摘要:
The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine containing nucleic acids encoding HIV-1 gag mosaic proteins, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.
摘要:
The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.
摘要:
The present invention relates to nucleic acids encoding mosaic clade M HIV-1 Env polypeptides and to compositions and vectors comprising same. The nucleic acids of the invention are suitable for use in inducing an immune response to HIV-1 in a human.
摘要:
The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.
摘要:
The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.
摘要:
The present invention relates to mosaic clade M HIV-1 Env polypeptides and to compositions comprising same. The polypeptides of the invention are suitable for use in inducing an immune response to HIV-1 in a human.
摘要:
The present invention relates to an on-line application for advertising. More specifically, the present invention relates to an on-line portion or a web-based application that allows an artist working on an advertisement or other artistic work to provide a client with a preview of the advertisement. The application permits the client to provide comments directly, efficiently, and securely back to the artist. The client may highlight the areas that need modification, and may permit the client to add comments, files, renders, or other annotations to the artistic work.
摘要:
A method for forming within a reactor having a work zone of at least one cubic meter, composite articles particularly ceramic composites articles, for high temperature applications. The invention provides composite articles formed from the deposition on hot surfaces of a chemical vapor having entrained solid particles. A composite material is produced comprising a chemical vapor deposition matrix with the solid particles dispersed within the matrix. Applicants have designed reactors with work zones much larger than prior art CVC reactors greatly improving production efficiency. In a preferred embodiment the work zone volume is about 3.37 cubic meters. By carefully controlling the reactor gas flows and pressure within a large work zone, as well as the number of solid particles per flow rate of reactor gas, Applicants are able to efficiently produce composites with substantially improved quality as compared with CVD produced articles and as compared with articles produced with prior art CVC processes.
摘要:
Oxidation protection of a titanium-based alloy is provided with improved fatigue properties by a titanium aluminide coating of between 2 to 12 microns by diffusing the Al into the Ti at a temperature below the melting point of the Al. The coating is gas deposited and protects the titanium-based alloys from oxidation at high temperature utilization.
摘要:
A marine riser, which is hung from a drilling platform floating on a body of water and connected at its lower end to a wellhead, is buoyantly tensioned by one or more float cans with open bottoms. These float cans are connected at their upper end to the riser to which air under pressure is controllably supplied. The pressurized air blows out the water in each can to achieve the desired buoyancy. The float can may having an air dump valve interconnected with similar valves in the other cans. The function of these valves is to release the pressurized air in the can if the riser parts. At the upper end of the riser is a slip joint, which may include safety water-dampening gear to further reduce upward motion of a parted riser. The optional dampening gear comprises an annular piston formed by the upper section of the slip joint that forces water through ports in the exterior of the lower section of the slip joint as the riser below the slip joint moves upward. A method of running this riser includes the steps of lowering the riser with or without: the air under pressure flowing into the float cans, a ballast weight at the bottom end of the riser, and supplementary tensioning or motion compensating equipment. The riser's descent may be stopped at a point above a water bottom connector at which time motion compensating equipment may be engaged and then gradually lowered to make the connection. The foregoing is reversed when removing the riser from the water bottom connection.