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    Synthesis of acylarylenes and hyperbranched poly(aclarylene)s by metal-free cyclotrimerization of alkynes
    5.
    发明授权
    Synthesis of acylarylenes and hyperbranched poly(aclarylene)s by metal-free cyclotrimerization of alkynes 有权
    通过不含金属的炔炔环化三聚法合成酰基亚芳基和超支化聚（亚丙烯基）

    公开(公告)号：US08436118B2

    公开(公告)日：2013-05-07

    申请号：US12451527

    申请日：2008-03-04

    申请人： Benzhong Tang ,  Ka Wai Jim ,  Anjun Qin ,  Matthias Haeussler ,  Wing Yip Lam

    发明人： Benzhong Tang ,  Ka Wai Jim ,  Anjun Qin ,  Matthias Haeussler ,  Wing Yip Lam

    IPC分类号： C08F138/00 ,  C08F38/00 ,  C07C15/00 ,  C07C15/02

    CPC分类号： C08G63/20 ,  C08G63/00

    摘要： The present invention provides a new metal-free cyclotrimerization reaction of alkynes to produce a 1,3,5-triacylarylene or 1,3,5-triacylbenzene. This reaction is catalyzed by secondary amines, is strictly regioselective, highly functionality-tolerant, and the resulting product can be obtained in high yields. This reaction can be further applied for the preparation of novel branched (co)polymers bearing the triacylarylenes as structural units. The preparation of the (co)polymers is carried out as a one-pot single-step reaction procedure, giving branched oligomers and polymers in high yields up to 90%. The produced (co)polymers are also processible, easily film-forming, and thermally stable.

    摘要翻译： 本发明提供了一种新的无金属的炔炔环化三聚反应，产生1,3,5-三酰基亚芳基或1,3,5-三酰基苯。 该反应由仲胺催化，是严格区域选择性的，具有高度的官能度 - 耐受性，所得产物可以高产率获得。 该反应可以进一步用于制备具有三酰基亚芳基作为结构单元的新型支链（共）聚合物。 （共）聚合物的制备是作为一锅一步反应方法进行的，以高产率提供高达90％的支链低聚物和聚合物。 生产的（共）聚合物也是可加工的，容易成膜和热稳定的。

    Polytriazoles constructed by 1,3-dipolar cycloaddition
    6.
    发明授权
    Polytriazoles constructed by 1,3-dipolar cycloaddition 有权
    由1,3-偶极环加成构成的三叉唑

    公开(公告)号：US07772358B2

    公开(公告)日：2010-08-10

    申请号：US11896675

    申请日：2007-09-05

    申请人： Benzhong Tang ,  Anjun Qin ,  Matthias Haeussler

    发明人： Benzhong Tang ,  Anjun Qin ,  Matthias Haeussler

    IPC分类号： C08G73/08 ,  C07C247/02 ,  C07C247/16

    CPC分类号： C08F24/00 ,  C08F26/06 ,  C08F30/04

    摘要： A process of synthesizing hyperbranched polytriazoles, linear and hyperbranched poly(aroyltriazoles) by Huisgen 1,3-dipolar cycloaddition. The polytriazoles were prepared by A2+B3 method to avoid self-polymerization during monomer preparation and storage. The polymers are light emissive and can be crosslinked to generate well-resolution photopatterns upon UV irradiation. White light emission patterns were observed with fluorescence microscopy. The high molecular weight poly(aroyltriazoles) (up to 26000 Da) are prepared in high yields (up to 92.0%) and with high regioselectivity (the ratio of 1,4- and 1,5-disubstituted 1,2,3-triazole is equal or larger than 9:1). The polycyclomerization is not moisture or oxygen sensitive and therefore, no special precautions are necessary before and during the reaction. All the polymers are processible, easily film-forming, and curable into thermosets by heat or irradiation. The hyperbranched polymers can act as fluorescent adhesive materials with large tensile strength.

    摘要翻译： 通过Huisgen 1,3-偶极环加成合成超支化聚三唑，线性和超支化聚（芳酰基三唑）的方法。 通过A2 + B3方法制备聚三唑，以避免单体制备和储存过程中的自聚合。 聚合物是发光的并且可以交联以在UV照射时产生良好分辨率的光图案。 用荧光显微镜观察白光发射模式。 高分子量聚（芳基三唑）（高达26000Da）以高产率（高达92.0％）和高分辨率选择性（1,4和1,5-二取代的1,2,3-三唑的比例 等于或大于9：1）。 多重环化不是水分或氧气敏感的，因此在反应之前和期间都不需要特别的预防措施。 所有的聚合物都是可加工的，易成膜的，并且通过热或照射可固化成热固性材料。 超支化聚合物可以作为具有大拉伸强度的荧光粘合剂材料。

    SYNTHESIS OF ACYLARYLENES AND HYPERBRANCHED POLY(ACLARYLENE)S BY METAL-FREE CYCLOTRIMERIZATION OF ALKYNES
    7.
    发明申请
    SYNTHESIS OF ACYLARYLENES AND HYPERBRANCHED POLY(ACLARYLENE)S BY METAL-FREE CYCLOTRIMERIZATION OF ALKYNES 有权
    通过金属无环烷基化方法合成乙烯和高分子聚（丙烯）

    公开(公告)号：US20100129757A1

    公开(公告)日：2010-05-27

    申请号：US12451527

    申请日：2008-03-04

    申请人： Benzhong Tang ,  Ka Wai Jim ,  Anjun Qin ,  Matthias Haeussler ,  Wing Yip Lam

    发明人： Benzhong Tang ,  Ka Wai Jim ,  Anjun Qin ,  Matthias Haeussler ,  Wing Yip Lam

    IPC分类号： G03F7/20 ,  C08G63/78 ,  C08G63/00 ,  C08G73/00

    CPC分类号： C08G63/20 ,  C08G63/00

    摘要： The present invention provides a new metal-free cyclotrimerization reaction of alkynes to produce a 1,3,5-triacylarylene or 1,3,5-triacylbenzene. This reaction is catalyzed by secondary amines, is strictly regioselective, highly functionality-tolerant, and the resulting product can be obtained in high yields. This reaction can be further applied for the preparation of novel branched (co)polymers bearing the triacylarylenes as structural units. The preparation of the (co)polymers is carried out as a one-pot single-step reaction procedure, giving branched oligomers and polymers in high yields up to 90%. The produced (co)polymers are also processible, easily film-forming, and thermally stable.

    摘要翻译： 本发明提供了一种新的无金属的炔炔环化三聚反应，产生1,3,5-三酰基亚芳基或1,3,5-三酰基苯。 该反应由仲胺催化，是严格区域选择性的，具有高度的官能度 - 耐受性，所得产物可以高产率获得。 该反应可以进一步用于制备具有三酰基亚芳基作为结构单元的新型支链（共）聚合物。 （共）聚合物的制备是作为一锅一步反应方法进行的，以高产率提供高达90％的支链低聚物和聚合物。 生产的（共）聚合物也是可加工的，容易成膜和热稳定的。

    Polytriazoles constructed by 1, 3-dipolar cycloaddition
    8.
    发明申请
    Polytriazoles constructed by 1, 3-dipolar cycloaddition 有权
    通过1,3-偶极环加成构成的三叉唑

    公开(公告)号：US20080103273A1

    公开(公告)日：2008-05-01

    申请号：US11896675

    申请日：2007-09-05

    申请人： Benzhong Tang ,  Anjun Qin ,  Matthias Haeussler

    发明人： Benzhong Tang ,  Anjun Qin ,  Matthias Haeussler

    IPC分类号： C08F38/00 ,  C08F24/00 ,  C08F26/06 ,  C08F30/04

    CPC分类号： C08F24/00 ,  C08F26/06 ,  C08F30/04

    摘要： A process of synthesizing hyperbranched polytriazoles, linear and hyperbranched poly(aroyltriazoles) by Huisgen 1,3-dipolar cycloaddition. The polytriazoles were prepared by A2+B3 method to avoid self-polymerization during monomer preparation and storage. The polymers are light emissive and can be crosslinked to generate well-resolution photopatterns upon UV irradiation. White light emission patterns were observed with fluorescence microscopy. The high molecular weight poly(aroyltriazoles) (up to 26000 Da) are prepared in high yields (up to 92.0%) and with high regioselectivity (the ratio of 1,4- and 1,5-disubstituted 1,2,3-triazole is equal or larger than 9:1). The polycyclomerization is not moisture or oxygen sensitive and therefore, no special precautions are necessary before and during the reaction. All the polymers are processible, easily film-forming, and curable into thermosets by heat or irradiation. The hyperbranched polymers can act as fluorescent adhesive materials with large tensile strength.

    摘要翻译： 通过Huisgen 1,3-偶极环加成合成超支化聚三唑，线性和超支化聚（芳酰基三唑）的方法。 聚三唑通过A 2 N + B 3 N 3方法制备，以避免单体制备和储存期间的自聚合。 聚合物是发光的并且可以交联以在UV照射时产生良好分辨率的光图案。 用荧光显微镜观察白光发射模式。 高分子量聚（芳基三唑）（高达26000Da）以高产率（高达92.0％）和高分辨率选择性（1,4和1,5-二取代的1,2,3-三唑的比例 等于或大于9：1）。 多重环化不是水分或氧气敏感的，因此在反应之前和期间都不需要特别的预防措施。 所有的聚合物都是可加工的，易成膜的，并且通过热或照射可固化成热固性材料。 超支化聚合物可以作为具有大拉伸强度的荧光粘合剂材料。

    Aggregation-induced emission luminogens for metal ion detection
    9.
    发明授权
    Aggregation-induced emission luminogens for metal ion detection 有权
    用于金属离子检测的聚集诱发发射发光体

    公开(公告)号：US09228949B2

    公开(公告)日：2016-01-05

    申请号：US13602641

    申请日：2012-09-04

    申请人： Benzhong Tang ,  Yuning Hong ,  Wai Tung Leung

    发明人： Benzhong Tang ,  Yuning Hong ,  Wai Tung Leung

    IPC分类号： G01N21/64 ,  G01N31/22 ,  G01N33/20 ,  G01N33/18 ,  G01N33/00 ,  G01N21/31 ,  G01N33/84

    CPC分类号： G01N21/643 ,  G01N21/3103 ,  G01N31/22 ,  G01N33/0045 ,  G01N33/1813 ,  G01N33/20 ,  G01N33/84 ,  G01N2021/6417

    摘要： Pyridine-containing polyenes and their applications as metal ion sensors. These polyenes are practically nonluminescent in the solution state but become highly emissive as nanoparticle suspensions in aqueous solutions or thin films in the solid state, due to aggregation-induced emission (AIE). The nanoaggregates of these compounds can work as “turn-off” fluorescent chemosensors for metal ions and display different fluorescence responses to various metal ions. For example, a characteristic red shift in the emission spectra is observed with a terpyridine-containing luminogen in the presence of Zn2+. However, the terpyridine-containing luminogen displays a magenta color upon selectively binding with Fe2+. This allows easy identification of both Zn2+ and Fe2+ ions in aqueous media. The function of the polyenes can be easily tuned by altering the substituent groups. Due to their AIE properties, these polyenes can be used in aqueous solutions and in solid substrates for metal sensing.

    摘要翻译： 含吡啶的多烯及其作为金属离子传感器的应用。 这些多烯在溶液状态下实际上是非发光的，但由于聚集诱发发射（AIE），在固体状态的水溶液或薄膜中作为纳米颗粒悬浮液而变得高度发射。 这些化合物的纳米聚集体可以作为金属离子的“关闭”荧光化学传感器，并且对各种金属离子显示不同的荧光响应。 例如，在Zn 2+的存在下，用含三联吡啶的发光体观察到发射光谱中的特征红移。 然而，含三联吡啶的发光体在选择性地与Fe2 +结合时显示品红色。 这允许在水性介质中容易地鉴定Zn 2+和Fe 2+离子。 可以通过改变取代基来容易地调节多烯的功能。 由于它们的AIE性质，这些多烯可以用于水溶液和用于金属感测的固体基质中。

    Water-soluble AIE luminogen for monitoring and retardation of amyloid fibrillation of insulin
    10.
    发明授权
    Water-soluble AIE luminogen for monitoring and retardation of amyloid fibrillation of insulin 有权
    用于监测和阻滞胰岛素淀粉样纤颤的水溶性AIE发光体

    公开(公告)号：US08679738B2

    公开(公告)日：2014-03-25

    申请号：US13359514

    申请日：2012-01-27

    申请人： Benzhong Tang ,  Yuning Hong ,  Sijie Chen ,  Ryan Tsz Kin Kwok

    发明人： Benzhong Tang ,  Yuning Hong ,  Sijie Chen ,  Ryan Tsz Kin Kwok

    IPC分类号： C12Q1/00 ,  G01N33/53 ,  G01N33/543

    CPC分类号： G01N21/6428 ,  G01N33/542 ,  G01N2021/6432 ,  G01N2021/7786 ,  G01N2333/4709 ,  G01N2333/62

    摘要： The presently described subject matter is directed to a water-soluble conjugated polyene compound and the derivatives thereof that exhibit aggregation induced emission, as well as any water dispersible, fluorescent, polymeric microparticles, nanoparticles, and/or pharmaceutical composition comprising the water-soluble conjugated polyene compound and/or the derivatives thereof. Also provided are methods of making and using the compound, derivatives and particles of the presently described subject matter. The presently described water-soluble conjugated polyene compound are useful as bioprobes for the detection of biomacromolecules, in the manufacture of sensors, in monitoring and retarding formation of amyloid protein fibril in vitro and in vivo, and in developing anti-cancer drugs.

    摘要翻译： 目前描述的主题涉及表现出聚集诱导发射的水溶性共轭多烯化合物及其衍生物，以及任何水分散性，荧光，聚合物微粒，纳米颗粒和/或药物组合物，其包含水溶性共轭 多烯化合物和/或其衍生物。 还提供制备和使用目前描述的主题的化合物，衍生物和颗粒的方法。 目前描述的水溶性共轭多烯化合物可用作检测生物大分子，在制造传感器中，用于体外和体内监测和阻滞淀粉样蛋白原纤维形成以及开发抗癌药物的生物探针。