公开(公告)号：US07022284B2

公开(公告)日：2006-04-04

申请号：US10434887

申请日：2003-05-09

申请人： Ben F. Brian ,  John Thomas Buckley ,  Jean-Pierre Dueri ,  Mehrdad Farhangnia ,  Steven K. Stringer

发明人： Ben F. Brian ,  John Thomas Buckley ,  Jean-Pierre Dueri ,  Mehrdad Farhangnia ,  Steven K. Stringer

IPC分类号： A61M1/34 ,  A61M1/36 ,  A61M37/00

CPC分类号： A61M1/1698 ,  A61M1/262 ,  A61M1/267 ,  A61M2205/502 ,  A61M2205/505 ,  A61M2209/084 ,  B01D19/0031 ,  Y10S128/03 ,  Y10S261/28

摘要： Apparatus for oxygenating and pumping blood includes a housing defining a blood flow path including, in series, a gas collection plenum, a pump space and a blood oxygenation element. A pump disposed in the pump space is configured to draw blood from the gas collection plenum and propel blood from the pump space through a heat exchanger and the blood oxygenation element. The heat exchanger includes a heat exchange plate and a coolant space.

公开(公告)号：US06960322B2

公开(公告)日：2005-11-01

申请号：US10616116

申请日：2003-07-08

申请人： Steven K. Stringer ,  Kevin L. Hultquist ,  Mehrdad Farhangnia ,  Ben F. Brian, III ,  Fred I. Linker ,  James M. Culp ,  Jean-Pierre Dueri ,  Thomas A. Afzal

发明人： Steven K. Stringer ,  Kevin L. Hultquist ,  Mehrdad Farhangnia ,  Ben F. Brian, III ,  Fred I. Linker ,  James M. Culp ,  Jean-Pierre Dueri ,  Thomas A. Afzal

IPC分类号： A61M1/14 ,  A61M1/10 ,  A61M1/36 ,  A61M37/00 ,  B01D47/08 ,  B01D53/22 ,  C02F1/44

CPC分类号： A61M1/3626 ,  A61M1/1006 ,  A61M1/101 ,  A61M1/1013 ,  A61M1/1025 ,  A61M1/262 ,  A61M1/267 ,  A61M1/3606 ,  A61M1/3627 ,  A61M1/3666 ,  Y10S261/28

摘要： Apparatus and methods for pumping and oxygenating blood are provided that include a gas removal system. An integrated blood processing unit is provided in which a gas removal/blood filter, pump and blood oxygenation element are mounted within a common housing. The gas removal system includes a sensor mounted on the housing to sense the presence of gas, and a valve is operably coupled to the sensor to evacuate gas from the system when the sensor detects an accumulation of gas.

摘要翻译： 提供了用于泵送和充氧血液的装置和方法，其包括气体去除系统。 提供了一种集成血液处理单元，其中气体去除/血液过滤器，泵和血氧元件安装在公共壳体内。 气体去除系统包括安装在壳体上以感测气体存在的传感器，并且当传感器检测到气体积聚时，阀可操作地耦合到传感器以从系统排出气体。

公开(公告)号：US07541000B2

公开(公告)日：2009-06-02

申请号：US11236269

申请日：2005-09-26

申请人： Steven K. Stringer ,  Kevin L. Hultquist ,  Mehrdad Farhangnia ,  Ben F. Brian, III ,  Fred I. Linker ,  James M. Culp ,  Jean-Pierre Dueri ,  Thomas A. Afzal

发明人： Steven K. Stringer ,  Kevin L. Hultquist ,  Mehrdad Farhangnia ,  Ben F. Brian, III ,  Fred I. Linker ,  James M. Culp ,  Jean-Pierre Dueri ,  Thomas A. Afzal

IPC分类号： A61M1/14 ,  A61M37/00 ,  C02F1/44 ,  B01D53/22 ,  B01D47/08

CPC分类号： A61M1/3626 ,  A61M1/1006 ,  A61M1/101 ,  A61M1/1013 ,  A61M1/1025 ,  A61M1/262 ,  A61M1/267 ,  A61M1/3606 ,  A61M1/3627 ,  A61M1/3666 ,  Y10S261/28

摘要： Apparatus and methods for pumping and oxygenating blood are provided that include a gas removal system. An integrated blood processing unit is provided in which a gas removal/blood filter, pump and blood oxygenation element are mounted within a common housing. The gas removal system includes a sensor mounted on the housing to sense the presence of gas, and a valve is operably coupled to the sensor to evacuate gas from the system when the sensor detects an accumulation of gas.

摘要翻译： 提供了用于泵送和充氧血液的装置和方法，其包括气体去除系统。 提供了一种集成血液处理单元，其中气体去除/血液过滤器，泵和血氧元件安装在公共壳体内。 气体去除系统包括安装在壳体上以感测气体存在的传感器，并且当传感器检测到气体积聚时，阀可操作地耦合到传感器以从系统排出气体。

公开(公告)号：US06730267B2

公开(公告)日：2004-05-04

申请号：US09780923

申请日：2001-02-09

申请人： Steven K. Stringer ,  Kevin L. Hultquist ,  Mehrdad Farhangnia ,  Ben F. Brian, III ,  Fred I. Linker ,  James M. Culp ,  Jean-Pierre Dueri ,  Thomas A. Afzal

发明人： Steven K. Stringer ,  Kevin L. Hultquist ,  Mehrdad Farhangnia ,  Ben F. Brian, III ,  Fred I. Linker ,  James M. Culp ,  Jean-Pierre Dueri ,  Thomas A. Afzal

IPC分类号： A61M114

CPC分类号： A61M1/3626 ,  A61M1/1006 ,  A61M1/101 ,  A61M1/1013 ,  A61M1/1025 ,  A61M1/262 ,  A61M1/267 ,  A61M1/3606 ,  A61M1/3627 ,  A61M1/3666 ,  Y10S261/28

摘要： Apparatus and methods for pumping and oxygenating blood are provided that include a gas removal system. An integrated blood processing unit is provided in which a gas removal/blood filter, pump and blood oxygenation element are mounted within a common housing. The gas removal system includes a sensor mounted on the housing to sense the presence of gas, and a valve is operably coupled to the sensor to evacuate gas from the system when the sensor detects an accumulation of gas.

公开(公告)号：US07022099B2

公开(公告)日：2006-04-04

申请号：US10392441

申请日：2003-03-17

申请人： A. Kenneth Litzie ,  Steven K. Stringer ,  Mehrdad Farhangnia ,  Muslim Tyebjee ,  Thomas A. Afzal ,  Ben F. Brian, III

发明人： A. Kenneth Litzie ,  Steven K. Stringer ,  Mehrdad Farhangnia ,  Muslim Tyebjee ,  Thomas A. Afzal ,  Ben F. Brian, III

IPC分类号： A61M37/00 ,  A61M1/14 ,  A61M1/34 ,  B01D35/16 ,  B01D24/00

CPC分类号： A61M1/3629 ,  A61M1/1006 ,  A61M1/101 ,  A61M1/1029 ,  A61M1/1086 ,  A61M2027/004 ,  A61M2205/33 ,  A61M2205/3303 ,  A61M2205/3334 ,  Y10S128/03

摘要： Apparatus for processing blood in an extracorporeal circuit with automatic flow control is provided in which error conditions are sensed and system operation is modulated responsive to the error conditions. The apparatus includes an extracorporeal blood processing system, at least one sensor that senses the presence or absence of gas or monitors venous pressure, and a controller operably coupled to the blood processing system to selectively reduce pump speed or to reconfigure flow paths within the blood processing system responsive to the sensor output.

公开(公告)号：US06773670B2

公开(公告)日：2004-08-10

申请号：US10067434

申请日：2002-02-05

申请人： Steven K. Stringer ,  Kevin L. Hultquist ,  Mehrdad Farhangnia ,  Fred I. Linker ,  Ben F. Brian, III

发明人： Steven K. Stringer ,  Kevin L. Hultquist ,  Mehrdad Farhangnia ,  Fred I. Linker ,  Ben F. Brian, III

IPC分类号： A61M136

CPC分类号： A61M1/3626 ,  A61M1/1006 ,  A61M1/101 ,  A61M1/262 ,  A61M1/267 ,  A61M1/3606 ,  A61M1/3627 ,  A61M1/3643 ,  A61M1/3644 ,  A61M1/3666 ,  Y10S128/03 ,  Y10S261/28 ,  Y10S417/902

摘要： Apparatus and methods for removing gas from a blood handling system. A filter apparatus for monitoring and removing gas is provided comprising of a gas removal/blood filter, a sensor to sense the presence of gas, and a valve operably coupled to the sensor to evacuate gas from the apparatus when the sensor detects an accumulation of gas. When used with a previously known blood handling system, the present filter apparatus facilitates priming and the addition of additional blood handling elements during operation of the blood handling system.

摘要翻译： 从血液处理系统中除去气体的装置和方法。 提供了一种用于监测和去除气体的过滤装置，其包括气体去除/血液过滤器，用于感测气体存在的传感器，以及可操作地耦合到传感器的阀，当传感器检测到气体的积聚时，从装置排出气体 。 当与先前已知的血液处理系统一起使用时，本过滤装置有利于在血液处理系统的操作期间起动和添加额外的血液处理元件。

公开(公告)号：US20060177343A1

公开(公告)日：2006-08-10

申请号：US11397423

申请日：2006-04-03

申请人： Ben Brian ,  John Buckley ,  Jean-Pierre Dueri ,  Mehrdad Farhangnia ,  Steven Stringer

发明人： Ben Brian ,  John Buckley ,  Jean-Pierre Dueri ,  Mehrdad Farhangnia ,  Steven Stringer

IPC分类号： A61M1/36

CPC分类号： A61M1/1698 ,  A61M1/262 ,  A61M1/267 ,  A61M2205/502 ,  A61M2205/505 ,  A61M2209/084 ,  B01D19/0031 ,  Y10S128/03 ,  Y10S261/28

摘要： Apparatus for oxygenating and pumping blood includes a housing defining a blood flow path including, in series, a gas collection plenum, a pump space and a blood oxygenation element. A pump disposed in the pump space is configured to draw blood from the gas collection plenum and propel blood from the pump space through a heat exchanger and the blood oxygenation element. The heat exchanger includes a heat exchange plate and a coolant space.

摘要翻译： 用于对血液进行充氧和抽血的装置包括限定血流路径的壳体，其包括串联的气体收集气室，泵空间和血氧元件。 设置在泵空间中的泵构造成从气体收集室抽取血液，并且通过热交换器和血氧元件推动来自泵空间的血液。 热交换器包括热交换板和冷却剂空间。

公开(公告)号：US20060029515A1

公开(公告)日：2006-02-09

申请号：US11236269

申请日：2005-09-26

申请人： Steven Stringer ,  Kevin Hultquist ,  Mehrdad Farhangnia ,  Ben Brian ,  Fred Linker ,  James Culp ,  Jean-Pierre Dueri ,  Thomas Afzal

发明人： Steven Stringer ,  Kevin Hultquist ,  Mehrdad Farhangnia ,  Ben Brian ,  Fred Linker ,  James Culp ,  Jean-Pierre Dueri ,  Thomas Afzal

IPC分类号： A61M1/14

CPC分类号： A61M1/3626 ,  A61M1/1006 ,  A61M1/101 ,  A61M1/1013 ,  A61M1/1025 ,  A61M1/262 ,  A61M1/267 ,  A61M1/3606 ,  A61M1/3627 ,  A61M1/3666 ,  Y10S261/28

摘要： Apparatus and methods for pumping and oxygenating blood are provided that include a gas removal system. An integrated blood processing unit is provided in which a gas removal/blood filter, pump and blood oxygenation element are mounted within a common housing. The gas removal system includes a sensor mounted on the housing to sense the presence of gas, and a valve is operably coupled to the sensor to evacuate gas from the system when the sensor detects an accumulation of gas.

摘要翻译： 提供用于泵送和充氧血液的装置和方法，其包括气体去除系统。 提供了一种集成血液处理单元，其中气体去除/血液过滤器，泵和血氧元件安装在公共壳体内。 气体去除系统包括安装在壳体上以感测气体存在的传感器，并且当传感器检测到气体积聚时，阀可操作地耦合到传感器以从系统排出气体。

公开(公告)号：US20130253474A1

公开(公告)日：2013-09-26

申请号：US13842744

申请日：2013-03-15

申请人： Mehrdad Farhangnia ,  Mark C. Yang ,  Mark Taber

发明人： Mehrdad Farhangnia ,  Mark C. Yang ,  Mark Taber

IPC分类号： A61M25/09

CPC分类号： A61M25/09 ,  A61M25/0026 ,  A61M25/0068 ,  A61M25/0071 ,  A61M25/0074 ,  A61M25/008 ,  A61M25/01 ,  A61M25/04 ,  A61M25/1002 ,  A61M25/1011 ,  A61M2025/0046 ,  A61M2025/0681 ,  A61M2025/1045

摘要： The invention provides for methods and catheter apparatus for passing one or more guidewires (via the use of one or more telescoping guidewire lumens) through a chronic total occlusion of a vasculature. The catheter apparatus may include: a catheter shaft having a distal end; one or more telescoping guidewire lumen catheters passing longitudinally through the shaft, wherein the one or more guidewire lumen catheters are capable of telescoping beyond the distal end of the catheter shaft; an expansible distal portion of the shaft; and a retractable sheath covering at least a portion of the expansible distal portion of the shaft, wherein retracting the retractable sheath from the expansible distal portion of the shaft directly activates the expansible distal portion of the shaft causing expansion of the expansible distal portion of the shaft.

公开(公告)号：US20120330336A1

公开(公告)日：2012-12-27

申请号：US13536497

申请日：2012-06-28

申请人： John B. Simpson ,  Himanshu Patel ,  Greg Stine ,  Brett Follmer ,  Michael H. Rosenthal ,  Mehrdad Farhangnia

发明人： John B. Simpson ,  Himanshu Patel ,  Greg Stine ,  Brett Follmer ,  Michael H. Rosenthal ,  Mehrdad Farhangnia

IPC分类号： A61B17/22

CPC分类号： A61B17/320758 ,  A61B10/04 ,  A61B17/32075 ,  A61B17/320783 ,  A61B2010/0225 ,  A61B2017/00685 ,  A61B2017/320032 ,  A61B2017/320791

摘要： A method of removing material from a blood flow lumen includes providing a device having a cutting element and an opening, the cutting element being movable relative to the opening. The method then includes advancing the device through a patient's vascular system to the blood flow lumen. Finally, the method involves moving the cutting element and the opening relative to the blood flow lumen so that a continuous piece of material is severed by the cutting element and directed into the opening as the cutting element and opening move through the blood flow lumen, the continuous piece of severed material being directed into the device for removal from the patient. The method may include providing a device having a rotatable cutter that, in some embodiments, is not parallel to the longitudinal axis of the device, is movable, has retracted and deployed positions, or any combination thereof.

摘要翻译： 从血流腔去除材料的方法包括提供具有切割元件和开口的装置，所述切割元件可相对于所述开口移动。 该方法然后包括将装置通过患者的血管系统推进到血流腔。 最后，该方法包括相对于血液流动腔移动切割元件和开口，使得当切割元件和开口移动通过血流腔时，连续片材被切割元件切断并引导到开口中， 连续切断的材料被引导到装置中以从患者身上取出。 该方法可以包括提供具有可旋转切割器的装置，其在一些实施例中不平行于装置的纵向轴线，是可移动的，具有缩回和展开位置或其任何组合。