公开(公告)号：US20040175291A1

公开(公告)日：2004-09-09

申请号：US10760810

申请日：2004-01-20

发明人： Richard H. Tullis

IPC分类号： A61M037/00 ,  A61M001/14 ,  A61M001/34

CPC分类号： A61M1/3486 ,  A61L2/02 ,  A61L2/022 ,  A61M1/3472

摘要： The present invention relates to a method for using lectins that bind to pathogens having high mannose surface glycoproteins or fragments thereof which contain high mannose glycoproteins, to remove them from infected blood or plasma in an extracorporeal setting. Accordingly, the present invention provides a method for reducing viral load in an individual comprising the steps of obtaining blood or plasma from the individual, passing the blood or plasma through a porous hollow fiber membrane wherein lectin molecules are immobilized within the porous exterior portion of the membrane, collecting pass-through blood or plasma and reinfusing the pass-through blood or plasma into the individual.

摘要翻译： 本发明涉及一种使用与具有高甘露糖糖蛋白的高甘露糖表面糖蛋白或其片段的病原体结合的凝集素的方法，其包含高甘露糖糖蛋白，以在体外设置中将其从感染的血液或血浆中除去。 因此，本发明提供一种降低个体病毒载量的方法，其包括以下步骤：从个体获得血液或血浆，使血液或血浆通过多孔中空纤维膜，其中凝集素分子固定在多孔的外部部分 膜，收集直通血液或血浆，并将直通血液或血浆重新输入个体。

公开(公告)号：US20040013566A1

公开(公告)日：2004-01-22

申请号：US10402463

申请日：2003-03-28

发明人： Stephen E. Myrick ,  Gregory P. Watson ,  William R. Patterson ,  Paul J. Zalesky

IPC分类号： A61M001/14 ,  A61M001/34

CPC分类号： A61M1/3621 ,  A61M1/32 ,  A61M1/3626 ,  A61M2202/0208 ,  A61M2202/0476 ,  B01F3/04758

摘要： A device generates a gas-enriched physiologic fluid and combines it with a bodily fluid to create a gas-enriched bodily fluid. The device may take the form of a disposable cartridge. The cartridge may include a fluid supply chamber for delivering physiologic fluid under pressure to an atomizer. The atomizer delivers fluid droplets into a gas-pressurized atomization chamber to enrich the physiologic fluid with the gas. The gas-enriched physiologic fluid is delivered to a mixing chamber in the cartridge where the gas-enriched physiologic fluid is mixed with a bodily fluid, such as blood, to create a gas-enriched bodily fluid.

摘要翻译： 装置产生气体富集的生理流体并将其与体液结合以产生富含气体的体液。 该装置可以采取一次性盒式的形式。 药筒可以包括用于将生理液体在压力下输送到雾化器的流体供应室。 雾化器将流体液滴输送到气体加压的雾化室中以与气体一起富集生理液体。 将气体富集的生理液体输送到药筒中的混合室，其中富含气体的生理液体与诸如血液的体液混合，以产生富含气体的体液。

公开(公告)号：US20030138348A1

公开(公告)日：2003-07-24

申请号：US10051465

申请日：2002-01-18

发明人： David Bell ,  William J. Schnell ,  David S. Utterberg

IPC分类号： A61M001/34 ,  A61M037/00

CPC分类号： A61M1/367 ,  A61M1/3658 ,  A61M39/223 ,  A61M39/28

摘要： A tubular set portion for circulating blood between a patient and an extracorporeal blood treatment device. The set portion comprises: an arterial tube for conveying blood from a patient toward the blood treatment device; a venous tube for conveying blood from the blood treatment device back towards the patient; and a pair of spaced, transverse tubes that each connect between the arterial tube and the venous tube, each of the tubes being capable of clamp sealing. The arterial and venous tubes are clamp sealable between the spaced, transverse tubes. Flow reversal on the patient's side of this device is possible by appropriate clamping of two opposed tube sections of the rectangular array which may be formed by the joined tube sections, while flow remains unchanged on the side of the tubular set portion that is connected to the extracorporeal blood treatment device.

摘要翻译： 一种用于在患者和体外血液处理装置之间循环血液的管状固定部分。 设置部分包括：用于将血液从患者输送到血液处理装置的动脉管; 用于将血液从血液处理装置输送回患者的静脉管; 以及一对间隔开的横向管，每个管连接在动脉管和静脉管之间，每个管能够夹紧密封。 动脉和静脉管可夹紧在间隔开的横向管之间。 可以通过适当地夹紧矩形阵列的两个相对的管部分，这可以由连接的管部分形成，而在该装置的患者侧的流动逆转可以在连接到管状部分的管状部分的一侧保持不变 体外血液处理装置。

公开(公告)号：US20040081580A1

公开(公告)日：2004-04-29

申请号：US10658665

申请日：2003-09-09

发明人： Doug Hole ,  Christopher Miller

IPC分类号： A61M001/14 ,  A61M037/00 ,  C02F001/44 ,  A61M001/36 ,  A61M001/34

CPC分类号： A61M1/3687 ,  A61K33/00 ,  A61M1/1698 ,  A61M2202/0275 ,  A61K2300/00

摘要： The present invention relates to a method for the systemic delivery of the nitric oxide moiety either as a dissolved gas or through the administration of nitric oxide donors in an extracorporeal circuit to reduce whole body bacterial contamination by pathogenic or toxic substrates. The utilization of an extracorporeal circuit with the entrainment of nitric oxide is viewed as a novel modality in the medical management of bacteremia (blood poisoning) and/or septicemia in mammals.

摘要翻译： 本发明涉及一种全身性递送一氧化氮部分作为溶解气体或通过在体外循环中施用一氧化氮供体的方法，以减少病原体或有毒底物引起的全身细菌污染。 使用伴有一氧化氮的体外循环被认为是哺乳动物菌血症（血液中毒）和/或败血症的医学管理中的一种新型方式。

公开(公告)号：US20040069709A1

公开(公告)日：2004-04-15

申请号：US10650935

申请日：2003-08-27

发明人： James M. Brugger ,  Jeffrey H. Burbank ,  Dennis M. Treu

IPC分类号： B01D061/00 ,  B01D061/30 ,  A61M001/14 ,  A61M001/34

CPC分类号： B01D61/145 ,  A61M1/1692 ,  A61M1/3437 ,  A61M1/3441 ,  A61M1/3444 ,  A61M1/3462 ,  A61M1/3465 ,  A61M1/3643 ,  A61M1/3644 ,  A61M2205/12 ,  A61M2205/705 ,  B01D61/18 ,  C02F1/444

摘要： A sterilized fluid management kit for use in renal replacement therapy isolates a replacement fluid container from touch contamination and provides for sterilization of replacement fluid by filtering using an installed filter that is hermetically connected to the replacement fluid container. A method is described where replacement fluid is automatically generated before treatment.

摘要翻译： 用于肾替代治疗的灭菌流体管理套件将置换液体容器与接触污染隔离，并通过使用安装的过滤器进行过滤来灭菌替换流体，该过滤器与替换流体容器密封连接。 描述了在治疗之前自动生成置换液的方法。

公开(公告)号：US20040052681A1

公开(公告)日：2004-03-18

申请号：US10244181

申请日：2002-09-13

发明人： Jd Mortensen ,  Robert N. Schaap ,  Barry Bagley

IPC分类号： A61M037/00 ,  A61M001/34 ,  A61M001/14

CPC分类号： A61M1/16 ,  A61M1/1625 ,  A61M1/1698 ,  Y10S128/03 ,  Y10S261/28

摘要： A compliant blood gas exchanger is provided including a housing having a first end cap, a second end cap, and an elastomeric sidewall or sleeve extending there between forming a chamber. A hollow fiber assembly is disposed in the chamber. The hollow fiber assembly has a first mounting collar, a second mounting collar and a plurality of hollow fibers disposed there between. The first end cap is disposed in communication with the first mounting collar and the second end cap is disposed in communication with the second mounting collar. The end caps are connected to a gas inlet and a gas outlet. The chamber is in communication with a blood inlet and a blood outlet. The elastomeric sidewall is responsive to internal and external pressures affecting the chamber. The first chamber can also be placed adjacent to a second chamber and both chambers placed within a rigid outer housing. Thus, a dual-chamber pulsatile blood gas exchanger can be provided. That is, the second chamber may be in connection with a pump mechanism or vacuum mechanism such that the chamber creates a pulsatile flow within the first chamber.

摘要翻译： 提供了一种兼容的血液气体交换器，其包括具有第一端盖，第二端盖和在其之间延伸形成腔室的弹性体侧壁或套管的壳体。 中空纤维组件设置在腔室中。 中空纤维组件具有第一安装套环，第二安装环和布置在其间的多个中空纤维。 第一端盖设置成与第一安装轴环连通，并且第二端盖设置成与第二安装轴环连通。 端盖连接到气体入口和气体出口。 腔室与血液入口和血液出口连通。 弹性体侧壁响应影响腔室的内部和外部压力。 第一室也可以放置在第二室附近，并且两个室都放置在刚性外壳内。 因此，可以提供双室脉动血液换气器。 也就是说，第二室可以与泵机构或真空机构连接，使得室在第一室内产生脉动流。

公开(公告)号：US20030144646A1

公开(公告)日：2003-07-31

申请号：US10258437

申请日：2002-10-24

发明人： Erik Se ,  Per Olsson

IPC分类号： A61B019/00 ,  A61M037/00 ,  A61M001/34

CPC分类号： A61M1/02 ,  A61M1/0013 ,  A61M1/0017 ,  A61M1/3633

摘要： The invention relates to a method and an apparatus for collecting and transporting liquids, for example blood, into one or more closed packages, for instance so called transfer bags (11, 12), or alternatively, directly transfering the blood into another liquid system, for instance a heart-lung machine, without any admixture of air or any other gas or gas mixture. The blood is collected without contact by human hand and without contamination of the blood and under sterile conditions. The apparatus comprises a suction nozzle (4) for sucking up the liquid or a liquid/air/gas mixture, a suction hose (5) for directing the liquid to a defoaming separator (7) for separating air from the liquid, and a recipient (8) in which the deacrated liquid is filtered and collected. When a certain volume has been collected, the liquid is directed without introducing air into said closed packages (11, 12) or communicated to another liquid system. The recipient (8) comprises a replaceable, flexible so-called canister bag (9) for collecting the liquid and arranged in a stiff, closed container (10) and provided with filters (17, 18) as well as filling and tapping conduits (22, 23). The recipient (8) and the corresponding packages (11, 12) are connected to the suction source (1) of the system for filling and tapping of the liquid.

摘要翻译： 本发明涉及一种用于将液体（例如血液）收集和输送到一个或多个封闭的包装中的方法和装置，例如所谓的转运袋（11,12），或者将血液直接转移到另一个液体系统中， 例如心肺机，没有空气或任何其他气体或气体混合物的混合物。 血液不用人的手接触而不被血液收集并且在无菌条件下被收集。 该装置包括用于吸入液体或液体/空气/气体混合物的吸嘴（4），用于将液体引导至用于从液体中分离空气的消泡分离器（7）的吸入软管（5） （8），其中过滤和收集脱水液体。 当已经收集了一定体积时，液体被引导而不将空气引入所述封闭的包装（11,12）中或者连通到另一个液体系统。 接收器（8）包括可替换的柔性所谓的罐袋（9），用于收集液体并且布置在刚性密闭的容器（10）中，并且设置有过滤器（17,18）以及填充和攻丝管道 22,23）。 接收器（8）和相应的包装（11,12）连接到系统的抽吸源（1），用于填充和分流液体。

公开(公告)号：US20040219060A1

公开(公告)日：2004-11-04

申请号：US10804583

申请日：2004-03-18

发明人： Edgardo Costa Maianti ,  Nicola Ghelli ,  Ivo Panzani

IPC分类号： A61M001/14 ,  A61M037/00 ,  A61M001/34 ,  A61M001/36

CPC分类号： A61M1/3627 ,  A61M1/1006 ,  A61M1/101 ,  A61M1/1698 ,  A61M1/3606 ,  A61M1/3666 ,  A61M1/3667

摘要： A device for processing blood in extracorporeal blood circuit, which comprises, integrated in a single monolithic assembly, a bubble trap, a centrifugal pump, a heat exchanger, an oxygenator and an arterial filter.

摘要翻译： 用于处理体外血液回路中的血液的装置，其包括集成在单个整体组件中的气泡阱，离心泵，热交换器，氧合器和动脉过滤器。

公开(公告)号：US20030175149A1

公开(公告)日：2003-09-18

申请号：US10100692

申请日：2002-03-18

发明人： Bruce Searles ,  Edward M. Darling ,  Xiao-Mang You

IPC分类号： A61M001/14 ,  A61M037/00 ,  A61M001/34

CPC分类号： A61M1/1698

摘要： An oxygenator capable of a small priming volume includes a housing defining an interior cavity. The interior cavity of the housing is subdivided into at least two chambers by a membrane. One of the chambers is a blood chamber and the other chambers are gas chambers. The oxygenator also includes an inlet tube passing through the housing and piercing the membrane to deliver blood directly into the blood chamber.

摘要翻译： 能够具有小起动体积的氧合器包括限定内腔的壳体。 壳体的内腔通过膜细分为至少两个腔室。 其中一个腔室是血液腔室，另一个腔室是气体腔室。 氧合器还包括通过壳体并刺穿膜以将血液直接输送到血液腔中的入口管。

公开(公告)号：US20030138350A1

公开(公告)日：2003-07-24

申请号：US10306274

申请日：2002-11-27

发明人： John MacOviak ,  Wilfred J. Samson ,  Steve Baker ,  James J. Leary

IPC分类号： A61M001/14 ,  A61M037/00 ,  A61M001/34

CPC分类号： A61M25/1011 ,  A61M1/3653 ,  A61M1/3659 ,  A61M25/0032 ,  A61M2025/0034 ,  A61M2025/0036

摘要： A circulatory support system and method for circulatory support are described for performing cardiopulmonary bypass using differential perfusion and/or isolated segmental perfusion of the circulatory system. The circulatory support system includes one or more venous cannulae for draining blood from the venous side of the patient's circulatory system, one or more arterial cannulae for perfusing the arterial side of the patient's circulatory system, and one or more blood circulation pumps connected between the venous cannulae and the arterial cannulae. The arterial cannulae and the venous cannulae of the circulatory support system may take one of several possible configurations. The circulatory support system is configured to segment a patient's circulatory system into one or more isolated circulatory loops. The circulatory loops may be isolated from one another and/or from the remainder of the patient's circulatory system on the venous side, as well as on the arterial side, for isolated closed loop circulatory support of separate organ systems. The circulatory support system is suitable for use in minimally-invasive cardiac surgery, using thoracoscopic, port-access or minithoracotomy techniques, or for standard open-chest cardiac surgery.