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    Protective proteins of S. agalactiae, combinations thereof and methods of using the same
    2.
    发明授权
    Protective proteins of S. agalactiae, combinations thereof and methods of using the same 有权
    无乳糖乳杆菌的保护性蛋白质，其组合及其使用方法

    公开(公告)号：US08343510B2

    公开(公告)日：2013-01-01

    申请号：US12522636

    申请日：2008-01-10

    申请人： Beatrice Senn ,  Eszter Nagy ,  Andreas Meinke ,  Alexander Von Gabain ,  Barbara Maierhofer ,  Ulrike Stierschneider ,  Manfred Berger ,  Christina Neubauer ,  Katherine Cohen

    发明人： Beatrice Senn ,  Eszter Nagy ,  Andreas Meinke ,  Alexander Von Gabain ,  Barbara Maierhofer ,  Ulrike Stierschneider ,  Manfred Berger ,  Christina Neubauer ,  Katherine Cohen

    IPC分类号： A61K39/09 ,  C07K14/315 ,  C12P21/04

    CPC分类号： A61K39/092 ,  A61K39/00 ,  A61K2039/505 ,  A61K2039/53 ,  C07K14/315 ,  C07K16/1275

    摘要： The invention relates to a composition comprising at least two protective proteins against Streptococcus agalactiae (S. agalactiae) or functionally active variant thereof; a protective peptide against S. agalactiae; one or more nucleic acid(s) encoding the at least two proteins and/or the protective peptide; a method of producing the composition; a pharmaceutical composition, especially a vaccine, comprising the composition and/or at least one protective peptide; methods for producing antibodies; a mixture of antibodies against the at least two proteins of the composition; the use of the composition and/or at least one protective peptide and/or one or more nucleic acid(s) for the manufacture of a medicament for the immunization or treatment of a subject; methods of diagnosing a S. agalactiae infection; a method for identifying a ligand capable of binding the composition and/or at least one protective peptide; and the use of the composition and/or at least one protective peptide for the isolation and/or purification and/or identification of an interaction partner of the composition and/or peptide.

    摘要翻译： 本发明涉及一种组合物，其包含至少两种针对无乳链球菌（无乳链球菌）或其功能活性变体的保护性蛋白质; 针对无乳糖乳杆菌的保护性肽; 编码所述至少两种蛋白质和/或保护性肽的一种或多种核酸; 一种制备该组合物的方法; 包含该组合物和/或至少一种保护性肽的药物组合物，特别是疫苗; 生产抗体的方法; 针对组合物的至少两种蛋白质的抗体的混合物; 组合物和/或至少一种保护性肽和/或一种或多种核酸用于制备用于免疫或治疗受试者的药物的用途; 诊断无乳乳酸菌感染的方法; 用于鉴定能够结合组合物和/或至少一种保护性肽的配体的方法; 以及组合物和/或至少一种保护性肽用于分离和/或纯化和/或鉴定组合物和/或肽的相互作用配偶体的用途。

    Peptides protective against S. pneumoniae and compositions, methods and uses relating thereto
    4.
    发明授权
    Peptides protective against S. pneumoniae and compositions, methods and uses relating thereto 失效
    保护针对肺炎链球菌的肽及其组合物，方法和用途

    公开(公告)号：US08241643B2

    公开(公告)日：2012-08-14

    申请号：US12933020

    申请日：2009-03-17

    申请人： Andreas Meinke ,  Astrid Teubenbacher ,  Beatrice Senn ,  Manuel Zerbs ,  Markus Hanner ,  Jutta Pikalo ,  Eszter Nagy ,  Carmen Giefing-Krōll ,  Alexander Von Gabain

    发明人： Andreas Meinke ,  Astrid Teubenbacher ,  Beatrice Senn ,  Manuel Zerbs ,  Markus Hanner ,  Jutta Pikalo ,  Eszter Nagy ,  Carmen Giefing-Krōll ,  Alexander Von Gabain

    IPC分类号： A61K39/09 ,  C07K14/315

    CPC分类号： A61K39/092 ,  C07K14/3156 ,  G01N33/56944 ,  G01N2333/3156 ,  G01N2469/20

    摘要： The present invention relates to a protective peptide of Streptococcus pneumoniae (S. pneumoniae) or a functionally active variant thereof; a composition comprising at least two of such peptides or variants; one or more nucleic acid(s) encoding such peptide or variant; a pharmaceutical composition comprising such peptide or variant, composition, or nucleic acid(s); a method of producing an antibody using such peptide or variant or composition; the use of such peptide or variant and/or composition and/or nucleic acid(s) for the manufacture of a medicament; a method of diagnosing a S. pneumoniae infection using such peptide or variant, composition or a primer and/or probe specific for the nucleic acid(s); a method for identifying a ligand capable of binding to such peptide or variant; and the use of such peptide or variant for the isolation, purification and/or identification of an interaction partner of the peptide.

    摘要翻译： 本发明涉及肺炎链球菌（Streptococcus pneumoniae）（肺炎链球菌）或其功能活性变体的保护肽; 包含至少两种这样的肽或变体的组合物; 一种或多种编码这种肽或变体的核酸; 包含这种肽或变体，组合物或核酸的药物组合物; 使用这种肽或变体或组合物产生抗体的方法; 使用这样的肽或变体和/或组合物和/或核酸来制造药物; 使用这样的肽或变体，组合物或对核酸特异性的引物和/或探针来诊断肺炎链球菌感染的方法; 用于鉴定能够结合该肽或变体的配体的方法; 以及这种肽或变体用于分离，纯化和/或鉴定肽的相互作用配偶体的用途。

    PEPTIDES PROTECTIVE AGAINST S. PNEUMONIAE AND COMPOSITIONS, METHODS AND USES RELATING THERETO
    5.
    发明申请
    PEPTIDES PROTECTIVE AGAINST S. PNEUMONIAE AND COMPOSITIONS, METHODS AND USES RELATING THERETO 失效
    抗菌肽抗菌素及其组合物，方法和用途

    公开(公告)号：US20110091494A1

    公开(公告)日：2011-04-21

    申请号：US12933020

    申请日：2009-03-17

    申请人： Andreas Meinke ,  Astrid Teubenbacher ,  Beatrice Senn ,  Manuel Zerbs ,  Markus Hanner ,  Jutta Pikalo ,  Eszter Nagy ,  Carmen Giefing ,  Alexander Von Gabain

    发明人： Andreas Meinke ,  Astrid Teubenbacher ,  Beatrice Senn ,  Manuel Zerbs ,  Markus Hanner ,  Jutta Pikalo ,  Eszter Nagy ,  Carmen Giefing ,  Alexander Von Gabain

    IPC分类号： A61K39/00 ,  C12P21/06 ,  C12N5/00 ,  C12N15/63 ,  A61K38/04 ,  A61K38/16 ,  C07K14/00 ,  C07H21/04

    CPC分类号： A61K39/092 ,  C07K14/3156 ,  G01N33/56944 ,  G01N2333/3156 ,  G01N2469/20

    摘要： The present invention relates to a protective peptide of Streptococcus pneumoniae (S. pneumoniae) or a functionally active variant of the protective peptide; a composition comprising at least two protective peptides or functionally active variants thereof; a composition comprising at least two proteins selected from the group consisting of i) a first type of protective peptide or functionally active variant thereof, ii) a second type of protective peptide or functionally active variant thereof and iii) a supportive peptide or a functionally active variant thereof; one or more nucleic acid(s) encoding the protective peptide or functionally active variant thereof or the at least two proteins comprised in the composition; a pharmaceutical composition comprising the protective peptide or functionally active variant thereof, the composition, or the nucleic acid(s); a method of producing an antibody using the protective peptide or functionally active variant thereof or the composition; the use of the protective peptide or functionally active variant thereof and/or the composition and/or the nucleic acid(s) for the manufacture of a medicament for the immunization or treatment of a subject; a method of diagnosing a S. pneumoniae infection using the protective peptide or a functionally active variant thereof, the composition or a primer and/or probe specific for the nucleic acid(s); a method for identifying a ligand capable of binding to a protective peptide or functionally active variant thereof; and the use of a protective peptide or functionally active variant thereof for the isolation and/or purification and/or identification of an interaction partner of the peptide.

    摘要翻译： 本发明涉及肺炎链球菌（Streptococcus pneumoniae）（肺炎链球菌）的保护肽或保护性肽的功能活性变体; 包含至少两种保护性肽或其功能活性变体的组合物; 包含至少两种选自i）第一类保护性肽或其功能活性变体的蛋白质的组合物，ii）第二类型的保护性肽或其功能活性变体，和iii）支持性肽或功能活性的 其变体; 一种或多种编码保护性肽或其功能活性变体的核酸或组合物中包含的至少两种蛋白质; 包含保护性肽或其功能活性变体，组合物或核酸的药物组合物; 使用保护性肽或其功能活性变体或组合物制备抗体的方法; 保护性肽或其功能活性变体和/或组合物和/或核酸在制备用于免疫或治疗受试者的药物中的用途; 使用保护性肽或其功能活性变体诊断肺炎链球菌感染的方法，所述组合物或对所述核酸特异性的引物和/或探针; 用于鉴定能够结合保护性肽或其功能活性变体的配体的方法; 以及使用保护性肽或其功能活性变体来分离和/或纯化和/或鉴定肽的相互作用配偶体。

    PEPTIDES PROTECTIVE AGAINST E. FAECALIS, METHODS AND USES RELATING THERETO
    6.
    发明申请
    PEPTIDES PROTECTIVE AGAINST E. FAECALIS, METHODS AND USES RELATING THERETO 审中-公开
    抗生素的保护作用与其相关的E. FAECALIS，方法和用途

    公开(公告)号：US20130243779A1

    公开(公告)日：2013-09-19

    申请号：US13147612

    申请日：2010-02-04

    申请人： Eszter Nagy ,  Beatrice Tschanun ,  Markus Hanner ,  Manfred Berger ,  Andreas Meinke ,  Alexander Von Gabain ,  Barbara Murray ,  Kavindra Singh

    发明人： Eszter Nagy ,  Beatrice Tschanun ,  Markus Hanner ,  Manfred Berger ,  Andreas Meinke ,  Alexander Von Gabain ,  Barbara Murray ,  Kavindra Singh

    IPC分类号： C07K14/335 ,  C07K16/12

    CPC分类号： C07K14/335 ,  A61K39/012 ,  A61K2039/55566 ,  C07K16/1267 ,  G01N33/56916

    摘要： The present invention relates to a protective peptide of Enterococcus faecalis (E. faecalis) or a functional active variant thereof, optionally further consisting of additional amino acid residue(s); a nucleic acid coding for the same; a pharmaceutical composition comprising said peptide or said nucleic acid; an antibody or functional active fragment thereof specifically binding to the antigen; a hybridoma cell line which produces said antibody; a method for producing said antibody; a pharmaceutical composition comprising said antibody; the use of said peptide or said nucleic acid for the manufacture of a medicament for the immunization or treatment of a subject; the use of said antibody or functional fragment thereof for the manufacture of a medicament for the treatment of an infection; a method of diagnosing an E. faecalis infection; and the use of said peptide for the isolation and/or purification and/or identification of an interaction partner of the peptide.

    摘要翻译： 本发明涉及粪肠球菌（粪肠球菌）或其功能性活性变体的保护性肽，任选地还包含另外的氨基酸残基; 编码该核酸的核酸; 包含所述肽或所述核酸的药物组合物; 与抗原特异性结合的抗体或功能活性片段; 产生所述抗体的杂交瘤细胞系; 一种生产所述抗体的方法; 包含所述抗体的药物组合物; 所述肽或所述核酸用于制备用于免疫或治疗受试者的药物的用途; 所述抗体或其功能片段在制备用于治疗感染的药物中的用途; 一种诊断粪肠球菌感染的方法; 以及所述肽用于分离和/或纯化和/或鉴定肽的相互作用配偶体的用途。

    PEPTIDES PROTECTIVE AGAINST S. PNEUMONIAE AND COMPOSITIONS, METHODS AND USES RELATING THERETO
    7.
    发明申请
    PEPTIDES PROTECTIVE AGAINST S. PNEUMONIAE AND COMPOSITIONS, METHODS AND USES RELATING THERETO 审中-公开
    抗菌肽抗菌素及其组合物，方法和用途

    公开(公告)号：US20100047263A1

    公开(公告)日：2010-02-25

    申请号：US12514960

    申请日：2007-11-19

    申请人： Eszter Nagy ,  Carmen Giefing ,  Alexander Von Gabain ,  Markus Hanner ,  Jutta Pikalo ,  Beatrice Senn ,  Michael Schunn ,  Gabriele Swatosch ,  Manuel Zerbs

    发明人： Eszter Nagy ,  Carmen Giefing ,  Alexander Von Gabain ,  Markus Hanner ,  Jutta Pikalo ,  Beatrice Senn ,  Michael Schunn ,  Gabriele Swatosch ,  Manuel Zerbs

    IPC分类号： A61K39/00 ,  C12Q1/68 ,  G01N33/53 ,  C12N5/20 ,  A61K38/16 ,  A61K31/7088 ,  C07K14/00 ,  C07K16/00 ,  C07H21/04

    CPC分类号： G01N33/56944 ,  G01N2469/20

    摘要： The present invention relates to a protective peptide or a functionally active variant of the protective peptide; a composition comprising at least two proteins selected from the group consisting of i) a first type of protective peptide or functionally active variant thereof, ii) a second type of protective peptide or functionally active variant thereof and iii) a supportive peptide or a functionally active variant thereof; one or more nucleic acid(s) encoding the protective peptide or functionally active variant thereof or the at least two proteins comprised in the composition; a pharmaceutical composition comprising the protective peptide or functionally active variant thereof, the composition, or the nucleic acid(s); a method of producing an antibody using the protective peptide or functionally active variant thereof or the composition; the use of the protective peptide or functionally active variant thereof and/or the composition and/or the nucleic acid(s) for the manufacture of a medicament for the immunization or treatment of a subject; a method of diagnosing a S. pneumoniae infect ion using the protective peptide or a functionally active variant thereof, the composition or a primer and/or probe specific for the nucleic acid(s); a method for identifying a ligand capable of binding to a protective peptide or variant thereof; and the use of a protective peptide or variant thereof for the isolation and/or purification and/or identification of an interaction partner of the peptide.

    摘要翻译： 本发明涉及保护性肽或保护性肽的功能活性变体; 包含至少两种选自i）第一类保护性肽或其功能活性变体的蛋白质的组合物，ii）第二类型的保护性肽或其功能活性变体，和iii）支持性肽或功能活性的 其变体; 一种或多种编码保护性肽或其功能活性变体的核酸或组合物中包含的至少两种蛋白质; 包含保护性肽或其功能活性变体，组合物或核酸的药物组合物; 使用保护性肽或其功能活性变体或组合物制备抗体的方法; 保护性肽或其功能活性变体和/或组合物和/或核酸在制备用于免疫或治疗受试者的药物中的用途; 使用保护性肽或其功能活性变体诊断肺炎链球菌感染的方法，所述组合物或对核酸特异性的引物和/或探针; 用于鉴定能够结合保护性肽或其变体的配体的方法; 以及使用保护性肽或其变体来分离和/或纯化和/或鉴定该肽的相互作用配偶体。

    Borrelia antigens
    9.
    发明授权
    Borrelia antigens 失效
    疏螺旋体抗原

    公开(公告)号：US08303961B2

    公开(公告)日：2012-11-06

    申请号：US13410915

    申请日：2012-03-02

    申请人： Urban Lundberg ,  Andreas Meinke ,  Eszter Nagy ,  Alexander Von Gabain ,  Birgit Noiges ,  Dieter Gelbmann ,  Albina Poljak ,  Christine Triska

    发明人： Urban Lundberg ,  Andreas Meinke ,  Eszter Nagy ,  Alexander Von Gabain ,  Birgit Noiges ,  Dieter Gelbmann ,  Albina Poljak ,  Christine Triska

    IPC分类号： A61K39/02 ,  C12P21/04 ,  C12N1/20

    CPC分类号： C07K7/08 ,  A61K39/00 ,  A61K2039/53 ,  C07K7/06 ,  C07K14/20 ,  Y02A50/401

    摘要： The present invention relates to an isolated nucleic acid molecule encoding a protein, preferably a hyperimmune serum-reactive antigen from Borrelia, a vector comprising such nucleic acid molecule, a host cell comprising such vector, a protein, preferably a hyperimmune serum-reactive antigen from Borrelia, a process for producing such protein, a process for producing a cell which expresses such protein, an antibody that binds to such protein, a hybridoma cell producing such antibody, a method for producing such antibody, a pharmaceutical composition comprising such nucleic acid molecule, protein, or antibody, use of such nucleic acid molecule, protein, or antibody for the manufacture of a medicament, a method for identifying an antagonist capable of reducing or inhibiting the activity of such protein, a method for diagnosis or treatment of an infection with a pathogen causing Lyme disease or an infection with Borrelia burgdorferi s.l.

    摘要翻译： 本发明涉及编码蛋白质，优选来自疏螺旋体的超免疫血清反应性抗原的分离的核酸分子，包含此类核酸分子的载体，包含该载体的宿主细胞，优选来自超免疫血清反应性抗原的超免疫血清反应性抗原 疏螺旋体，生产这种蛋白质的方法，生产表达这种蛋白质的细胞的方法，与这种蛋白质结合的抗体，产生这种抗体的杂交瘤细胞，制备这种抗体的方法，包含这种核酸分子的药物组合物 ，蛋白质或抗体，使用此类核酸分子，蛋白质或抗体制备药物，鉴定能够降低或抑制该蛋白质活性的拮抗剂的方法，诊断或治疗感染的方法 造成莱姆病的病原体或布氏疏螺旋体感染

    NONTYPABLE HAEMOPHILUS INFLUENZAE ANTIGENS
    10.
    发明申请
    NONTYPABLE HAEMOPHILUS INFLUENZAE ANTIGENS 失效
    不可替代的海马流感病毒抗体

    公开(公告)号：US20120045457A1

    公开(公告)日：2012-02-23

    申请号：US13148695

    申请日：2010-02-15

    申请人： Alexander Von Gabain ,  Eszter Nagy ,  Andreas Meinke ,  Sanja Selak ,  Markus Hanner ,  Margarita Smidt ,  Michaela Weissgram ,  Birgit Noiges ,  Stefan Seidel ,  Julia Bacher ,  Christina Satke ,  Wolfgang Schueler ,  Martin Oleksiewicz

    发明人： Alexander Von Gabain ,  Eszter Nagy ,  Andreas Meinke ,  Sanja Selak ,  Markus Hanner ,  Margarita Smidt ,  Michaela Weissgram ,  Birgit Noiges ,  Stefan Seidel ,  Julia Bacher ,  Christina Satke ,  Wolfgang Schueler ,  Martin Oleksiewicz

    IPC分类号： A61K39/102 ,  C07K16/12 ,  A61K39/40 ,  C07K14/285 ,  A61P31/04 ,  C12N5/10 ,  C12P21/00 ,  C12N5/16 ,  G01N33/569 ,  C12N1/21 ,  C12N1/19 ,  C12N1/15 ,  C12N15/31 ,  C12N15/63

    CPC分类号： C07K14/285 ,  A61K39/00 ,  A61K2039/53

    摘要： The present invention relates to isolated nucleic acid molecules which encode an antigen from a nontypable Haemophilus influenzae (H. influenzae) species, a vector which comprises such nucleic acid molecule, and a host cell comprising such vector. Furthermore, the invention provides antigens from a nontypable Haemophilus influenzae species, as well as fragments and variants thereof, a process for producing such antigens, and a process for producing a cell, which expresses such antigen. More specifically such antigens are produced by or associated with bacterial infections caused by nontypable Haemophilus influenzae. Moreover, the present invention provides antibodies binding to such antigen, a hybridoma cell producing such antibodies, methods for producing such antibodies, a pharmaceutical composition comprising such nucleic acid molecule, antigen, vector or antibody, the use of such nucleic acid molecule, antigen, vector or antibody for the preparation of a pharmaceutical composition, methods for identifying an antagonist capable of binding such antigen or of reducing or inhibiting the interaction activity of such antigen, methods for diagnosing an infection with nontypable Haemophilus influenzae and methods for the treatment or prevention of an infection with nontypable Haemophilus influenzae.

    摘要翻译： 本发明涉及编码来自不可流行的流感嗜血杆菌（流感嗜血杆菌）物种的抗原的分离的核酸分子，包含该核酸分子的载体和包含该载体的宿主细胞。 此外，本发明提供了来自不可渗透的流感嗜血杆菌物种的抗原，以及其片段和变体，产生这种抗原的方法，以及表达这种抗原的细胞的制备方法。 更具体地说，这种抗原由不流行的流感嗜血杆菌引起的细菌感染产生或与其相关。 此外，本发明提供了与这种抗原结合的抗体，产生此类抗体的杂交瘤细胞，产生此类抗体的方法，包含该核酸分子，抗原，载体或抗体的药物组合物，使用此类核酸分子，抗原， 用于制备药物组合物的载体或抗体，用于鉴定能够结合此类抗原的拮抗剂或降低或抑制该抗原的相互作用活性的方法，用于诊断不可流式流感嗜血杆菌感染的方法和用于治疗或预防 感染非典型流感嗜血杆菌。