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公开(公告)号:US20090143455A1
公开(公告)日:2009-06-04
申请号:US12083782
申请日:2006-10-19
申请人: Benjamin Pelcman , Andrei Sanin , Peter Nilsson , Thomas Boesen , Stine Byskov Vogensen , Hasse Kromann , Thomas Groth
发明人: Benjamin Pelcman , Andrei Sanin , Peter Nilsson , Thomas Boesen , Stine Byskov Vogensen , Hasse Kromann , Thomas Groth
IPC分类号: A61K31/415 , C07D231/10 , A61P29/00 , A61P11/00 , A61P1/00 , A61P9/00 , A61P17/00 , A61P19/02 , A61P25/00 , A61P35/00
CPC分类号: C07D231/12 , C07D231/14 , C07D231/16
摘要: There is provided compounds of formula I, wherein R1, R2, X1, X2 and n have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a lipoxygenase (e.g. 15-lipoxygenase) is desired and/or required, and particularly in the treatment of inflammation.
摘要翻译: 提供式I化合物,其中R1,R2,X1,X2和n具有本说明书中给出的含义及其药学上可接受的盐,该化合物可用于治疗脂氧合酶活性抑制的疾病 (例如15-脂氧合酶)是期望和/或需要的,特别是在治疗炎症中。
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公开(公告)号:US20070225318A1
公开(公告)日:2007-09-27
申请号:US11663208
申请日:2005-09-19
申请人: Peter Nilsson , Andrei Sanin , Benjamin Pelcman
发明人: Peter Nilsson , Andrei Sanin , Benjamin Pelcman
IPC分类号: A61K31/4155 , A61K31/4375 , A61K31/47 , C07D215/00 , C07D231/10 , C07D471/04
CPC分类号: C07D471/04 , C07D231/14 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D487/14 , C07D491/04 , C07D491/056 , C07D493/04 , C07D495/04
摘要: There is provided compounds of formula (I), wherein R1, R2, Ra and Rb have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a lipoxygenase (e.g. 15-lipoxygenase) is desired and/or required, and particularly in the treatment of inflammation.
摘要翻译: 提供式(I)化合物,其中R 1,R 2,R a和R b都是 具有说明书中给出的含义及其药学上可接受的盐,该化合物可用于治疗期望和/或需要抑制脂氧合酶(例如,15-脂肪氧合酶)的活性的疾病,特别是在治疗中 的炎症。
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公开(公告)号:US20090088463A1
公开(公告)日:2009-04-02
申请号:US12084426
申请日:2006-10-30
申请人: Benjamin Pelcman , Andrei Sanin , Peter Nilsson
发明人: Benjamin Pelcman , Andrei Sanin , Peter Nilsson
IPC分类号: A61K31/415 , C07D231/14 , A61P29/00
CPC分类号: C07D231/14
摘要: There is provided compounds of formula (I), wherein X1 to X5 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a lipoxygenase (e.g. 15-lipoxygenase) is desired and/or required, and particularly in the treatment of inflammation.
摘要翻译: 提供式(I)化合物,其中X1至X5具有说明书中给出的含义及其药学上可接受的盐,该化合物可用于治疗脂氧合酶活性抑制的疾病(例如15- 脂氧合酶)是期望和/或需要的,特别是在治疗炎症中。
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公开(公告)号:US20090186918A1
公开(公告)日:2009-07-23
申请号:US12084400
申请日:2006-10-27
申请人: Benjamin Pelcman , Andrei Sanin , Peter Nilsson , Hasse Kromann
发明人: Benjamin Pelcman , Andrei Sanin , Peter Nilsson , Hasse Kromann
IPC分类号: A61K31/4709 , C07D401/12 , A61K31/4439
CPC分类号: C07D417/14 , C07D249/04 , C07D401/12 , C07D403/12
摘要: There is provided compounds of formula (I) wherein W is an optionally substituted aryl or heteroaryl group, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a lipoxygenase (e.g. 15-lipoxygenase) is desired and/or required, and particularly in the treatment of inflammation.
摘要翻译: 提供了其中W是任选取代的芳基或杂芳基的式(I)化合物及其药学上可接受的盐,该化合物可用于治疗其中抑制脂氧合酶活性的疾病(例如,15-脂氧合酶 )是期望和/或需要的,特别是在炎症的治疗中。
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公开(公告)号:US20090143440A1
公开(公告)日:2009-06-04
申请号:US12084331
申请日:2006-10-27
申请人: Benjamin Pelcman , Andrei Sanin , Peter Nilsson , Thomas Groth , Hasse Kromann
发明人: Benjamin Pelcman , Andrei Sanin , Peter Nilsson , Thomas Groth , Hasse Kromann
IPC分类号: A61K31/4439 , C07D403/12 , A61P25/12
CPC分类号: C07D401/12
摘要: There is provided compounds of formula (I), wherein R1, R2, X1, X2 and n have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a lipoxygenase (e.g. 15-lipoxygenase) is desired and/or required, and particularly in the treatment of inflammation.
摘要翻译: 提供式(I)化合物,其中R 1,R 2,X 1,X 2和n具有本说明书中给出的含义及其药学上可接受的盐,该化合物可用于治疗其中抑制 脂氧合酶(例如,15-脂氧合酶)是期望和/或需要的,特别是在治疗炎症中。
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公开(公告)号:US20080090836A1
公开(公告)日:2008-04-17
申请号:US11663180
申请日:2005-09-19
申请人: Peter Nilsson , Andrei Sanin , Benjamin Pelcman , Thomas Boesen
发明人: Peter Nilsson , Andrei Sanin , Benjamin Pelcman , Thomas Boesen
IPC分类号: A61K31/415 , A61K31/454 , A61K31/496 , A61P29/00 , C07D207/34 , C07D401/02 , C07D403/02
CPC分类号: C07D231/14 , C07D403/12 , C07D409/12
摘要: There is provided compounds of formula (I), wherein Ra, Rb, R1, R2, R3, X and Y have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a lipoxygenase (e.g. 15-lipoxygenase) is desired and/or required, and particularly in the treatment of inflammation.
摘要翻译: 提供式(I)化合物,其中R a,R b,R i,R i,R 2, R 3,X和Y具有说明书中给出的含义及其药学上可接受的盐,该化合物可用于治疗其中抑制脂氧合酶活性的疾病(例如15- 脂氧合酶)是期望和/或需要的,特别是在治疗炎症中。
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公开(公告)号:US20060183780A1
公开(公告)日:2006-08-17
申请号:US10547996
申请日:2004-03-12
申请人: Anders Hallberg , Wesley Schaal , Mats Larhed , Kristofer Olofsson , Benjamin Pelcman , Andrei Sanin
发明人: Anders Hallberg , Wesley Schaal , Mats Larhed , Kristofer Olofsson , Benjamin Pelcman , Andrei Sanin
IPC分类号: A61K31/4439 , A61K31/427 , A61K31/4152 , C07D417/02 , C07D403/02
CPC分类号: C07D231/14 , C07D231/18 , C07D231/40 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要: There is provided a compound of formula (I), wherein R1, R2, R3, X and Y have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a lipoxygenase (e.g. 15-lipoxygenase) is desired and/or required, and particularly in the treatment of inflammation.
摘要翻译: 提供式(I)的化合物,其中R 1,R 2,R 3,X和Y具有在 描述及其药学上可接受的盐,该化合物可用于治疗期望和/或需要抑制脂氧合酶(例如,15-脂肪氧合酶)的活性,特别是治疗炎症的疾病。
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公开(公告)号:US20120004244A1
公开(公告)日:2012-01-05
申请号:US13256003
申请日:2010-03-12
IPC分类号: A61K31/44 , C07D401/10 , A61K31/4439 , C07D405/10 , A61K31/443 , C07D239/42 , A61K31/505 , C07D213/79 , A61P37/08 , A61P11/00 , A61P17/00 , A61P1/00 , A61P29/00 , A61P9/00 , A61P11/02 , A61P31/04 , A61P31/12 , A61P31/10 , A61P27/02 , A61P25/00 , C07D213/74
CPC分类号: C07D405/12 , C07D213/50 , C07D213/65 , C07D213/74 , C07D401/10 , C07D409/12
摘要: There is provided compounds of formula I, wherein E1, E2a, E2b, E2c, E4, D1, D2, D3, L1, Y1, L2 and Y2 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of leukotriene C4 synthase is desired and/or required, and particularly in the treatment of a respiratory disorder and/or inflammation.
摘要翻译: 提供式I化合物,其中E1,E2a,E2b,E2c,E4,D1,D2,D3,L1,Y1,L2和Y2具有说明书中给出的含义及其药学上可接受的盐,该化合物是有用的 用于治疗期望和/或需要抑制白细胞三烯C4合酶的疾病,特别是治疗呼吸障碍和/或炎症的疾病。
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公开(公告)号:US20110319431A1
公开(公告)日:2011-12-29
申请号:US13256122
申请日:2010-03-15
IPC分类号: A61K31/505 , A61K31/196 , C07D239/47 , C07D213/78 , C07C59/84 , A61P31/12 , A61P11/00 , A61P29/00 , A61P37/08 , A61P11/06 , A61P9/00 , A61P27/16 , A61P27/02 , A61P17/00 , A61P1/00 , A61P13/00 , A61P25/00 , A61P7/06 , A61P31/04 , A61P31/10 , A61K31/44
CPC分类号: C07C323/63 , C07C317/48 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07C2603/74 , C07D213/50 , C07D213/65 , C07D213/74 , C07D317/46 , C07D335/02 , C07D401/10 , C07D405/12 , C07D409/12
摘要: There is provided compounds of formula I, wherein Y, ring A, D1, D2a, D2b, D3, L1, Y1, L3 and Y3 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of leukotriene C4 synthase is desired and/or required, and particularly in the treatment of a respiratory disorder and/or inflammation.
摘要翻译: 提供了式I化合物,其中Y,环A,D1,D2a,D2b,D3,L1,Y1,L3和Y3具有说明书中给出的含义及其药学上可接受的盐,该化合物可用于治疗 需要和/或需要抑制白细胞三烯C4合酶的疾病,特别是治疗呼吸障碍和/或炎症的疾病。
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公开(公告)号:US20110112193A1
公开(公告)日:2011-05-12
申请号:US12992074
申请日:2009-05-05
IPC分类号: A61K31/255 , C07C311/35 , C07C229/64 , A61K31/196 , C07C303/36 , C07C227/16 , A61P11/00 , A61P29/00 , A61P11/06 , A61P37/08 , A61P17/00 , A61P27/02 , A61P25/00 , A61P13/00 , A61P5/00 , A61P31/04 , A61P31/12 , A61P31/10 , A61P7/06 , A61P35/00
CPC分类号: C07C311/27 , C07C229/64
摘要: There is provided compounds of formula (I), wherein ring A, D1, D2a, D2b, D3, L1, Y1, L3 and Y3 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of leukotriene C4 synthase is desired and/or required, and particularly in the treatment of a respiratory disorder and/or inflammation.
摘要翻译: 提供式(I)化合物,其中环A,D1,D2a,D2b,D3,L1,Y1,L3和Y3在说明书中给出的含义及其药学上可接受的盐,该化合物可用于治疗 需要和/或需要抑制白细胞三烯C4合酶的疾病,特别是治疗呼吸障碍和/或炎症的疾病。
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