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公开(公告)号：US20160271228A1
公开(公告)日：2016-09-22
申请号：US15080026
申请日：2016-03-24
CPC分类号： A61K38/39 , A61K9/06 , A61K9/14 , A61K31/77 , A61K35/32 , A61K47/10 , A61K47/34 , A61K47/42 , A61L24/0031 , A61L24/043 , A61L26/0052 , A61L26/0066 , A61L26/008 , A61L2400/04 , C08L71/02 , C08L89/00
摘要： The invention discloses a hemostatic composition comprising: a) a biocompatible polymer in particulate form suitable for use in hemostasis, and b) one hydrophilic polymeric component comprising reactive groups.
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公开(公告)号：US20130177601A1
公开(公告)日：2013-07-11
申请号：US13663098
申请日：2012-10-29
发明人： Katarzyna I. Gorna , Andreas Goessl , Heinz Gulle
IPC分类号： A61L24/04
CPC分类号： C08G81/00 , A61B17/56 , A61B2017/00933 , A61K31/765 , A61L24/043 , A61L24/046 , A61L2400/04 , A61L2430/02 , C08L71/02
摘要： Bone hemostat compositions, and methods for their use and manufacture are provided. Exemplary hemostatic compositions include polymeric components such as random and non-random copolymers, natural polymers, ceramics, reactive group polymers, and combinations thereof. Bone compositions may be used during surgical procedures, and may be applied to bone to inhibit or prevent bleeding from bone.
摘要翻译： 提供了骨质止血剂组合物及其使用和制造方法。 示例性止血组合物包括聚合物组分，例如无规和非无规共聚物，天然聚合物，陶瓷，反应性基团聚合物及其组合。 骨组合物可以在外科手术中使用，并且可以应用于骨以抑制或预防骨出血。
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公开(公告)号：US10322170B2
公开(公告)日：2019-06-18
申请号：US15080026
申请日：2016-03-24
IPC分类号： A61K9/06 , A61K38/39 , A61K31/77 , A61L24/04 , A61L26/00 , A61L24/00 , A61K35/32 , A61K9/14 , A61K47/34 , A61K47/10 , A61K47/42
摘要： The invention discloses a hemostatic composition comprising: a) a biocompatible polymer in particulate form suitable for use in hemostasis, and b) one hydrophilic polymeric component comprising reactive groups.
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公开(公告)号：US09278160B2
公开(公告)日：2016-03-08
申请号：US13738400
申请日：2013-01-10
发明人： John J. Barry , Andreas Goessl , Heinz Gulle , Monika Mangold , Melitta Bilban
CPC分类号： A61L27/54 , A61L27/225 , A61L27/227 , A61L27/46 , A61L27/502 , A61L27/58
摘要： The present invention teaches a micro-porous injectable, soft elastic, fully resorbable fibrin-based composition for use as a soft tissue lumen and void filler. The composition of the present application exhibits physical characteristics, such as mechanical properties, typically seen in elastomers and mechanical stability, which is superior to fibrin alone. A variety of properties of the composition of the present invention can be effectively fine-tuned and altered by adjusting type and content of the particles as well as of the plasticizer contained in the void filler composition.
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公开(公告)号：US20130287818A1
公开(公告)日：2013-10-31
申请号：US13663050
申请日：2012-10-29
发明人： Katarzyna I. Gorna , Andreas Goessl , Heinz Gulle
IPC分类号： C08G81/00
CPC分类号： C08G81/00 , A61B17/56 , A61B2017/00933 , A61K31/765 , A61L24/043 , A61L24/046 , A61L2400/04 , A61L2430/02 , C08L71/02
摘要： Bone hemostat compositions, and methods for their use and manufacture are provided. Exemplary hemostatic compositions include polymeric components such as random and non-random copolymers, natural polymers, ceramics, reactive group polymers, and combinations thereof. Bone compositions may be used during surgical procedures, and may be applied to bone to inhibit or prevent bleeding from bone.
摘要翻译： 提供了骨质止血剂组合物及其使用和制造方法。 示例性止血组合物包括聚合物组分，例如无规和非无规共聚物，天然聚合物，陶瓷，反应性基团聚合物及其组合。 骨组合物可以在外科手术中使用，并且可以应用于骨以抑制或预防骨出血。
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公开(公告)号：US09724449B2
公开(公告)日：2017-08-08
申请号：US14828284
申请日：2015-08-17
发明人： John J. Barry , Andreas Goessl , Heinz Gulle , Monika Mangold , Melitta Bilban
IPC分类号： A01N43/00 , A61K31/33 , A61F13/00 , A61K38/48 , A61L27/26 , A61L24/00 , A61L24/02 , A61L24/10 , A61L27/12 , A61L27/22 , A61L27/54 , A61L27/58 , A61F2/28 , A61F2/44 , A61F2/46 , A61F2/30
CPC分类号： A61L27/26 , A61F2/28 , A61F2/44 , A61F2/4601 , A61F2002/2817 , A61F2002/2828 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61F2310/00293 , A61F2310/00377 , A61L24/0015 , A61L24/0042 , A61L24/02 , A61L24/106 , A61L24/108 , A61L27/12 , A61L27/225 , A61L27/227 , A61L27/54 , A61L27/58 , A61L2300/202 , A61L2300/418 , A61L2300/44 , A61L2300/622 , A61L2400/06 , A61L2430/02
摘要： The present invention relates to a biodegradable injectable composition for bone augmentation comprising fibrin, a contrast agent and calcium salt-containing particles, as well as a method for bone augmentation in a patient suffering from a bone disorder comprising injecting said composition into a non-mineralized or hollow portion of said bone.
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公开(公告)号：US09512277B2
公开(公告)日：2016-12-06
申请号：US13663098
申请日：2012-10-29
发明人： Katarzyna I. Gorna , Andreas Goessl , Heinz Gulle
CPC分类号： C08G81/00 , A61B17/56 , A61B2017/00933 , A61K31/765 , A61L24/043 , A61L24/046 , A61L2400/04 , A61L2430/02 , C08L71/02
摘要： Bone hemostat compositions, and methods for their use and manufacture are provided. Exemplary hemostatic compositions include polymeric components such as random and non-random copolymers, natural polymers, ceramics, reactive group polymers, and combinations thereof. Bone compositions may be used during surgical procedures, and may be applied to bone to inhibit or prevent bleeding from bone.
摘要翻译： 提供了骨质止血剂组合物及其使用和制造方法。 示例性止血组合物包括聚合物组分，例如无规和非无规共聚物，天然聚合物，陶瓷，反应性基团聚合物及其组合。 骨组合物可以在外科手术中使用，并且可以应用于骨以抑制或预防骨出血。
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公开(公告)号：US20130090291A1
公开(公告)日：2013-04-11
申请号：US13648885
申请日：2012-10-10
CPC分类号： A61K38/39 , A61K9/06 , A61K9/14 , A61K31/77 , A61K35/32 , A61K47/10 , A61K47/34 , A61K47/42 , A61L24/0031 , A61L24/043 , A61L26/0052 , A61L26/0066 , A61L26/008 , A61L2400/04 , C08L71/02 , C08L89/00
摘要： The invention discloses a hemostatic composition comprising: a) a biocompatible polymer in particulate form suitable for use in hemostasis, and b) one hydrophilic polymeric component comprising reactive groups.
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公开(公告)号：US20150352253A1
公开(公告)日：2015-12-10
申请号：US14828284
申请日：2015-08-17
发明人： John J. Barry , Andreas Goessl , Heinz Gulle , Monika Mangold , Melitta Bilban
CPC分类号： A61L27/26 , A61F2/28 , A61F2/44 , A61F2/4601 , A61F2002/2817 , A61F2002/2828 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61F2310/00293 , A61F2310/00377 , A61L24/0015 , A61L24/0042 , A61L24/02 , A61L24/106 , A61L24/108 , A61L27/12 , A61L27/225 , A61L27/227 , A61L27/54 , A61L27/58 , A61L2300/202 , A61L2300/418 , A61L2300/44 , A61L2300/622 , A61L2400/06 , A61L2430/02
摘要： The present invention relates to a biodegradable injectable composition for bone augmentation comprising fibrin, a contrast agent and calcium salt-containing particles, as well as a method for bone augmentation in a patient suffering from a bone disorder comprising injecting said composition into a non-mineralized or hollow portion of said bone.
摘要翻译： 本发明涉及包含纤维蛋白，造影剂和含钙盐颗粒的用于骨增生的可生物降解的可注射组合物，以及在患有骨病的患者中骨增大的方法，包括将所述组合物注射入非矿化 或所述骨的中空部分。
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公开(公告)号：US20130209370A1
公开(公告)日：2013-08-15
申请号：US13738400
申请日：2013-01-10
发明人： John J. Barry , Andreas Goessl , Heinz Gulle , Monika Mangold , Melitta Bilban
CPC分类号： A61L27/54 , A61L27/225 , A61L27/227 , A61L27/46 , A61L27/502 , A61L27/58
摘要： The present invention teaches a micro-porous injectable, soft elastic, fully resorbable fibrin-based composition for use as a soft tissue lumen and void filler. The composition of the present application exhibits physical characteristics, such as mechanical properties, typically seen in elastomers and mechanical stability, which is superior to fibrin alone. A variety of properties of the composition of the present invention can be effectively fine-tuned and altered by adjusting type and content of the particles as well as of the plasticizer contained in the void filler composition.
摘要翻译： 本发明教导了用作软组织腔和空隙填充剂的微孔可注射的，软弹性的，完全可吸收的基于纤维蛋白的组合物。 本申请的组合物显示出物理特性，例如通常在弹性体中看到的机械性能和机械稳定性，其优于单独的纤维蛋白。 通过调节颗粒以及空隙填料组合物中所含的增塑剂的类型和含量，可以有效地微调和改变本发明组合物的各种性能。
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