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公开(公告)号：US07022099B2
公开(公告)日：2006-04-04
申请号：US10392441
申请日：2003-03-17
申请人： A. Kenneth Litzie , Steven K. Stringer , Mehrdad Farhangnia , Muslim Tyebjee , Thomas A. Afzal , Ben F. Brian, III
发明人： A. Kenneth Litzie , Steven K. Stringer , Mehrdad Farhangnia , Muslim Tyebjee , Thomas A. Afzal , Ben F. Brian, III
CPC分类号： A61M1/3629 , A61M1/1006 , A61M1/101 , A61M1/1029 , A61M1/1086 , A61M2027/004 , A61M2205/33 , A61M2205/3303 , A61M2205/3334 , Y10S128/03
摘要： Apparatus for processing blood in an extracorporeal circuit with automatic flow control is provided in which error conditions are sensed and system operation is modulated responsive to the error conditions. The apparatus includes an extracorporeal blood processing system, at least one sensor that senses the presence or absence of gas or monitors venous pressure, and a controller operably coupled to the blood processing system to selectively reduce pump speed or to reconfigure flow paths within the blood processing system responsive to the sensor output.
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2.发明授权Integrated blood handling system having active gas removal system and methods of use 失效具有活性气体去除系统和使用方法的综合血液处理系统公开(公告)号：US06960322B2
公开(公告)日：2005-11-01
申请号：US10616116
申请日：2003-07-08
申请人： Steven K. Stringer , Kevin L. Hultquist , Mehrdad Farhangnia , Ben F. Brian, III , Fred I. Linker , James M. Culp , Jean-Pierre Dueri , Thomas A. Afzal
发明人： Steven K. Stringer , Kevin L. Hultquist , Mehrdad Farhangnia , Ben F. Brian, III , Fred I. Linker , James M. Culp , Jean-Pierre Dueri , Thomas A. Afzal
CPC分类号： A61M1/3626 , A61M1/1006 , A61M1/101 , A61M1/1013 , A61M1/1025 , A61M1/262 , A61M1/267 , A61M1/3606 , A61M1/3627 , A61M1/3666 , Y10S261/28
摘要： Apparatus and methods for pumping and oxygenating blood are provided that include a gas removal system. An integrated blood processing unit is provided in which a gas removal/blood filter, pump and blood oxygenation element are mounted within a common housing. The gas removal system includes a sensor mounted on the housing to sense the presence of gas, and a valve is operably coupled to the sensor to evacuate gas from the system when the sensor detects an accumulation of gas.
摘要翻译： 提供了用于泵送和充氧血液的装置和方法，其包括气体去除系统。 提供了一种集成血液处理单元，其中气体去除/血液过滤器，泵和血氧元件安装在公共壳体内。 气体去除系统包括安装在壳体上以感测气体存在的传感器，并且当传感器检测到气体积聚时，阀可操作地耦合到传感器以从系统排出气体。
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公开(公告)号：US07541000B2
公开(公告)日：2009-06-02
申请号：US11236269
申请日：2005-09-26
申请人： Steven K. Stringer , Kevin L. Hultquist , Mehrdad Farhangnia , Ben F. Brian, III , Fred I. Linker , James M. Culp , Jean-Pierre Dueri , Thomas A. Afzal
发明人： Steven K. Stringer , Kevin L. Hultquist , Mehrdad Farhangnia , Ben F. Brian, III , Fred I. Linker , James M. Culp , Jean-Pierre Dueri , Thomas A. Afzal
CPC分类号： A61M1/3626 , A61M1/1006 , A61M1/101 , A61M1/1013 , A61M1/1025 , A61M1/262 , A61M1/267 , A61M1/3606 , A61M1/3627 , A61M1/3666 , Y10S261/28
摘要： Apparatus and methods for pumping and oxygenating blood are provided that include a gas removal system. An integrated blood processing unit is provided in which a gas removal/blood filter, pump and blood oxygenation element are mounted within a common housing. The gas removal system includes a sensor mounted on the housing to sense the presence of gas, and a valve is operably coupled to the sensor to evacuate gas from the system when the sensor detects an accumulation of gas.
摘要翻译： 提供了用于泵送和充氧血液的装置和方法，其包括气体去除系统。 提供了一种集成血液处理单元，其中气体去除/血液过滤器，泵和血氧元件安装在公共壳体内。 气体去除系统包括安装在壳体上以感测气体存在的传感器，并且当传感器检测到气体积聚时，阀可操作地耦合到传感器以从系统排出气体。
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公开(公告)号：US06730267B2
公开(公告)日：2004-05-04
申请号：US09780923
申请日：2001-02-09
申请人： Steven K. Stringer , Kevin L. Hultquist , Mehrdad Farhangnia , Ben F. Brian, III , Fred I. Linker , James M. Culp , Jean-Pierre Dueri , Thomas A. Afzal
发明人： Steven K. Stringer , Kevin L. Hultquist , Mehrdad Farhangnia , Ben F. Brian, III , Fred I. Linker , James M. Culp , Jean-Pierre Dueri , Thomas A. Afzal
IPC分类号： A61M114
CPC分类号： A61M1/3626 , A61M1/1006 , A61M1/101 , A61M1/1013 , A61M1/1025 , A61M1/262 , A61M1/267 , A61M1/3606 , A61M1/3627 , A61M1/3666 , Y10S261/28
摘要： Apparatus and methods for pumping and oxygenating blood are provided that include a gas removal system. An integrated blood processing unit is provided in which a gas removal/blood filter, pump and blood oxygenation element are mounted within a common housing. The gas removal system includes a sensor mounted on the housing to sense the presence of gas, and a valve is operably coupled to the sensor to evacuate gas from the system when the sensor detects an accumulation of gas.
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5.发明授权Integrated blood oxygenator and pump system having means for reducing microbubble generation 失效具有减少微泡产生的手段的集成式血液充氧器和泵系统公开(公告)号：US06379618B1
公开(公告)日：2002-04-30
申请号：US09223676
申请日：1998-12-30
IPC分类号： A61M114
CPC分类号： F28F21/062 , A61M1/1006 , A61M1/101 , A61M1/1013 , A61M1/1025 , A61M1/1036 , A61M1/1625 , A61M1/1629 , A61M1/1698 , A61M1/262 , A61M1/267 , A61M2205/366
摘要： Improvements to integrated blood pump/oxygenator having a rotating hollow fiber bundle assembly that both oxygenates and pumps blood are provided. A plurality of vanes arranged along a central shaft of the device increase pressure near the center of the fiber bundle to prevent microbubble generation and blood trauma. Shearing loads imposed on the fiber elements of the fiber bundle are reduced by the addition of a reinforcement structure, while the gas flow path is configured to minimize flooding and loss of oxygenation efficiency due to occasional rupture of fiber elements. Blood trauma may be further reduced by contouring the vanes and other components of the device.
摘要翻译： 具有提供含氧化合物和泵血液的旋转中空纤维束组件的集成血液泵/充氧器的改进。 沿着装置的中心轴布置的多个叶片增加了纤维束中心附近的压力，以防止微泡产生和血液创伤。 施加在纤维束的纤维元件上的剪切载荷通过添加加强结构而减少，而气体流动路径被配置为最小化由于纤维元件的偶尔破裂引起的淹没和氧合效率的损失。 通过对设备的叶片和其它部件进行轮廓化可以进一步减少血液创伤。
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公开(公告)号：US08998989B2
公开(公告)日：2015-04-07
申请号：US13563303
申请日：2012-07-31
申请人： Daniel H. Kim , Thomas A. Afzal , Michael L. Reo , Uriel Hiram Chee , In Haeng Cho , Kunwoo Lee , Curtis W. Frank , Sun-Kyu Ha
发明人： Daniel H. Kim , Thomas A. Afzal , Michael L. Reo , Uriel Hiram Chee , In Haeng Cho , Kunwoo Lee , Curtis W. Frank , Sun-Kyu Ha
CPC分类号： A61F2/4425 , A61B17/86 , A61F2/30742 , A61F2/30767 , A61F2/30965 , A61F2/442 , A61F2/4611 , A61F2002/30069 , A61F2002/30133 , A61F2002/30383 , A61F2002/30462 , A61F2002/305 , A61F2002/3052 , A61F2002/30523 , A61F2002/30563 , A61F2002/30566 , A61F2002/30578 , A61F2002/30596 , A61F2002/30604 , A61F2002/30733 , A61F2002/30841 , A61F2002/30884 , A61F2002/30904 , A61F2002/448 , A61F2002/4495 , A61F2002/4622 , A61F2002/4627 , A61F2002/4628 , A61F2220/0025 , A61F2220/0075 , A61F2230/0015 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00161 , A61F2310/00179 , A61L2430/38
摘要： Prosthetic intervertebral discs and methods for using the same are described. The subject prosthetic discs include upper and lower endplates separated by a compressible core member. The prosthetic discs described herein include one-piece, two-piece, three-piece, and four-piece structures. The subject prosthetic discs exhibit stiffness in the vertical direction, torsional stiffness, bending stiffness in the sagittal plane, and bending stiffness in the front plane, where the degree of these features can be controlled independently by adjusting the components of the discs. The interface mechanism between the endplates and the core members of several embodiments of the described prosthetic discs enables a very easy surgical operation for implantation.
摘要翻译： 描述了假体椎间盘及其使用方法。 主体假体盘包括由可压缩的芯构件分开的上端板和下端板。 本文所述的假体盘包括一件式，两件式，三件式和四件式结构。 主体假体椎板在垂直方向上呈现刚度，扭转刚度，矢状平面中的弯曲刚度和前平面中的弯曲刚度，其中可以通过调节椎间盘的部件来独立地控制这些特征的程度。 所描述的假体盘的几个实施例的端板和芯构件之间的界面机构能够实现非常容易的用于植入的外科手术。
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公开(公告)号：US20120296431A1
公开(公告)日：2012-11-22
申请号：US13563303
申请日：2012-07-31
申请人： Daniel H. Kim , Thomas A. Afzal , Michael L. Reo , Uriel Hiram Chee , In Haeng Cho , Kunwoo Lee , Curtis W. Frank , Sun-Kyu Ha
发明人： Daniel H. Kim , Thomas A. Afzal , Michael L. Reo , Uriel Hiram Chee , In Haeng Cho , Kunwoo Lee , Curtis W. Frank , Sun-Kyu Ha
IPC分类号： A61F2/44
CPC分类号： A61F2/4425 , A61B17/86 , A61F2/30742 , A61F2/30767 , A61F2/30965 , A61F2/442 , A61F2/4611 , A61F2002/30069 , A61F2002/30133 , A61F2002/30383 , A61F2002/30462 , A61F2002/305 , A61F2002/3052 , A61F2002/30523 , A61F2002/30563 , A61F2002/30566 , A61F2002/30578 , A61F2002/30596 , A61F2002/30604 , A61F2002/30733 , A61F2002/30841 , A61F2002/30884 , A61F2002/30904 , A61F2002/448 , A61F2002/4495 , A61F2002/4622 , A61F2002/4627 , A61F2002/4628 , A61F2220/0025 , A61F2220/0075 , A61F2230/0015 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00161 , A61F2310/00179 , A61L2430/38
摘要： Prosthetic intervertebral discs and methods for using the same are described. The subject prosthetic discs include upper and lower endplates separated by a compressible core member. The prosthetic discs described herein include one-piece, two-piece, three-piece, and four-piece structures. The subject prosthetic discs exhibit stiffness in the vertical direction, torsional stiffness, bending stiffness in the sagittal plane, and bending stiffness in the front plane, where the degree of these features can be controlled independently by adjusting the components of the discs. The interface mechanism between the endplates and the core members of several embodiments of the described prosthetic discs enables a very easy surgical operation for implantation.
摘要翻译： 描述了假体椎间盘及其使用方法。 主体假体盘包括由可压缩的芯构件分开的上端板和下端板。 本文所述的假体盘包括一件式，两件式，三件式和四件式结构。 主体假体椎板在垂直方向上呈现刚度，扭转刚度，矢状平面中的弯曲刚度和前平面中的弯曲刚度，其中可以通过调节椎间盘的部件来独立地控制这些特征的程度。 所描述的假体盘的几个实施例的端板和芯构件之间的界面机构能够实现非常容易的用于植入的外科手术。
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公开(公告)号：US20080172129A1
公开(公告)日：2008-07-17
申请号：US11968186
申请日：2008-01-01
申请人： Daniel H. Kim , Thomas A. Afzal , Michael L. Reo , Uriel Hiram Chee , In Haeng Cho , Kunwoo Lee , Curtis W. Frank , Sung Kyu Ha
发明人： Daniel H. Kim , Thomas A. Afzal , Michael L. Reo , Uriel Hiram Chee , In Haeng Cho , Kunwoo Lee , Curtis W. Frank , Sung Kyu Ha
CPC分类号： A61F2/4425 , A61B17/86 , A61F2/30742 , A61F2/30767 , A61F2/30965 , A61F2/442 , A61F2/4611 , A61F2002/30069 , A61F2002/30133 , A61F2002/30383 , A61F2002/30462 , A61F2002/305 , A61F2002/3052 , A61F2002/30523 , A61F2002/30563 , A61F2002/30566 , A61F2002/30578 , A61F2002/30596 , A61F2002/30604 , A61F2002/30733 , A61F2002/30841 , A61F2002/30884 , A61F2002/30904 , A61F2002/448 , A61F2002/4495 , A61F2002/4622 , A61F2002/4627 , A61F2002/4628 , A61F2220/0025 , A61F2220/0075 , A61F2230/0015 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00161 , A61F2310/00179 , A61L2430/38
摘要： Prosthetic intervertebral discs and methods for using the same are described. The subject prosthetic discs include upper and lower endplates separated by a compressible core member. The prosthetic discs described herein include one-piece, two-piece, three-piece, and four-piece structures. The subject prosthetic discs exhibit stiffness in the vertical direction, torsional stiffness, bending stiffness in the saggital plane, and bending stiffness in the front plane, where the degree of these features can be controlled independently by adjusting the components of the discs. The interface mechanism between the endplates and the core members of several embodiments of the described prosthetic discs enables a very easy surgical operation for implantation.
摘要翻译： 描述了假体椎间盘及其使用方法。 主体假体盘包括由可压缩的芯构件分开的上端板和下端板。 本文所述的假体盘包括一件式，两件式，三件式和四件式结构。 主体假体椎板在垂直方向上呈现刚度，扭转刚度，屈曲平面中的弯曲刚度和前平面中的弯曲刚度，其中可以通过调节椎间盘的部件来独立地控制这些特征的程度。 所描述的假体盘的几个实施例的端板和芯构件之间的界面机构能够实现非常容易的用于植入的外科手术。
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公开(公告)号：US09364337B2
公开(公告)日：2016-06-14
申请号：US13414535
申请日：2012-03-07
申请人： Daniel H. Kim , Thomas A. Afzal , Michael L. Reo , Uriel Hiram Chee , In Haeng Cho , Kunwoo Lee , Curtis W. Frank , Sung Kyu Ha
发明人： Daniel H. Kim , Thomas A. Afzal , Michael L. Reo , Uriel Hiram Chee , In Haeng Cho , Kunwoo Lee , Curtis W. Frank , Sung Kyu Ha
CPC分类号： A61F2/4425 , A61B17/86 , A61F2/30742 , A61F2/30767 , A61F2/30965 , A61F2/442 , A61F2/4611 , A61F2002/30069 , A61F2002/30133 , A61F2002/30383 , A61F2002/30462 , A61F2002/305 , A61F2002/3052 , A61F2002/30523 , A61F2002/30563 , A61F2002/30566 , A61F2002/30578 , A61F2002/30596 , A61F2002/30604 , A61F2002/30733 , A61F2002/30841 , A61F2002/30884 , A61F2002/30904 , A61F2002/448 , A61F2002/4495 , A61F2002/4622 , A61F2002/4627 , A61F2002/4628 , A61F2220/0025 , A61F2220/0075 , A61F2230/0015 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00161 , A61F2310/00179 , A61L2430/38
摘要： Prosthetic intervertebral discs and methods for using the same are described. The subject prosthetic discs include upper and lower endplates separated by a compressible core member. The prosthetic discs described herein include one-piece, two-piece, three-piece, and four-piece structures. The subject prosthetic discs exhibit stiffness in the vertical direction, torsional stiffness, bending stiffness in the saggital plane, and bending stiffness in the front plane, where the degree of these features can be controlled independently by adjusting the components of the discs. The interface mechanism between the endplates and the core members of several embodiments of the described prosthetic discs enables a very easy surgical operation for implantation.
摘要翻译： 描述了假体椎间盘及其使用方法。 主体假体盘包括由可压缩的芯构件分开的上端板和下端板。 本文所述的假体盘包括一件式，两件式，三件式和四件式结构。 主体假体椎板在垂直方向上呈现刚度，扭转刚度，屈曲平面中的弯曲刚度和前平面中的弯曲刚度，其中可以通过调节椎间盘的部件来独立地控制这些特征的程度。 所描述的假体盘的几个实施例的端板和芯构件之间的界面机构能够实现非常容易的用于植入的外科手术。
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公开(公告)号：US07905921B2
公开(公告)日：2011-03-15
申请号：US10903276
申请日：2004-07-30
申请人： Daniel H. Kim , Thomas A. Afzal , Michael L. Reo , Uriel Hiram Chee , In Haeng Cho , Kunwoo Lee , Curtis W. Frank , Sung Kyu Ha
发明人： Daniel H. Kim , Thomas A. Afzal , Michael L. Reo , Uriel Hiram Chee , In Haeng Cho , Kunwoo Lee , Curtis W. Frank , Sung Kyu Ha
IPC分类号： A61F2/44
CPC分类号： A61F2/4425 , A61B17/86 , A61F2/30742 , A61F2/30767 , A61F2/30965 , A61F2/442 , A61F2/4611 , A61F2002/30069 , A61F2002/30133 , A61F2002/30383 , A61F2002/30462 , A61F2002/305 , A61F2002/3052 , A61F2002/30523 , A61F2002/30563 , A61F2002/30566 , A61F2002/30578 , A61F2002/30596 , A61F2002/30604 , A61F2002/30733 , A61F2002/30841 , A61F2002/30884 , A61F2002/30904 , A61F2002/448 , A61F2002/4495 , A61F2002/4622 , A61F2002/4627 , A61F2002/4628 , A61F2220/0025 , A61F2220/0075 , A61F2230/0015 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00161 , A61F2310/00179 , A61L2430/38
摘要： Prosthetic intervertebral discs and methods for using the same are described. The subject prosthetic discs include upper and lower endplates separated by a compressible core member. The prosthetic discs described herein include one-piece, two-piece, three-piece, and four-piece structures. The subject prosthetic discs exhibit stiffness in the vertical direction, torsional stiffness, bending stiffness in the saggital plane, and bending stiffness in the front plane, where the degree of these features can be controlled independently by adjusting the components of the discs. The interface mechanism between the endplates and the core members of several embodiments of the described prosthetic discs enables a very easy surgical operation for implantation.
摘要翻译： 描述了假体椎间盘及其使用方法。 主体假体盘包括由可压缩的芯构件分开的上端板和下端板。 本文所述的假体盘包括一件式，两件式，三件式和四件式结构。 主体假体椎板在垂直方向上呈现刚度，扭转刚度，屈曲平面中的弯曲刚度和前平面中的弯曲刚度，其中可以通过调节椎间盘的部件来独立地控制这些特征的程度。 所描述的假体盘的几个实施例的端板和芯构件之间的界面机构能够实现非常容易的用于植入的外科手术。
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