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公开(公告)号:US20050124070A1
公开(公告)日:2005-06-09
申请号:US10959392
申请日:2004-10-05
申请人: Bernard Moss , Arban Domi
发明人: Bernard Moss , Arban Domi
IPC分类号: C12N1/21 , C12N7/01 , C12N15/70 , C12N15/863 , C12N15/866 , A61K39/12 , C12N7/02 , C12N15/74
CPC分类号: C12N15/86 , C12N15/70 , C12N2710/14143 , C12N2710/24043 , C12N2710/24143 , C12N2770/24143 , C12N2800/204
摘要: The invention relates to a VAC-BAC shuttle vector system for creation of recombinant poxviruses from DNA cloned in a bacterial artificial chromosome.
摘要翻译: 本发明涉及一种用于从克隆在细菌人造染色体中的DNA产生重组痘病毒的VAC-BAC穿梭载体系统。
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公开(公告)号:US07494813B2
公开(公告)日:2009-02-24
申请号:US10959392
申请日:2004-10-05
申请人: Bernard Moss , Arban Domi
发明人: Bernard Moss , Arban Domi
CPC分类号: C12N15/86 , C12N15/70 , C12N2710/14143 , C12N2710/24043 , C12N2710/24143 , C12N2770/24143 , C12N2800/204
摘要: The invention relates to a VAC-BAC shuttle vector system for creation of recombinant poxviruses from DNA cloned in a bacterial artificial chromosome.
摘要翻译: 本发明涉及一种用于从克隆在细菌人造染色体中的DNA产生重组痘病毒的VAC-BAC穿梭载体系统。
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公开(公告)号:US20130266989A1
公开(公告)日:2013-10-10
申请号:US13792103
申请日:2013-03-10
申请人: Christopher L. Parks , Kevin J. Wright , Maoli Yuan , Christy K. Jurgens , Xinsheng Zhang , Arban Domi , Simon Hoffenberg , Maria J. Chiuchiolo , Svetlana Rabinovich , Aaron J. Wilson , Ivo C. Lorenz
发明人: Christopher L. Parks , Kevin J. Wright , Maoli Yuan , Christy K. Jurgens , Xinsheng Zhang , Arban Domi , Simon Hoffenberg , Maria J. Chiuchiolo , Svetlana Rabinovich , Aaron J. Wilson , Ivo C. Lorenz
IPC分类号: C12N15/68
CPC分类号: C12N15/68 , A61K39/12 , A61K39/21 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C12N7/00 , C12N15/67 , C12N15/86 , C12N2740/16122 , C12N2740/16134 , C12N2760/16034 , C12N2760/18443 , C12N2760/20243
摘要: The present invention relates to methods of developing gene inserts that are more compatible with the host vectors by modifying a protein sequence to lessen potential interference with vector propagation while ensuring that the protein is expressed and processed efficiently and maintains desired structural features, and designing a gene with a nucleotide sequence that resembles the base composition of the host vector genome.
摘要翻译: 本发明涉及通过修饰蛋白质序列来改变与宿主载体更相容的基因插入物的方法,以减少对载体繁殖的潜在干扰,同时确保蛋白质被有效地表达和加工并保持所需的结构特征,并设计基因 其核苷酸序列类似于宿主载体基因组的基本组成。
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4.
公开(公告)号:US20170258890A1
公开(公告)日:2017-09-14
申请号:US15498554
申请日:2017-04-27
申请人: John Coleman , Josephine Helena Cox , Arban Domi , Hiroto Hara , Takashi Hironaka , Makoto Inoue , Dagna Skoog Laufer , Angela Grazia Lombardo , Christopher L. Parks , Eddy Sayeed , Maoli Yuan , Xinsheng Zhang
发明人: John Coleman , Josephine Helena Cox , Arban Domi , Hiroto Hara , Takashi Hironaka , Makoto Inoue , Dagna Skoog Laufer , Angela Grazia Lombardo , Christopher L. Parks , Eddy Sayeed , Maoli Yuan , Xinsheng Zhang
IPC分类号: A61K39/21 , C07K14/005 , C12N15/86 , C12N7/00
CPC分类号: A61K39/21 , A61K39/12 , A61K2039/5256 , A61K2039/53 , A61K2039/543 , A61K2039/545 , A61K2039/55511 , A61K2039/55555 , A61K2039/57 , A61K2039/575 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2740/16034 , C12N2740/16134 , C12N2740/16234 , C12N2740/16271 , C12N2740/16334 , C12N2760/18443 , C12N2760/18843 , C12N2760/18871 , C12N2760/20243
摘要: The present invention relates to genetically stable replication competent Sendai virus vector(s) containing optimized HIV genes, methods for making the same and cell substrates qualified for vaccine production which may comprise genetically stable replication competent Sendai virus vector(s) containing optimized HIV genes.
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