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1.发明申请COMPOSITION AND METHODS FOR THE PREVENTION AND TREATMENT OF DIET-INDUCED OBESITY 有权用于预防和治疗饮食诱导的肥胖的组合物和方法公开(公告)号：US20160377598A1
公开(公告)日：2016-12-29
申请号：US14697562
申请日：2015-04-27
IPC分类号： G01N33/50 , A61K47/26 , A61K38/46 , C07K16/28 , C12N15/113
CPC分类号： G01N33/5044 , A01K67/0276 , A01K2207/25 , A01K2217/075 , A01K2227/105 , A01K2267/0362 , A61K38/465 , A61K47/26 , C07K16/28 , C07K2317/76 , C12N15/1138 , C12N2310/11 , C12N2310/12 , C12N2310/14 , C12N2310/531 , C12N2320/30 , C12Y301/00
摘要： The invention provides a method for treating or preventing diet-induced obesity in a subject comprising administering an agent in an effective amount so that expression or activity of the P2Y2 receptor is decreased or inhibited in the subject thereby treating or preventing diet-induced obesity in the subject.
摘要翻译： 本发明提供了治疗或预防受试者饮食诱导的肥胖症的方法，其包括施用有效量的药剂，使得受试者的P2Y2受体的表达或活性降低或抑制，从而治疗或预防饮食诱导的肥胖症 学科。
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公开(公告)号：US10024846B2
公开(公告)日：2018-07-17
申请号：US14697562
申请日：2015-04-27
IPC分类号： G01N33/50 , A01K67/027 , C07K16/28 , C12N15/113 , A61K38/46 , A61K47/26
摘要： The invention provides a method for treating or preventing diet-induced obesity in a subject comprising administering an agent in an effective amount so that expression or activity of the P2Y2 receptor is decreased or inhibited in the subject thereby treating or preventing diet-induced obesity in the subject.
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公开(公告)号：US20140377380A1
公开(公告)日：2014-12-25
申请号：US14241720
申请日：2012-08-29
IPC分类号： A61K31/4365 , A61K33/00
CPC分类号： A61K31/4365 , A61K31/519 , A61K31/64 , A61K31/7076 , A61K33/00 , A61K45/06 , A61K2300/00
摘要： Disclosed is a treatment of diabetes insipidus. Methods of treating diabetes insipidus disorders associated with P2Y receptors using the compounds and compositions are also disclosed.
摘要翻译： 披露了治疗尿崩症。 还公开了使用该化合物和组合物治疗与P2Y受体相关的尿崩症的方法。
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公开(公告)号：US09539246B2
公开(公告)日：2017-01-10
申请号：US14241720
申请日：2012-08-29
IPC分类号： A61K33/00 , A61K31/4365 , A61K31/519 , A61K45/06 , A61K31/64 , A61K31/7076
CPC分类号： A61K31/4365 , A61K31/519 , A61K31/64 , A61K31/7076 , A61K33/00 , A61K45/06 , A61K2300/00
摘要： Disclosed is a treatment of diabetes insipidus. Methods of treating diabetes insipidus disorders associated with P2Y receptors using the compounds and compositions are also disclosed.
摘要翻译： 披露了治疗尿崩症。 还公开了使用该化合物和组合物治疗与P2Y受体相关的尿崩症的方法。
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公开(公告)号：US11767294B2
公开(公告)日：2023-09-26
申请号：US16407367
申请日：2019-05-09
发明人： R. Yongxin Zhao , Yue Zhang , Yourang Ma
IPC分类号： C07D207/40 , A61K45/06 , A61K47/64 , A61K47/68
CPC分类号： C07D207/40 , A61K45/06 , A61K47/64 , A61K47/6803 , A61K47/6811 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6863 , A61K47/6867 , Y02A50/30
摘要： A conjugate of a potent cytotoxic agent with a cell-surface receptor binding molecule having a Formula (I), wherein T, L, m, n, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, and R13 are defined herein, can be used for targeted treatment of cancer, autoimmune disease, and infectious disease.
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公开(公告)号：US10920422B2
公开(公告)日：2021-02-16
申请号：US15774951
申请日：2017-09-26
申请人： Yue Zhang
发明人： Yue Zhang
IPC分类号： E04C2/32 , B32B15/04 , B32B3/12 , E04C2/36 , B32B15/00 , B23K1/00 , E04C2/08 , E04C2/34 , B32B3/20 , E04B1/74
摘要： Disclosed are a hollow pipe-sandwiching metal plate and applications thereof. The hollow pipe-sandwiching metal plate comprises a first panel, a second panel, and multiple hollow pipes between the first panel and the second panel; gaps are arranged among the hollow pipes, and the hollow pipes are connected to the first panel and the second panel by brazing. The present disclosure further includes the applications of the hollow pipe-sandwiching metal plate. The hollow pipe-sandwiching metal plate has advantages, such as light weight, high strength, low stress, high temperature resistance, pressure bearing, thermal insulation and vibration isolation. The metal plate will not deform due to thermal difference, thereby providing permanent service life of the metal plate.
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公开(公告)号：US20180328037A1
公开(公告)日：2018-11-15
申请号：US15774951
申请日：2017-09-26
申请人： Yue ZHANG
发明人： Yue Zhang
CPC分类号： E04C2/32 , B32B3/12 , B32B15/00 , B32B15/043 , E04B2001/748 , E04C2/30 , E04C2/365
摘要： Disclosed are a hollow pipe-sandwiching metal plate and applications thereof. The hollow pipe-sandwiching metal plate comprises a first panel, a second panel, and multiple hollow pipes between the first panel and the second panel; gaps are arranged among the hollow pipes, and the hollow pipes are connected to the first panel and the second panel by brazing. The present disclosure further includes the applications of the hollow pipe-sandwiching metal plate. The hollow pipe-sandwiching metal plate has advantages, such as light weight, high strength, low stress, high temperature resistance, pressure bearing, thermal insulation and vibration isolation. The metal plate will not deform due to thermal difference, thereby providing permanent service life of the metal plate.
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公开(公告)号：US09632098B2
公开(公告)日：2017-04-25
申请号：US13878230
申请日：2011-10-08
申请人： Xiaofeng Zeng , Yue Zhang , Zhinan Shou , Hua Mao , Hongbin Sun , Jie Qian , Yongjun Han , Weina Situ
发明人： Xiaofeng Zeng , Yue Zhang , Zhinan Shou , Hua Mao , Hongbin Sun , Jie Qian , Yongjun Han , Weina Situ
IPC分类号： G01N33/68 , C07K14/705 , C07K14/52 , C07K16/18 , G01N33/564 , A61K38/19
CPC分类号： G01N33/6893 , A61K38/19 , C07K14/52 , C07K14/705 , C07K16/18 , G01N33/564 , G01N33/6854 , G01N2800/52
摘要： The present application provides compositions and methods useful for detecting and monitoring autoimmune diseases in a human subject. The methods comprise providing a moesin fragment for binding to an anti-moesin autoantibody and contacting the moesin fragment with a sample obtained from the human subject. The moesin fragment comprises the entire N-terminal FERM domain of a human moesin protein. The human subject has or is suspected of having an autoimmune disease such as connective tissue disease, systemic sclerosis, Sjogren's syndrome, or systemic lupus erythematosus.
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公开(公告)号：US20170023554A1
公开(公告)日：2017-01-26
申请号：US15125896
申请日：2015-03-13
申请人： David G. Whitten , Harry Pappas , Eric H. Hill , Yue Zhang , Eva Yung Hua Chi , Arjun Thapa , Ying wang , Patrick L. Donabedian , Kiran Bhaskar
发明人： David G. Whitten , Harry Pappas , Eric H. Hill , Yue Zhang , Eva Yung Hua Chi , Arjun Thapa , Ying wang , Patrick L. Donabedian , Kiran Bhaskar
摘要： Various embodiments relate to p-phenylene ethynylene compounds as bioactive and detection agents. In various embodiments, the present invention provides a method of inducing germination of microbial spores including contacting the microbial spores with a p-phenylene ethynylene compound. In various embodiments, the present invention provides a method for detecting an enzyme, a method of protein analysis, or a method of detecting a chemical agent, including introducing a p-phenylene ethylylene compound to a composition including an enzyme substrate, and analyzing the fluorescence of the p-phenylene ethynylene compound. Various embodiments provide sensors that include a p-phenylene ethynylene compound and an enzyme substrate.
摘要翻译： 各种实施方案涉及作为生物活性和检测剂的对亚苯基亚乙炔化合物。 在各种实施方案中，本发明提供诱导微生物孢子发芽的方法，包括使微生物孢子与对亚苯基亚乙炔基化合物接触。 在各种实施方案中，本发明提供了检测酶的方法，蛋白质分析方法或检测化学试剂的方法，包括将对亚苯基亚乙烯基化合物引入到包含酶底物的组合物中，并分析荧光 的对亚苯基亚乙炔基化合物。 各种实施方案提供包括对亚苯基亚乙炔化合物和酶底物的传感器。
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10.发明授权Glycyrrhetinic acid-mediated nanoparticles of hepatic targeted drug delivery system, process for preparing the same and use thereof 有权甘草次酸介导的肝靶向药物递送系统的纳米颗粒，其制备方法及其用途公开(公告)号：US09173852B2
公开(公告)日：2015-11-03
申请号：US12338966
申请日：2008-12-18
申请人： Zhi Yuan , Wei Huang , Qin Tian , Chuangnian Zhang , Liang Han , Tong Liu , Yue Zhang , Yue Chen
发明人： Zhi Yuan , Wei Huang , Qin Tian , Chuangnian Zhang , Liang Han , Tong Liu , Yue Zhang , Yue Chen
CPC分类号： A61K9/5146 , A61K9/5161 , A61K9/5192 , A61K47/593 , A61K47/60 , A61K47/61 , A61K47/645 , A61K47/6935 , Y10S977/773 , Y10S977/906
摘要： Disclosed are a hepatic targeted drug delivery system and a process for preparing the same. Also disclosed is a method for treating liver cancer.
摘要翻译： 公开了肝靶向药物递送系统及其制备方法。 还公开了一种治疗肝癌的方法。
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