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公开(公告)号：US10385317B2
公开(公告)日：2019-08-20
申请号：US13483379
申请日：2012-05-30
申请人： Beth Shaz , Christopher D. Hillyer
发明人： Beth Shaz , Christopher D. Hillyer
IPC分类号： G01N33/80 , C12N5/078 , A61K35/14 , A61M1/02 , A01N1/02 , A61K35/16 , A61K35/18 , A61K35/19 , A61M1/34
摘要： The disclosure provides methods of making a red blood cell, plasma, and platelet products having a uniform dose and volume. The method comprises pooling a plurality of blood units, leukoreducing the blood and inactivating any pathogen contained therein. Plasma, RBCs, and platelets are then divided into uniform dose and volume units which have an extended shelf life.
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公开(公告)号：US20120252001A1
公开(公告)日：2012-10-04
申请号：US13483379
申请日：2012-05-30
申请人： Beth Shaz , Christopher D. Hillyer
发明人： Beth Shaz , Christopher D. Hillyer
IPC分类号： A01N1/02
CPC分类号： C12N5/0641 , A01N1/02 , A01N1/021 , A01N1/0226 , A61K35/14 , A61K35/16 , A61K35/18 , A61K35/19 , A61M1/0272 , A61M1/342 , A61M1/3496 , A61M2202/0429 , A61M2202/20 , C12N5/0644
摘要： The disclosure provides methods of making a red blood cell, plasma, and platelet products having a uniform dose and volume. The method comprises pooling a plurality of blood units, leukoreducing the blood and inactivating any pathogen contained therein. Plasma, RBCs, and platelets are then divided into uniform dose and volume units which have an extended shelf life.
摘要翻译： 本公开提供了制备具有均匀剂量和体积的红细胞，血浆和血小板产物的方法。 该方法包括汇集多个血液单元，白细胞减少血液并灭活其中所含的任何病原体。 然后将血浆，红细胞和血小板分成具有延长的保质期的均匀剂量和体积单位。
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公开(公告)号：US08512942B2
公开(公告)日：2013-08-20
申请号：US13306759
申请日：2011-11-29
IPC分类号： A01N1/02
CPC分类号： C12N5/0641 , A01N1/02 , A01N1/021 , A01N1/0226 , A61K35/14 , A61K35/16 , A61K35/18 , A61K35/19 , A61M1/0272 , A61M1/342 , A61M1/3496 , A61M2202/0429 , A61M2202/20 , C12N5/0644
摘要： The disclosure provides methods of making a cell-containing product having a uniform amount of cells therein. The method comprises pooling red blood cells from a plurality of blood units, and inactivating any pathogen contained therein. A storage solution added to the cellular component results in a cell-containing product that is essentially pathogen and white blood cell free and has an extended shelf life of about 42 to about 100 days. The cell-containing product is further divided into units which comprise a uniform dose of RBCs per unit.
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公开(公告)号：US20120135391A1
公开(公告)日：2012-05-31
申请号：US13306759
申请日：2011-11-29
IPC分类号： C12N5/078
CPC分类号： C12N5/0641 , A01N1/02 , A01N1/021 , A01N1/0226 , A61K35/14 , A61K35/16 , A61K35/18 , A61K35/19 , A61M1/0272 , A61M1/342 , A61M1/3496 , A61M2202/0429 , A61M2202/20 , C12N5/0644
摘要： The disclosure provides methods of making a cell-containing product having a uniform amount of cells therein. The method comprises pooling red blood cells from a plurality of blood units, and inactivating any pathogen contained therein. A storage solution added to the cellular component results in a cell-containing product that is essentially pathogen and white blood cell free and has an extended shelf life of about 42 to about 100 days. The cell-containing product is further divided into units which comprise a uniform dose of RBCs per unit.
摘要翻译： 本公开提供了制备其中具有均匀量的细胞的含细胞产物的方法。 所述方法包括从多个血液单元汇集红细胞，并灭活其中所含的任何病原体。 添加到细胞组分中的储存溶液导致基本上是病原体和无白血球的含细胞产物，并且具有约42至约100天的延长的保质期。 含细胞的产物进一步分为每单位含有均匀剂量的RBC的单位。
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公开(公告)号：US07425309B2
公开(公告)日：2008-09-16
申请号：US10602981
申请日：2003-06-24
IPC分类号： G01N33/00
CPC分类号： G01N35/028 , B01L3/5025 , B01L3/50255 , B01L2200/16 , B01L2300/0829 , B01L2300/0851 , G01N2035/00356 , G01N2035/00485 , G01N2035/0097
摘要： An immunological or immunohematological assay system is disclosed that includes a vessel capable of containing an assay sample, an incubator, a sample separation system, an image acquisition system, and a pipettor. The immunological assay system may also include a washer. Also disclosed is an immunological assay method that includes the steps of placing a immunological assay sample in a vessel, which may include a filter; adding testing reagents to the vessel; incubating the sample and reagent mixture in the vessel; separating the sample and reagent mixture in the vessel into components that have and have not reacted; and analyzing the vessel to determine the presence of interactions between the sample and reagents. The bottom of the vessel is preferably of a material that aids in spreading out the reacted components of the sample evenly over the bottom of the vessel so that interactions can more easily be analyzed.
摘要翻译： 公开了免疫或免疫血液学测定系统，其包括能够包含测定样品，培养箱，样品分离系统，图像采集系统和移液器的容器。 免疫测定系统还可以包括洗衣机。 还公开了一种免疫测定方法，其包括将免疫测定样品置于容器中的步骤，容器可以包括过滤器; 向该容器加入测试试剂; 将样品和试剂混合物孵育在容器中; 将容器中的样品和试剂混合物分离成具有且没有反应的组分; 并分析血管以确定样品和试剂之间的相互作用的存在。 容器的底部优选是有助于将样品的反应组分均匀地扩散到容器底部的材料，使得可以更容易地分析相互作用。
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公开(公告)号：US07713708B2
公开(公告)日：2010-05-11
申请号：US11679589
申请日：2007-02-27
IPC分类号： G01N33/53
CPC分类号： B01L3/50255 , B01L3/5025 , B01L2300/0829 , B01L2300/0851 , G01N35/028 , G01N2035/00356 , G01N2035/00485 , G01N2035/0097 , Y10T436/11 , Y10T436/111666
摘要： An immunological or immunohematological assay system is disclosed that includes a filter vessel capable of containing an assay sample, an incubator, a sample separation system, an image acquisition system, and a robotic pipettor. The immunological assay system may also include a washer. Also disclosed is an immunological assay method that includes the steps of placing a immunological assay sample in a filter vessel, which includes a filter, adding testing reagents to the filter vessel, incubating the sample and reagent mixture in the filter vessel, separating the sample and reagent mixture in the filter vessel into components above and below the filter, and analyzing the filter vessel to determine the presence of interactions between the sample and reagents.
摘要翻译： 公开了免疫学或免疫血液学测定系统，其包括能够包含测定样品，培养箱，样品分离系统，图像采集系统和机器人移液器的过滤器容器。 免疫测定系统还可以包括洗衣机。 还公开了一种免疫测定方法，其包括以下步骤：将免疫测定样品置于过滤容器中，所述过滤容器包括过滤器，向过滤器容器中加入测试试剂，将样品和试剂混合物孵育在过滤容器中，分离样品和 将过滤容器中的试剂混合物转化成过滤器上方和下方的组分，并分析过滤器容器以确定样品与试剂之间的相互作用的存在。
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公开(公告)号：US07189357B2
公开(公告)日：2007-03-13
申请号：US09773826
申请日：2001-01-31
IPC分类号： G01N35/00
CPC分类号： B01L3/50255 , B01L3/5025 , B01L2300/0829 , B01L2300/0851 , G01N35/028 , G01N2035/00356 , G01N2035/00485 , G01N2035/0097 , Y10T436/11 , Y10T436/111666
摘要： An immunological or immunohematological assay system is disclosed that includes a filter vessel capable of containing an assay sample, an incubator, a sample separation system, an image acquisition system, and a robotic pipettor. The immunological assay system may also include a washer. Also disclosed is an immunological assay method that includes the steps of placing a immunological assay sample in a filter vessel, which includes a filter, adding testing reagents to the filter vessel, incubating the sample and reagent mixture in the filter vessel, separating the sample and reagent mixture in the filter vessel into components above and below the filter, and analyzing the filter vessel to determine the presence of interactions between the sample and reagents.
摘要翻译： 公开了免疫学或免疫血液学测定系统，其包括能够包含测定样品，培养箱，样品分离系统，图像采集系统和机器人移液器的过滤器容器。 免疫测定系统还可以包括洗衣机。 还公开了一种免疫测定方法，其包括以下步骤：将免疫测定样品置于过滤容器中，所述过滤容器包括过滤器，向过滤器容器中加入测试试剂，将样品和试剂混合物孵育在过滤容器中，分离样品和 将过滤容器中的试剂混合物转化成过滤器上方和下方的组分，并分析过滤器容器以确定样品与试剂之间的相互作用的存在。
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