-
公开(公告)号：US20170273980A1
公开(公告)日：2017-09-28
申请号：US15512494
申请日：2015-09-17
发明人： Anne MENGEL , Hans-Georg LERCHEN , Manfred MÖWES , Thomas MÜLLER , Lars BÄRFACKER , Marion HITCHCOCK , Arwed CLEVE , Joachim KUHNKE , Hans BRIEM , Gerhard SIEMEISTER , Wilhelm BONE , Amaury Ernesto FERNANDEZ-MONTALVAN , Jens SCHRÖDER , Ursula MÖNNING , Simon HOLTON
IPC分类号： A61K31/506 , C07D403/14 , C07D401/14
CPC分类号： A61K31/506 , C07D401/14 , C07D403/14
摘要： Compounds of formula (I) as defined herein and their use as pharmaceuticals.
-
公开(公告)号：US20170101391A1
公开(公告)日：2017-04-13
申请号：US15317924
申请日：2015-06-17
发明人： Keith GRAHAM , Ulrich KLAR , Hans BRIEM , Marion HITCHCOCK , Lars BÄRFACKER , Knut EIS , Volker SCHULZE , Gerhard SIEMEISTER , Wilhelm BONE , Jens SCHRÖDER , Simon HOLTON , Philip LIENAU , René TEMPEL , Helmut SONNENSCHEIN , Jozsef BÁLINT , Heinz GRAUBAUM
IPC分类号： C07D401/04 , A61K31/4439 , C07D403/04 , A61K31/506 , C07D401/14 , A61K31/444 , C07D405/14 , C07D471/04 , A61K31/437 , A61K31/501 , A61K31/4725 , C07D409/14 , A61K31/4709 , A61K31/5377 , C07D491/056 , A61K31/436 , C07D417/14 , C07D413/14 , A61K45/06
CPC分类号： C07D401/04 , A61K31/436 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/4725 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D491/056
摘要： Compounds of formula (I) which are inhibitors of Bub1 kinase, processes for their production and their use as pharmaceuticals.
-
公开(公告)号：US20160326159A1
公开(公告)日：2016-11-10
申请号：US15032957
申请日：2014-10-27
发明人： Anne MENGEL , Anja RICHTER , Marion HITCHCOCK , Hans BRIEM , Gerhard SIEMEISTER , Wilhelm BONE , Amaury Ernesto FERNANDEZ-MONTALVAN , Jens SCHRÖDER , Simon HOLTON , Cornelia PREUßE , Ursula MÖNNING
IPC分类号： C07D417/14 , C07D403/14 , A61K31/4439 , A61K31/506 , C07D401/14 , A61K45/06 , A61K31/5377
CPC分类号： C07D417/14 , A61K31/4439 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D401/14 , C07D403/14
摘要： Compounds of formula (I), processes for their preparation and their use as pharmaceuticals.
-
公开(公告)号：US20160145267A1
公开(公告)日：2016-05-26
申请号：US14899469
申请日：2014-06-17
发明人： Marion HITCHCOCK , Anne MENGEL , Hans BRIEM , Jens GEISLER , Gerhard SIEMEISTER , Wilhelm BONE , Amaury Ernesto FERNANDEZ-MONTALVAN , Jens SCHRÖDER , Simon HOLTON , Ursula MÖNNING
IPC分类号： C07D498/04 , A61K31/506 , A61K45/06 , A61K31/5377 , A61K31/53 , A61K31/5383 , C07D401/14 , C07D403/14
CPC分类号： C07D498/04 , A61K31/506 , A61K31/53 , A61K31/5377 , A61K31/5383 , A61K45/06 , C07D401/14 , C07D403/14
摘要： Compounds of formula (I), which are inhibitors of Bub1 kinase, processes for their production and their use as pharmaceuticals.
-
公开(公告)号：US20190047980A1
公开(公告)日：2019-02-14
申请号：US16063370
申请日：2016-12-15
发明人： Volker SCHULZE , Tobias HEINRICH , Florian PRINZ , Julien LEFRANC , Jens SCHRÖDER , Anne MENGEL , Wilhelm BONE , Joszef BÁLINT , Antje Margret WENGNER , Knut EIS , Horst IRLBACHER , Marcus KOPPITZ , Ulf BÖMER , Benjamin BADER , Hans BRIEM , Philip LIENAU , Clara CHRIST , Detlef STÖCKIGT , Roman HILLIG
IPC分类号： C07D401/12 , A61P35/00 , C07D401/14 , C07D487/08 , C07D471/08 , C07D451/14 , C07D409/14 , C07D405/14
摘要： The present invention covers heteroarylbenzimidazole compounds of general formula (I) in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative and/or inflammatory disorders, as a sole agent or in combination with other active ingredients.
-
公开(公告)号：US20170305882A1
公开(公告)日：2017-10-26
申请号：US15512473
申请日：2015-09-17
发明人： Anne MENGEL , Hans-Georg LERCHEN , Thomas MÜLLER , Lars BÄRFACKER , Marion HITCHCOCK , Arwed CLEVE , Hans BRIEM , Gerhard SIEMEISTER , Wilhelm BONE , Amaury Ernesto FERNÁNDEZ-MONTÁLVAN , Jens SCHRÖDER , Ursula MÖNNING , Simon HOLTON
IPC分类号： C07D401/14 , C07D403/14 , A61K45/06 , C07D405/14 , A61K31/506
CPC分类号： C07D401/14 , A61K31/506 , A61K45/06 , C07D403/14 , C07D405/14
摘要： Compounds of formula (I) and their use as pharmaceuticals.
-
公开(公告)号：US20170275270A1
公开(公告)日：2017-09-28
申请号：US15512507
申请日：2015-09-15
发明人： Lars BÄRFACKER , Thomas MÜLLER , Anne MENGEL , Marion HITCHCOCK , Arwed CLEVE , Hans BRIEM , Gerhard SIEMEISTER , Wilhelm BONE , Amaury Ernesto FERNANDEZ-MONTALVAN , Jens SCHRÖDER , Ursula MÖNNING
IPC分类号： C07D401/14 , A61K31/5377 , C07D405/14 , C07F7/18 , A61K31/695 , A61K31/517 , C07D403/14 , C07D487/04 , A61K31/519 , A61K31/53 , C07D417/14 , C07D491/052 , C07D491/048 , C07D471/04 , C07D495/04 , A61K45/06 , A61K31/506
CPC分类号： C07D401/14 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K31/695 , A61K45/06 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/048 , C07D491/052 , C07D495/04 , C07F7/1804
摘要： Compounds of formula (I) and their use as pharmaceuticals.
-
公开(公告)号：US20180256591A1
公开(公告)日：2018-09-13
申请号：US15974536
申请日：2018-05-08
发明人： Lars WORTMANN , Ulrich LÜCKING , Julien LEFRANC , Hans BRIEM , Marcus KOPPITZ , Knut EIS , Franz VON NUSSBAUM , Benjamin BADER , Antje Margret WENGNER , Gerhard SIEMEISTER , Wilhelm BONE , Philip LIENAU , Joanna GRUDZINSKA-GOEBEL , Dieter MOOSMAYER , Uwe EBERSPÄCHER , Hans SCHICK
IPC分类号： A61K31/541 , A61K31/55 , A61K31/5377 , A61K31/5386 , C07D471/04 , A61K31/675 , A61K45/06 , C07D491/22 , C07D519/00 , C07F9/6561
摘要： The present invention relates to substituted 2-(morpholin-4-yl)-1,7-naphthyridine compounds of general formula (I) or (Ib), to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disease as a sole agent or in combination with other active ingredients.
-
公开(公告)号：US20170216304A1
公开(公告)日：2017-08-03
申请号：US15501079
申请日：2015-08-03
发明人： Lars WORTMANN , Ulrich LÜCKING , Julien LEFRANC , Hans BRIEM , Marcus KOPPITZ , Knut EIS , Franz VON NUSSBAUM , Benjamin BADER , Antje Margret WENGNER , Gerhard SIEMEISTER , Wilhelm BONE , Philip LIENAU , Joanna GRUDZINSKA-GOEBEL , Dieter MOOSMAYER , Uwe EBERSPÄCHER , Hans SCHICK
IPC分类号： A61K31/541 , A61K31/5386 , A61K31/5377 , C07D491/22 , C07F9/6561 , C07D471/04 , C07D519/00 , A61K31/55 , A61K31/675
CPC分类号： A61K31/541 , A61K31/5377 , A61K31/5386 , A61K31/55 , A61K31/675 , A61K45/06 , C07D471/04 , C07D491/22 , C07D519/00 , C07F9/6561
摘要： The present invention relates to substituted 2-(morpholin-4-yl)-1,7-naphthyridine compounds of general formula (I) or (Ib), to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disease as a sole agent or in combination with other active ingredients.
-
公开(公告)号：US20160151370A1
公开(公告)日：2016-06-02
申请号：US14900575
申请日：2014-06-17
发明人： Marion HITCHCOCK , Anne MENGEL , Hans BRIEM , Ulrich LÜCKING , Gerhard SIEMEISTER , Wilhelm BONE , Jens SCHRÖDER , Michaela BAIRLEIN , Ursula MÖNNING , Michael BRÜNING
IPC分类号： A61K31/506 , A61K45/06 , C07D401/14
CPC分类号： A61K31/506 , A61K45/06 , C07D401/14
摘要： Compounds of formula (I) and their use as pharmaceutical.
摘要翻译： 式（I）化合物及其作为药物的用途。
-
-
-
-
-
-
-
-
-
搜索结果
14 条记录 (耗时 0.065 秒)
