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    High purity imidazoline-based amphoacetate surfactants
    1.
    发明授权
    High purity imidazoline-based amphoacetate surfactants 有权
    高纯度咪唑啉基二乙酸酯表面活性剂

    公开(公告)号：US6057282A

    公开(公告)日：2000-05-02

    申请号：US378841

    申请日：1999-08-23

    申请人： Bharat Desai ,  Peter Lees ,  Jean-Marc Ricca ,  David J. Tracy

    发明人： Bharat Desai ,  Peter Lees ,  Jean-Marc Ricca ,  David J. Tracy

    IPC分类号： A61K8/00 ,  A61K8/40 ,  A61K8/44 ,  A61K8/49 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q19/10 ,  B01F17/00 ,  B01F17/16 ,  B01F17/22 ,  B01F17/28 ,  C07C233/36 ,  C07C233/38 ,  C07D233/02 ,  C07D233/04 ,  C07D233/14 ,  C11D1/40 ,  C11D1/88 ,  C11D3/43 ,  C11D7/32 ,  C11D7/50 ,  B01F17/18 ,  B01F17/32

    CPC分类号： C11D7/5022 ,  A61K8/442 ,  A61K8/4946 ,  A61Q19/10 ,  A61Q5/02 ,  B01F17/0042 ,  B01F17/0085 ,  C07C233/36 ,  C07C233/38 ,  C07D233/02 ,  C11D1/40 ,  C11D1/88 ,  C11D3/43 ,  C11D7/3209 ,  C11D7/3218 ,  C11D7/5013 ,  C11D7/5018 ,  Y10S516/915

    摘要： Imadazoline-based amphoacetates of higher purity, containing essentially negligible amounts of unalkylated amido amines, lower amounts of glycolic acid salts and monochloroacetate salts, superior to currently available conventional amphoacetates, are provided. This is demonstrated by their improved surface-active properties. Lower inherent irritation properties may be expected due to improved purity.The higher purity amphoacetates can be obtained via processes utilizing precise pH control during the reaction of imidazoline, or its open-chain derivatives, with alkylating agents, e.g. sodium monochloroacetate. The pH can be controlled by adding the base slowly or automatically in response to a pH metering device to maintain a constant pH, or by a series of staged additions which are calculated to maintain pH within a stated range. The reaction may also be carried out by conducting the initial hydrolysis of the imidazoline ring structure, followed by alkylation. These higher-purity amphoacetates contain essentially fully alkylated products and lower amounts of glycolic acid derivatives, even though a ratio of SMCA to substituted imidazoline, or its open-ring derivative, of less than 1.5:1.0 and close to 1.0:1.0 is used.

    摘要翻译： 提供了更高纯度的基于咪达唑啉的两性乙酸盐，其含有基本上可忽略量的未烷基化的酰胺胺，较低量的乙醇酸盐和一氯乙酸盐，优于现有常规的两性乙酸盐。 这通过其改进的表面活性特性证明。 由于纯度的提高，预期会降低固有的刺激性能。 可以通过在咪唑啉或其开链衍生物与烷基化试剂反应期间利用精确的pH控制的方法获得较高纯度的两性乙酸酯。 一氯乙酸钠。 可以通过缓慢或自动地加入碱来控制pH，以响应于pH计量装置以保持恒定的pH，或通过一系列分级添加剂来计算，以将pH保持在规定范围内。 该反应也可以通过进行咪唑啉环结构的初始水解，然后进行烷基化来进行。 尽管SMCA与取代的咪唑啉或其开环衍生物的比例小于1.5：1.0且接近1.0：1.0，但这些较高纯度的两性乙酸盐基本上含有完全烷基化产物和较少量的乙醇酸衍生物。

    Process for the preparation of high purity imidazoline based amphoacetate surfactants
    2.
    发明授权
    Process for the preparation of high purity imidazoline based amphoacetate surfactants 失效
    制备高纯度咪唑啉基二乙酸酯表面活性剂的方法

    公开(公告)号：US5952291A

    公开(公告)日：1999-09-14

    申请号：US55368

    申请日：1998-04-06

    申请人： Bharat Desai ,  Peter Lees ,  Jean-Marc Ricca ,  David J. Tracy

    发明人： Bharat Desai ,  Peter Lees ,  Jean-Marc Ricca ,  David J. Tracy

    IPC分类号： A61K8/00 ,  A61K8/40 ,  A61K8/44 ,  A61K8/49 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q19/10 ,  B01F17/00 ,  B01F17/16 ,  B01F17/22 ,  B01F17/28 ,  C07C233/36 ,  C07C233/38 ,  C07D233/02 ,  C07D233/04 ,  C07D233/14 ,  C11D1/40 ,  C11D1/88 ,  C11D3/43 ,  C11D7/32 ,  C11D7/50 ,  B01F17/32

    CPC分类号： C11D7/5022 ,  A61K8/442 ,  A61K8/4946 ,  A61Q19/10 ,  A61Q5/02 ,  B01F17/0042 ,  B01F17/0085 ,  C07C233/36 ,  C07C233/38 ,  C07D233/02 ,  C11D1/40 ,  C11D1/88 ,  C11D3/43 ,  C11D7/3209 ,  C11D7/3218 ,  C11D7/5013 ,  C11D7/5018 ,  Y10S516/915

    摘要： Imadazoline-based amphoacetates of higher purity, containing essentially negligible amounts of unalkylated amido amines, lower amounts of glycolic acid salts and monochloroacetate salts, superior to currently available conventional amphoacetates, are provided. This is demonstrated by their improved surface-active properties. Lower inherent irritation properties may be expected due to improved purity.The higher purity amphoacetates can be obtained via processes utilizing precise pH control during the reaction of imidazoline, or its open-chain derivatives, with alkylating agents, e.g. sodium monochloroacetate. The pH can be controlled by adding the base slowly or automatically in response to a pH metering device to maintain a constant pH, or by a series of staged additions which are calculated to maintain pH within a stated range. The reaction may also be carried out by conducting the initial hydrolysis of the imidazoline ring structure, followed by alkylation. These higher-purity amphoacetates contain essentially fully alkylated products and lower amounts of glycolic acid derivatives, even though a ratio of SMCA to substituted imidazoline, or its open-ring derivative, of less than 1.5:1.0 and close to 1.0:1.0 is used.

    摘要翻译： 提供了更高纯度的基于咪达唑啉的两性乙酸盐，其含有基本上可忽略量的未烷基化的酰胺胺，较低量的乙醇酸盐和一氯乙酸盐，优于现有常规的两性乙酸盐。 这通过其改进的表面活性特性证明。 由于纯度的提高，预期会降低固有的刺激性能。 可以通过在咪唑啉或其开链衍生物与烷基化试剂反应期间利用精确的pH控制的方法获得较高纯度的两性乙酸酯，例如。 一氯乙酸钠。 可以通过缓慢或自动地加入碱来控制pH，以响应于pH计量装置以保持恒定的pH，或通过一系列分级添加剂来计算，以将pH保持在规定范围内。 该反应也可以通过进行咪唑啉环结构的初始水解，然后进行烷基化来进行。 尽管SMCA与取代的咪唑啉或其开环衍生物的比例小于1.5：1.0且接近1.0：1.0，但这些较高纯度的两性乙酸盐基本上含有完全烷基化产物和较少量的乙醇酸衍生物。