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公开(公告)号：US20220163929A1
公开(公告)日：2022-05-26
申请号：US17432995
申请日：2020-02-19
摘要： Described herein is a method and a system for automated simultaneous control of at least two process characteristics of a continuous production process with at least one fluid stream, at least two unit operations, at least one process control system and at least one conditioning volume.
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公开(公告)号：US20220099638A1
公开(公告)日：2022-03-31
申请号：US17429585
申请日：2020-02-04
发明人： Peter SCHWAN , Heiko BRANDT , Martin LOBEDANN , Sven-Oliver BORCHERT , Martin POGGEL , Rubin HILLE , Alexandros PAPADOPOULOS , Thomas MRZIGLOD
摘要： What is disclosed herein describes a system and a method for influencing a sequential chromatography.
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公开(公告)号：US20160375159A1
公开(公告)日：2016-12-29
申请号：US15125130
申请日：2015-03-06
发明人： Martin LOBEDANN , Stephan KLUTZ , Safa Kutup KURT
IPC分类号： A61L2/00
CPC分类号： A61L2/0088 , A61L2/10 , A61L2202/15 , A61L2202/21
摘要： The invention provides an apparatus and a process for continuous virus inactivation. The apparatus for continuous virus inactivation in a product stream comprises a tube or hose 1 having an inlet 4 and an outlet 5 in each case connected to a product flow line 8 for conveying the product stream, where the tube or the hose 1 is curved and/or helically coiled with a number n of windings around a coil axis h and has one or more changes in direction and/or bends 2 in the coil axis h having an angle α of from 45° to 180° to alter the direction of action of the normals of the centrifugal force and the apparatus is characterized by a Dean number>0 and a torsion parameter>0.
摘要翻译： 本发明提供了用于连续病毒灭活的装置和方法。 用于在产品流中连续病毒灭活的装置包括管或软管1，其具有入口4和出口5，每个入口4和出口5连接到用于输送产品流的产品流动管线8，其中管或软管1弯曲， /或螺旋线圈绕线圈轴线h周围的n个绕组，并且在线圈轴线h中具有角度α为45°至180°的方向和/或弯曲部2上的一个或多个变化，以改变作用方向 离心力的法线和装置的特征在于Dean数> 0和扭转参数> 0。
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公开(公告)号：US20220073560A1
公开(公告)日：2022-03-10
申请号：US17309991
申请日：2020-01-08
发明人： Bastian BUDDE , Peter SCHWAN , Sven-Oliver BORCHERT , Benjamin MAISER , Sven CLASSEN , Jürgen LENZ , Laura DAVID , Martin LOBEDANN
摘要： Described herein is a method for transferring of batch production process for a monoclonal antibody to a continuous production process for the same monoclonal antibody.
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公开(公告)号：US20190316213A1
公开(公告)日：2019-10-17
申请号：US16343125
申请日：2017-10-20
发明人： Benjamin MAISER , Peter SCHWAN , Laura DAVID , Martin LOBEDANN
IPC分类号： C12Q1/70
摘要： Disclosed herein is a method for validation of continuous viral clearance comprising the steps of providing a probe to be validated, spiking the probe in a valid manner, performing viral clearance, sampling the spiked probe and analyzing the sample of the spiked probe of step d).
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公开(公告)号：US20220090712A1
公开(公告)日：2022-03-24
申请号：US17299713
申请日：2019-11-21
发明人： Peter SCHWAN , Ingo STEINMEISTER , Martin LOBEDANN
摘要： Herein is described a pressure resistant shell for stabilizing a welding seam of a weldable tubing as well as a method of using it.
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公开(公告)号：US20210221842A1
公开(公告)日：2021-07-22
申请号：US17192384
申请日：2021-03-04
发明人： Peter SCHWAN , Martin LOBEDANN , Jens BERNSHAUSEN
摘要： The invention relates to a modular production plant for continuous production and/or preparation of biopharmaceutical products, a computer-implemented method for process control of the modular plant for production of biopharmaceutical and biological macromolecular products, in particular of proteins, e.g. monoclonal antibodies, vaccines, nucleic acids such as DNA, RNA and plasmids and derivatives thereof.
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8.发明申请ULTRAFILTRATION UNIT FOR CONTINUOUS BUFFER OR MEDIUM EXCHANGE FROM A PROTEIN SOLUTION 审中-公开来自蛋白质溶液的连续缓冲或中间交换的超滤单元公开(公告)号：US20170056825A1
公开(公告)日：2017-03-02
申请号：US15119126
申请日：2015-02-13
摘要： The invention relates to an ultrafiltration unit for continuous buffer or medium exchange, a method for continuous buffer or medium exchange in the ultrafiltration unit, and a plant in particular for (semi)continuous production of biopharmaceutical and biological macromolecular products in particular, such as proteins, e.g. monoclonal antibodies and vaccines, comprising the ultrafiltration unit according to the invention.
摘要翻译： 本发明涉及用于连续缓冲或介质交换的超滤单元，在超滤单元中连续缓冲或介质交换的方法，特别是用于（半）连续生产生物药物和生物大分子产物，特别是诸如蛋白质的植物 ，例如 单克隆抗体和疫苗，其包含根据本发明的超滤单元。
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公开(公告)号：US20210069359A1
公开(公告)日：2021-03-11
申请号：US16772068
申请日：2018-09-18
摘要： The invention provides a unit operation formed by a device and its use for continuous virus inactivation of a continuous flow of a process fluid. The unit operation formed by a device comprises a single inlet at one end and an outlet at the opposite end and at least one HFI, characterized in that the HFI further comprises at least one installation.
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公开(公告)号：US20200038778A1
公开(公告)日：2020-02-06
申请号：US16481915
申请日：2018-02-16
发明人： Peter SCHWAN , Martin LOBEDANN
摘要： What is described herein relates to the use of a dense membrane module as pathogen barrier as well as the use of at least one dense membrane module and/or at least one nanoporous membrane module in a method for the continuous, processing of a healthcare product, a method for the continuous, pathogen-reduced, modular processing of a healthcare product, wherein at least one dense membrane module and/or at least one nanoporous membrane module is employed for degassing and/or debubbling a fluid stream, wherein the fluid stream is passed over the membrane module characterized in that the fluid stream is passed from top to bottom over the membrane module and a unit operation for the continuous, pathogen-reduced, modular processing of a healthcare product comprising at least one dense membrane module and/or at least one nanoporous membrane module.
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