A61M1/3696 ,  A61M2205/128 ,  A61M2230/30 ,  B01D21/0012 ,  B01D21/262 ,  B01D2221/10 ,  B04B5/0442 ,  B04B7/00 ,  B04B7/08 ,  B04B2005/045 ,  B04B2005/0492

Abstract: A yoke rotates an umbilicus about a rotational axis, which, in turn, imparts rotation to a blood processing chamber coupled to the umbilicus. The yoke carries first and second umbilicus support surfaces that inhibit travel of the umbilicus in radial directions toward and away from the rotational axis.

Abstract translation: 轭绕旋转轴线旋转脐状物，旋转轴线又将旋转赋予与脐带连接的血液处理室。 轭架承载第一和第二脐支撑表面，其阻止脐部沿径向朝向和远离旋转轴线行进。

公开(公告)号：US20020011449A1

公开(公告)日：2002-01-31

申请号：US09901986

申请日：2001-07-10

Applicant: Baxter International Inc.

Inventor： Matthew R. Muller ,  Michel L. F. Joie ,  Mark R. Vandlik

IPC: C02F001/00

CPC classification number: B01D21/302 ,  A61M1/0236 ,  A61M1/367 ,  A61M1/3696 ,  A61M1/38 ,  A61M2205/128 ,  A61M2205/3393 ,  A61M2230/207 ,  B01D17/0217 ,  B01D21/2444 ,  B01D21/245 ,  B01D21/26 ,  B01D21/262 ,  B01D21/34 ,  B01D2221/08 ,  B01D2221/10

Abstract: Red blood cell sensing systems and methods rely upon straightforward measurement geometries. the systems and methods comprise an incident light source, an optical sensor, and a blood collection tube. The systems and methods hold the blood collection tube a predetermined radial distance from the incident light source where a linear relationship exists between sensed reflected light measured by the optical sensor and red blood cell hematocrit in a range of at least 10 to 90. The systems and methods make possible accurate red blood sensing without use of special optical cuvettes, mirrors, or focusing lenses. The systems and methods also make possible the use of standard transparent plastic tubing, without reliance upon special optical cuvettes.

Abstract translation: 红细胞感测系统和方法依赖于简单的测量几何。 系统和方法包括入射光源，光学传感器和采血管。 系统和方法将采血管保持与入射光源预定的径向距离，其中在由光学传感器测量的感测反射光与红细胞血细胞比容之间存在线性关系，范围在至少10至90°。系统和 方法可以在不使用特殊的光学比色杯，镜子或聚焦镜片的情况下进行准确的红血传感。 系统和方法也可以使用标准的透明塑料管，而不依赖于特殊的光学比色皿。