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    SYSTEMS AND METHODS FOR OPTIMIZING INSULIN DOSAGE
    3.
    发明申请
    SYSTEMS AND METHODS FOR OPTIMIZING INSULIN DOSAGE 有权
    用于优化胰岛素剂量的系统和方法

    公开(公告)号：US20110015511A1

    公开(公告)日：2011-01-20

    申请号：US12818310

    申请日：2010-06-18

    申请人： Steven Bousamra ,  Stefan Weinert ,  Juergen Rasch-Menges ,  P. Douglas Walling ,  John F. Price ,  Heino Eikmeier ,  Birgit Kraeling ,  Karl Werner ,  Ulrich Porsch

    发明人： Steven Bousamra ,  Stefan Weinert ,  Juergen Rasch-Menges ,  P. Douglas Walling ,  John F. Price ,  Heino Eikmeier ,  Birgit Kraeling ,  Karl Werner ,  Ulrich Porsch

    IPC分类号： A61B5/145 ,  G06F19/00 ,  G01N33/48 ,  G09B23/28

    CPC分类号： A61B5/0002 ,  A61B5/05 ,  A61B5/14532 ,  A61B5/14546 ,  A61M31/00 ,  A61M2230/201 ,  C12Q1/006 ,  G06F19/00 ,  G06F19/3418 ,  G06F19/3456 ,  G16H10/20 ,  G16H10/40 ,  G16H20/17 ,  G16H80/00

    摘要： Embodiments of a testing method suitable for diabetic persons to optimize their administered insulin dosage comprise collecting one or more sampling sets of biomarker data, wherein each sampling set comprises a sufficient plurality of non-adverse sampling instances and wherein each sampling instance comprises an acceptable biomarker reading at a single point in time recorded upon compliance with adherence criteria, determining a biomarker sampling parameter from each sampling set, comparing the biomarker sampling parameter to a target biomarker range, calculating an insulin adjustment parameter associated with the biomarker sampling parameter if the biomarker sampling parameter falls outside the target biomarker range, adjusting the insulin dosage by the insulin adjustment parameter if the biomarker sampling parameter falls outside the target biomarker range and if the insulin dosage does not exceed maximum dosage, and exiting the testing method if the adjusted insulin dosage is optimized. The insulin dosage is optimized when one or more biomarker sampling parameters fall within a target biomarker range.

    摘要翻译： 适于糖尿病患者优化其施用的胰岛素剂量的测试方法的实施方案包括收集一个或多个生物标志物数据的采样组，其中每个采样组包括足够多个非不良采样实例，并且其中每个采样实例包括可接受的生物标志物读数 在符合遵守标准的单个时间点上，从每个采样组确定生物标志物采样参数，将生物标志物采样参数与目标生物标志物范围进行比较，计算与生物标志物采样参数相关联的胰岛素调节参数，如果生物标志物采样参数 如果生物标志物采样参数落在目标生物标志物范围之外，并且如果胰岛素剂量不超过最大剂量，并且如果调整的胰岛素剂量是最佳的则退出测试方法，则超出目标生物标志物范围，通过胰岛素调节参数调整胰岛素剂量 zed。 当一个或多个生物标志物采样参数落入目标生物标志物范围内时，胰岛素剂量被优化。

    Blood Glucose Measuring Device with Reliable Transmission of Values to an External Device
    4.
    发明申请
    Blood Glucose Measuring Device with Reliable Transmission of Values to an External Device 审中-公开
    具有可靠的价值传输到外部设备的血糖测量装置

    公开(公告)号：US20140005951A1

    公开(公告)日：2014-01-02

    申请号：US14016878

    申请日：2013-09-03

    申请人： Karl Werner ,  Ulrich Porsch ,  Stefan Riebel

    发明人： Karl Werner ,  Ulrich Porsch ,  Stefan Riebel

    IPC分类号： G06F19/00

    CPC分类号： G06F21/64 ,  G06F19/3418 ,  G06F21/51 ,  G16H10/40 ,  G16H40/63

    摘要： A blood glucose measuring device and method for transmitting measured bG values to an external device such as a computer with improved data integrity for greater reliability is disclosed. The measuring device comprises a measuring means for determining measured blood glucose values, a measured value memory in which the measured blood glucose values are stored, a data interface that is configured for a data exchange with an external data reading apparatus, and a data file system which comprises a data reading application which can be accessed by the external data reading apparatus in order to read the stored measured blood glucose values, wherein the data system file further comprises a test application that is configured to execute an integrity test for the data reading application by forming a current digital signature for the data reading application and comparing this with a digital test signature provided in the data file system.

    摘要翻译： 公开了一种用于将测量的bG值发送到具有改进的数据完整性的外部设备（例如计算机）以获得更高可靠性的血糖测量装置和方法。 测量装置包括用于确定测量的血糖值的测量装置，其中存储测量的血糖值的测量值存储器，被配置为与外部数据读取装置进行数据交换的数据接口，以及数据文件系统 其包括数据读取应用程序，其可由外部数据读取装置访问以便读取所存储的测量血糖值，其中所述数据系统文件还包括被配置为对所述数据读取应用程序执行完整性测试的测试应用程序 通过形成用于数据读取应用的当前数字签名并将其与数据文件系统中提供的数字测试签名进行比较。

    Blood glucose measuring device with reliable transmission of values to an external device
    5.
    发明授权
    Blood glucose measuring device with reliable transmission of values to an external device 有权

    公开(公告)号：US10430613B2

    公开(公告)日：2019-10-01

    申请号：US14016878

    申请日：2013-09-03

    申请人： Karl Werner ,  Ulrich Porsch ,  Stefan Riebel

    发明人： Karl Werner ,  Ulrich Porsch ,  Stefan Riebel

    IPC分类号： G01N33/48 ,  G06F21/64 ,  G06F19/00 ,  G06F21/51 ,  G16H40/63 ,  G16H10/40

    摘要： A blood glucose measuring device and method for transmitting measured bG values to an external device such as a computer with improved data integrity for greater reliability is disclosed. The measuring device comprises a measuring means for determining measured blood glucose values, a measured value memory in which the measured blood glucose values are stored, a data interface that is configured for a data exchange with an external data reading apparatus, and a data file system which comprises a data reading application which can be accessed by the external data reading apparatus in order to read the stored measured blood glucose values, wherein the data system file further comprises a test application that is configured to execute an integrity test for the data reading application by forming a current digital signature for the data reading application and comparing this with a digital test signature provided in the data file system.

    Portable analytical device
    7.
    发明授权
    Portable analytical device 有权
    便携式分析仪

    公开(公告)号：US09149215B2

    公开(公告)日：2015-10-06

    申请号：US12158558

    申请日：2006-12-20

    申请人： Karl Werner ,  Nader Afshar ,  Morris J. Young ,  Alan Greenburg ,  Paul Galley

    发明人： Karl Werner ,  Nader Afshar ,  Morris J. Young ,  Alan Greenburg ,  Paul Galley

    IPC分类号： A61B5/145 ,  G01N33/487 ,  A61B5/00 ,  G06F19/00

    CPC分类号： G01N27/3273 ,  A61B5/0002 ,  A61B5/14532 ,  A61B2562/0295 ,  G01N21/78 ,  G01N21/8483 ,  G01N33/48792 ,  G01N33/66 ,  G01N2201/0221 ,  G06F19/00 ,  G06F19/3456 ,  G16H10/65 ,  G16H40/63

    摘要： A portable analytical device is provided for analysis of a component of a body fluid. A measuring facility within the device may carry out the analysis on a test element inserted therein. The test element may contain a reagent that reacts with a liquid sample of the body fluid when the test element is contacted thereby to produce a change that is characteristic of the analysis. A processor may process measuring values determined by the measuring facility to yield analytical measuring data taking into account calibration values. A standardized, wire-based computer interface may be provided on the analytical device via which the analytical device can be operated by a computer, the analytical measuring data can be transmitted from the analytical device to the computer, the analytical device can be supplied with electrical power by the computer, and the analytical device can provide software to be read-out by the computer.

    摘要翻译： 提供便携式分析装置用于分析体液的组分。 设备内的测量设备可以对插入其中的测试元件进行分析。 当测试元件接触时，测试元件可以含有与体液的液体样品反应的试剂，从而产生作为分析特征的变化。 处理器可以处理由测量设备确定的测量值，以产生考虑校准值的分析测量数据。 可以在分析装置上提供标准化的基于线的计算机接口，通过该分析装置，分析装置可以由计算机操作，分析测量数据可以从分析装置传输到计算机，分析装置可以提供电 计算机的电源，分析设备可以提供由计算机读取的软件。

    Measurement system with distributed functions
    9.
    发明授权
    Measurement system with distributed functions 有权
    测量系统具有分布式功能

    公开(公告)号：US08603394B2

    公开(公告)日：2013-12-10

    申请号：US12114266

    申请日：2008-05-02

    申请人： Joachim Hoenes ,  Bruno Thoes ,  Joerg Scherer ,  Karl Werner ,  Volker Zimmer

    发明人： Joachim Hoenes ,  Bruno Thoes ,  Joerg Scherer ,  Karl Werner ,  Volker Zimmer

    IPC分类号： G01N15/06

    CPC分类号： G01N33/48771 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1468 ,  A61B2562/0295 ,  Y10T436/11

    摘要： An analysis system is provided which comprises an integrated analysis device and a test strip magazine, for determining an analyte in a body fluid, wherein the analysis system comprises a first group comprising reusable components and a second group of components comprising a plurality of disposable articles. The second group includes non-electronic and electronic components, with critical interfaces configured between two or more such components, wherein non-electronic components can be disconnected from electronic components at a disconnection point. In one embodiment, critical interfaces are produced and tested during production of the analysis system.

    摘要翻译： 提供了一种分析系统，其包括用于确定体液中的分析物的集成分析装置和测试条盒，其中所述分析系统包括包含可重复使用部件的第一组和包括多个一次性制品的第二组部件。 第二组包括非电子和电子部件，其中关键接口配置在两个或更多个这样的组件之间，其中非电子部件可以在断开点处与电子部件断开连接。 在一个实施例中，在生产分析系统期间生产和测试关键界面。

    Process for producing sterile suspensions of slightly soluble basic peptide complexes, sterile suspensions of slightly soluble basic peptide complexes, pharmaceutical formulations containing them, and the use thereof as medicaments
    10.
    发明授权
    Process for producing sterile suspensions of slightly soluble basic peptide complexes, sterile suspensions of slightly soluble basic peptide complexes, pharmaceutical formulations containing them, and the use thereof as medicaments 失效
    用于生产微溶碱性肽复合物的无菌悬浮液，微溶性碱性肽复合物的无菌悬浮液，含有它们的药物制剂及其作为药物的用途的方法

    公开(公告)号：US07871977B2

    公开(公告)日：2011-01-18

    申请号：US11304548

    申请日：2005-12-16

    申请人： Matthias Rischer ,  Horst Mueller ,  Karl Werner ,  Juergen Engel

    发明人： Matthias Rischer ,  Horst Mueller ,  Karl Werner ,  Juergen Engel

    IPC分类号： A01N37/18 ,  A61K38/00

    CPC分类号： A61K9/19 ,  A61K9/0019 ,  A61K9/10 ,  A61K31/19 ,  A61K38/09 ,  A61K47/26 ,  G06F19/00 ,  A61K2300/00

    摘要： The present invention provides a novel process for producing sterile suspensions of slightly soluble basic peptide complexes. The present invention further provides a novel process for producing sterile lyophilizates of slightly soluble basic peptide complexes. In addition, a novel process for producing sterile suspensions suitable for the parenteral administration of slightly soluble basic peptide complexes is provided. The invention moreover provides sterile suspensions and sterile lyophilizates of slightly soluble basic peptide complexes, and pharmaceutical formulations comprising them. The provided sterile suspensions, sterile lyophilizates and pharmaceutical formulations comprising them are particularly suitable for use in a parenteral dosage form as medicaments for the treatment and prophylaxis of diseases and pathological states in mammals, especially in humans.

    摘要翻译： 本发明提供了一种生产微溶性碱性肽复合物的无菌悬浮液的新方法。 本发明还提供了用于生产微溶性碱性肽复合物的无菌冻干物的新方法。 此外，提供了一种用于生产适于胃肠外施用微溶性碱性肽复合物的无菌悬浮液的新方法。 此外，本发明提供了无菌悬浮液和微溶性碱性肽复合物的无菌冻干物，以及包含它们的药物制剂。 提供的无菌悬浮液，无菌冻干物和包含它们的药物制剂特别适用于肠胃外剂型，作为用于治疗和预防哺乳动物，特别是人的疾病和病理状态的药物。