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    Cryostatic microtome
    4.
    发明授权
    Cryostatic microtome 失效
    冷冻切片机

    公开(公告)号：US5761977A

    公开(公告)日：1998-06-09

    申请号：US692647

    申请日：1996-08-01

    申请人： Wolfgang Jakobi ,  Christian Niesporek ,  Hans Heid

    发明人： Wolfgang Jakobi ,  Christian Niesporek ,  Hans Heid

    IPC分类号： G01N1/06 ,  B26D7/06

    CPC分类号： G01N1/06 ,  G01N2001/066 ,  Y10T83/04 ,  Y10T83/0538 ,  Y10T83/536 ,  Y10T83/541

    摘要： A cryostatic microtome with an automatic approach of the preparation automatically stops the feed movement between the microtome knife and a frozen preparation towards each other upon a mechanical contact between the knife and the preparation. An electrical voltage of a few volts is applied between the microtome knife and the preparation. A small current which appears, due to the intrinsic conductivity of the preparation, upon mechanical contact between the preparation and the microtome knife, and a smaller voltage drop at the preparation resulting therefrom, is current amplified by means of a preamplifier connected as an impedance converter and subsequently measured. The feed movement between the preparation and the microtome knife is automatically stopped when the voltage at the amplifier output falls below a predefined threshold voltage. The preset threshold voltage is temperature dependent and is calculated by a control processor corresponding to the temperature of the cryostat, based on a function and function coefficients. The temperature dependence of the threshold voltage ensures a reliable and precise approach of the preparation throughout the entire temperature range usual in cryomicrotomy.

    摘要翻译： 具有自动制备方法的低温切片机在刀和制剂之间的机械接触时自动停止切片机与冷冻制品之间的进给运动。 在切片刀和制剂之间施加几伏的电压。 由于制剂的固有导电性，在制剂和切片机之间的机械接触以及由此产生的制剂上的较小的电压降，出现的小电流通过前置放大器电流放大，该前置放大器连接为阻抗转换器 并随后测量。 当放大器输出端的电压低于预定阈值电压时，准备与切片刀之间的进给运动自动停止。 预设阈值电压是温度依赖性的，并且由与低温恒温器的温度对应的控制处理器基于功能和功能系数来计算。 阈值电压的温度依赖性确保了在冷冻切片术通常的整个温度范围内准确的准确方法。

    Microtome
    5.
    发明授权
    Microtome 失效
    切片机

    公开(公告)号：US5535654A

    公开(公告)日：1996-07-16

    申请号：US281430

    申请日：1994-07-27

    申请人： Christian Niesporek ,  Hans Heid

    发明人： Christian Niesporek ,  Hans Heid

    IPC分类号： G01N1/06 ,  B26D7/06

    CPC分类号： G01N1/06 ,  G01N2001/065 ,  Y10T83/531 ,  Y10T83/536 ,  Y10T83/6499 ,  Y10T83/6508

    摘要： A microtome (2) with a sample holder (51) for a sample (22) to be thinly sectioned and with a knife holder (12) for a cutting knife (10) is described, wherein the sample holder (51), for performing a cutting movement (arrow 54) relative to the knife holder (12), can be driven in a first spatial direction (arrows 54, 56) by means of a first drive device (53), and for performing a coarse adjustment and a section thickness adjusting movement in a second spatial direction (arrow 24) perpendicular to the first spatial direction (54, 56) by means of an electrical second drive device (50). In the vicinity of the cutting knife (10), for defined delimitation of the coarse adjustment movement of the sample holder (51) in the second spatial direction, a delimiting device (20) is provided, which is connected over control means (44), preferably an electronic control, with the electrical second drive device (50).

    摘要翻译： 描述了具有用于样品（22）被分割成薄片的样品架（51）和用于切割刀（10）的刀架（12）的切片机（2），其中用于执行 可以通过第一驱动装置（53）在第一空间方向（箭头54,56）上驱动相对于刀保持器（12）的切割运动（箭头54），并且用于执行粗调和部分 通过电气第二驱动装置（50）垂直于第一空间方向（54,56）的第二空间方向（箭头24）的厚度调整运动。 在切割刀（10）附近，为了在第二空间方向上对样品架（51）进行粗略调节运动的限定，提供了一个定界装置（20），其连接在控制装置（44）上， ，优选地是电子控制器，与电气第二驱动装置（50）连接。