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公开(公告)号：US08999289B2
公开(公告)日：2015-04-07
申请号：US11386959
申请日：2006-03-22
申请人： Kenneth C. Anderson , James E. Bradner , Edward Franklin Greenberg , Teru Hideshima , Nicholas Paul Kwiatkowski , Ralph Mazitschek , Stuart L. Schreiber , Jared Shaw , Stephen J. Haggarty
发明人： Kenneth C. Anderson , James E. Bradner , Edward Franklin Greenberg , Teru Hideshima , Nicholas Paul Kwiatkowski , Ralph Mazitschek , Stuart L. Schreiber , Jared Shaw , Stephen J. Haggarty
IPC分类号： A61K51/00 , A61K31/357 , A61K31/35 , A61K31/4965 , A61K31/69 , A61K45/06 , A61K49/00 , G01N33/50 , A61K38/50
CPC分类号： A61K38/05 , A61K31/35 , A61K31/357 , A61K31/422 , A61K31/4965 , A61K31/69 , A61K38/50 , A61K45/06 , A61K49/0008 , G01N33/5011 , A61K2300/00
摘要： The invention relates to methods of treating protein degradation disorders, such cellular proliferative disorders (e.g., cancer) and protein deposition disorders (e.g., neurodegenerative disorders). The invention provides methods and pharmaceutical compositions for treating these diseases using aggresome inhibitors or combinations of aggresome inhibitors and proteasome inhibitors. The invention further relates to methods and pharmaceutical compositions for treating multiple myeloma. New HDAC/TDAC inhibitors and aggresome inhibitors are also provided as well as synthetic methodologies for preparing these compounds.
摘要翻译： 本发明涉及治疗蛋白质降解病症，细胞增殖性疾病（例如癌症）和蛋白质沉积病症（例如神经变性疾病）的方法。 本发明提供了使用聚集抑制剂或聚集抑制剂和蛋白酶体抑制剂的组合来治疗这些疾病的方法和药物组合物。 本发明还涉及用于治疗多发性骨髓瘤的方法和药物组合物。 还提供了新的HDAC / TDAC抑制剂和聚集抑制剂以及用于制备这些化合物的合成方法。
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2.发明申请公开(公告)号：US20120214757A1
公开(公告)日：2012-08-23
申请号：US13242209
申请日：2011-09-23
IPC分类号： A61K31/69 , A61K31/197 , A61P35/00 , A61K31/704
CPC分类号： A61K31/69 , A61K31/195 , A61K31/198 , A61K31/573 , A61K31/704 , A61K38/05 , A61K45/06 , A61K2300/00
摘要： The present invention relates to therapeutic compositions for treating cancer or preventing the growth of cancer cells, e.g., tumor growth, in a subject. The present invention also relates to methods for treating cancer, e.g., inhibiting tumor growth, in a subject who has become resistant to treatment, by administering to a subject an effective amount of a proteasome inhibitor and an effective amount of a therapeutic agent, e.g., a chemotherapeutic agent. The present invention further relates to methods for purging bone marrow, i.e., removing cancer cells from bone marrow, by exposing the bone marrow cells to a proteasome inhibitor and a therapeutic agent, e.g., a chemotherapeutic agent.
摘要翻译： 本发明涉及用于治疗癌症或预防受试者中癌细胞生长，例如肿瘤生长的治疗组合物。 本发明还涉及通过向受试者施用有效量的蛋白酶体抑制剂和有效量的治疗剂来治疗已经变得耐受治疗的受试者的癌症的方法，例如抑制肿瘤生长，例如， 化疗剂。 本发明还涉及通过将骨髓细胞暴露于蛋白酶体抑制剂和治疗剂例如化学治疗剂来清除骨髓，即从骨髓中除去癌细胞的方法。
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3.发明授权公开(公告)号：US08685954B2
公开(公告)日：2014-04-01
申请号：US13242209
申请日：2011-09-23
CPC分类号： A61K31/69 , A61K31/195 , A61K31/198 , A61K31/573 , A61K31/704 , A61K38/05 , A61K45/06 , A61K2300/00
摘要： The present invention relates to therapeutic compositions for treating cancer or preventing the growth of cancer cells, e.g., tumor growth, in a subject. The present invention also relates to methods for treating cancer, e.g., inhibiting tumor growth, in a subject who has become resistant to treatment, by administering to a subject an effective amount of a proteasome inhibitor and an effective amount of a therapeutic agent, e.g., a chemotherapeutic agent. The present invention further relates to methods for purging bone marrow, i.e., removing cancer cells from bone marrow, by exposing the bone marrow cells to a proteasome inhibitor and a therapeutic agent, e.g., a chemotherapeutic agent.
摘要翻译： 本发明涉及用于治疗癌症或预防受试者中癌细胞生长，例如肿瘤生长的治疗组合物。 本发明还涉及通过向受试者施用有效量的蛋白酶体抑制剂和有效量的治疗剂来治疗已经变得耐受治疗的受试者的癌症的方法，例如抑制肿瘤生长，例如， 化疗剂。 本发明还涉及通过将骨髓细胞暴露于蛋白酶体抑制剂和治疗剂例如化学治疗剂来清除骨髓，即从骨髓中除去癌细胞的方法。
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4.发明授权公开(公告)号：US08026230B2
公开(公告)日：2011-09-27
申请号：US11119473
申请日：2005-04-29
CPC分类号： A61K31/69 , A61K31/195 , A61K31/198 , A61K31/573 , A61K31/704 , A61K38/05 , A61K45/06 , A61K2300/00
摘要： The present invention relates to therapeutic compositions for treating cancer or preventing the growth of cancer cells, e.g., tumor growth, in a subject. The present invention also relates to methods for treating cancer, e.g., inhibiting tumor growth, in a subject who has become resistant to treatment, by administering to a subject an effective amount of a proteasome inhibitor and an effective amount of a therapeutic agent, e.g., a chemotherapeutic agent. The present invention further relates to methods for purging bone marrow, i.e., removing cancer cells from bone marrow, by exposing the bone marrow cells to a proteasome inhibitor and a therapeutic agent, e.g., a chemotherapeutic agent.
摘要翻译： 本发明涉及用于治疗癌症或预防受试者中癌细胞生长，例如肿瘤生长的治疗组合物。 本发明还涉及通过向受试者施用有效量的蛋白酶体抑制剂和有效量的治疗剂来治疗已经变得耐受治疗的受试者的癌症的方法，例如抑制肿瘤生长，例如， 化疗剂。 本发明还涉及通过将骨髓细胞暴露于蛋白酶体抑制剂和治疗剂例如化学治疗剂来清除骨髓，即从骨髓中除去癌细胞的方法。
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5.发明申请COMBINATIONS OF HISTONE DEACETYLASE INHIBITORS AND IMMUNOMODULATORY DRUGS 审中-公开组织脱乙酰壳多糖酶抑制剂和免疫调节剂的组合公开(公告)号：US20150105358A1
公开(公告)日：2015-04-16
申请号：US14508072
申请日：2014-10-07
IPC分类号： A61K31/505 , C07D401/04 , C07D239/42 , A61K31/454 , A61K31/573
CPC分类号： A61K31/505 , A61K31/454 , A61K31/573 , C07D239/42 , C07D401/04 , A61K2300/00
摘要： The invention relates to combinations comprising an HDAC inhibitor and an immunomodulatory drug for the treatment of multiple myeloma in a subject in need thereof. The combinations may, optionally, further comprise an anti-inflammatory agent, such as dexamethasone. Also provided herein are methods for treating multiple myeloma in a subject in need thereof comprising administering to the subject an effective amount of one of the above combinations.
摘要翻译： 本发明涉及包含HDAC抑制剂和用于在有需要的受试者中治疗多发性骨髓瘤的免疫调节药物的组合。 组合可以任选地进一步包含抗炎剂，例如地塞米松。 本文还提供了在有需要的受试者中治疗多发性骨髓瘤的方法，包括向受试者施用有效量的上述组合之一。
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6.发明授权Compositions, kits, and methods for identification, assessment, prevention, and therapy of cancer 有权用于癌症鉴别，评估，预防和治疗的组合物，试剂盒和方法公开(公告)号：US08211634B2
公开(公告)日：2012-07-03
申请号：US11706155
申请日：2007-02-13
申请人： Ronald A. DePinho , Kenneth C. Anderson , Ruben D. Carrasco , Giovanni Tonon , Cameron W. Brennan , John D. Shaughnessy, Jr. , Lynda Chin
发明人： Ronald A. DePinho , Kenneth C. Anderson , Ruben D. Carrasco , Giovanni Tonon , Cameron W. Brennan , John D. Shaughnessy, Jr. , Lynda Chin
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/574
CPC分类号： C12Q1/6837 , C12Q1/6841 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/178 , C12Q2537/157
摘要： The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating human cancer. A variety of chromosomal regions (MCRs) and markers corresponding thereto, are provided, wherein alterations in the copy number of one or more of the MCRs and/or alterations in the amount, structure, and/or activity of one or more of the markers is correlated with the presence of cancer.
摘要翻译： 本发明涉及用于检测，表征，预防和治疗人类癌症的组合物，试剂盒和方法。 提供了多种染色体区域（MCR）和与之对应的标记物，其中一个或多个MCR的拷贝数和/或一个或多个标记物的量，结构和/或活性的变化的改变 与癌症的存在相关。
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公开(公告)号：US5425189A
公开(公告)日：1995-06-20
申请号：US181660
申请日：1994-01-14
CPC分类号： E02F9/2816 , E02F9/2808
摘要： The application describes a method and apparatus for raking with heavy equipment. The apparatus includes a plurality of raking teeth attached to the top portion of a heavy equipment bucket. The apparatus is adaptable to such diverse heavy equipment as front loaders and backhoes. The method includes the use of top mounted teeth to rake pile and load raked material.
摘要翻译： 该应用描述了用于重型设备耙的方法和设备。 该装置包括附接到重型设备桶的顶部的多个耙齿。 该装置适用于诸如前装载机和反铲之类的各种重型设备。 该方法包括使用顶部安装的齿耙耙桩和装载倾斜材料。
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公开(公告)号：US20100172893A1
公开(公告)日：2010-07-08
申请号：US12514360
申请日：2007-11-12
申请人： Kenneth C. Anderson , Nicholas Mitsiades , Joseph Negri , Douglas W. McMillin , Constantine S. Siades
发明人： Kenneth C. Anderson , Nicholas Mitsiades , Joseph Negri , Douglas W. McMillin , Constantine S. Siades
IPC分类号： A61K31/704 , A61K31/5377 , A61K39/00 , A61K31/573 , A61K31/69 , A61P35/00 , A61K39/395
CPC分类号： A61K31/52 , A61K45/06 , A61K2300/00
摘要： Herein is provided methods and compositions for treating cancer. In one embodiment, a method is provided for treating a patient suffering from cancer, the method comprising administering to the patient an effective amount of reversine, reversine analog or reversine containing agent. In another embodiment, compositions comprising reversine are provided. Such compositions may further comprise additional active agents and other additives. The compositions and methods provided herein are useful, for example, in the area of medicine.
摘要翻译： 本文提供了治疗癌症的方法和组合物。 在一个实施方案中，提供了一种用于治疗患有癌症的患者的方法，所述方法包括向患者施用有效量的逆转，逆转类似物或逆转剂。 在另一个实施方案中，提供了包含逆转的组合物。 这样的组合物还可以包含另外的活性剂和其它添加剂。 本文提供的组合物和方法可用于例如医学领域。
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9.发明申请公开(公告)号：US20090286770A1
公开(公告)日：2009-11-19
申请号：US11721094
申请日：2005-12-07
IPC分类号： A61K31/553 , C07D245/06 , A61P35/00
CPC分类号： A61K31/407 , A61K31/553
摘要： The present invention relates to the use of staurosporines derivatives for the preparation of a drug for the treatment of diseases involving ras or FGFR3 signalling pathways and l or c-fos transcription, especially for the curative and/or prophylactic treatment of myeloma or multiple Myeloma, and to a method of treating diseases involving ras or FGFR3 signalling pathways and/or c-fos transcription.
摘要翻译： 本发明涉及星形孢菌素衍生物用于制备用于治疗涉及ras或FGFR3信号传导途径和l或c-fos转录的疾病的药物的用途，特别是用于治疗和/或预防性治疗骨髓瘤或多发性骨髓瘤， 以及治疗涉及ras或FGFR3信号传导途径和/或c-fos转录的疾病的方法。
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公开(公告)号：US5518224A
公开(公告)日：1996-05-21
申请号：US297491
申请日：1994-08-29
申请人： Kenneth C. Anderson
发明人： Kenneth C. Anderson
CPC分类号： B66F7/0641 , B25H1/0014
摘要： A foot-operated motorcycle lift stand. The cyclist drives the motorcycle over the lift stand in its lowermost compact position. While manually steadying the motorcyle, the cyclist actuates a foot lever to shift the stand platform into lifting engagement with the undercarriage of the motorcycle by means of legs which pivotally secure the platform to a base and which, in motion, describe a parallelogram. The foot lever pivots from its position adjacent one of the legs of the stand to an upstanding position, where additional foot pressure creates a turning moment to shift the legs and platform to a stable raised position. The cyclist's hands are then free to secure the lift stand with positive locking means which lock the stand in place. When not in use, the lift stand can be conveniently stored in an upright position whereby edges of the platform and base provide stable resting means.
摘要翻译： 脚踏摩托车举升架。 骑自行车者将摩托车驱动在升降台上最低的紧凑位置。 在手动稳定摩托车的同时，骑自行车者致动脚踏板，以通过将平台枢转地固定在基座上并且在运动中描述平行四边形的腿将支架平台移动到与摩托车的起落架升降接合。 脚踏板从其与支架的一个腿相邻的位置枢转到直立位置，其中额外的脚压产生转动力矩以将腿部和平台移动到稳定的升高位置。 骑自行车者的手然后可以用积极的锁定装置来固定升降台，从而将支架锁定在适当位置。 当不使用时，提升架可以方便地存放在直立位置，由此平台和底座的边缘提供稳定的搁置装置。
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